DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment l(1)G0007 and DHX9

DIOPT Version :9

Sequence 1:NP_572947.1 Gene:l(1)G0007 / 32373 FlyBaseID:FBgn0026713 Length:1222 Species:Drosophila melanogaster
Sequence 2:NP_001348.2 Gene:DHX9 / 1660 HGNCID:2750 Length:1270 Species:Homo sapiens


Alignment Length:1093 Identity:270/1093 - (24%)
Similarity:446/1093 - (40%) Gaps:283/1093 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   201 DRDRDRSMSERSVHTPREPGTPGGSSGGISNSSWDDEDGE-------------FGQRKSDWDMP- 251
            :::|.:.|.|..|.        |.:..|:.||: :.:|.:             ..:.||: ::| 
Human    28 NKNRQKFMCEVQVE--------GYNYTGMGNST-NKKDAQSNAARDFVNYLVRINEIKSE-EVPA 82

  Fly   252 -----------TPRRHGNKSGDWSVRSGGSRRNHGRQDDTVRPTPAHRYNQWAHGRKRSGATPWG 305
                       ||....|..||.....||             |.|.|...: |......||:.:|
Human    83 FGVASPPPLTDTPDTTANAEGDLPTTMGG-------------PLPPHLALK-AENNSEVGASGYG 133

  Fly   306 ------------EDPESLDLWEEEQRRLDREWYNIDEG----YDDENNPFGGPNSEYFRKREEQL 354
                        :|..|....:|.|..|:.|..:::.|    :..||..  ...::||:|.:.|.
Human   134 VPGPTWDRGANLKDYYSRKEEQEVQATLESEEVDLNAGLHGNWTLENAK--ARLNQYFQKEKIQG 196

  Fly   355 EQKRT----------------------KRISAQQRQNNRDNELWERNRMLT-------SGVVTL- 389
            |.|.|                      :||.|::..:|:  :|..::..|:       .|||.. 
Human   197 EYKYTQVGPDHNRSFIAEMTIYIKQLGRRIFAREHGSNK--KLAAQSCALSLVRQLYHLGVVEAY 259

  Fly   390 ----------------ISVNDDFDEEALERVHLLVHHIIPPFLDGRIVFTKQPEPVVPVKDPTSD 438
                            ::::.|.:.:....:..|...|:||           ||      ||:..
Human   260 SGLTKKKEGETVEPYKVNLSQDLEHQLQNIIQELNLEILPP-----------PE------DPSVP 307

  Fly   439 MALLARKGSALVRNYREQK------ERRKAQKKHWELSGTKLGNIMGVQRPQDEDDMRFDKEKDK 497
            :||...|.:....:.|:.:      ...::....|..|....|.:......|...|:     |::
Human   308 VALNIGKLAQFEPSQRQNQVGVVPWSPPQSNWNPWTSSNIDEGPLAFATPEQISMDL-----KNE 367

  Fly   498 ADYRKDQKFADHMRDQDTGGKSDFSRKKTISEQRRFLPVFASRQELLNVIRENSVIIIVGETGSG 562
            ..|:.:|       |.|.         :.|.::|..|||.....|:|..|.:|||:||.|.||.|
Human   368 LMYQLEQ-------DHDL---------QAILQERELLPVKKFESEILEAISQNSVVIIRGATGCG 416

  Fly   563 KTTQLTQYLHEDGYSKRGMIGC----TQPRRVAAMSVAKRVSDEMDTQLGEDVGYAIRFEDCTSE 623
            ||||:.|::.:|.........|    |||||::|:|||:||:.|...:.|:..||::|||.....
Human   417 KTTQVPQFILDDFIQNDRAAECNIVVTQPRRISAVSVAERVAFERGEEPGKSCGYSVRFESILPR 481

  Fly   624 -RTVIKYMTDGILLRESLRDPELDSYSAIIMDEAHERSLSTDVLFGLLREIVARRHDLKLIVTSA 687
             ...|.:.|.|:|||:  .:..:...|.:|:||.|||.::||.|..:||::|....::::::.||
Human   482 PHASIMFCTVGVLLRK--LEAGIRGISHVIVDEIHERDINTDFLLVVLRDVVQAYPEVRIVLMSA 544

  Fly   688 TMDSSKFATFFGNVPTFTIPGRTFPVDVMF----------------------------------- 717
            |:|:|.|..:|.|.|...:.|||:||...|                                   
Human   545 TIDTSMFCEYFFNCPIIEVYGRTYPVQEYFLEDCIQMTHFVPPPKDKKKKDKDDDGGEDDDANCN 609

  Fly   718 -------------------SKNTCEDYVESAVK--QALQVHLTPNEGDMLIFMPG-------QED 754
                               .|.|..:.:|:.:|  :.|.|     .|.:|:|:||       |:.
Human   610 LICGDEYGPETRLSMSQLNEKETPFELIEALLKYIETLNV-----PGAVLVFLPGWNLIYTMQKH 669

