DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(1)G0007 and ddx-35

DIOPT Version :9

Sequence 1:	NP_572947.1	Gene:	l(1)G0007 / 32373	FlyBaseID:	FBgn0026713	Length:	1222	Species:	Drosophila melanogaster
Sequence 2:	NP_497420.1	Gene:	ddx-35 / 175308	WormBaseID:	WBGene00022056	Length:	732	Species:	Caenorhabditis elegans

Alignment Length:	717	Identity:	274/717 - (38%)
Similarity:	425/717 - (59%)	Gaps:	41/717 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   481 QRPQDEDDMR--FDKEKDKADYRKDQKFADHMRDQDTGGKSDFSRKK-----------TISEQRR 532
            |.|:.....|  |.:..|.||..:........|..:..|.:....::           .|.:||.
Worm    11 QEPRKGAGARRGFARPDDSADAPRTGPLIFEERSTENAGAAPPIEEQLKVHNNPYASLNIQQQRI 75

  Fly   533 FLPVFASRQELLNVIRENSVIIIVGETGSGKTTQLTQYLHEDGYSKRG-MIGCTQPRRVAAMSVA 596
            .||:|.:|..:|.:......||||||||.||:||:.|:|.|.|::..| .|..|||||||.:::|
Worm    76 RLPIFKNRGHILYMCERYRTIIIVGETGCGKSTQVPQFLLEAGWAADGRQIVITQPRRVAVVTLA 140

  Fly   597 KRVSDEMDTQLGEDVGYAIRFEDCTSERTVIKYMTDGILLRESLRDPELDSYSAIIMDEAHERSL 661
            .||::|.|..||.||||.:||:|.:.:.|.:|:||||:||||.|.||.|..||.|::|||||||.
Worm   141 TRVAEEKDCILGHDVGYTVRFDDVSDKDTKVKFMTDGLLLREILADPLLSKYSIIMIDEAHERSC 205

  Fly   662 STDVLFGLLREIVARRHDLKLIVTSATMDSSKFATFF-----GN-----VPTFTIPGRTFPVDVM 716
            :||:|.||||:|:..|:||::||:|||:|:..|..||     ||     ....::.|||.||.|.
Worm   206 NTDILLGLLRKIIQIRNDLRIIVSSATLDAELFKDFFEMNETGNSDKDTAGIISVEGRTHPVAVH 270

  Fly   717 FSKNTCEDYVESAVKQALQVHLTPNEGDMLIFMPGQEDIEVTCEVLEERLAEIDNAPALSILPIY 781
            .:|.:..||.:|||...:.:|...|.||:|:|:.||:::|..||.|.|....:.|...|.::|.|
Worm   271 HTKTSVPDYCQSAVDTVINIHKHENPGDILVFLTGQDEVEDVCEKLRELAGNLKNCDRLWVVPCY 335

  Fly   782 SQLPSDLQAKIFQKSSDGLRKCVVATNIAETSLTVDGIIYVIDSGYCKLKVYNPRIGMDALQIYP 846
            ..||:..|.|.|..:..|.||.||||||||.|:|:.||.||||:||.||:..:...|::.|....
Worm   336 GALPAREQMKAFDSTPHGTRKVVVATNIAEASITIPGICYVIDTGYVKLRAQHAANGVETLMRVT 400

  Fly   847 ISQANANQRSGRAGRTGPGQAYRLYTQRQYKDELLALTVPEIQRTNLANTVLLLKSLGVVDLLQF 911
            :|:|:|.||:|||||..||:.||||.:.:: :.....|||||||..:|:|:|.||:|||.::.:|
Worm   401 VSKASAEQRAGRAGRIRPGKCYRLYPESEF-ERFAEGTVPEIQRCQMASTILQLKALGVQNVHRF 464

  Fly   912 HFMDPPPQDNILNSLYQLWILGALDHTGALTT-LGRQMAEFPLDPPQCQMLIVACRMGCSAEVLI 975
            |::.|||...::|.|..|:.|||:|.|..||: ||.|||||||.|...:.|:.:...|||.|::.
Worm   465 HYLSPPPSWAMINGLELLYALGAIDETSQLTSPLGLQMAEFPLPPMHSKCLLKSAEFGCSTEMVT 529

  Fly   976 IVSMLSVPSIFYRPKGREDEADGVREKFQRPESDHLTYLNVYQQWRQNNYSSTWCNEHFIHIKAM 1040
            ||:|:.:..:|..|..:..:||.:|:||...|.||:|.|||:.::.:|..|..||::||::.:.:
Worm   530 IVAMMQIQDVFITPYRQRHQADVIRKKFAVEEGDHMTMLNVFTKFVENGRSKKWCSDHFVNYRGL 594

  Fly  1041 RKVREVRQQLKDIMTQ------QNLSVISCGIDWDIVRKCICSAYFYQAARLKGIGEYVNLRTGM 1099
            .:...||.||..::.:      .:..:|:|.   :.:|:|:.:.:|.|||:....|:|:.::...
Worm   595 MRADNVRSQLVRLLKRFEIEKVSSRGLINCS---ENIRQCLVTGFFSQAAQYHYTGKYMTVKESF 656

  Fly  1100 PCHLHPTSALYGLGTTPDYVVYHELIMTAKEYMQCATAVDGYWLAELGPMFFSVKESGRSGREKK 1164
            |.:::..|::......|.:|::.|::   ::.::..|.::..||.||.|.::   |.|..|...:
Worm   657 PFNMYKGSSIMFKKDYPKWVIFTEVM---QDSIRDVTVIEPEWLYELAPHYY---EFGTEGELAE 715

  Fly  1165 KQ 1166
            |:
Worm   716 KR 717

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(1)G0007	NP_572947.1	DEXDc	529..715	CDD:214692	97/196 (49%)
		DEXDc	551..689	CDD:238005	78/138 (57%)
		HELICc	722..870	CDD:238034	65/147 (44%)
		HA2	932..1014	CDD:214852	36/82 (44%)
		OB_NTP_bind	1048..1148	CDD:285018	22/105 (21%)
ddx-35	NP_497420.1	HrpA	70..702	CDD:224557	260/638 (41%)
		DEXDc	96..233	CDD:238005	78/136 (57%)
		Helicase_C	284..416	CDD:278689	57/131 (44%)
		HA2	484..568	CDD:214852	36/83 (43%)
		OB_NTP_bind	602..704	CDD:285018	23/107 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D354219at2759
OrthoFinder	1	1.000	-	-		FOG0000059
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100085
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	6	5.680