DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment l(1)G0007 and DQX1

DIOPT Version :9

Sequence 1:	NP_572947.1	Gene:	l(1)G0007 / 32373	FlyBaseID:	FBgn0026713	Length:	1222	Species:	Drosophila melanogaster
Sequence 2:	NP_598376.2	Gene:	DQX1 / 165545	HGNCID:	20410	Length:	717	Species:	Homo sapiens

Alignment Length:	681	Identity:	206/681 - (30%)
Similarity:	339/681 - (49%)	Gaps:	45/681 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   522 SRKKTISEQRRFLPVFASRQELLNVIREN--SVIIIVGETGSGKTTQLTQYLHE----DGYSKRG 580
            ||...:.:||:.||::|:|...|..:..|  .|:::.||.||||:||:.|:..|    .|:.| |
Human    33 SRYYELLKQRQALPIWAARFTFLEQLESNPTGVVLVSGEPGSGKSTQIPQWCAEFALARGFQK-G 96

  Fly   581 MIGCTQPRRVAAMSVAKRVSDEMDTQLGEDVGYAIRFEDCTSERTVIKYMTDGILLRESLRDPEL 645
            .:..|||..:||.|:|.||:||||..||.:|||:|..||||...|::::..|.:||:|.......
Human    97 QVTVTQPYPLAARSLALRVADEMDLTLGHEVGYSIPQEDCTGPNTLLRFCWDRLLLQEVASTRGT 161

  Fly   646 DSYSAIIMDEAHERSLSTDVLFGLLREIVARRH----DLKLIVTSATMDSSKFATFFGNVPTFTI 706
            .::..:::|||.|||:::|.|.|||::  ||..    ||:::|.:......|...|:||.|...|
Human   162 GAWGVLVLDEAQERSVASDSLQGLLQD--ARLEKLPGDLRVVVVTDPALEPKLRAFWGNPPIVHI 224

  Fly   707 P----GRTFPVDVMFSKNTCEDYVESAVKQALQVHLTPNEGDMLIFMPGQEDIEVTCEVLEERLA 767
            |    .|..|:   :......|.||:|.:..|::......||:|:|:|.:|:|.:.||.|...:.
Human   225 PREPGERPSPI---YWDTIPPDRVEAACQAVLELCRKELPGDVLVFLPSEEEISLCCESLSREVE 286

  Fly   768 E--IDNAPALSILPIYSQLPSDLQAKIFQKSSDGLRKCVVATNIAETSLTVDGIIYVIDSGYCKL 830
            .  :...|. .:||::......:|| :::...  .||.||...:|:.|.::..|.:|||||....
Human   287 SLLLQGLPP-RVLPLHPDCGRAVQA-VYEDMD--ARKVVVTHWLADFSFSLPSIQHVIDSGLELR 347

  Fly   831 KVYNPRIGMDALQIYPISQANANQRSGRAGRTGPGQAYRLYTQRQYKDELLALTVPEIQRTNLAN 895
            .||||||..:...:.|||:..|..|..||....||....||.:...:.|...|..|.:...||::
Human   348 SVYNPRIRAEFQVLRPISKCQAEARRLRARGFPPGSCLCLYPKSFLELEAPPLPQPRVCEENLSS 412

  Fly   896 TVLLLKSLGVVDLLQFHFMDPPPQDNILNSLYQLWILGALDHTGALTTLGRQMAEFPLDPPQCQM 960
            .|||||...:.:..:.||:|.|..:.::.:|..|..|.|||..|.|:.||..::||||.|...:.
Human   413 LVLLLKRRQIAEPGECHFLDQPAPEALMQALEDLDYLAALDDDGDLSDLGVILSEFPLAPELAKA 477

  Fly   961 LIVACRMGCSAEVLIIVSMLSVPSIFYRPKGREDEADGVREKFQRPESDHLTYLNVYQQWRQNNY 1025
            |:.:|...|..|:|.:.:||:....|.||....:|| .:|...:..:.||.:.:.||:.:.|:..
Human   478 LLASCEFDCVDEMLTLAAMLTAAPGFTRPPLSAEEA-ALRRALEHTDGDHSSLIQVYEAFIQSGA 541

  Fly  1026 SSTWCNEHFIHIKAMRKVREVRQQLKDIM--TQQNLSVISCGIDWD--IVRKCICSAYFYQAAR- 1085
            ...||....::..|:.:..::|.:|.::|  .:..||:.:.|.:.:  .::|.:.|.||.:.||
Human   542 DEAWCQARGLNWAALCQAHKLRGELLELMQRIELPLSLPAFGSEQNRRDLQKALVSGYFLKVARD 606

  Fly  1086 LKGIGEYVNLRTGMPCHLHPTS--------ALYGLGTTPDYVVYHELIMTAKEYMQCATAVDGYW 1142
            ..|.|.|:.|     .|.|...        :.......|.:|:||...::....:...:.:....
Human   607 TDGTGNYLLL-----THKHVAQLSSYCCYRSRRAPARPPPWVLYHNFTISKDNCLSIVSEIQPQM 666

  Fly  1143 LAELGPMFFSVKESGRSGREKKKQAAEHLKE 1173
            |.||.|.:|.........|:...|..|.:.:
Human   667 LVELAPPYFLSNLPPSESRDLLNQLREGMAD 697

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(1)G0007	NP_572947.1	DEXDc	529..715	CDD:214692	75/199 (38%)
		DEXDc	551..689	CDD:238005	58/145 (40%)
		HELICc	722..870	CDD:238034	47/149 (32%)
		HA2	932..1014	CDD:214852	28/81 (35%)
		OB_NTP_bind	1048..1148	CDD:285018	24/112 (21%)
DQX1	NP_598376.2	Motor_domain	8..>89	CDD:277568	21/55 (38%)
		DEXDc	41..231	CDD:214692	73/192 (38%)
		DEXDc	65..204	CDD:238005	58/141 (41%)
		DEAQ box	170..173		2/2 (100%)
		HA2	<465..530	CDD:214852	20/65 (31%)
		OB_NTP_bind	565..674	CDD:285018	25/113 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	694..717		0/4 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D354219at2759
OrthoFinder	1	1.000	-	-		FOG0000059
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820