DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(1)G0007 and mog-1

DIOPT Version :9

Sequence 1:	NP_572947.1	Gene:	l(1)G0007 / 32373	FlyBaseID:	FBgn0026713	Length:	1222	Species:	Drosophila melanogaster
Sequence 2:	NP_499212.1	Gene:	mog-1 / 176409	WormBaseID:	WBGene00003389	Length:	1131	Species:	Caenorhabditis elegans

Alignment Length:	1249	Identity:	691/1249 - (55%)
Similarity:	857/1249 - (68%)	Gaps:	157/1249 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSDDDESGVHRLEGTAGQETRGGLVIRKPKDAGAGGGGGFKVPQG-SMLGLDKLAAKRRAEKERS 64
            |||....|  |||||:  :|.|||||:|.|   ..|......|.| |:||||:||:.:|
Worm     1 MSDKRADG--RLEGTS--DTFGGLVIKKKK---VEGDSKPTEPSGKSLLGLDRLASTKR------ 52

  Fly    65 ERLISFKDSEFDDTGGGSSTPQANASGASSEFAFKKPDTKSFEKLRGQLREHKDDTPSHTGGVSE 129
                                                      |..|.:| |..||.     ||:|
Worm    53 ------------------------------------------EHARKRL-EDDDDR-----GVTE 69

  Fly   130 KAR---ERLREHIQRDRKRGPVSSTAAEGRDRDRDWDRDRR-RDRDRDRDRDRDRRQHRERERDR 190
            ..|   |::.|                  :.|||| ||..: :.||.||.|||||.:  .||...
Worm    70 SVRKGIEKVHE------------------KHRDRD-DRGMKYKSRDDDRRRDRDRSE--RREPSS 113

  Fly   191 HRSWDRDRGRDRDRDRSMSERSVHTPR--EPGTPGGSSGGISNSSWDDEDGEFGQRK-SDWDMPT 252
            .|.|     :||..|:        |||  .|.||       |..|||.:|.|...|| :.|||||
Worm   114 RRGW-----KDRSGDQ--------TPRFKVPDTP-------SRMSWDQDDREGSSRKRNSWDMPT 158

  Fly   253 PRRHGNK----------SGDWSV----RSGGSRRNHGRQDDTVRPTPAHRYNQWAHGRKRSGATP 303
            ||...::          |..|..    |....||.|.:.:|:||..            |...|.|
Worm   159 PRGERDRKRYMDSERSISSAWRSERRNRDDEKRRRHRKPEDSVRSV------------KEEKAEP 211

  Fly   304 WGEDPESLDLWEEEQRRLDREWYNIDEGYDDENNPFGGPNSEYFRKREEQLEQKRTK-RISAQQR 367
            ...|.|....|||||:.||||||:.:..:|||.|||...:.|:..|||:|.::|..| |::.:|:
Worm   212 TFHDDEERAQWEEEQKNLDREWYDNEGAFDDEYNPFNKVSDEFVEKREKQWQEKTQKPRLTVKQQ 276

  Fly   368 QNNRDNELWERNRMLTSGVVTLI-SVNDDFDEEALE-RVHLLVHHIIPPFLDGRIVFTKQPEPVV 430
            ...|:|||||.||:..||||.:. .::..|::|..| ||.:||.:|:|||||||||||||.:|::
Worm   277 AIKRENELWENNRLHRSGVVAMADELSSIFEDETDENRVTILVQNIVPPFLDGRIVFTKQAQPII 341

  Fly   431 PVKDPTSDMALLARKGSALVRNYREQKERRKAQKKHWELSGTKLGNIMGVQRPQD-----EDDMR 490
            ||.|.|.|||:.|.:||..||..||.::|:|||.|||||:|:||||:|||:..:|     |||
Worm   342 PVVDTTCDMAVSAARGSVAVRKRREVEDRKKAQDKHWELAGSKLGNLMGVKEKKDETADPEDD-- 404

  Fly   491 FDKEKDKADYRKDQKFADHMRDQDTGGKSDFSRKKTISEQRRFLPVFASRQELLNVIRENSVIII 555
                 |..:|::..:||.||:|.:  ..|||:.:|:|.:||.:|||||.||:::||||||:|:||
Worm   405 -----DSGNYKESHQFASHMKDNE--AVSDFAMEKSIKQQREYLPVFACRQKMMNVIRENNVVII 462

  Fly   556 VGETGSGKTTQLTQYLHEDGYSKRGMIGCTQPRRVAAMSVAKRVSDEMDTQLGEDVGYAIRFEDC 620
            ||||||||||||.|||.|||:...|:|||||||||||||||:||:|||...||:|||||||||||
Worm   463 VGETGSGKTTQLAQYLLEDGFGDSGLIGCTQPRRVAAMSVARRVADEMGVDLGQDVGYAIRFEDC 527

  Fly   621 TSERTVIKYMTDGILLRESLRDPELDSYSAIIMDEAHERSLSTDVLFGLLREIVARRHDLKLIVT 685
            |||:|:||||||||||||.|.|..||.||||||||||||||:||||||||||::|:|.|||||||
Worm   528 TSEKTIIKYMTDGILLRECLGDGSLDQYSAIIMDEAHERSLNTDVLFGLLREVIAKRADLKLIVT 592

