Protein Alignment Prp16 and Dhx8

DIOPT Version :10

• Sequence 1: NP_572947.1
• Gene: Prp16 / 32373
• FlyBaseID: FBgn0026713
• Length: 1222
• Species: Drosophila melanogaster
• Sequence 2: NP_659080.2
• Gene: Dhx8 / 217207
• MGIID: 1306823
• Length: 1244
• Species: Mus musculus
• Alignment Length: 1254
• Identity: 502/1254 - (40%)
• Similarity: 704/1254 - (56%)
• Gaps: 204/1254 - (16%)

  Fly    60 EKERSERLIS----------FKDS------EFDDTGGGS-----STPQANASGASSEFAFKKPDT 103
            :|:.:|.:||          ||.|      ||.|:...:     .|.:..|..::|:....||.|
Mouse    46 DKDLAEFVISLAEKNTTFDTFKASLVKNGAEFTDSLISNLLRLIQTMRPPAKPSTSKDPVVKPKT 110

  Fly   104 KSFEKLR---------------------------GQLREHKDDTPSHTGGVSEKARERLREHIQR 141
            :. ||||                           ..|:|.:...||..|  .||.|:  .||..|
Mouse   111 EK-EKLRELFPVLCQPDNPSARTMLDEEDVKVAVDVLKELEALMPSAAG--QEKQRD--PEHRDR 170

  Fly   142 DRKRGPVSSTAAEGRDRDRDWDRDRRRDRDRDRDRDRDRRQHRERERDRHRSWDRDRGRDRDRDR 206
            .:|:     ..:..||||||.||||.||||||||||:||.:.|:|||||.|..:||..| |.|.|
Mouse   171 TKKK-----KRSRSRDRDRDRDRDRDRDRDRDRDRDKDRERDRDRERDRERDRERDHKR-RHRSR 229

  Fly   207 SMSERSVHTPREPGTPGGS---SGGISNSSWDD-EDGE-FGQRKSD-W-----DMPTPRRHGNKS 260
            |.|    |:.....|.|.|   |...|.|.:.| :|.| :|:|..| |     |.|.|....  .
Mouse   230 SRS----HSRTRERTKGKSRYRSRSRSQSPFKDRKDREKYGERNLDRWRDKHVDRPPPEEPA--I 288

  Fly   261 GD-------------WSVRSGGSRRNHGRQDDTVRPTPAHRYNQWAHGRKRSGATPWGEDPESLD 312
            ||             ..|:..|.|:   |.:..|..:...|     .||..:.|          |
Mouse   289 GDIYNGKVTSIMQFGCFVQLEGLRK---RWEGLVHISELRR-----EGRVANVA----------D 335

  Fly   313 LWEEEQR-----------RLDREWYNIDEGYDDENNP------FGGPNSEYFRK----------- 349
            :..:.||           :......::|:...::.||      .|..|.|...:
Mouse   336 VVSKGQRVKVKVLSFTGTKTSLSMKDVDQETGEDLNPNRRRNLVGETNEETSMRNPDRPTHLSLV 400

  Fly   350 -----REEQLEQKRTKRISAQQRQNNRDNELWERNRMLTSGVVT------------LISVNDDFD 397
                 .::.||:||..|||        |.|.||..:|:.:.|::            ::...||.:
Mouse   401 SAPEVEDDSLERKRLTRIS--------DPEKWEIKQMIAANVLSKEEFPDFDEETGILPKVDDEE 457

  Fly   398 EEALERVHLLVHHIIPPFLDGRIVFTKQPEPVVPVKDPTSDMALLARKGSALVRNYREQKE-RRK 461
            :|.|| :.|:...  ||||.|....:....|:..||:|...::..|...|||.:..||.|: :|:
Mouse   458 DEDLE-IELVEEE--PPFLRGHTKQSMDMSPIKIVKNPDGSLSQAAMMQSALAKERRELKQAQRE 519

  Fly   462 AQ--------KKHW-----ELSGTKL-GNIMGV-QRPQDEDDMRFDKEKDKADYRKDQKFADHMR 511
            |:        .|||     :..|.:: .|:.|: ..|.|..:.            |...|.
Mouse   520 AEMDSIPMGLNKHWVDPLPDAEGRQIAANMRGIGMMPNDIPEW------------KKHAFG---- 568

  Fly   512 DQDTGGKSDFSRKKTIS--EQRRFLPVFASRQELLNVIRENSVIIIVGETGSGKTTQLTQYLHED 574
                |.|:.:.:|..:|  |||..||::..:::|:..:.:|.::|::||||||||||:||||.|.
Mouse   569 ----GNKASYGKKTQMSILEQRESLPIYKLKEQLVQAVHDNQILIVIGETGSGKTTQITQYLAEA 629

