DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(1)G0007 and mog-5

DIOPT Version :9

Sequence 1:	NP_572947.1	Gene:	l(1)G0007 / 32373	FlyBaseID:	FBgn0026713	Length:	1222	Species:	Drosophila melanogaster
Sequence 2:	NP_495019.1	Gene:	mog-5 / 173920	WormBaseID:	WBGene00003393	Length:	1200	Species:	Caenorhabditis elegans

Alignment Length:	1144	Identity:	468/1144 - (40%)
Similarity:	656/1144 - (57%)	Gaps:	145/1144 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    92 ASSEFAFKKPDTK-----SFEKLRG------QLREHKDDTPSHTGGVSEKARERLREHIQRDRKR 145
            |.:..|.:|.|.:     ..||:.|      :|::..|         |::.|.|.|.. .||||
Worm   114 AMANTAKEKEDNEDDLMAQLEKMEGRYESEKRLQKESD---------SKRNRSRSRSR-SRDRK- 167

  Fly   146 GPVSSTAAEGRDRDRDWDRD-RRRDRDRDRDRDRDRRQHRERERDRHRSWDRDRGRDRDRDRSMS 209
                      |.|.|..||| |||.|.|:..||||||. |:|:|||.|. || ||.||.|||
Worm   168 ----------RRRSRSGDRDRRRRSRSREDRRDRDRRD-RDRDRDRGRG-DR-RGDDRQRDR--- 216

  Fly   210 ERSVHTPREPGTPGGSSGGISNSSWDDEDGEFGQRKSDWDMPTPRRHGNKSGDWSVRSGGSRRNH 274
                   |:....||:.        ..|..|.|:      :...|.:..:|....:...|.|:
Worm   217 -------RDRRDDGGAR--------KSEVAEIGK------IYDGRVNSIQSFGAFITLEGFRQ-- 258

  Fly   275 GRQDDTVRPTPA--HRYNQWAHGRKRSGATPWGEDPESLDLWEEEQRRLDREWYNIDEGYDDENN 337
             :|:..|..:..  .|....|...||      ||:.: :.:.:.|..::......:|:...::.|
Worm   259 -KQEGLVHISQIRNERVQTVADVLKR------GENVK-VKVNKIENGKISLSMKEVDQNSGEDLN 315

  Fly   338 PFGGPNSEYFRKREEQLE------QKRTKRISAQQRQNNRDN----------------------E 374
            |           ||..|.      :.||...|.....|...:                      |
Worm   316 P-----------RETDLNPDAIGVRPRTPPASTSSWMNPEASGVGQGPSTSIGGGKARVRISTPE 369

  Fly   375 LWERNRMLTSGVVTLISVNDDFDEEA-----------LERVHLLVHHIIPPFLDGRIVFTKQPEP 428
            .||..:|..:||:|...: .|||||.           .|.:.:.:....|.||.|......:.||
Worm   370 RWELRQMQGAGVLTATDM-PDFDEEMGVLRNYDDESDGEDIEIELVEDEPDFLRGYGKGGAEIEP 433

  Fly   429 VVPVKDPTSDMALLARKGSALVRNYRE-----QKERRKAQKKHWELSGTKLGNIMGVQR---PQD 485
            |..||:|...:|..|....||.:..:|     |:||....:|.:..:...|..:.|.|.   ..|
Worm   434 VKVVKNPDGSLAQAALMQGALSKERKETKIQAQRERDMDTQKGFSSNARILDPMSGNQSTAWSAD 498

  Fly   486 EDDMRFDKEKDKADYRKDQKFADHMRDQDTGGKSDFSRKKTIS--EQRRFLPVFASRQELLNVIR 548
            |...|.:|.|:..::.|      |:   ..|||:.:.|:..:|  |||..||:||.::.|:..:.
Worm   499 ESKDRNNKMKEMPEWLK------HV---TAGGKATYGRRTNLSMVEQRESLPIFALKKNLMEAMI 554

  Fly   549 ENSVIIIVGETGSGKTTQLTQYLHEDGYSKRGMIGCTQPRRVAAMSVAKRVSDEMDTQLGEDVGY 613
            :|.::::|||||||||||:|||..|.|..:||.||||||||||||||||||::|...:||.||||
Worm   555 DNQILVVVGETGSGKTTQMTQYAIEAGLGRRGKIGCTQPRRVAAMSVAKRVAEEYGCKLGTDVGY 619

  Fly   614 AIRFEDCTSERTVIKYMTDGILLRESLRDPELDSYSAIIMDEAHERSLSTDVLFGLLREIVARRH 678
            .||||||||:.|:|||||||:||||.|.||:|..||.|::||||||::.||||||||:....:|.
Worm   620 TIRFEDCTSQDTIIKYMTDGMLLRECLIDPDLSGYSLIMLDEAHERTIHTDVLFGLLKAAARKRP 684

