Protein Alignment Prp16 and ythc-2

DIOPT Version :10

• Sequence 1: NP_572947.1
• Gene: Prp16 / 32373
• FlyBaseID: FBgn0026713
• Length: 1222
• Species: Drosophila melanogaster
• Sequence 2: NP_492260.1
• Gene: ythc-2 / 172615
• WormBaseID: WBGene00009922
• Length: 1425
• Species: Caenorhabditis elegans
• Alignment Length: 923
• Identity: 209/923 - (22%)
• Similarity: 346/923 - (37%)
• Gaps: 330/923 - (35%)

  Fly   525 KTISEQRRFLPVFASRQELLNVIRENSVIIIVGETGSGKTTQLTQYL----HEDGYSKRGMIGCT 585
            |.:.:.|..||......::|..|...:|:||.|.||.|||||:.|::    ||:....|.|:  |
 Worm   172 KELQKVRNSLPASKYCDQVLKSISSCNVVIISGGTGCGKTTQVPQFILDEAHENNKHVRVMV--T 234

  Fly   586 QPRRVAAMSVAKRVSDEMDTQLGEDVGYAIRFEDCTSERTVIKYMTDGILLRESLRDPELDSYSA 650
            ||||:||:|:|:||:.|....:|..|||.:|.:...|:.||:.|.|.|:|||....||.....:.
 Worm   235 QPRRIAAISIAERVARERGEPIGRTVGYQVRLDSRRSDDTVLTYCTTGVLLRMLTSDPVASGITH 299

  Fly   651 IIMDEAHERSLSTDVLFGLLREIVARRHDLKLIVTSATMDSSK--FATFFGN------------- 700
            |:|||.|||.::||.|...|||.:..|.|||:|:.|||::.:.  |:.:|.|
 Worm   300 IVMDEIHEREINTDYLLIALRECLKMRPDLKVILMSATIEGNMQLFSNYFENHSMDVIRIESRAF 364

  Fly   701 -VPTF------------------------------------------------------------ 704
             |..|
 Worm   365 DVKVFYLDQILAMTGYQPPESKAFFSTAEYEEEDWKDEIEAVEREEKDKAKQRAADSSLSTLSKP 429

  Fly   705 -----------------------------------------------------------TIPGRT 710
                                                                       |.|...
 Worm   430 VTKMAANTKRNSPIEEREWTSGPCSTPDGDIIDERAMRQYMNIIGNPDIRPVITVEFRPTTPNSV 494

  Fly   711 FPVDVMFSKN-------------------------TCED-------------------------- 724
            |..||.::.|                         |||:
 Worm   495 FINDVKYTTNPNQSAQALLQQKRERCLMPRGPLTFTCENPASTTKSPPSPTPTLGISSGLAKFTP 559

  Fly   725 ------------YVESAVKQALQVHL--------------------------------------- 738
                        .:|...|:.|:..|
 Worm   560 FGGFGEKQRISTLLEKKFKEELKTALPDRTVYYHPQMNDVVDKTDFSKLRFGEKYNLFYGSSSNN 624

  Fly   739 ----------------TPNEGDMLIFMPGQEDIEVTCEVLEERLAEIDNAPALSILPIYSQLPSD 787
                            :|..|.:|:|:||.|||:...:.::.....:.|...:.:||::||:.|.
 Worm   625 SVDYVLLDQVIQYLADSPVFGTILVFLPGYEDIQQMLKAIDCWKNSLKNMKNVIVLPLHSQMTSI 689

  Fly   788 LQAKIFQKSSDGLRKCVVATNIAETSLTVDGIIYVIDSGYCKLKVYNPRIGMDALQIYPISQANA 852
            ....||:......||.::||||||.|:|::.:|:|:|:|..|.|.::....:..|.:.||:::||
 Worm   690 NHGDIFKSVPKDTRKIILATNIAEASITIEDVIFVVDTGKVKEKSFDHEAKLSTLTVKPIARSNA 754

  Fly   853 NQRSGRAGRTGPGQAYRLYTQRQYKDELLALTVPEIQRTNLANTVLLLKSLGVVDLLQFHFM--- 914
            :||||||||...|...||||:::| :.:....:.|::|..:.:..|..|......|....|:
 Worm   755 DQRSGRAGRVANGYCIRLYTEQEY-NSMPETQIAEMKRAAIYDVTLHAKLFAPKTLKISEFLSLA 818

  Fly   915 -DPPPQDNILNSLYQLWILGAL-------DHTG--------------------ALTTLGRQMAEF 951
             :||.:::||.::..|..:||.       |::|                    .||.|||.||..
 Worm   819 PEPPEKESILQAITFLEQIGAFYTPIKIYDNSGNEEGLKNDEEAENSENPEDPELTDLGRLMARL 883

  Fly   952 PLDPPQCQMLIVACRMGCSAEVLIIVSMLS--VPSIFYRPKGREDEADGVREKFQRPESDHLTYL 1014
            ||||...:||:....:.|...::.:|::|:  .|.:....:.|:.::....|..|:..||||.|:
 Worm   884 PLDPQLSRMLLFGLALKCLTPIVNLVALLASREPYVLALSEDRDLQSKMKFEMAQQDLSDHLLYI 948

  Fly  1015 NVYQQW--RQNNYSSTWCNEHFIHIKAMRKVREVRQQL-------KDIMTQQNLSVISCGID--- 1067
            .:..::  :.|:..:.:|.:||::...||.|:..|:||       |.|....|..|::...|
 Worm   949 RLCNEFCSKNNSQQNQFCRDHFLNFSTMRMVQGTRRQLLRELVRAKLINISPNRDVLTVLTDHHF 1013

  Fly  1068 ------WDIVRKCICSAYF------YQAARLKGIGEYVNLRTGMPCHLHPTS----ALYGLGTTP 1116
                  |.:::..|.:..:      ...:.||.:..:    ...|..|||:|    .:..:|.:.
 Worm  1014 NQFSQCWPMIQAVIAAGCYPFIGVSASESNLKKVQTF----NDKPAFLHPSSMVKKQIVKMGKSE 1074

  Fly  1117 -----DYVVYHEL 1124
                 :||.:.|:
 Worm  1075 KSPRVEYVAFQEM 1087

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Prp16	NP_572947.1	HrpA	534..>1148	CDD:441249	207/914 (23%)
ythc-2	NP_492260.1	R3H	21..100	CDD:214647
		DEXHc_RHA-like	198..359	CDD:438707	68/162 (42%)
		HrpA	<630..>988	CDD:441249	102/358 (28%)
		OB_NTP_bind	1023..1116	CDD:400182	12/69 (17%)