Protein Alignment Prp16 and Dhx29

DIOPT Version :10

• Sequence 1: NP_572947.1
• Gene: Prp16 / 32373
• FlyBaseID: FBgn0026713
• Length: 1222
• Species: Drosophila melanogaster
• Sequence 2: NP_766182.2
• Gene: Dhx29 / 218629
• MGIID: 2145374
• Length: 1365
• Species: Mus musculus
• Alignment Length: 1394
• Identity: 318/1394 - (22%)
• Similarity: 563/1394 - (40%)
• Gaps: 380/1394 - (27%)

  Fly    10 HRLEGTAGQETRGGLVIRKPKDAGAGGGGGFK---------VPQGSMLGLDKLAAKRRAEKERSE 65
            |:..|.|...........:..:|||.|....|         ||.|:          |....::..
Mouse     8 HKAPGAAAMRAAVSASRARSAEAGAVGEAQSKKPVARPAPAVPTGA----------REPRVKQGP 62

  Fly    66 RLISFKDSEFDDTGGGSSTPQANASGASSEFAFKKPDTKSFEKLRGQLREHK---DDTPSHTGGV 127
            ::.||..:  :|:||     .||...:..:...   :.|..:::.|.:.|||   .|..:.:|.:
Mouse    63 KIYSFNSA--NDSGG-----SANLDKSILKVVI---NNKLEQRIIGVINEHKKQNSDRGAISGRL 117

  Fly   128 SEKARERLREHIQ------RDRKRGPVSSTAAEGRDRDR--DWDRDRRRDRDRDRDRDRDRRQHR 184
            |.|..:.|...:|      :|.: ..:::|...|.|...  ||......|........::..:.:
Mouse   118 SAKKLQDLYMALQAFSFKTKDIE-DAMTNTLLHGGDLHSALDWLCLNLSDDALPEGFSQEFEEQQ 181

  Fly   185 ERERDRHRSW---------DRDRGRDRDRDRSMSERSVHTPREPGTPGGSSGGISNSSW------ 234
            .:.|.:.:|.         .:.:.:.::.|..:..:...|..|          ::...|
Mouse   182 PKSRPKFQSVQIQATLSPPQQTKTKRQEEDPKIKPKKEETTVE----------VNMKEWILRYAE 236

  Fly   235 --DDE---DGEFGQRKSDWDMPTPR-----------------------RHGNKSGDWSVRSGGSR 271
              |:|   :|..|..:.:...|..|                       :.|.|.....:
Mouse   237 QQDEEEKGEGSKGLEEEEKFDPNQRYLNLAARLLDAKEQAAAFKLEKNKQGQKEAQEKI------ 295

  Fly   272 RNHGRQDDTVRPTP--------AHRYNQWAHGRKRSGATPWGEDPESLDLWE------EEQRRLD 322
            |...|:.:|:...|        :|:.|:    :|:.......|...:|:|:|      ||::...
Mouse   296 RKFQREMETLEDHPIFNPAIKISHQQNE----KKKPAPATEAESALNLNLFEKSAAATEEEKGKK 356

  Fly   323 REWYNIDEGYDDENNPFGGPNSEYF-----RKREEQLEQKRTKRISAQQRQNNRDNELWE-RNRM 381
            :|.::: ..:|.....:.|.:.:.|     ||...:......::::.        ...|: |.|:
Mouse   357 KEPHDV-RNFDYTARSWTGKSPKQFLIDWVRKNLPKSPNPSFEKVAV--------GRYWKCRVRV 412

  Fly   382 LTSGVVTLISVNDDFDEEALERVHL-------------LVHHIIPPFLDGRIVFTKQPEPVVPVK 433
            :.|....|:.......|:.::..||             .||.::||
Mouse   413 VRSEDDVLVVCPTILTEDGMQAQHLGATLALYRLVKGQSVHQLLPP------------------- 458

  Fly   434 DPTSDMALLARKGSALVRNYR--------EQKERRKAQK----KHWELSGTKLGNIMGVQRPQDE 486
                              .||        |:|:|.:..|    |..:|...||.|.: .|:.|.:
Mouse   459 ------------------TYRDVWLEWSDEEKKREELNKMETNKPRDLFIAKLLNKL-KQQQQQQ 504

  Fly   487 DDMRFDKEKDKADYRKDQKFADHMRDQDTGG--------------KSDFSRKKT------ISEQR 531
            ...|.:.||..:: ..::.:.:.:.|:|...              :|.|.|.::      :.::|
Mouse   505 QQQRPESEKGGSE-DPEESWENLVSDEDLAALSLEPTSAEDLAPVRSLFRRLQSTPKYQRLLKER 568

  Fly   532 RFLPVFASRQELLNVIRENSVIIIVGETGSGKTTQLTQYLHED------GYSKRGMIGCTQPRRV 590
            :.||||..|..::..::.:.|:::.|||||||:||:..:|.||      |..|..:: ||||||:
Mouse   569 QQLPVFKHRDSIVETLKRHRVVVVAGETGSGKSTQVPHFLLEDLLLDECGARKCNIV-CTQPRRI 632

