DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(1)G0007 and dhx15

DIOPT Version :9

Sequence 1:	NP_572947.1	Gene:	l(1)G0007 / 32373	FlyBaseID:	FBgn0026713	Length:	1222	Species:	Drosophila melanogaster
Sequence 2:	NP_001108613.1	Gene:	dhx15 / 321931	ZFINID:	ZDB-GENE-030131-650	Length:	769	Species:	Danio rerio

Alignment Length:	748	Identity:	308/748 - (41%)
Similarity:	464/748 - (62%)	Gaps:	55/748 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   468 ELSGTKLGNIMGVQRPQDEDDMRFDKEKDKADYRKDQKFADHMRDQDTGGKSDFS---------- 522
            |.|.:|..:..|..|.:|.|:...|:::|:...|...:..|..||::...||..:
Zfish    12 EYSSSKKRSSDGKDRDRDRDERSKDRDRDRDRERDRDRDRDRDRDRERDSKSSSAALSSSVSGSG 76

  Fly   523 -----------------------RKKTISEQRRFLPVFASRQELLNVIRENSVIIIVGETGSGKT 564
                                   |...|.::|..|||:..::...:::..:...::|||||||||
Zfish    77 ILPLKQASMHQQINPFTNLPHTPRYYEILKKRLQLPVWEYKERFNDILNRHQSFVLVGETGSGKT 141

  Fly   565 TQLTQYLHEDGYS----KRGMIGCTQPRRVAAMSVAKRVSDEMDTQLGEDVGYAIRFEDCTSERT 625
            ||:.|:..:...|    ||| :.|||||||||||||:||:||||..||::|||:||||||:|.:|
Zfish   142 TQIPQWCVDMVRSLPGPKRG-VACTQPRRVAAMSVAQRVADEMDVMLGQEVGYSIRFEDCSSAKT 205

  Fly   626 VIKYMTDGILLRESLRDPELDSYSAIIMDEAHERSLSTDVLFGLLREIVARRHDLKLIVTSATMD 690
            ::||||||:||||::.||.|:.|..||:||||||:|:||:|.|:|:|:|.:|.|||:||.|||:|
Zfish   206 ILKYMTDGMLLREAMNDPLLERYGVIILDEAHERTLATDILMGVLKEVVRQRSDLKVIVMSATLD 270

  Fly   691 SSKFATFFGNVPTFTIPGRTFPVDVMFSKNTCEDYVESAVKQALQVHL-TPNEGDMLIFMPGQED 754
            :.||..:|.|.|..||||||.||::.::.....||:|:|::..:|:|: ..:|||:|:|:.|||:
Zfish   271 AGKFQVYFDNCPLLTIPGRTHPVEIFYTPEPERDYLEAAIRTVIQIHMCEEDEGDVLLFLTGQEE 335

  Fly   755 IEVTCEVLEERLAEI-DNAPALSILPIYSQLPSDLQAKIFQ----KSSDGL--RKCVVATNIAET 812
            |:..|:.::..:.:: .:...:.|:|:||.||...|.:||:    :..:|.  ||.||:||||||
Zfish   336 IDEACKRIKREIDDLGPDVGDIKIIPLYSTLPPQQQQRIFEPPPPRKPNGAIGRKVVVSTNIAET 400

  Fly   813 SLTVDGIIYVIDSGYCKLKVYNPRIGMDALQIYPISQANANQRSGRAGRTGPGQAYRLYTQRQYK 877
            |||:||:::|||.|:.|.|||||||.:::|.:..||:|:|.||:||||||.||:.:||||::.||
Zfish   401 SLTIDGVVFVIDPGFAKQKVYNPRIRVESLLVTAISKASAQQRAGRAGRTRPGKCFRLYTEKAYK 465

  Fly   878 DELLALTVPEIQRTNLANTVLLLKSLGVVDLLQFHFMDPPPQDNILNSLYQLWILGALDHTGALT 942
            .|:...|.|||.|:||.:.||.||.||:.||:.|.|||||..:.::.:|..|..|.||:..|.||
Zfish   466 TEMQDNTYPEILRSNLGSVVLQLKKLGIDDLVHFDFMDPPAPETLMRALELLNYLAALNDDGDLT 530

  Fly   943 TLGRQMAEFPLDPPQCQMLIVACRMGCSAEVLIIVSMLSVPSIFYRPKGREDEADGVREKFQRPE 1007
            .||..||||||||...:|:|.:|...||.|||.|.:|||||..|.||...:..||..:.:|...:
Zfish   531 ELGSMMAEFPLDPQLAKMVIASCDFNCSNEVLSITAMLSVPQCFVRPTEAKKAADESKMRFAHID 595

  Fly  1008 SDHLTYLNVYQQWRQNNYSSTWCNEHFIHIKAMRKVREVRQQLKDIMTQQNL---SVISCGIDWD 1069
            .||||.||||..::||:.|..||.::||:.:::.....|||||..||.:.||   |......|:.
Zfish   596 GDHLTLLNVYHAFKQNHESVQWCYDNFINYRSLMSADNVRQQLSRIMDRFNLPRRSTEFTSRDYY 660

  Fly  1070 I-VRKCICSAYFYQAARLKGIGEYVNLRTGMPCHLHPTSALYGLGTTPDYVVYHELIMTAKEYMQ 1133
            | :|:.:.:.:|.|.|.|:..|.|:.::......|||::.   |...|::|:|:|.::|.|.|::
Zfish   661 INIRRALVTGFFMQVAHLERTGHYLTVKDNQVVQLHPSTV---LDHKPEWVLYNEFVLTTKNYIR 722

  Fly  1134 CATAVDGYWLAELGPMFFSVKESGRSGREKKKQ 1166
            ..|.:...||.::.|.::.:....:.  |.|:|
Zfish   723 TCTDIKPEWLVKIAPQYYEMSNFPQC--EAKRQ 753

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(1)G0007	NP_572947.1	DEXDc	529..715	CDD:214692	105/189 (56%)
		DEXDc	551..689	CDD:238005	86/141 (61%)
		HELICc	722..870	CDD:238034	68/155 (44%)
		HA2	932..1014	CDD:214852	40/81 (49%)
		OB_NTP_bind	1048..1148	CDD:285018	31/103 (30%)
dhx15	NP_001108613.1	DEXDc	105..296	CDD:214692	105/191 (55%)
		DEXDc	128..269	CDD:238005	86/141 (61%)
		HELICc	356..449	CDD:197757	47/92 (51%)
		HA2	519..602	CDD:214852	40/82 (49%)
		OB_NTP_bind	636..739	CDD:285018	32/105 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D113216at33208
OrthoFinder	1	1.000	-	-		FOG0000059
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100085
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X141
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.720