DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(1)G0007 and kz

DIOPT Version :9

Sequence 1:	NP_572947.1	Gene:	l(1)G0007 / 32373	FlyBaseID:	FBgn0026713	Length:	1222	Species:	Drosophila melanogaster
Sequence 2:	NP_001284815.1	Gene:	kz / 31205	FlyBaseID:	FBgn0001330	Length:	1192	Species:	Drosophila melanogaster

Alignment Length:	1052	Identity:	286/1052 - (27%)
Similarity:	453/1052 - (43%)	Gaps:	272/1052 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   331 GYDDENNPFGGPNSEYFRKREEQL---EQKRTKRISAQQRQNNR---DNELWERNRMLTSGVVTL 389
            || ||.|....|:    .||..::   :.:..|.:|.:||::.:   |.:..:..|....|.:..
  Fly    40 GY-DEANALVLPS----EKRATKIKVDKVQHVKILSKKQRKHLQAIVDKKKKKEGRAQLLGDLAA 99

  Fly   390 ISVNDDFDEE----------ALERVHLLVHHIIPPFLDGRIVFTKQPE-PVVPVKDPTSDMALLA 443
            :.:.::..::          .|:|:         |.||..:...|:.: .|:..|...|.:.:.|
  Fly   100 VQIPEEELQQYTSISQVQTVGLKRL---------PTLDEYLAKKKERQAQVLAEKSSASGLRVNA 155

  Fly   444 RKGS---ALVRNYREQKERRKAQKKHWELSGTKLGNIMGVQRPQDEDDMRFDKEKDKADYRKD-- 503
            .|||   .||    |::|..:|::|:        .|::.|:. .|||....|::.::|..:..
  Fly   156 IKGSKRKLLV----EEEEELQAKRKN--------PNVISVEE-DDEDSSSSDEDDEEAPAQSAPI 207

  Fly   504 -------------------QKFADHMRDQDTGGKSDF---SRKKTISEQRRFLPVFASRQELLNV 546
                               :|............::.:   .|...:...|..||:.|..|:::..
  Fly   208 AIPTPVSIAPPQIAVKPPIKKLKPEPNPPACIHQTVYVPVHRTTEVQNARLRLPILAEEQQVMET 272

  Fly   547 IRENSVIIIVGETGSGKTTQLTQYLHEDGYSKRGMIGCTQPRRVAAMSVAKRVSDEMDTQLGEDV 611
            |.||.::|:.|||||||||||.|:|:|.||::..|||.|:||||||::::|||:.||:....| |
  Fly   273 INENPIVIVAGETGSGKTTQLPQFLYEAGYAQHKMIGVTEPRRVAAIAMSKRVAHEMNLPESE-V 336

  Fly   612 GYAIRFEDCTSERTVIKYMTDGILLRESLRDPELDSYSAIIMDEAHERSLSTDVLFGLLREIVAR 676
            .|.||||...:..|.||:||||:||:|...|..|..||.||:|||||||:.||:|.|||..||..
  Fly   337 SYLIRFEGNVTPATRIKFMTDGVLLKEIETDFLLSKYSVIILDEAHERSVYTDILVGLLSRIVPL 401

  Fly   677 RH----DLKLIVTSATMDSSKFATFFGNVPTFTIP-------GRTFPVDVMFSKNTCEDYVESAV 730
            ||    .||||:.|||:..|.|..   |...|.||       .|.|||.:.|.|.|.:|||..|.
  Fly   402 RHKRGQPLKLIIMSATLRVSDFTE---NTRLFKIPPPLLKVEARQFPVTIHFQKRTPDDYVAEAY 463

  Fly   731 KQALQVHLTPNEGDMLIFMPGQEDIEVTCEVL----------------------EERLAEIDNAP 773
            ::.|::|....||.:|||:.||:::......|                      ||:...||:|.
  Fly   464 RKTLKIHNKLPEGGILIFVTGQQEVNQLVRKLRRTFPYHHAPTKDVAKNGKVSEEEKEETIDDAA 528

  Fly   774 A---------------------------------------------------------------- 774
            :
  Fly   529 STVEDPKELEFDMKRVIRNIRKSKKKFLAQMALPKINLDDYKLPGDDTEADMHEQPDEDDEQEGL 593

