DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(1)G0007 and ddx-15

DIOPT Version :9

Sequence 1:	NP_572947.1	Gene:	l(1)G0007 / 32373	FlyBaseID:	FBgn0026713	Length:	1222	Species:	Drosophila melanogaster
Sequence 2:	NP_741147.1	Gene:	ddx-15 / 175771	WormBaseID:	WBGene00018967	Length:	739	Species:	Caenorhabditis elegans

Alignment Length:	716	Identity:	297/716 - (41%)
Similarity:	444/716 - (62%)	Gaps:	53/716 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   497 KADYRKDQKFADHMRDQDTGGKSDFSRKKTIS-------------------------EQRRFLPV 536
            :.|.|:........|.:....:|...||:.|.                         |:|..|||
Worm    14 RGDRRRSPNRRSRSRSRSPHRRSSPDRKRQIGAVGNMKIQINPYNNQPFSNRYWAIWEKRSQLPV 78

  Fly   537 FASRQELLNVIRENSVIIIVGETGSGKTTQLTQYLHE----------DGYSKRGMIGCTQPRRVA 591
            :..:::.:.::|.|..|.:|||||||||||:.|:..|          .|.::  ::.||||||||
Worm    79 WEYKEKFMELLRNNQCITLVGETGSGKTTQIPQWAVEFMKQQQQGQPPGQAR--LVACTQPRRVA 141

  Fly   592 AMSVAKRVSDEMDTQLGEDVGYAIRFEDCTSERTVIKYMTDGILLRESLRDPELDSYSAIIMDEA 656
            |||||.||::|||..||::|||:||||||.|||||:||.|||:||||::..|.||.|..:|:|||
Worm   142 AMSVATRVAEEMDVVLGQEVGYSIRFEDCISERTVLKYCTDGMLLREAMNSPLLDKYKVLILDEA 206

  Fly   657 HERSLSTDVLFGLLREIVARRHDLKLIVTSATMDSSKFATFFGNVPTFTIPGRTFPVDVMFSKNT 721
            |||:|:||:|.||::|||..|.|:|:::.|||:|:.||..:|.:.|..::|||||||::.|:.|.
Worm   207 HERTLATDILMGLIKEIVRNRADIKVVIMSATLDAGKFQRYFEDCPLLSVPGRTFPVEIFFTPNA 271

  Fly   722 CEDYVESAVKQALQVHLTPN-EGDMLIFMPGQEDIEVTCEVLEERLAEID-NAPALSILPIYSQL 784
            .:||:|:|::..:|:|:... |||:|:|:.|||:||..|:.::..:..:. :|.|||.:|:||.|
Worm   272 EKDYLEAAIRTVIQIHMVEEVEGDILLFLTGQEEIEEACKRIDREIQALGADAGALSCIPLYSTL 336

  Fly   785 PSDLQAKIFQKSSDG------LRKCVVATNIAETSLTVDGIIYVIDSGYCKLKVYNPRIGMDALQ 843
            |...|.:||:.:...      .||||::|||||||||:||:::|||.|:.|.|||||||.:::|.
Worm   337 PPAAQQRIFEPAPPNRPNGAISRKCVISTNIAETSLTIDGVVFVIDPGFSKQKVYNPRIRVESLL 401

  Fly   844 IYPISQANANQRSGRAGRTGPGQAYRLYTQRQYKDELLALTVPEIQRTNLANTVLLLKSLGVVDL 908
            :.|||:|:|.||:||||||.||:.:||||:..|..|:...|.|||.|:||.:.||.||.||..||
Worm   402 VCPISKASAMQRAGRAGRTKPGKCFRLYTETAYGSEMQDQTYPEILRSNLGSVVLQLKKLGTEDL 466

  Fly   909 LQFHFMDPPPQDNILNSLYQLWILGALDHTGALTTLGRQMAEFPLDPPQCQMLIVACRMGCSAEV 973
            :.|.|||||..:.::.:|..|..|.|::..|.||.||..||||||||...:|||.:..:.||.|:
Worm   467 VHFDFMDPPAPETLMRALELLNYLQAINDDGELTELGSLMAEFPLDPQLAKMLITSTELNCSNEI 531

  Fly   974 LIIVSMLSVPSIFYRPKGREDEADGVREKFQRPESDHLTYLNVYQQWRQNNYSSTWCNEHFIHIK 1038
            |.|.:|||||..:.||.....|||..:.:|...:.||||.||||..::||.....||.::||:.:
Worm   532 LSITAMLSVPQCWVRPNEMRTEADEAKARFAHIDGDHLTLLNVYHSFKQNQEDPQWCYDNFINYR 596

  Fly  1039 AMRKVREVRQQLKDIMTQQNLSVISCGI---DWDI-VRKCICSAYFYQAARLKGIGEYVNLRTGM 1099
            .|:....||.||..:|.:.||..:|...   |:.: :||.:.:.:|.|.|.|:..|.||.::...
Worm   597 TMKTADTVRTQLSRVMDKYNLRRVSTDFKSRDYYLNIRKALVAGFFMQVAHLERSGHYVTVKDNQ 661

  Fly  1100 PCHLHPTSALYGLGTTPDYVVYHELIMTAKEYMQCATAVDGYWLAELGPMFFSVKESGRSGREKK 1164
            ..:|||::.   |...|::.:|:|.::|.|.:::..|.|...||.::.|.::.: ::...|..|:
Worm   662 LVNLHPSTV---LDHKPEWALYNEFVLTTKNFIRTVTDVRPEWLLQIAPQYYDL-DNFPDGDTKR 722

  Fly  1165 K 1165
            |
Worm   723 K 723

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(1)G0007	NP_572947.1	DEXDc	529..715	CDD:214692	103/195 (53%)
		DEXDc	551..689	CDD:238005	83/147 (56%)
		HELICc	722..870	CDD:238034	72/155 (46%)
		HA2	932..1014	CDD:214852	38/81 (47%)
		OB_NTP_bind	1048..1148	CDD:285018	29/103 (28%)
ddx-15	NP_741147.1	Motor_domain	41..>106	CDD:277568	17/64 (27%)
		DEXDc	70..266	CDD:214692	103/197 (52%)
		DEXDc	95..239	CDD:238005	83/145 (57%)
		HELICc	327..419	CDD:197757	48/91 (53%)
		HA2	489..572	CDD:214852	38/82 (46%)
		OB_NTP_bind	607..709	CDD:285018	30/104 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D113216at33208
OrthoFinder	1	1.000	-	-		FOG0000059
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100085
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X141
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.820