Protein Alignment Prp16 and cdc28

DIOPT Version :10

• Sequence 1: NP_572947.1
• Gene: Prp16 / 32373
• FlyBaseID: FBgn0026713
• Length: 1222
• Species: Drosophila melanogaster
• Sequence 2: NP_595686.2
• Gene: cdc28 / 2540707
• PomBaseID: SPBC19C2.01
• Length: 1055
• Species: Schizosaccharomyces pombe
• Alignment Length: 1054
• Identity: 393/1054 - (37%)
• Similarity: 582/1054 - (55%)
• Gaps: 132/1054 - (12%)

  Fly   199 GRDRDRDRSMSERSVHT-----PREPGTPGGS-------SGGI-----SNSSWD--------DED 238
            |.|.| |.::.| ..||     |||...|..:       ..||     .|||:|        :..
pombe    47 GMDGD-DPAVKE-FAHTLYARIPREGSRPKENYNARKKKEQGILQMERLNSSYDLLIEPQSHETP 109

  Fly   239 GEFGQRKSDWDMPTPR----RHGNKSGDW------SVRSGGSRRNHGRQDDTVRPT-PAHRYNQW 292
            |:..::||  ...||:    |......:|      .|..|.:  :|..::|:|... ..|.|.:
pombe   110 GKPLKKKS--RSKTPKREIARRQRDEDEWESDEYEEVVDGSA--SHPIEEDSVSTDFQNHDYEK- 169

  Fly   293 AHGRKRSGATPWGEDPESLDL--------WEEEQRRLDREWYNIDEGYDDENNPFG--------- 340
                        ..|||:..|        :||..||.|.| ...:|..:|.::.|.
pombe   170 ------------SSDPETERLNDLREREEFEERLRRKDLE-AATNEFVEDYSSKFSSEELALRKL 221

  Fly   341 GPNSEYFRKREEQLEQKRTKRI---SAQQ-----RQNNRDNELWERNRMLTSGVVTLISVNDDFD 397
            ..:.|.:||...:|.:|..::.   .|||     |:..||.|.......||...:..:....:..
pombe   222 ADDPESWRKLASELRKKSRQQYLKPRAQQQLEILRREIRDEEQLFAGEKLTQAEIRELEKKKELL 286

  Fly   398 EEALERVHLLVHHIIPPFLDGRIVFTKQPEPVVPVKDPTSDMALL--ARKGSALVRNYREQKERR 460
            ..|.||..|                .||.......:|..::...|  .||...|.:.|::..|..
pombe   287 RIAEERQRL----------------EKQATEYQMPEDYFTEQGKLDRKRKEEVLYQRYKDSNEGE 335

  Fly   461 K-------AQKKHWELSGTKLGNIMGVQRPQDEDDMRFD---KEKDKADYRKDQKFADHMRDQDT 515
            :       |:::.||........:..........:.:||   .|..:.|:..|.|.:.. ...||
pombe   336 QNEVTMGAAEQQRWEAQQINKALLFDQNEWLPPGEKQFDFVFDESQQIDFLLDTKLSAE-NPVDT 399

  Fly   516 GGKSDFSRKKTISEQRRFLPVFASRQELLNVIRENSVIIIVGETGSGKTTQLTQYLHEDGYSK-R 579
            ...:|...:|::...|:.|||:..:.:||..|.|..|::||.||||||||||.|:|||.||:| .
pombe   400 DKMTDVKVEKSLESSRKSLPVYQYKDDLLKAINEYQVLLIVAETGSGKTTQLPQFLHEAGYTKGN 464

  Fly   580 GMIGCTQPRRVAAMSVAKRVSDEMDTQLGEDVGYAIRFEDCTSERTVIKYMTDGILLRESLRDPE 644
            ..|.|||||||||||||.||:.|||.:||::|||:||||:.|||:|||||:|||:||||.|.:|:
pombe   465 KKICCTQPRRVAAMSVAARVAKEMDVRLGQEVGYSIRFENATSEKTVIKYLTDGMLLREFLTEPD 529