  Fly   591 AAMSVAKRVSDEMDTQLGED-----VGYAIRFEDCTSERTVIKYMTDGILLRESLRDPELDSYSA 650
            :|:|:|.||.:|:..:.|..     .||.||.|...||.|.:.|.|.|:|||:...|..|...|.
Mouse   633 SAVSLATRVCEELGCESGPGGRNSLCGYQIRMESRASESTRLLYCTTGVLLRKLQEDGLLADVSH 697

  Fly   651 IIMDEAHERSLSTDVLFGLLREIVARRHDLKLIVTSATMDSSKFATFFGNVPTFTIPGRTFPVDV 715
            :|:||.||||:.:|.|..:|:||:.:|.||.||:.|||:||.||:|:|.:.|...|.||::||:|
Mouse   698 VIVDEVHERSVQSDFLLVILKEILQKRSDLHLILMSATVDSDKFSTYFTHCPILRISGRSYPVEV 762

  Fly   716 ------------MFSKNT--CEDYVE--------------------------------------- 727
                        :..|::  |:.::|
Mouse   763 FHLEDIVEETGFVLEKDSEYCQKFLEEEEEITINVTSKAGGVKKYQEYIPVQSGASPELNPFYQK 827

  Fly   728 -SAVKQALQVHLTPN-----------------------EGDMLIFMPGQEDIEVTCEVL------ 762
             |:..|...:::.|:                       ||.:|||:||...|:...::|
Mouse   828 YSSRTQHAILYMNPHKINLDLILELLVYLDKSPQFRNIEGAVLIFLPGLAHIQQLYDLLSSDRRF 892

  Fly   763 -EERLAEIDNAPALSILPIYSQLPSDLQAKIFQKSSDGLRKCVVATNIAETSLTVDGIIYVIDSG 826
             .||         ..::.::|.|.:..||..|.....|:||.|:|||||||.:|:..:::|||:|
Mouse   893 YSER---------YQVIALHSVLSTQDQAAAFMFPPPGVRKIVLATNIAETGITIPDVVFVIDTG 948

  Fly   827 YCKLKVYNPRIGMDALQIYPISQANANQRSGRAGRTGPGQAYRLYTQRQYKDELLALTVPEIQRT 891
            ..|...|:....|.:|....:|:|:|.||.|||||...|..:||||:.:: :..|..:||||.|.
Mouse   949 RTKENKYHESSQMSSLVETFVSKASALQRQGRAGRVRDGFCFRLYTRERF-EGFLDYSVPEILRV 1012

  Fly   892 NLANTVL-LLK-SLGVVDLLQFHFMDPPPQDNILNSLYQLWILGALD-HTGALTTLGRQMAEFPL 953
            .|....| ::| .||..:......:|||....|.|::..|..:||.: :...||.||:.:|..|:
Mouse  1013 PLEELCLHIMKCDLGSPEDFLSKALDPPQLQVISNAMNLLRKIGACEPNEPKLTPLGQHLAALPV 1077

  Fly   954 DPPQCQMLIVACRMGCSAEVLIIVSMLSVPSIFYRPKGREDEADGVREKFQRPESDHLTYLNVYQ 1018
            :....:|||.....||...|..:.::::..|.|..|.||:||||..:......:|||||..|.|.
Mouse  1078 NVKIGKMLIFGAIFGCLEPVATLAAVMTEKSPFITPIGRKDEADLAKSSLAVADSDHLTIYNAYL 1142

  Fly  1019 QWR----QNNYSS--TWCNEHFIHIKAMRKVREVRQQLKDIMT---------------QQNLS-- 1060
            .|:    :..:.|  ::|..:|::..::..:.:|:|:|..::.               .|.||
Mouse  1143 GWKKAQQEGGFRSEISYCQRNFLNRTSLLTLEDVKQELMKLVKAAGFSSSPSWEGRKGPQTLSFQ 1207

  Fly  1061 -------VISCGIDWDIVRKCICSAYFYQAARLKGIGEYVNLRTGMPC---------HLHPTSAL 1109
                   |::.|: :|.|.|.:|:             :.|::...:.|         .:||:|..
Mouse  1208 DIALLKAVLAAGL-YDSVGKIMCT-------------KSVDVTEKLACMVETAQGKAQVHPSSVN 1258

  Fly  1110 YGLGTTPDYVVYHELIMTAKEYMQCATAV 1138
            ..| .|..:::|.|.:...:.|::..|.:
Mouse  1259 RDL-QTYGWLLYQEKVRYTRVYLRETTLI 1286

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Prp16	NP_572947.1	HrpA	534..>1148	CDD:441249	214/742 (29%)
Dhx29	NP_766182.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..74		15/77 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	174..222		3/47 (6%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	235..257		4/21 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	500..524		4/24 (17%)
		HrpA	570..>1226	CDD:441249	201/667 (30%)
		DEAH box. /evidence=ECO:0000255|HAMAP-Rule:MF_03068	701..704		2/2 (100%)
		OB_NTP_bind	1212..1298	CDD:400182	17/90 (19%)