DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(1)G0007 and Dhx36

DIOPT Version :9

Sequence 1:	NP_572947.1	Gene:	l(1)G0007 / 32373	FlyBaseID:	FBgn0026713	Length:	1222	Species:	Drosophila melanogaster
Sequence 2:	NP_001101148.1	Gene:	Dhx36 / 310461	RGDID:	1308767	Length:	1000	Species:	Rattus norvegicus

Alignment Length:	1170	Identity:	295/1170 - (25%)
Similarity:	492/1170 - (42%)	Gaps:	319/1170 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   189 DRHRSWDRDRGRDRDRDRSMSERSVHTPREPGTPGGSSGGISNSSWDDEDGEFGQRKSDWDMPTP 253
            |.|:||.||.|                ||..|...|..||             |.|
  Rat     4 DYHQSWSRDGG----------------PRGSGQGSGGGGG-------------GSR--------- 30

  Fly   254 RRHGNKSGDWSVRSGGSRRNHGRQDDTVRPTPAHRYNQWAHGRKRSGATPWGEDPESLDLW---- 314
               |:..|      ||.|...||.       |||     ..||:             :.||
  Rat    31 ---GSGGG------GGGRGGRGRH-------PAH-----LKGRE-------------IGLWYAKK 61

  Fly   315 ----EEEQRRLDREWYNIDEGYDDENNPFGGPNSEYFRKREEQLEQKRTKRISAQQRQNNRDNEL 375
                .:|..|.:|...::||                  :||||:.|    .:::.|.:|::|:|.
  Rat    62 QTQKNKEAERQERAVVHMDE------------------RREEQIVQ----LLNSVQAKNDKDSEA 104

  Fly   376 ---WERNRMLTSGVVTLISVNDDFDEEALERVHLLVHHIIPPFLDGRIVFTKQPEPVVPVKDPTS 437
               |....  ..|..|.:|.....:.|..              ||
  Rat   105 QISWFAPE--DHGYGTEVSSEKKINSEKK--------------LD-------------------- 133

  Fly   438 DMALLARKGSALVRNYREQKERRKAQKKHWELSGTKLGNIMGVQRPQDEDDMRFDKEKDKADYRK 502
                            .::|:....:||.:.::          .:...:.|..:..::::.:...
  Rat   134 ----------------NQEKKLLNQEKKTYRIT----------DKSYIDRDSEYLLQQNEPNLGL 172

  Fly   503 DQKFADHMRDQDTGGKSDFSRKKT---ISEQRRF---LPVFASRQELLNVIRENSVIIIVGETGS 561
            ||:..:           |..:|||   ..|.:||   ||.:..::||:|:|..:.|.:|.||||.
  Rat   173 DQQLLE-----------DLQKKKTDPRYIEMQRFRKKLPSYGMQKELVNLINNHQVTVISGETGC 226

  Fly   562 GKTTQLTQYLHEDGYSKRGM-----IGCTQPRRVAAMSVAKRVSDEMDTQL--GEDVGYAIRFED 619
            |||||:||:: .|.|.:||:     |.||||||::|:|||:||:.|.....  |...||.||.:.
  Rat   227 GKTTQVTQFI-LDNYIERGIGSACRIVCTQPRRISAISVAERVAAERAESCGNGNSTGYQIRLQS 290

  Fly   620 -CTSERTVIKYMTDGILLRESLRDPELDSYSAIIMDEAHERSLSTDVLFGLLREIVARRHDLKLI 683
             ...::..|.|.|.||:|:....|..|.|.|.|::||.|||:|.:|||..::::::..|.|||:|
  Rat   291 RLPRKQGSILYCTTGIILQWLQSDSRLSSVSHIVLDEIHERNLQSDVLMTVIKDLLHFRSDLKVI 355

  Fly   684 VTSATMDSSKFATFFGNVPTFTIPGRTFPV------DVM---------------FSKNTCEDYV- 726
            :.|||:::.||:.:|||.|...|||.||||      |::               |.:...:.:|
  Rat   356 LMSATLNAEKFSEYFGNCPMIHIPGFTFPVVEYLLEDIIEKIRYFPEQKEHRSQFKRGFMQGHVN 420

  Fly   727 --ESAVKQAL------------------------------------------QVHLTPNEGDMLI 747
              |...|:|:                                          .:.|...:|.:|:
  Rat   421 RQEKEEKEAIYKERWPAYIKELQTRYSASTIDVLEMMDDDKVDLNLIAALIRYIVLEEEDGAILV 485

  Fly   748 FMPGQEDIEVTCEVLEERLAEIDNAPALSILPIYSQLPSDLQAKIFQKSSDGLRKCVVATNIAET 812
            |:||.::|....::|..::  :..:....|:|::|.:|:..|.::|:|:..|:||.|:|||||||
  Rat   486 FLPGWDNISTLHDLLMSQV--MFKSDRFLIIPLHSLMPTVNQTQVFKKTPPGVRKIVIATNIAET 548

  Fly   813 SLTVDGIIYVIDSGYCKLKVYNPRIGMDALQIYPISQANANQRSGRAGRTGPGQAYRLYT--QRQ 875
            |:|:|.::||||.|..|...::.:..:..:....:|:|||.||.|||||..||..|.||.  :..
  Rat   549 SITIDDVVYVIDGGKIKETHFDTQNNISTMSAEWVSKANAKQRKGRAGRVQPGHCYHLYNGLRAS 613

