Protein Alignment Prp16 and Dhx38

DIOPT Version :10

• Sequence 1: NP_572947.1
• Gene: Prp16 / 32373
• FlyBaseID: FBgn0026713
• Length: 1222
• Species: Drosophila melanogaster
• Sequence 2: NP_001386123.1
• Gene: Dhx38 / 292007
• RGDID: 1310345
• Length: 1227
• Species: Rattus norvegicus
• Alignment Length: 1263
• Identity: 772/1263 - (61%)
• Similarity: 954/1263 - (75%)
• Gaps: 86/1263 - (6%)

  Fly     5 DESGVHRLEGTAGQETRGGLVIRKPKDAGAGGGGGFK--VPQGSMLGLDKLAAKRRAEKE----- 62
            :::.:||||||......|||:. |.|.| |.....||  .|:.|:||||.||:.:|.|:|
  Rat     6 EDASIHRLEGTNLDSQVGGLIC-KTKSA-ASEQHVFKAPAPRPSLLGLDLLASLKRREREEKDDG 68

  Fly    63 ---RSERLISFKDSEFDDTGGGSSTPQANASGASSEFAFKKPDTKSFEKLRGQLREHKDDTPSHT 124
               :..|:.|:||.|      .|...|.:|.....|.|     .:|..:.| ..|..:.:||||.
  Rat    69 EDKKKSRISSYKDWE------ESKDDQKDAEEDGDEQA-----GRSSRRDR-HYRSARVETPSHP 121

  Fly   125 GGVSEKARERLREHIQRDRKRGPVSSTAAEGRDRDRDWDRDRRRDRDRDRDRDRDRRQHRERERD 189
            |||||:..||.|:. :|||:...|.:::.|.:||    .:::.||||.||.||||     ||:|.
  Rat   122 GGVSEEFWERSRQR-ERDRREHGVYASSKEDKDR----KKEKSRDRDHDRKRDRD-----ERDRS 176

  Fly   190 RHRS-WDRDRGRDRDRDRSMSERSVHTPREPGTPGGSSGGISNSSWDDEDGEFG-QRKSDWDMPT 252
            ||.| .:||.|.:|...|:..|...|.|::..||       |.|:|::||..:| .|:|.|:.|:
  Rat   177 RHSSRSERDGGSERSSRRNEPESPRHRPKDAATP-------SRSTWEEEDSGYGSSRRSQWETPS 234

  Fly   253 P----------RRHGNKSGDWSVRSGGSRRNHGRQDDTVRPTPAHRYNQWAHGRKRSGATPW--- 304
            |          .|...:..|.||||..|       |||..|||:::||:||..|:..|:||.
  Rat   235 PTPSYRDSERSHRPSTRDRDRSVRSKSS-------DDTPLPTPSYKYNEWADDRRHLGSTPRLSR 292

  Fly   305 -------GEDPESLDL------WEEEQRRLDREWYNIDEGYDDENNPFGGPNSEYFRKREEQLEQ 356
                   ||:..:.|.      ||::||:.||:||.:|||||:.:||....:.:|.|:||:.|.:
  Rat   293 GRGRREDGEEGIAFDTEEERQQWEDDQRQADRDWYMMDEGYDEFHNPLAYSSEDYVRRREQHLHK 357

  Fly   357 KRTKRISAQQRQNNRDNELWERNRMLTSGVVTLISVNDDFDEEALERVHLLVHHIIPPFLDGRIV 421
            ::.||||||:||.|.|||.||.|||||||||..:.|::||:|:...:|||:||:::|||||||||
  Rat   358 QKQKRISAQRRQINEDNERWETNRMLTSGVVHRLEVDEDFEEDNAAKVHLMVHNLVPPFLDGRIV 422

  Fly   422 FTKQPEPVVPVKDPTSDMALLARKGSALVRNYREQKERRKAQKKHWELSGTKLGNIMGVQRPQDE 486
            ||||||||:||||.|||:|::|||||..||.:||||||||||.|||||:|||||:||||::.::.
  Rat   423 FTKQPEPVIPVKDATSDLAIIARKGSQTVRKHREQKERRKAQHKHWELAGTKLGDIMGVKKEEEP 487

  Fly   487 DDMRFDKEKDKADYRKDQKFADHMRDQDTGGKSDFSRKKTISEQRRFLPVFASRQELLNVIRENS 551
            |  :...|..|.|||.:|||||||::: :...|:|::||:|.|||::||:||.:||||.:||:||
  Rat   488 D--KAMTEDGKVDYRTEQKFADHMKEK-SEASSEFAKKKSILEQRQYLPIFAVQQELLTIIRDNS 549

  Fly   552 VIIIVGETGSGKTTQLTQYLHEDGYSKRGMIGCTQPRRVAAMSVAKRVSDEMDTQLGEDVGYAIR 616
            ::|:|||||||||||||||||:|||:..|||||||||||||||||||||:||...|||:||||||
  Rat   550 IVIVVGETGSGKTTQLTQYLHQDGYTDYGMIGCTQPRRVAAMSVAKRVSEEMGGNLGEEVGYAIR 614