  Fly   645 LDSYSAIIMDEAHERSLSTDVLFGLLREIVARRHDLKLIVTSATMDSSKFATFFGNVPTFTIPGR 709
            |.|||.||:||||||:|.||:||||:::|...|.|||::::|||:|:.||:.:|...|.|.:|||
pombe   530 LASYSVIIIDEAHERTLHTDILFGLVKDIARFRPDLKVLISSATIDAEKFSAYFDEAPVFYVPGR 594

  Fly   710 TFPVDVMFSKNTCEDYVESAVKQALQVHLTPNEGDMLIFMPGQEDIEV-------TCEVLEERLA 767
            .:|||:.::.....:|:::|:...||:|.|...||:|:|:.||::||:       .|.:|.:|:
pombe   595 RYPVDIYYTPQPEANYIQAAITTILQIHTTQPAGDILVFLTGQDEIELMSENMQELCRILGKRI- 658

  Fly   768 EIDNAPALSILPIYSQLPSDLQAKIFQKSSDGLRKCVVATNIAETSLTVDGIIYVIDSGYCKLKV 832
                 |.:.:.|||:.|||:||||||..:..|.||.|:||||||||:|:||:.:|||||:.|..:
pombe   659 -----PEIILCPIYANLPSELQAKIFDPTPPGARKVVLATNIAETSITIDGVNFVIDSGFVKQNM 718

  Fly   833 YNPRIGMDALQIYPISQANANQRSGRAGRTGPGQAYRLYTQRQYKDELLALTVPEIQRTNLANTV 897
            ||||.||::|...|.|:|:|:||:|||||.|||:.:||||:|.|.:||..:|.||||||||.|.|
pombe   719 YNPRTGMESLVSVPCSRASADQRAGRAGRVGPGKCFRLYTRRTYNNELDMVTSPEIQRTNLTNIV 783

  Fly   898 LLLKSLGVVDLLQFHFMDPPPQDNILNSLYQLWILGALDHTGALTTLGRQMAEFPLDPPQCQMLI 962
            |||||||:.:||.|.|||.||.:.::.||..|:.||||::.|.||.|||||||||.||...:.||
pombe   784 LLLKSLGINNLLDFDFMDAPPPETLMRSLELLYALGALNNRGELTKLGRQMAEFPTDPMLSKSLI 848

  Fly   963 VACRMGCSAEVLIIVSML-SVPSIFYRPKGREDEADGVREKFQRPESDHLTYLNVYQQWRQNNYS 1026
            .:.:.||..|||.||||| ...|:|||||.:..|||..|..|.:|..||||.|:::.:|...::|
pombe   849 ASSKYGCVEEVLSIVSMLGEASSLFYRPKDKIMEADKARANFTQPGGDHLTLLHIWNEWVDTDFS 913

  Fly  1027 STWCNEHFIHIKAMRKVREVRQQLKDIMTQQNLSVISCGID-WDIVRKCICSAYFYQAARLKGIG 1090
            ..|..|:|:..|::.:.|:||.||.::..:..:.:::...: .|.::|.|.:.||..||||...|
pombe   914 YNWARENFLQYKSLCRARDVRDQLANLCERVEIELVTNSSESLDPIKKAITAGYFSNAARLDRSG 978

  Fly  1091 E-YVNLRTGMPCHLHPTSALYGLGTTPDYVVYHELIMTAKEYMQCATAVDGYWLAELGPMFF--- 1151
            : |..:::....::||:|::  ....|..::|.||::|.|||.:..|.:...||.|:.|.:|
pombe   979 DSYRTVKSNQTVYIHPSSSV--AEKKPKVIIYFELVLTTKEYCRQITEIQPEWLLEISPHYFKPE 1041

  Fly  1152 SVKESGRSGREKKK 1165
            :::|..::.:..|:
pombe  1042 NIEELQKTQKRHKR 1055

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Prp16	NP_572947.1	HrpA	534..>1148	CDD:441249	304/624 (49%)
cdc28	NP_595686.2	PTZ00121	<68..>357	CDD:173412	66/322 (20%)
		DUF4670	<213..322	CDD:464815	24/124 (19%)
		HrpA	417..>1039	CDD:441249	305/629 (48%)