DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(1)G0007 and Dhx32

DIOPT Version :9

Sequence 1:	NP_572947.1	Gene:	l(1)G0007 / 32373	FlyBaseID:	FBgn0026713	Length:	1222	Species:	Drosophila melanogaster
Sequence 2:	NP_001123511.1	Gene:	Dhx32 / 361667	RGDID:	1311740	Length:	751	Species:	Rattus norvegicus

Alignment Length:	735	Identity:	216/735 - (29%)
Similarity:	388/735 - (52%)	Gaps:	56/735 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   480 VQRPQDEDDMR----------FDKEKDKADYRKDQKFA-DHMRDQDTGGKSDFSRKKTISEQRRF 533
            ::...||:::.          |.:..|.:|..::...| :.:......|....||...:.::|..
  Rat     4 LREEMDEEELEHPNASPEKRYFPESLDSSDGDEEGVLACEDLELNPFDGLPYSSRYYKLLKEREE 68

  Fly   534 LPVFASRQELLNVIRENSVIIIVGETGSGKTTQLTQYLHEDGYS---KRGMIGCTQPRRVAAMSV 595
            ||::..:...:..:.:|.|:::.|::..||::|:.|:..|...|   :.|.:.|||..:..|:.:
  Rat    69 LPIWKEKYSFMESLLQNQVVLVSGDSKCGKSSQVPQWCAEYCLSIHYQHGGVICTQVHKQTAVQL 133

  Fly   596 AKRVSDEMDTQLGEDVGYAIRFEDCTSERTVIKYMTDGILLRESLRDPELDSYSAIIMDEAHERS 660
            |.||:||||..:|.:|||.|.||:|.:..|:::|.||.:|.||.:.:|.|.||..||:|:.||||
  Rat   134 ALRVADEMDVNIGHEVGYVIPFENCCTTETILRYCTDDMLQREMMSNPFLGSYGVIILDDVHERS 198

  Fly   661 LSTDVLFGLLREIVARRHDLKLIVTSATMDSSKFATFFGNVPTFTIPGRTFPVDVMFSKNTCEDY 725
            |:||||.|||::::..|.:||||:..:....|:.::::||||...:..: .||:|::.....:|.
  Rat   199 LATDVLLGLLKDVLLARPELKLIINCSPFLISRLSSYYGNVPLLEVRNK-HPVEVVYLSGAQKDP 262

  Fly   726 VESAVKQALQVHLTPNEGDMLIFMPGQEDIEVTCEVLEERLAEID-NAPALSILPIYSQ------ 783
            .||.|:...::|.:..:||:::|:..::|||.|.|::.:..:.:: :...|.::|:|.:
  Rat   263 FESVVRLIFEIHRSGEQGDVVVFLACEQDIEKTYEIVCQEGSNLNPDVGELVVIPLYPKEKCSLF 327

  Fly   784 LPSDLQAKIFQKSSDGLRKCVVATNIAETSLTVDGIIYVIDSGYCKLKVYNPRIGMDALQIYPIS 848
            .|.|...|..|.|.   |:.|:.|:..|:.:....:.:|||.|..:.:||||||..::|.:.|||
  Rat   328 RPVDETEKRCQASQ---RRVVLTTSCGESLIWSHTVRFVIDVGLERRQVYNPRIRANSLVLQPIS 389

  Fly   849 QANANQRSGRAGRTGPGQAYRLYTQRQYKDELLALTVPEIQRTNLANTVLLLKSLGVVDLLQFHF 913
            |:.|..|....|.:..|:.:.|||:.....::..|...|:|..||.:.||.:|.:.:..|.:..|
  Rat   390 QSQAEIRKQLLGSSPSGKLFCLYTEEFASKDMRPLKPAEMQEANLTSMVLFMKRVDIAGLGRCDF 454

  Fly   914 MDPPPQDNILNSLYQLWILGALDHTGALTTLGRQMAEFPLDPPQCQMLIVACRMGCSAEVLIIVS 978
            |:.|..::::.:|..|..|.|||:.|.|:..|..|:||||||...:.::.:|...|..|:|.|.:
  Rat   455 MNRPAPESLMQALEDLDYLAALDNDGNLSEFGIIMSEFPLDPQLSKSILASCEFDCVDEMLTIAA 519

  Fly   979 MLSVPSIF-YRPKGREDEADGVREKFQRPESDHLTYLNVYQQWRQNNYSS-------TWCNEHFI 1035
            |::.||.| :.|.|.|:.|....:.|..||.||.|.:|:|..::....:|       |||:..|:
  Rat   520 MVTAPSCFLHVPHGAEEAAVTCWKTFLHPEGDHFTLINIYNAYQDTVLNSANEHCVETWCHNCFL 584

  Fly  1036 HIKAMRKVREVRQQLKDIM-------------TQQNLSVISCGIDWDIVRKCICSAYFYQAAR-L 1086
            ...|:|....:|.:|.:|:             :|:|      |::   ::|.:.|.||.|.|| :
  Rat   585 SCSALRMADVIRAELLEIIKRIELPYAEPAFGSQEN------GLN---IKKALLSGYFMQIARDV 640

  Fly  1087 KGIGEYVNLRTGMPCHLHPTSALYGLGTTPDYVVYHELIMTAKEYMQCATAVDGYWLAELGPMFF 1151
            .|.|.|:.|.......|||.|:.......|::|::|:..::...|::..:||......:|.|.::
  Rat   641 DGSGNYLMLTHKQVAQLHPLSSYAITKKMPEWVLFHQFSISENNYIRVTSAVSPELFMQLVPQYY 705

  Fly  1152 SVKESGRSGREKKKQAAEHL 1171
            .........::..:||:.||
  Rat   706 FSNLPPSESKDILQQASGHL 725

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(1)G0007	NP_572947.1	DEXDc	529..715	CDD:214692	70/188 (37%)
		DEXDc	551..689	CDD:238005	59/140 (42%)
		HELICc	722..870	CDD:238034	44/154 (29%)
		HA2	932..1014	CDD:214852	33/82 (40%)
		OB_NTP_bind	1048..1148	CDD:285018	27/113 (24%)
Dhx32	NP_001123511.1	HrpA	19..687	CDD:224557	206/680 (30%)
		DEXDc	86..202	CDD:238005	47/115 (41%)
		HA2	472..556	CDD:214852	33/83 (40%)
		OB_NTP_bind	597..704	CDD:285018	28/115 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D113216at33208
OrthoFinder	1	1.000	-	-		FOG0000059
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820