  Fly   755 IEVTCEVLEERLAEIDNAPALSILPIYSQLPSDLQAKIFQKSSDGLRKCVVATNIAETSLTVDGI 819
            :|:.......|         ..|||::||:|.:.|.|:|.....|:.|.:::|||||||:|::.:
Human   670 LEMNPHFGSHR---------YQILPLHSQIPREEQRKVFDPVPVGVTKVILSTNIAETSITINDV 725

  Fly   820 IYVIDSGYCKLKVYNPRIGMDALQIYPISQANANQRSGRAGRTGPGQAYRLYTQRQYKDELLALT 884
            :|||||...|:|::.....|........|:.|..||.|||||..||..:.|.::.:: :.|....
Human   726 VYVIDSCKQKVKLFTAHNNMTNYATVWASKTNLEQRKGRAGRVRPGFCFHLCSRARF-ERLETHM 789

  Fly   885 VPEIQRTNLANTVLLLKSLGVVDLLQF--HFMDPPPQDNILNSLYQLWILGALDHTGALTTLGRQ 947
            .||:.||.|....|.:|.|.:..:.||  ..::|||.|.::.:.:.|..|.|||....||.|||.
Human   790 TPEMFRTPLHEIALSIKLLRLGGIGQFLAKAIEPPPLDAVIEAEHTLRELDALDANDELTPLGRI 854

  Fly   948 MAEFPLDPPQCQMLIVACRMGCSAEVLIIVSMLSVPSIFYRPKGREDEADG-VREKFQRPE-SDH 1010
            :|:.|::|...:|:|    |||...|...:..::..:.|..|...|.:..| :...|.... |||
Human   855 LAKLPIEPRFGKMMI----MGCIFYVGDAICTIAAATCFPEPFINEGKRLGYIHRNFAGNRFSDH 915

  Fly  1011 LTYLNVYQQWRQNNYSS-----TWCNEHFIHIKAMRKVREVRQQLKDIMTQQNLSVISCGIDWDI 1070
            :..|:|:|.|.......     .:|....:::..:|...|.:.|||:|:       |:.|...| 
Human   916 VALLSVFQAWDDARMGGEEAEIRFCEHKRLNMATLRMTWEAKVQLKEIL-------INSGFPED- 972

  Fly  1071 VRKCICSAYFYQAARLKGIGEYVNLRTGMPCHLHPTSALYGLGTTPDYVVYHE 1123
               |:.:..|              ..||...:|....:|...|..|: |.||:
Human   973 ---CLLTQVF--------------TNTGPDNNLDVVISLLAFGVYPN-VCYHK 1007

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
l(1)G0007NP_572947.1 DEXDc 529..715 CDD:214692 74/190 (39%)
DEXDc 551..689 CDD:238005 54/142 (38%)
HELICc 722..870 CDD:238034 50/156 (32%)
HA2 932..1014 CDD:214852 26/83 (31%)
OB_NTP_bind 1048..1148 CDD:285018 18/76 (24%)
DHX9NP_001348.2 Interaction with CREBBP. /evidence=ECO:0000269|PubMed:9323138 1..250 48/249 (19%)
DSRM 5..69 CDD:214634 9/49 (18%)
siRNA-binding. /evidence=ECO:0000269|PubMed:23361462, ECO:0007744|PDB:3VYY 5..9
siRNA-binding. /evidence=ECO:0000269|PubMed:23361462, ECO:0007744|PDB:3VYY 53..55 0/1 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 83..118 10/47 (21%)
DSRM 181..251 CDD:214634 13/73 (18%)
siRNA-binding. /evidence=ECO:0000269|PubMed:23361462, ECO:0007744|PDB:3VYX 182..186 0/5 (0%)
Interaction with BRCA1. /evidence=ECO:0000269|PubMed:9662397 230..325 19/113 (17%)
siRNA-binding. /evidence=ECO:0000305|PubMed:23361462 234..236 1/3 (33%)
Necessary for interaction with RNA polymerase II holoenzyme. /evidence=ECO:0000269|PubMed:9323138 255..664 112/453 (25%)
Necessary for interaction with H2AX. /evidence=ECO:0000269|PubMed:15613478 313..952 188/680 (28%)
MTAD. /evidence=ECO:0000269|PubMed:11416126 331..380 10/69 (14%)
HrpA 381..1095 CDD:224557 196/674 (29%)
Core helicase. /evidence=ECO:0000305|PubMed:25062910 398..809 131/427 (31%)
DEIH box 511..514 2/2 (100%)
Nuclear localization signal (NLS1). /evidence=ECO:0000255 586..595 0/8 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 588..608 0/19 (0%)
HA2. /evidence=ECO:0000269|PubMed:25062910 831..919 27/91 (30%)
OB-fold. /evidence=ECO:0000269|PubMed:20696886, ECO:0000269|PubMed:25062910, ECO:0000269|PubMed:25149208 958..1074 18/76 (24%)
RGG. /evidence=ECO:0000269|PubMed:10207077, ECO:0000269|PubMed:25062910, ECO:0000269|PubMed:25149208, ECO:0000269|PubMed:9111062 1150..1270
Nuclear localization signal (NLS2). /evidence=ECO:0000269|PubMed:16375861 1155..1173
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1229..1248
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG1643
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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