DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(1)G0007 and Dhx15

DIOPT Version :9

Sequence 1:	NP_572947.1	Gene:	l(1)G0007 / 32373	FlyBaseID:	FBgn0026713	Length:	1222	Species:	Drosophila melanogaster
Sequence 2:	NP_001178526.1	Gene:	Dhx15 / 289693	RGDID:	1308072	Length:	795	Species:	Rattus norvegicus

Alignment Length:	788	Identity:	316/788 - (40%)
Similarity:	468/788 - (59%)	Gaps:	92/788 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   470 SGTKLGNIMGVQRPQDEDDMRFDKEKDKADYRKDQKFADHMRDQD--------------TGG--- 517
            ||.|.....|..|.:|.|  |.|:.||: |..:|:...:..|:::              :.|
  Rat    15 SGKKRAGTDGKDRERDRD--REDRSKDR-DRERDRGDREREREKEKEKELRASTNAMLISAGLPP 76

  Fly   518 -KSDFSRKKT-------------------------------------------ISEQRRFLPVFA 538
             |:..|...|                                           |.::|..|||:.
  Rat    77 LKASHSAHSTHSAHSTHSTHSAHSTHTGHAGHTSLPQCINPFTNLPHTPRYYDILKKRLQLPVWE 141

  Fly   539 SRQELLNVIRENSVIIIVGETGSGKTTQLTQ----YLHEDGYSKRGMIGCTQPRRVAAMSVAKRV 599
            .:....:::..:...::|||||||||||:.|    |:......||| :.|||||||||||||:||
  Rat   142 YKDRFTDILVRHQSFVLVGETGSGKTTQIPQWCVEYMRSLPGPKRG-VACTQPRRVAAMSVAQRV 205

  Fly   600 SDEMDTQLGEDVGYAIRFEDCTSERTVIKYMTDGILLRESLRDPELDSYSAIIMDEAHERSLSTD 664
            :||||..||::|||:||||||:|.:|::||||||:||||::.||.|:.|..||:||||||:|:||
  Rat   206 ADEMDVMLGQEVGYSIRFEDCSSAKTILKYMTDGMLLREAMNDPLLERYGVIILDEAHERTLATD 270

  Fly   665 VLFGLLREIVARRHDLKLIVTSATMDSSKFATFFGNVPTFTIPGRTFPVDVMFSKNTCEDYVESA 729
            :|.|:|:|:|.:|.|||:||.|||:|:.||..:|.|.|..||||||.||::.::.....||:|:|
  Rat   271 ILMGVLKEVVRQRSDLKVIVMSATLDAGKFQIYFDNCPLLTIPGRTHPVEIFYTPEPERDYLEAA 335

  Fly   730 VKQALQVHL-TPNEGDMLIFMPGQEDIEVTCEVLEERLAEIDN-APA---LSILPIYSQLPSDLQ 789
            ::..:|:|: ...|||:|:|:.|||:|:..|:.::.   |:|: .|.   :.|:|:||.||...|
  Rat   336 IRTVIQIHMCEEEEGDLLLFLTGQEEIDEACKRIKR---EVDDLGPEVGDIKIIPLYSTLPPQQQ 397

  Fly   790 AKIFQ----KSSDGL--RKCVVATNIAETSLTVDGIIYVIDSGYCKLKVYNPRIGMDALQIYPIS 848
            .:||:    |..:|.  ||.||:|||||||||:||:::|||.|:.|.|||||||.:::|.:..||
  Rat   398 QRIFEPPPPKKQNGAIGRKVVVSTNIAETSLTIDGVVFVIDPGFAKQKVYNPRIRVESLLVTAIS 462

  Fly   849 QANANQRSGRAGRTGPGQAYRLYTQRQYKDELLALTVPEIQRTNLANTVLLLKSLGVVDLLQFHF 913
            :|:|.||:||||||.||:.:||||::.||.|:...|.|||.|:||.:.||.||.||:.||:.|.|
  Rat   463 KASAQQRAGRAGRTRPGKCFRLYTEKAYKTEMQDNTYPEILRSNLGSVVLQLKKLGIDDLVHFDF 527

  Fly   914 MDPPPQDNILNSLYQLWILGALDHTGALTTLGRQMAEFPLDPPQCQMLIVACRMGCSAEVLIIVS 978
            ||||..:.::.:|..|..|.||:..|.||.||..||||||||...:|:|.:|...||.|||.|.:
  Rat   528 MDPPAPETLMRALELLNYLAALNDDGDLTELGSMMAEFPLDPQLAKMVIASCDYNCSNEVLSITA 592

  Fly   979 MLSVPSIFYRPKGREDEADGVREKFQRPESDHLTYLNVYQQWRQNNYSSTWCNEHFIHIKAMRKV 1043
            |||||..|.||...:..||..:.:|...:.||||.||||..::||:.|..||.::||:.:::...
  Rat   593 MLSVPQCFVRPTEAKKAADEAKMRFAHIDGDHLTLLNVYHAFKQNHESVQWCYDNFINYRSLMSA 657

  Fly  1044 REVRQQLKDIMTQQNL---SVISCGIDWDI-VRKCICSAYFYQAARLKGIGEYVNLRTGMPCHLH 1104
            ..|||||..||.:.||   |......|:.| :||.:.:.||.|.|.|:..|.|:.::......||
  Rat   658 DNVRQQLSRIMDRFNLPRRSTDFTSRDYYINIRKALVTGYFMQVAHLERTGHYLTVKDNQVVQLH 722

  Fly  1105 PTSALYGLGTTPDYVVYHELIMTAKEYMQCATAVDGYWLAELGPMFFSVKESGRSGREKKKQAAE 1169
            |::.   |...|::|:|:|.::|.|.|::..|.:...||.::.|.::.:....:.  |.|:|...
  Rat   723 PSTV---LDHKPEWVLYNEFVLTTKNYIRTCTDIKPEWLVKIAPQYYDMSNFPQC--EAKRQLDR 782

  Fly  1170 HLKEMEEQ 1177
            .:.:::.:
  Rat   783 IIAKLQSK 790

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(1)G0007	NP_572947.1	DEXDc	529..715	CDD:214692	105/189 (56%)
		DEXDc	551..689	CDD:238005	86/141 (61%)
		HELICc	722..870	CDD:238034	72/158 (46%)
		HA2	932..1014	CDD:214852	40/81 (49%)
		OB_NTP_bind	1048..1148	CDD:285018	33/103 (32%)
Dhx15	NP_001178526.1	HrpA	124..763	CDD:224557	294/645 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D113216at33208
OrthoFinder	1	1.000	-	-		FOG0000059
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100085
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X141
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.720