Protein Alignment Prp16 and DHX29

DIOPT Version :10

• Sequence 1: NP_572947.1
• Gene: Prp16 / 32373
• FlyBaseID: FBgn0026713
• Length: 1222
• Species: Drosophila melanogaster
• Sequence 2: NP_061903.2
• Gene: DHX29 / 54505
• HGNCID: 15815
• Length: 1369
• Species: Homo sapiens
• Alignment Length: 1306
• Identity: 298/1306 - (22%)
• Similarity: 533/1306 - (40%)
• Gaps: 338/1306 - (25%)

  Fly    44 QGSMLGLDKLAAKRRAEKERSERLISFKDSEFDDT-------GGG----------SSTPQANASG 91
            :|.:.|  :|.||:..:...:.:..|||..:.:|.       ||.          :.:..|...|
Human   112 KGMISG--RLTAKKLQDLYMALQAFSFKTKDIEDAMTNTLLYGGDLHSALDWLCLNLSDDALPEG 174

  Fly    92 ASSEFAFKKPDTKSFEKLRGQLREHKDDTPSHTGGVSEKARERLREHIQRDRKRGPVSSTAAEGR 156
            .|.||..::|.::.           |..:|.....:|...:.:.:.:     :..|.|....|.:
Human   175 FSQEFEEQQPKSRP-----------KFQSPQIQATISPPLQPKTKTY-----EEDPKSKPKKEEK 223

  Fly   157 DRD---RDWDRDRRRDRDRDRDRDRDRRQHRERERDRHRSWDRDRGRDRDRDRSMSERSVHTPRE 218
            :.:   ::|..             |...|..|.|::     :..:..:.:.....:||.:|
Human   224 NMEVNMKEWIL-------------RYAEQQNEEEKN-----ENSKSLEEEEKFDPNERYLH---- 266

  Fly   219 PGTPGGSSGGISNSSWD--DEDGEFGQRKSDWDMPTPRRHGNKSGDWSVRSGGSRRNHGRQDDTV 281
                      ::....|  ::...|...|:        :.|.|.....:      |...|:.:|:
Human   267 ----------LAAKLLDAKEQAATFKLEKN--------KQGQKEAQEKI------RKFQREMETL 307

  Fly   282 RPTP--------AHRYNQWAHGRKRSGATPWGEDPESLDLWE------EEQRRLDREWYNIDEGY 332
            ...|        :|:.|:    ||:......||...:.:|:|      ||::...:|.::: ..:
Human   308 EDHPVFNPAMKISHQQNE----RKKPPVATEGESALNFNLFEKSAAATEEEKDKKKEPHDV-RNF 367

  Fly   333 DDENNPFGGPNSEYF-----RKREEQLEQKRTKRISAQQRQNNRDNELWE-RNRMLTSGVVTLIS 391
            |.....:.|.:.:.|     ||...:......:::..        ...|: |.|::.|....|:.
Human   368 DYTARSWTGKSPKQFLIDWVRKNLPKSPNPSFEKVPV--------GRYWKCRVRVIKSEDDVLVV 424

  Fly   392 VNDDFDEEALERVHL-------------LVHHIIPPFLDGRIVFTKQPEPVVPVKDPTSDMALLA 443
            ......|:.::..||             .||.::||
Human   425 CPTILTEDGMQAQHLGATLALYRLVKGQSVHQLLPP----------------------------- 460

  Fly   444 RKGSALVRNYRE-QKERRKAQKKHWELSGTK--------LGNIMGVQRPQDEDDMRFDKEKDKAD 499
                    .||: ..|...|:||..||:..:        :..::...:.|.:...:..:.|.:..
Human   461 --------TYRDVWLEWSDAEKKREELNKMETNKPRDLFIAKLLNKLKQQQQQQQQHSENKRENS 517

  Fly   500 YRKDQKFADHMRDQDTGGKS-------------DFSRK-------KTISEQRRFLPVFASRQELL 544
            ...::.:.:.:.|:|....|             :..||       :.:.::|:.||||..|..::
Human   518 EDPEESWENLVSDEDFSALSLESANVEDLEPVRNLFRKLQSTPKYQKLLKERQQLPVFKHRDSIV 582

  Fly   545 NVIRENSVIIIVGETGSGKTTQLTQYLHED------GYSKRGMIGCTQPRRVAAMSVAKRVSDEM 603
            ..::.:.|:::.|||||||:||:..:|.||      ..||..:: ||||||::|:|:|.||.||:
Human   583 ETLKRHRVVVVAGETGSGKSTQVPHFLLEDLLLNEWEASKCNIV-CTQPRRISAVSLANRVCDEL 646