  Fly   686 SATMDSSKFATFF-GNVPTFTIPGRTFPVDVMFSKNTCEDYVESAVKQALQVHLTPNEGDMLIFM 749
            |||||:.|||.|| ||.||||||||||||::..::...||||::|||||:.:||...:||:||||
Worm   593 SATMDADKFADFFGGNCPTFTIPGRTFPVELFHARTPVEDYVDAAVKQAVTIHLGGMDGDILIFM 657

  Fly   750 PGQEDIEVTCEVLEERLAEIDNAPALSILPIYSQLPSDLQAKIFQKSSDGLRKCVVATNIAETSL 814
            |||||||.|||:::|:|.|:|.||.|::|||||||||||||||||::..|:||.:||||||||||
Worm   658 PGQEDIECTCEMIKEKLGELDEAPPLAVLPIYSQLPSDLQAKIFQRAPGGMRKAIVATNIAETSL 722

  Fly   815 TVDGIIYVIDSGYCKLKVYNPRIGMDALQIYPISQANANQRSGRAGRTGPGQAYRLYTQRQYKDE 879
            |||||::|||.|:||:||||||||||||.|:|:|||:||||:||||||||||.|||||:||:|||
Worm   723 TVDGILFVIDPGFCKMKVYNPRIGMDALSIFPVSQASANQRTGRAGRTGPGQCYRLYTERQFKDE 787

  Fly   880 LLALTVPEIQRTNLANTVLLLKSLGVVDLLQFHFMDPPPQDNILNSLYQLWILGALDHTGALTTL 944
            ||..||||||||||||.|||||||||.|||:|||||.|||||:|||:||||.|||||:||.||.:
Worm   788 LLKSTVPEIQRTNLANVVLLLKSLGVDDLLKFHFMDAPPQDNMLNSMYQLWTLGALDNTGQLTPM 852

  Fly   945 GRQMAEFPLDPPQCQMLIVACRMGCSAEVLIIVSMLSVPSIFYRPKGREDEADGVREKFQRPESD 1009
            ||:|.||||||...:|||::..||||.|||.||||||||:||:||||||:|||..:||||.||||
Worm   853 GRKMVEFPLDPTLSKMLIMSAEMGCSDEVLTIVSMLSVPAIFFRPKGREEEADAKKEKFQVPESD 917

  Fly  1010 HLTYLNVYQQWRQNNYSSTWCNEHFIHIKAMRKVREVRQQLKDIMTQQNLSVISCGIDWDIVRKC 1074
            |||:||||.|||.:.||:.||.::::|:||::||||||.|||:||....|.:||.|.:|||||||
Worm   918 HLTFLNVYIQWRTHKYSAKWCADNYLHVKALKKVREVRAQLKEIMQDLKLPLISNGSEWDIVRKC 982

  Fly  1075 ICSAYFYQAARLKGIGEYVNLRTGMPCHLHPTSALYGLGTTPDYVVYHELIMTAKEYMQCATAVD 1139
            ||||||:.||||||||||||:|||:||.|||||||:|:|..|||||||||||||||||||.||||
Worm   983 ICSAYFHNAARLKGIGEYVNVRTGIPCFLHPTSALFGMGFMPDYVVYHELIMTAKEYMQCVTAVD 1047

  Fly  1140 GYWLAELGPMFFSVKESGRSGREKKKQAAEHLKEMEEQMLKAQHEMEERKQQ---AAEREEQLAT 1201
            ..|||||||||:|:|||.:|.:|.|.::...::.||.:|.:||.|||.||::   |.:|.|....
Worm  1048 AIWLAELGPMFYSIKESKQSRKELKMESVRTVETMEAEMREAQKEMERRKEESDKAFKRPESSRR 1112

  Fly  1202 KQEIATPGNATPRR 1215
            ..|:.:....:.||
Worm  1113 VVEVGSKSARSERR 1126

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(1)G0007	NP_572947.1	DEXDc	529..715	CDD:214692	147/186 (79%)
		DEXDc	551..689	CDD:238005	110/137 (80%)
		HELICc	722..870	CDD:238034	107/147 (73%)
		HA2	932..1014	CDD:214852	58/81 (72%)
		OB_NTP_bind	1048..1148	CDD:285018	76/99 (77%)
mog-1	NP_499212.1	DUF1777	114..>239	CDD:285811	51/156 (33%)
		DEXDc	437..620	CDD:214692	144/182 (79%)
		DEXDc	458..596	CDD:238005	110/137 (80%)
		HELICc	622..778	CDD:238034	107/155 (69%)
		HA2	840..922	CDD:214852	58/81 (72%)
		OB_NTP_bind	956..1056	CDD:285018	76/99 (77%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159204
Domainoid	1	1.000	279	1.000	Domainoid score	I904
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8512
Inparanoid	1	1.050	1255	1.000	Inparanoid score	I82
Isobase	1	0.950	-	0	Normalized mean entropy	S613
OMA	1	1.010	-	-		QHG52596
OrthoDB	1	1.010	-	-		D113216at33208
OrthoFinder	1	1.000	-	-		FOG0000059
OrthoInspector	1	1.000	-	-		oto18268
orthoMCL	1	0.900	-	-		OOG6_100085
Panther	1	1.100	-	-	LDO	PTHR18934
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R986
SonicParanoid	1	1.000	-	-		X141
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	16	15.790