  Fly   775 -----------------------LSILPIYSQLPSDLQAKIFQKSSDGLRKCVVATNIAETSLTV 816
                                   |.:||:||.|.|:.|.:||....||.|.|||:||:||||||:
  Fly   594 EEDNDDELGLEDESGMGSGQRQPLWVLPLYSLLSSEKQNRIFLPVPDGCRLCVVSTNVAETSLTI 658

  Fly   817 DGIIYVIDSGYCKLKVYNPRIGMDALQIYPISQANANQRSGRAGRTGPGQAYRLYTQRQYKDELL 881
            ..|.||:|.|..|.::|:...|:.|..:...|:|:|:||:|||||...|..||||:...|.|...
  Fly   659 PHIKYVVDCGRQKTRLYDKLTGVSAFVVTYTSKASADQRAGRAGRISAGHCYRLYSSAVYNDCFE 723

  Fly   882 ALTVPEIQRTNLANTVLLLKSLGVVDLLQFHFMDPPPQDNILNSLYQLWILGAL--------DHT 938
            ..:.|:||:..:.:.:|.::.:|:..::.|.|..||.|..:..:..:|.:||||        |..
  Fly   724 DFSQPDIQKKPVEDLMLQMRCMGIDRVVHFPFPSPPDQVQLQAAERRLIVLGALEVAKTENTDLP 788

  Fly   939 GALTTLGRQMAEFPLDPPQCQMLIVACRMGCSAEVLIIVSMLSVPSIFYRPKGREDE--ADGVRE 1001
            .|:|.||..::.||:.|...:||.::.:.......:.:|:.|||..:......:.||  |.|. .
  Fly   789 PAVTRLGHVISRFPVAPRFGKMLALSHQQNLLPYTVCLVAALSVQEVLIETGVQRDEDVAPGA-N 852

  Fly  1002 KFQRPESDHLTYLNVYQQW-RQNNYS------------------------STWCNEHFIHIKAMR 1041
            :|.|..          |.| ...||.                        ..:|..:.:..|||.
  Fly   853 RFHRKR----------QSWAASGNYQLLGDPMVLLRAVGAAEYAGSQGRLPEFCAANGLRQKAMS 907

  Fly  1042 KVREVRQQLKDIMTQQNLSVISCGIDWDIVRKCICSAYFYQAARLKGIGEYVNLRTGM------- 1099
            :||::|.||.:.: ..|:|.:..|:|.::.......|.|.:...|.|:|:.|..:..:
  Fly   908 EVRKLRVQLTNEI-NLNVSDVELGVDPELKPPTDAQARFLRQILLAGMGDRVARKVPLADIADKE 971

  Fly  1100 ----------------PCHLHPTSALYGLGTTPDYVVYHELIM-----TAKEYMQCATAVDGYWL 1143
                            |..||.:|.|  ....|::|:|.|...     :.|.:::..||::..||
  Fly   972 ERRRLKYAYNCADMEEPAFLHVSSVL--RQKAPEWVIYQEAYELQNGDSTKMFIRGITAIEPEWL 1034

  Fly  1144 AELGPMFFSVKE 1155
            ....|:..:::|
  Fly  1035 LLYVPLLCNIRE 1046

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(1)G0007	NP_572947.1	DEXDc	529..715	CDD:214692	97/196 (49%)
		DEXDc	551..689	CDD:238005	78/141 (55%)
		HELICc	722..870	CDD:238034	64/256 (25%)
		HA2	932..1014	CDD:214852	24/91 (26%)
		OB_NTP_bind	1048..1148	CDD:285018	26/127 (20%)
kz	NP_001284815.1	HrpA	237..1058	CDD:224557	244/828 (29%)
		DEXDc	279..418	CDD:238005	78/139 (56%)
		P-loop_NTPase	369..>500	CDD:304359	56/133 (42%)
		HELICc	619..704	CDD:197757	41/84 (49%)
		HA2	774..859	CDD:214852	24/95 (25%)
		OB_NTP_bind	915..1039	CDD:285018	26/126 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45468057
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D354219at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18934
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.850