DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(1)G0007 and prh1

DIOPT Version :9

Sequence 1:	NP_572947.1	Gene:	l(1)G0007 / 32373	FlyBaseID:	FBgn0026713	Length:	1222	Species:	Drosophila melanogaster
Sequence 2:	NP_593091.1	Gene:	prh1 / 2541750	PomBaseID:	SPAC2G11.11c	Length:	719	Species:	Schizosaccharomyces pombe

Alignment Length:	701	Identity:	256/701 - (36%)
Similarity:	427/701 - (60%)	Gaps:	23/701 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly   456 QKERRKAQKKHWELSGTKLGNIMGVQRPQDEDDMRFDKEKDKADYRKDQKFADHMRDQDTGGKSD 520
            :|:.|||.|...:.|...:.|.:               |:| .|:..::.........:...::.
pombe    34 KKKNRKASKNTTKKSTVSVVNFL---------------EQD-TDFGANEVVGSDNSSPEKRSENS 82

  Fly   521 FSRKKTISEQRRFLPVFASRQELLNVIRENSVIIIVGETGSGKTTQLTQYLHEDGYSKRGMIGCT 585
            .|::|.|.|||:.||::.:...|...|::|.||::||||||||:||:.|:|:|..|::.|.:..|
pombe    83 PSKRKDILEQRKNLPIWEAHDTLCQQIQDNRVIVVVGETGSGKSTQIPQFLNECPYAQEGCVAIT 147

  Fly   586 QPRRVAAMSVAKRVSDEMDTQLGEDVGYAIRFEDCTSERTVIKYMTDGILLRESLRDPELDSYSA 650
            |||||||:::||||:.|...:|||.|||:|||:|.||::|.|||:|||:||||.:.||.|..|..
pombe   148 QPRRVAAVNLAKRVAAEQGCRLGEQVGYSIRFDDTTSKKTRIKYLTDGMLLRELINDPILSQYHT 212

  Fly   651 IIMDEAHERSLSTDVLFGLLREIVARRHDLKLIVTSATMDSSKFATFFGNVPTFTIPGRTFPVDV 715
            :|:||||||:|.||:|.|.:::|:.:|..|::|:.|||:::.:|:.||.......|.||.:||.:
pombe   213 LILDEAHERTLMTDMLLGFVKKIIKKRPALRVIIMSATLNAERFSEFFDGAEICYISGRQYPVQI 277

  Fly   716 MFSKNTCEDYVESAVKQALQVHLTPNEGDMLIFMPGQEDIEVTCEVLEERLAEI-DNAPALSILP 779
            .::.....||:::.::...|:|.....||:|:|:.||::||....:::....:: .|.|.:...|
pombe   278 HYTYTPEPDYLDACLRTIFQLHTKLPPGDILVFLTGQDEIEALEALIKSYSKQLPSNLPQIQACP 342

  Fly   780 IYSQLPSDLQAKIFQKSSDGLRKCVVATNIAETSLTVDGIIYVIDSGYCKLKVYNPRIGMDALQI 844
            :::.||.:.|.::|..:....||.|::|||||||:|:.||.||||:|..|:|.:|.::|:::|.:
pombe   343 LFASLPQEQQLQVFLPALANHRKVVLSTNIAETSVTISGIRYVIDTGLAKIKQFNSKLGLESLTV 407

  Fly   845 YPISQANANQRSGRAGRTGPGQAYRLYTQRQYKDELLALTVPEIQRTNLANTVLLLKSLGVVDLL 909
            .||||:.|.||||||||...||.||:||:..: |:|...|:|||:|.:|:..||.||:.|..|::
pombe   408 QPISQSAAMQRSGRAGREAAGQCYRIYTEADF-DKLPKETIPEIKRIDLSQAVLTLKARGQNDVI 471

  Fly   910 QFHFMDPPPQDNILNSLYQLWILGALDHTGALTTLGRQMAEFPLDPPQCQMLIVACRMGCSAEVL 974
            .||:||||.::.:|.:|..|:.:||||..|.:..||.||:..||.|...:.::.|....|.:||:
pombe   472 NFHYMDPPSKEGLLRALEHLYSIGALDDNGHINDLGYQMSLIPLLPSLARAVLAAREHNCLSEVI 536

  Fly   975 IIVSMLSVPSIFYRPKGREDEADGVREKFQRPESDHLTYLNVYQQWRQNNYSS--TWCNEHFIHI 1037
            .:||.||..|:|..|:.:.|||...|.||...|.|.||.||..:|:.::::.|  .||:::||:.
pombe   537 DVVSCLSTDSMFLFPQEKRDEAIEARLKFLHSEGDLLTCLNALRQYLESSHDSRKQWCSQNFINR 601

  Fly  1038 KAMRKVREVRQQLKDIMTQQNLSVISC-GIDWDIVRKCICSAYFYQAARLKGIGEYVNLRTGMPC 1101
            :|::.:.::|:||::...:....:.|. .::.:.:.....|.|....|.|...|.|..:......
pombe   602 RALKTILDIRKQLREHCLKDGWELNSSPEVNSENLLLSFLSGYITNTALLHPDGSYRTIIGNQTI 666

  Fly  1102 HLHPTSALYGLGTTPDYVVYHELIMTAKEYMQCATAVDGYWLAELGPMFFS 1152
            .:||:|:|:  |...:.::||||:.|.|.|::..:::...||..:.|.:.:
pombe   667 SIHPSSSLF--GKKVEAIMYHELVFTTKSYVRGVSSIRSNWLNAVAPHYLA 715

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(1)G0007	NP_572947.1	DEXDc	529..715	CDD:214692	92/185 (50%)
		DEXDc	551..689	CDD:238005	75/137 (55%)
		HELICc	722..870	CDD:238034	58/148 (39%)
		HA2	932..1014	CDD:214852	33/81 (41%)
		OB_NTP_bind	1048..1148	CDD:285018	23/100 (23%)
prh1	NP_593091.1	HrpA	58..711	CDD:224557	247/656 (38%)
		DEXDc	113..251	CDD:238005	75/137 (55%)
		HELICc	276..433	CDD:238034	58/156 (37%)
		HA2	493..576	CDD:214852	33/82 (40%)
		OB_NTP_bind	601..713	CDD:285018	26/113 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000059
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	4	3.770