  Fly   876 YKDELLALTVPEIQRTNLANTVLLLKSLGVVDLLQF--HFMDPPPQDNILNSLYQLWILGALDHT 938
            ..|:   ..:|||.||.|....|.:|.|.:..:..|  ..||||..:.::.|:..|..|.|||..
  Rat   614 LLDD---YQLPEILRTPLEELCLQIKILRLGGIAYFLSRLMDPPSDEAVVLSIKHLMELSALDKQ 675

  Fly   939 GALTTLGRQMAEFPLDPPQCQMLIVACRMGCSAEVLIIVSMLSVPSIFYRPKGREDEADGVREKF 1003
            ..||.||..:|..|::|...:|::......|...||.|.:.||....|..|.|:|..||..|::.
  Rat   676 EELTPLGVHLARLPVEPHIGKMILFGALFCCLDPVLTIAASLSFKDPFVIPLGKEKIADARRKEL 740

  Fly  1004 -QRPESDHLTYLNVYQQW-----RQNNYSSTWCNEHFIHIKAMRKVREVRQQLKD------IMTQ 1056
             :...|||||.:|.::.|     |...|...:|.|:|:....::.:..::.|..:      .::.
  Rat   741 AKETRSDHLTVVNAFEGWEEAKRRGFRYEKDYCWEYFLSSNTLQMLHNMKGQFAEHLLGAGFVSS 805

  Fly  1057 QNLSVISCGIDWD---IVRKCICSAYFYQAARLK-GIGE-----YVNLRTGMPCHLHPTSALYGL 1112
            ::.......|:.|   |::..||:..:.:.|::: .:|:     .|:.::.....:||.|.  .:
  Rat   806 RSPKDPKANINSDNEKIIKAVICAGLYPKVAKIRLNLGKKRKMVKVHTKSDGLVSIHPKSV--NV 868

  Fly  1113 GTTP---DYVVYHELIMTAKEYMQCATAVDGYWLAELGPMFFSVKESGRSGREKKKQAAE----- 1169
            ..|.   ::::||..:.|:..|:...|.|..|.|     :||....|.:..::::..|.:
  Rat   869 EQTDFHYNWLIYHLKMRTSSIYLYDCTEVSPYCL-----LFFGGDISIQKDKDQEIIAVDEWIVF 928

  Fly  1170 -------HL-----KEME---EQMLKAQHEMEERKQQAAEREEQLATKQEIATPGNATPRRTPAR 1219
                   ||     ||::   ::.::..|.::....::.:.....|....|.|...|.||..|.|
  Rat   929 QSPERIAHLVKGLRKELDILLQEKIECPHPVDWNDTKSRDCAVLSAILDLIKTQEKAIPRNLPPR 993

Fly 1220 1219
Rat 994 993

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(1)G0007	NP_572947.1	DEXDc	529..715	CDD:214692	86/202 (43%)
		DEXDc	551..689	CDD:238005	63/145 (43%)
		HELICc	722..870	CDD:238034	53/192 (28%)
		HA2	932..1014	CDD:214852	30/82 (37%)
		OB_NTP_bind	1048..1148	CDD:285018	21/117 (18%)
Dhx36	NP_001101148.1	HrpA	187..893	CDD:224557	214/713 (30%)
		Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250\|UniProtKB:Q05B79	257..309		19/51 (37%)
		DEAH box. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00541	326..329		2/2 (100%)
		RecA-like domain 2. /evidence=ECO:0000250\|UniProtKB:Q05B79	379..620		64/245 (26%)
		Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250\|UniProtKB:Q05B79	490..549		19/60 (32%)
		Nuclear localization signal. /evidence=ECO:0000250\|UniProtKB:Q9H2U1	509..520		3/10 (30%)
		WH domain. /evidence=ECO:0000250\|UniProtKB:Q05B79	621..690		25/68 (37%)
		Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250\|UniProtKB:Q05B79	630..689		19/58 (33%)
		OB-fold-like subdomains. /evidence=ECO:0000250\|UniProtKB:Q05B79	833..897		12/65 (18%)
		Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250\|UniProtKB:Q05B79	841..852		1/10 (10%)
		Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250\|UniProtKB:Q05B79	862..892		8/31 (26%)
		Necessary for nuclear and nucleolar caps localizations. /evidence=ECO:0000250\|UniProtKB:Q9H2U1	1..192		60/354 (17%)
		Required for the pre-miR-134 transport. /evidence=ECO:0000269\|PubMed:23651854	1..96		39/185 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..53		26/107 (24%)
		Required for recruitment to cytoplasmic stress granules. /evidence=ECO:0000250\|UniProtKB:Q9H2U1	1..43		20/85 (24%)
		Required for G4-DNA-and G4-RNA-binding. /evidence=ECO:0000250\|UniProtKB:Q9H2U1	45..97		18/98 (18%)
		DSM (DHX36-specific motif). /evidence=ECO:0000250\|UniProtKB:Q05B79, ECO:0000250\|UniProtKB:Q9H2U1	45..67		7/46 (15%)
		RecA-like domain 1. /evidence=ECO:0000250\|UniProtKB:Q05B79	98..378		99/353 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810