DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(1)G0007 and CG8915

DIOPT Version :9

Sequence 1:	NP_572947.1	Gene:	l(1)G0007 / 32373	FlyBaseID:	FBgn0026713	Length:	1222	Species:	Drosophila melanogaster
Sequence 2:	NP_001285369.1	Gene:	CG8915 / 32715	FlyBaseID:	FBgn0030833	Length:	976	Species:	Drosophila melanogaster

Alignment Length:	930	Identity:	240/930 - (25%)
Similarity:	398/930 - (42%)	Gaps:	186/930 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   340 GGPNSEYFRKREEQLEQKRTKRISAQQRQNNRDNELWERNRMLTSGVVTLISVNDDF-----DEE 399
            |||..    ..:::....:..:..|..:..:.|.::             |..:.|||     .|:
  Fly    37 GGPKG----TGKQKTRPGKNAKADAGDKLKSEDEKM-------------LRQLVDDFLQSCEPEK 84

  Fly   400 AL--------ERVHLLVHHIIPPFLDGRIVFTKQPEP--VVPVKDPTSDMALLARKGSALVRNYR 454
            .|        ..||.|..|      .|....:|.||.  |:.:..|.||
  Fly    85 QLPGLTKAQRSHVHRLAQH------RGLKTVSKGPEENRVLFISRPQSD---------------- 127

  Fly   455 EQKERRKAQKKHWELSGTK----------LGNIMG-VQR--PQDEDDMRFDKEKDKADYRKDQKF 506
                    .::.:.|..||          ||.:.| |:|  .....|::.:|::.| |.|....|
  Fly   128 --------GQQQYILCNTKLDICPPLLDVLGQMAGNVERRLMNSVGDLKCNKQQYK-DIRLPSNF 183

  Fly   507 ADHMRDQDTGGKSDFSRKKTISEQRRFLPVFASRQELLNVIRENSVIIIVGETGSGKTTQLTQYL 571
            .  :..|........:|.:.|..:||.||::..|:.:|||::.:.|:||.|.|||||:|||.||:
  Fly   184 G--LVGQRLIPPPQSNRNRNIQHERRSLPIYKQRESILNVLQRDQVLIIKGATGSGKSTQLPQYI 246

  Fly   572 HEDGYSKRG--MIGCTQPRRVAAMSVAKRVSDEMDTQLGEDVGYAIRFEDCTSERTVIKYMTDGI 634
            .|.....|.  .|..:||||:||:||::|:|.|.....|..|||.||.....|..||:...|.|.
  Fly   247 LEWAAEHRAPVRIVVSQPRRIAAISVSERISKERGEAPGTTVGYNIRMNRQCSSNTVLMLTTSGC 311

  Fly   635 LLRESLRDPE--LDSYSAIIMDEAHERSLSTDVLFGLLREIVARRHDLKLIVTSATMDSSKFATF 697
            |||....|.:  ..:.:.:|:||||||.|.||.|....:..:.:...|:|::.|||||....:.:
  Fly   312 LLRALAMDKKSFFKNTTHLIIDEAHERDLDTDFLLLATKLELQKNPHLRLVLMSATMDLEALSNY 376

  Fly   698 FGNVPTFTIPGRTFPVDVMFSKNTCEDYVESAVKQALQVH-------------LTPNE------- 742
            ||......:.||:|.|.:.        ::|..:.:...:|             .||:|
  Fly   377 FGGGTVMDVEGRSFEVSIY--------HLEDILSKTGYMHPRMEKFLGKPTGKETPSELLAAYYG 433

  Fly   743 ---------------------------GDMLIFMPGQEDIEVTCEVLEERLAEIDNAPALSILPI 780
                                       |.:::::||..|:......||..|..    ..::|:.:
  Fly   434 GNTIVHPDIDNDLIVSLLELLLRQGDAGAVIVYLPGYSDMTSLLARLESSLPR----EQITIILL 494

  Fly   781 YSQLPSDLQAKIFQKSSDGLR-KCVVATNIAETSLTVDGIIYVIDSGYCKLKVYNPRIGMDALQI 844
            :||:.:..|.|:| ::..|:| |.:::|||.:||:|:..::||||:|..|:|.|:..|....|.:
  Fly   495 HSQVDNSEQRKVF-RTYPGVRLKIILSTNIGQTSITIPDLLYVIDTGLAKMKTYDSTIDASQLTL 558

  Fly   845 YPISQANANQRSGRAGRTGPGQAYRLY-TQRQYKDELLALTVPEIQRTNLANTVLLLKSLGVVDL 908
            ..||||:|.||:|||||...|..|||| ..|..:..|  .|:|||.|..| :.:.||..|...|.
  Fly   559 TWISQADAKQRAGRAGRVCHGNCYRLYDNDRMARMNL--YTIPEIMRRTL-DEICLLTKLAAPDK 620

  Fly   909 LQFHF----MDPPPQDNILNSLYQLWILGALDHTGALTTLGRQMAEFPLDPPQCQMLIVACRMGC 969
            ...:|    :|.||:|.::.|..:|.:||.||....:|.||..:||.||.....:.|:.:..:.|
  Fly   621 KIENFLALALDTPPKDAVMQSCSRLKLLGVLDERDEVTPLGHIVAELPLGVQIGKCLVYSIYLRC 685

  Fly   970 SAEVLIIVSMLSV--PSIFYRPKGRED---------EADGVREKFQRPESDHLTYLNVYQQWR-- 1021
            ...::||.:..||  |.:....:|::.         ..||:        ||.|..:.:|:::.
  Fly   686 LDSMIIIAAYHSVRDPFVLNIERGKKSGQQISRVLFAGDGM--------SDSLAVIKLYEEFTNL 742

  Fly  1022 QNNYSSTWCNEHFIHIKAMRKVREVRQQLKDIM------TQQNLSVISC-GIDWDIVRKCICSAY 1079
            :......:|..:||...||.........|:|.:      ::.:..:.|. ..|.:::|..:.:..
  Fly   743 KRKDIGDFCERNFICRNAMEMFVSAASTLRDTVYRIFRFSEASARLASSFNNDTNMIRLALTAGL 807

  Fly  1080 FYQAARLKGIGEYVNLRTGMP-CHLHPTSALYGLGTTPD----YVVYHELIMTAKEY--MQCATA 1137
            :.:.|.:....:...:..|.| ..:..:|.|.|.....|    ::::.|...||.:.  ::..|.
  Fly   808 YPKLAYMDRENKNQLVAEGDPLVQVSRSSCLRGKKKQKDLASEWILFVEKTRTADQISSLEHTTL 872

  Fly  1138 VDGYWLAELGPMFFSVKESG 1157
            |.|..:|..|...|..:..|
  Fly   873 VSGLMVALAGGKRFITEAHG 892

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(1)G0007	NP_572947.1	DEXDc	529..715	CDD:214692	75/189 (40%)
		DEXDc	551..689	CDD:238005	58/141 (41%)
		HELICc	722..870	CDD:238034	51/195 (26%)
		HA2	932..1014	CDD:214852	24/92 (26%)
		OB_NTP_bind	1048..1148	CDD:285018	19/113 (17%)
CG8915	NP_001285369.1	R3H	64..123	CDD:100064	16/77 (21%)
		DEXDc	214..395	CDD:214692	71/180 (39%)
		DEXDc	226..368	CDD:238005	58/141 (41%)
		HELICc	479..575	CDD:197757	38/100 (38%)
		HA2	648..733	CDD:214852	24/92 (26%)
		OB_NTP_bind	783..884	CDD:285018	18/100 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45468097
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18934
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840