DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(1)G0007 and dhx16

DIOPT Version :9

Sequence 1:	NP_572947.1	Gene:	l(1)G0007 / 32373	FlyBaseID:	FBgn0026713	Length:	1222	Species:	Drosophila melanogaster
Sequence 2:	NP_956318.1	Gene:	dhx16 / 336645	ZFINID:	ZDB-GENE-030131-8589	Length:	1054	Species:	Danio rerio

Alignment Length:	1169	Identity:	430/1169 - (36%)
Similarity:	628/1169 - (53%)	Gaps:	219/1169 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 KVPQGSMLGLDKLAAKRRA-EKERSERLIS-FKDSEFDDTGGGSSTPQANASGASSEFAFKKPDT 103
            |.|:..::.....|.:|:. |.||..|..: .:|||.|.        :|...|...    ||...
Zfish    66 KAPKKHVVEKPARAIERQVMEMERKNRTYTLLEDSESDG--------EAAREGGKE----KKSKE 118

  Fly   104 KSFEKLRGQLREHKDDTPSHTGGVSEKARERLREHIQRDRKRGPVSSTAAEGRDRDRDWDRDRRR 168
            :...|.|..||:.:|::||.    ||:.:::........:|.|       :..:.:.:|:|.
Zfish   119 RDKGKKRKHLRQKRDESPSS----SEEDKKKSITFKDEPKKAG-------KEDEEEEEWERG--- 169

  Fly   169 DRDRDRDRDRDRRQHRERERDRHRSWDRDRGRDRDRDRSMSERSVHTPREPGTPGGSSGGISNSS 233
                    :|:|.|..| |||...  :|.:.:|:|:.|::.||:.....|...        ....
Zfish   170 --------ERERLQDLE-ERDAFA--ERVKQKDKDKTRNILERNDKKAYEEAQ--------KRIK 215

  Fly   234 WDDEDGEFGQRKSDWDMPTPRRHGNKSGDWSVRSGGSRRNHGRQDDTVRPTPAHRYNQWAHGRKR 298
            ..:||    :||.   :|..|:.             |||.:
Zfish   216 MAEED----KRKM---LPELRKQ-------------SRRQY------------------------ 236

  Fly   299 SGATPWGEDPESLDLWEEEQRRLDREWYNIDEGYDDENNPFGGPNSEYFRKRE-EQLEQKRTKRI 362
                          |.:.||.:|:    :::....||...|...|   ...|| :.||.|||.|.
Zfish   237 --------------LSKREQEKLE----DLEAEIKDEEYLFSTQN---LTDRERKDLEYKRTIRD 280

  Fly   363 SAQQRQNNRDNELWER-NRMLTSGVVTLISVNDDFDEEALERVHLLVHHIIPPFLDGRIVFTKQP 426
            .|::.:.....|..|| ||                             :.:|         .::.
Zfish   281 MAKEYKKAGAKEQEERKNR-----------------------------YYMP---------EEKR 307

  Fly   427 EPVVPVKDPTSDMALLARKG--------------SALVRNYREQKERR-KAQKKHWELSGTKLGN 476
            ...:|.||...:.....|:|              :.|....|:::||| |.:::.::|
Zfish   308 NKSIPQKDMDLEFEETPREGGGEQGRWEEARVATATLQFGARQERERRIKEEQERYQL------- 365

  Fly   477 IMGVQRPQDEDDM------------RFDKEKDKADYRKDQKFADHMRDQDTGGKSDFSRKKTISE 529
            |:      :|::|            ...:::.:.:..:.:|                 :|::|.|
Zfish   366 IL------EEEEMITFVSTAITMKGTLSEKESEPELSQAEK-----------------QKQSIQE 407

  Fly   530 QRRFLPVFASRQELLNVIRENSVIIIVGETGSGKTTQLTQYLHEDGYSKRGM-IGCTQPRRVAAM 593
            .||.||:|..|::||..|.::.:::|.||||||||||:.|||.|:||:|.|| ||||||||||||
Zfish   408 VRRSLPIFPYREDLLAAIGDHQILVIEGETGSGKTTQIPQYLLEEGYTKGGMKIGCTQPRRVAAM 472

  Fly   594 SVAKRVSDEMDTQLGEDVGYAIRFEDCTSERTVIKYMTDGILLRESLRDPELDSYSAIIMDEAHE 658
            |||.||:.||..:||.:|||:|||||||||||::||||||:||||.|.:|:|.|||.||:|||||
Zfish   473 SVAARVAQEMSVKLGNEVGYSIRFEDCTSERTILKYMTDGMLLREFLTEPDLASYSVIIIDEAHE 537