  Fly   679 DLKLIVTSATMDSSKFATFFGNVPTFTIPGRTFPVDVMFSKNTCEDYVESAVKQALQVHLTPNEG 743
            :||||:||||:||.||:.:|...|.||||||||||::::::....||:|:|....:|:|||...|
Worm   685 ELKLIITSATLDSVKFSEYFLEAPIFTIPGRTFPVEILYTREPESDYLEAAHITVMQIHLTEPPG 749

  Fly   744 DMLIFMPGQEDIEVTCEVLEERLAEI-DNAPALSILPIYSQLPSDLQAKIFQKSSDGLRKCVVAT 807
            |:|:|:.|||:|:.:||||.||:..: .:.|.|.|||:|..|||::|.:||..:..|.||.|:||
Worm   750 DVLVFLTGQEEIDTSCEVLYERMKSMGPDVPELIILPVYGALPSEMQTRIFDPAPAGKRKVVIAT 814

  Fly   808 NIAETSLTVDGIIYVIDSGYCKLKVYNPRIGMDALQIYPISQANANQRSGRAGRTGPGQAYRLYT 872
            ||||||||:|||.||:|.|:.|.|:|||:.|||:|.:.|||||.|.||||||||||||:.|||||
Worm   815 NIAETSLTIDGIFYVVDPGFVKQKIYNPKSGMDSLVVTPISQAAAKQRSGRAGRTGPGKCYRLYT 879

  Fly   873 QRQYKDELLALTVPEIQRTNLANTVLLLKSLGVVDLLQFHFMDPPPQDNILNSLYQLWILGALDH 937
            :|.::||:|...||||||||||:|:|.||::|:.:|:.|.|||.||.|:::.:|..|..|.|||.
Worm   880 ERAFRDEMLPTPVPEIQRTNLASTLLQLKAMGINNLIDFDFMDAPPLDSMITALNTLHTLSALDG 944

  Fly   938 TGALTTLGRQMAEFPLDPPQCQMLIVACRMGCSAEVLIIVSMLSVPSIFYRPKGREDEADGVREK 1002
            .|.||.|||:||||||:|...::||::..:|||.|||.||:||:|.:||||||.::|.||..:.|
Worm   945 DGLLTKLGRRMAEFPLEPSLSKLLIMSVDLGCSEEVLTIVAMLNVQNIFYRPKEKQDHADQKKAK 1009

  Fly  1003 FQRPESDHLTYLNVYQQWRQNNYSSTWCNEHFIHIKAMRKVREVRQQLKDIMTQQNLSVISCGID 1067
            |.:||.||||.|.||..|:.:::|..||.|:||.:::|::.:::|:||..||.:..|.::|||.|
Worm  1010 FHQPEGDHLTLLAVYNSWKNHHFSQPWCFENFIQVRSMKRAQDIRKQLLGIMDRHKLLMVSCGRD 1074

  Fly  1068 WDIVRKCICSAYFYQAARLKGIGEYVNLRTGMPCHLHPTSALYGLGTTPDYVVYHELIMTAKEYM 1132
            ...|:|.|||.:|..||:......|..|..|...::||:||.:  ...|::||||||:||.||||
Worm  1075 VSRVQKAICSGFFRNAAKRDPQEGYRTLTDGQNVYIHPSSACF--QQQPEWVVYHELVMTTKEYM 1137

  Fly  1133 QCATAVDGYWLAELGPMFFSVKESGRSGREKKKQAAEHL 1171
            :..||:|..||.|..|.||.:.:|.:....|:.|..:.|
Worm  1138 REVTAIDPKWLVEFAPSFFKIGDSTKLSTFKRNQKIDPL 1176

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(1)G0007	NP_572947.1	DEXDc	529..715	CDD:214692	118/185 (64%)
		DEXDc	551..689	CDD:238005	92/137 (67%)
		HELICc	722..870	CDD:238034	83/148 (56%)
		HA2	932..1014	CDD:214852	47/81 (58%)
		OB_NTP_bind	1048..1148	CDD:285018	43/99 (43%)
mog-5	NP_495019.1	S1_DHX8_helicase	234..311	CDD:240189	15/92 (16%)
		DEXDc	534..721	CDD:214692	118/186 (63%)
		DEXDc	557..695	CDD:238005	92/137 (67%)
		HELICc	766..870	CDD:197757	61/103 (59%)
		HA2	939..1021	CDD:214852	47/81 (58%)
		OB_NTP_bind	1055..1154	CDD:285018	43/100 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D354219at2759
OrthoFinder	1	1.000	-	-		FOG0000059
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100085
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X141
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.720