  Fly   617 FEDCTSERTVIKYMTDGILLRESLRDPELDSYSAIIMDEAHERSLSTDVLFGLLREIVARRHDLK 681
            |||||||.|:|||||||||||||||:.:||.||||||||||||||:||||||||||:||||.|||
  Rat   615 FEDCTSENTLIKYMTDGILLRESLREADLDHYSAIIMDEAHERSLNTDVLFGLLREVVARRSDLK 679

  Fly   682 LIVTSATMDSSKFATFFGNVPTFTIPGRTFPVDVMFSKNTCEDYVESAVKQALQVHLTPNEGDML 746
            |||||||||:.|||.||||||.|.|||||||||::|||...|||||:||||:|||||:...||:|
  Rat   680 LIVTSATMDADKFAAFFGNVPIFHIPGRTFPVDILFSKTPQEDYVEAAVKQSLQVHLSGAPGDIL 744

  Fly   747 IFMPGQEDIEVTCEVLEERLAEIDNAPALSILPIYSQLPSDLQAKIFQKSSDGLRKCVVATNIAE 811
            ||||||||||||.:.:.|.|.|::|||||::||||||||||||||||||:.||:|||:|||||||
  Rat   745 IFMPGQEDIEVTSDQIVEHLEELENAPALAVLPIYSQLPSDLQAKIFQKAPDGVRKCIVATNIAE 809

  Fly   812 TSLTVDGIIYVIDSGYCKLKVYNPRIGMDALQIYPISQANANQRSGRAGRTGPGQAYRLYTQRQY 876
            ||||||||::|||||||||||:|||||||||||||||||||||||||||||||||.:|||||..|
  Rat   810 TSLTVDGIMFVIDSGYCKLKVFNPRIGMDALQIYPISQANANQRSGRAGRTGPGQCFRLYTQSAY 874

  Fly   877 KDELLALTVPEIQRTNLANTVLLLKSLGVVDLLQFHFMDPPPQDNILNSLYQLWILGALDHTGAL 941
            |:|||..||||||||||||.|||||||||.||||||||||||:||:|||:||||||||||:||.|
  Rat   875 KNELLTTTVPEIQRTNLANVVLLLKSLGVQDLLQFHFMDPPPEDNMLNSMYQLWILGALDNTGGL 939

  Fly   942 TTLGRQMAEFPLDPPQCQMLIVACRMGCSAEVLIIVSMLSVPSIFYRPKGREDEADGVREKFQRP 1006
            |:.||.|.||||||...:||||:|.||||:|:|:||||||||:|||||||||:|:|.:||||..|
  Rat   940 TSTGRLMVEFPLDPALSKMLIVSCDMGCSSEILLIVSMLSVPAIFYRPKGREEESDQIREKFAVP 1004

  Fly  1007 ESDHLTYLNVYQQWRQNNYSSTWCNEHFIHIKAMRKVREVRQQLKDIMTQQNLSVISCGIDWDIV 1071
            |||||||||||.||:.||||:.|||:||||.||||||||||.||||||.||.:|:.|||.|||||
  Rat  1005 ESDHLTYLNVYLQWKNNNYSTIWCNDHFIHAKAMRKVREVRAQLKDIMVQQRMSLASCGTDWDIV 1069

  Fly  1072 RKCICSAYFYQAARLKGIGEYVNLRTGMPCHLHPTSALYGLGTTPDYVVYHELIMTAKEYMQCAT 1136
            |||||:|||:|||:|||||||||:||||||||||||:|:|:|.||||:|||||:||.||||||.|
  Rat  1070 RKCICAAYFHQAAKLKGIGEYVNIRTGMPCHLHPTSSLFGMGYTPDYIVYHELVMTTKEYMQCVT 1134

  Fly  1137 AVDGYWLAELGPMFFSVKESGRSGREKKKQAAEHLKEMEEQMLKAQHEMEERKQQAAEREEQLAT 1201
            ||||.|||||||||:|||::|:|.:|.:::|.|....|||:|..|:.::..|:|:..:|....:.
  Rat  1135 AVDGEWLAELGPMFYSVKQAGKSRQENRRRAKEEASAMEEEMALAEEQLRARRQEQEKRSPLGSV 1199

  Fly  1202 KQ-EIATPGN------ATPRRTPARIGL 1222
            :. :|.|||.      .||||||||.||
  Rat  1200 RSTKIYTPGRKEQGEPMTPRRTPARFGL 1227

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Prp16	NP_572947.1	HrpA	534..>1148	CDD:441249	490/613 (80%)
Dhx38	NP_001386123.1	PHA03307	<182..>297	CDD:223039	42/128 (33%)
		HrpA	532..>1146	CDD:441249	490/613 (80%)