  Fly   604 DTQLGED-----VGYAIRFEDCTSERTVIKYMTDGILLRESLRDPELDSYSAIIMDEAHERSLST 663
            ..:.|..     .||.||.|....|.|.:.|.|.|:|||:...|..|.:.|.:|:||.||||:.:
Human   647 GCENGPGGRNSLCGYQIRMESRACESTRLLYCTTGVLLRKLQEDGLLSNVSHVIVDEVHERSVQS 711

  Fly   664 DVLFGLLREIVARRHDLKLIVTSATMDSSKFATFFGNVPTFTIPGRTFPVDV------------M 716
            |.|..:|:||:.:|.||.||:.|||:||.||:|:|.:.|...|.||::||:|            :
Human   712 DFLLIILKEILQKRSDLHLILMSATVDSEKFSTYFTHCPILRISGRSYPVEVFHLEDIIEETGFV 776

  Fly   717 FSKNT--CEDYVESAVKQALQV----------------------------------------HLT 739
            ..|::  |:.::|...:..:.|                                        ::.
Human   777 LEKDSEYCQKFLEEEEEVTINVTSKAGGIKKYQEYIPVQTGAHADLNPFYQKYSSRTQHAILYMN 841

  Fly   740 PN-----------------------EGDMLIFMPGQEDIEVTCEVL-------EERLAEIDNAPA 774
            |:                       ||.:|||:||...|:...::|       .||
Human   842 PHKINLDLILELLAYLDKSPQFRNIEGAVLIFLPGLAHIQQLYDLLSNDRRFYSER--------- 897

  Fly   775 LSILPIYSQLPSDLQAKIFQKSSDGLRKCVVATNIAETSLTVDGIIYVIDSGYCKLKVYNPRIGM 839
            ..::.::|.|.:..||..|.....|:||.|:|||||||.:|:..:::|||:|..|...|:....|
Human   898 YKVIALHSILSTQDQAAAFTLPPPGVRKIVLATNIAETGITIPDVVFVIDTGRTKENKYHESSQM 962

  Fly   840 DALQIYPISQANANQRSGRAGRTGPGQAYRLYTQRQYKDELLALTVPEIQRTNLANTVL-LLK-S 902
            .:|....:|:|:|.||.|||||...|..:|:||:.:: :..:..:||||.|..|....| ::| :
Human   963 SSLVETFVSKASALQRQGRAGRVRDGFCFRMYTRERF-EGFMDYSVPEILRVPLEELCLHIMKCN 1026

  Fly   903 LGVVDLLQFHFMDPPPQDNILNSLYQLWILGALD-HTGALTTLGRQMAEFPLDPPQCQMLIVACR 966
            ||..:......:|||....|.|::..|..:||.: :...||.||:.:|..|::....:|||....
Human  1027 LGSPEDFLSKALDPPQLQVISNAMNLLRKIGACELNEPKLTPLGQHLAALPVNVKIGKMLIFGAI 1091

  Fly   967 MGCSAEVLIIVSMLSVPSIFYRPKGREDEADGVREKFQRPESDHLTYLNVYQQWR----QNNYSS 1027
            .||...|..:.::::..|.|..|.||:||||..:......:|||||..|.|..|:    :..|.|
Human  1092 FGCLDPVATLAAVMTEKSPFTTPIGRKDEADLAKSALAMADSDHLTIYNAYLGWKKARQEGGYRS 1156

  Fly  1028 --TWCNEHFIHIKAMRKVREVRQQLKDIMTQQNLSVISCGIDWDIVRKCICSAYFYQAARLKGI- 1089
              |:|..:|::..::..:.:|:|:|..::.....|..:....|: ..:...:..|.:.|.||.:
Human  1157 EITYCRRNFLNRTSLLTLEDVKQELIKLVKAAGFSSSTTSTSWE-GNRASQTLSFQEIALLKAVL 1220

  Fly  1090 --GEY-----------VNLRTGMPC---------HLHPTSALYGLGTTPDYVVYHELIMTAKEYM 1132
              |.|           |::...:.|         .:||:|....| .|..:::|.|.|..|:.|:
Human  1221 VAGLYDNVGKIIYTKSVDVTEKLACIVETAQGKAQVHPSSVNRDL-QTHGWLLYQEKIRYARVYL 1284

  Fly  1133 QCATAV 1138
            :..|.:
Human  1285 RETTLI 1290

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Prp16	NP_572947.1	HrpA	534..>1148	CDD:441249	214/732 (29%)
DHX29	NP_061903.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	27..75
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	176..226		10/65 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	502..526		2/23 (9%)
		HrpA	571..>1271	CDD:441249	208/712 (29%)
		DEXHc_DHX29	572..754	CDD:350733	77/182 (42%)
		DEAH box. /evidence=ECO:0000255|HAMAP-Rule:MF_03068	702..705		2/2 (100%)