  Fly   659 RSLSTDVLFGLLREIVARRHDLKLIVTSATMDSSKFATFFGNVPTFTIPGRTFPVDVMFSKNTCE 723
            |:|.||:||||:::|...|.|||::|.|||:|:.:|::||.:.|.|.||||.||||:.::|....
Zfish   538 RTLHTDILFGLIKDIARFRPDLKVLVASATLDTERFSSFFDDAPVFRIPGRRFPVDIYYTKAPEA 602

  Fly   724 DYVESAVKQALQVHLTPNEGDMLIFMPGQEDIEVTCEVLEERLAEI-DNAPALSILPIYSQLPSD 787
            ||:|:.|...||:|:|.:.||:|:|:.|||:||..||:|:||...: .....|.:||||:.||||
Zfish   603 DYLEACVVSVLQIHVTQSPGDVLVFLTGQEEIEACCELLQERCRRLGSKISELLVLPIYANLPSD 667

  Fly   788 LQAKIFQKSSDGLRKCVVATNIAETSLTVDGIIYVIDSGYCKLKVYNPRIGMDALQIYPISQANA 852
            :|||||..:..|.||.||||||||||||:||||||||.|:||.|.||.:.||::|.:.|.|:|:|
Zfish   668 MQAKIFNPTPPGARKVVVATNIAETSLTIDGIIYVIDPGFCKQKSYNAKTGMESLIVTPCSRASA 732

  Fly   853 NQRSGRAGRTGPGQAYRLYTQRQYKDELLALTVPEIQRTNLANTVLLLKSLGVVDLLQFHFMDPP 917
            |||:|||||...|:.:||||...:|.|:...||||||||||.|.||||||||:.||:.|.|||||
Zfish   733 NQRAGRAGRVAAGKCFRLYTAWAFKHEMEETTVPEIQRTNLGNVVLLLKSLGINDLIHFDFMDPP 797

  Fly   918 PQDNILNSLYQLWILGALDHTGALTTLGRQMAEFPLDPPQCQMLIVACRMGCSAEVLIIVSMLSV 982
            |.:.::.:|.||:.||||:|.|.||.|||:|||.|:||...:|::.:.:..||.|||.|.:||||
Zfish   798 PHETLVLALEQLYALGALNHLGELTKLGRRMAELPVDPMLSKMILASEQYKCSEEVLTIAAMLSV 862

  Fly   983 -PSIFYRPKGREDEADGVREKFQRPESDHLTYLNVYQQWRQNNYSSTWCNEHFIHIKAMRKVREV 1046
             .|||||||.:...||..|..|..|..|||..||||.||.::.||:.||.|:||..::|::.|:|
Zfish   863 NNSIFYRPKDKVVHADNARMNFVVPGGDHLVLLNVYTQWVESGYSTQWCFENFIQFRSMKRARDV 927

  Fly  1047 RQQLKDIMTQQNLSVISCGIDWDIVRKCICSAYFYQAARLKGIGEYVNLRTGMPCHLHPTSALYG 1111
            |.||:.:|.:..:.:.|...|...:||.:.:.|||..|||.. |.|..::.....::||.|:|:
Zfish   928 RDQLEGLMDRIEVELCSSNGDSMPIRKAVTAGYFYHTARLSK-GGYKTVKHQQTVYVHPNSSLF- 990

  Fly  1112 LGTTPDYVVYHELIMTAKEYMQCATAVDGYWLAELGPMFFSVKE----SGRSGREKKKQAAEHL 1171
             ...|.:::||||:.|.||:|:....::..||.|:.|.::..||    |.:....|:.:|.|.|
Zfish   991 -EEQPRWMIYHELVFTTKEFMRQVIEIESGWLLEVAPHYYKNKELEDSSSKKMPRKQGKAREEL 1053

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(1)G0007	NP_572947.1	DEXDc	529..715	CDD:214692	118/186 (63%)
		DEXDc	551..689	CDD:238005	94/138 (68%)
		HELICc	722..870	CDD:238034	81/148 (55%)
		HA2	932..1014	CDD:214852	43/82 (52%)
		OB_NTP_bind	1048..1148	CDD:285018	31/99 (31%)
dhx16	NP_956318.1	BLVR	<94..>142	CDD:283923	17/63 (27%)
		GBP_C	<177..296	CDD:303769	38/194 (20%)
		coiled coil	271..285	CDD:293879	7/13 (54%)
		DEXDc	407..594	CDD:214692	118/186 (63%)
		DEXDc	429..568	CDD:238005	94/138 (68%)
		Helicase_C	612..742	CDD:278689	75/129 (58%)
		HA2	811..895	CDD:214852	43/83 (52%)
		OB_NTP_bind	916..1028	CDD:285018	37/114 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D113216at33208
OrthoFinder	1	1.000	-	-		FOG0000059
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100085
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X141
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.720