  Fly   575 GYSKRGMIGCTQPRRVAAMSVAKRVSDEMDTQLGEDVGYAIRFEDCTSERTVIKYMTDGILLRES 639
            ||:.||.|||||||||||||||||||:|....||::|||.||||||||..|||||||||:||||.
Mouse   630 GYTSRGKIGCTQPRRVAAMSVAKRVSEEFGCCLGQEVGYTIRFEDCTSPETVIKYMTDGMLLREC 694

  Fly   640 LRDPELDSYSAIIMDEAHERSLSTDVLFGLLREIVARRHDLKLIVTSATMDSSKFATFFGNVPTF 704
            |.||:|..|:.|::||||||::.||||||||::.|.:|.|:||||||||:|:.||:.:|...|.|
Mouse   695 LIDPDLTQYAIIMLDEAHERTIHTDVLFGLLKKTVQKRQDMKLIVTSATLDAVKFSQYFYEAPIF 759

  Fly   705 TIPGRTFPVDVMFSKNTCEDYVESAVKQALQVHLTPNEGDMLIFMPGQEDIEVTCEVLEERLAEI 769
            ||||||:||:::::|....||:::::...:|:|||...||:|:|:.|||:|:..||:|.||:..:
Mouse   760 TIPGRTYPVEILYTKEPETDYLDASLITVMQIHLTEPPGDILVFLTGQEEIDTACEILYERMKSL 824

  Fly   770 -DNAPALSILPIYSQLPSDLQAKIFQKSSDGLRKCVVATNIAETSLTVDGIIYVIDSGYCKLKVY 833
             .:.|.|.|||:||.|||::|.:||..:..|.||.|:||||||||||:|||.||:|.|:.|.|||
Mouse   825 GPDVPELIILPVYSALPSEMQTRIFDPAPPGSRKVVIATNIAETSLTIDGIYYVVDPGFVKQKVY 889

  Fly   834 NPRIGMDALQIYPISQANANQRSGRAGRTGPGQAYRLYTQRQYKDELLALTVPEIQRTNLANTVL 898
            |.:.|:|.|.:.|||||.|.||:|||||||||:.|||||:|.|:||:|...||||||||||:|||
Mouse   890 NSKTGIDQLVVTPISQAQAKQRAGRAGRTGPGKCYRLYTERAYRDEMLTTNVPEIQRTNLASTVL 954

  Fly   899 LLKSLGVVDLLQFHFMDPPPQDNILNSLYQLWILGALDHTGALTTLGRQMAEFPLDPPQCQMLIV 963
            .||::|:.|||.|.|||.||.:.::.::.||:.|||||..|.||.|||:||||||:|..|:|||:
Mouse   955 SLKAMGINDLLSFDFMDAPPMETLITAMEQLYTLGALDDEGLLTRLGRRMAEFPLEPMLCKMLIM 1019

  Fly   964 ACRMGCSAEVLIIVSMLSVPSIFYRPKGREDEADGVREKFQRPESDHLTYLNVYQQWRQNNYSST 1028
            :..:|||.|:|.|||||||.::|||||.::..||..:.||.:.|.||||.|.||..|:.|.:|:.
Mouse  1020 SVHLGCSEEMLTIVSMLSVQNVFYRPKDKQALADQKKAKFHQTEGDHLTLLAVYNSWKNNKFSNP 1084

  Fly  1029 WCNEHFIHIKAMRKVREVRQQLKDIMTQQNLSVISCGIDWDIVRKCICSAYFYQAARLKGIGEYV 1093
            ||.|:||..:::|:.:::|:|:..||.:..|.|:|||.....|:|.|||.:|..||:......|.
Mouse  1085 WCYENFIQARSLRRAQDIRKQMLGIMDRHKLDVVSCGKSTVRVQKAICSGFFRNAAKKDPQEGYR 1149

  Fly  1094 NLRTGMPCHLHPTSALYGLGTTPDYVVYHELIMTAKEYMQCATAVDGYWLAELGPMFFSVKESGR 1158
            .|......::||:|||:  ...|::||||||::|.||||:..|.:|..||.|..|.||.|.:..:
Mouse  1150 TLIDQQVVYIHPSSALF--NRQPEWVVYHELVLTTKEYMREVTTIDPRWLVEFAPAFFKVSDPTK 1212

  Fly  1159 SGREKKKQAAEHLKEMEEQ 1177
            ..::||:|..|.|....|:
Mouse  1213 LSKQKKQQRLEPLYNRYEE 1231

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Prp16	NP_572947.1	HrpA	534..>1148	CDD:441249	332/614 (54%)
Dhx8	NP_659080.2	GH2-like_DHX8	25..92	CDD:409668	10/45 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	152..289		64/152 (42%)
		S1_DHX8_helicase	289..367	CDD:240189	15/95 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	361..396		6/34 (18%)
		HrpA	580..>1211	CDD:441249	340/632 (54%)
		DEAH box	709..712		2/2 (100%)