DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(1)G0007 and Dhx9

DIOPT Version :9

Sequence 1:	NP_572947.1	Gene:	l(1)G0007 / 32373	FlyBaseID:	FBgn0026713	Length:	1222	Species:	Drosophila melanogaster
Sequence 2:	XP_011246220.1	Gene:	Dhx9 / 13211	MGIID:	108177	Length:	1384	Species:	Mus musculus

Alignment Length:	1020	Identity:	255/1020 - (25%)
Similarity:	414/1020 - (40%)	Gaps:	262/1020 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   225 SSG-GISNSSWDDEDG--EFGQRKSDWDMPTPRR----------HGNKSGDWSVRSGGSRRNHGR 276
            ||| |....:||....  ::..||.:.::.....          |||    |::.:..:|.|...
Mouse   132 SSGYGSPGPTWDRGANLKDYYSRKEEQEVQATLESEEVDLNAGLHGN----WTLENAKARLNQYF 192

  Fly   277 QDDTVRPTPAHRYNQWAHGRKRSGATPWGEDPESLDLWEEEQRRLDREWYNIDEGYDDENNPFGG 341
            |.:.::                      ||                   |...:...|.|..|..
Mouse   193 QKEKIQ----------------------GE-------------------YKYTQVGPDHNRSFIA 216

  Fly   342 PNSEYFRKREEQL---EQKRTKRISAQQRQNNRDNELWERNRMLTSGVVTLIS------------ 391
            ..:.|.::...::   |....|:::||....:...:|:.      .||:...|
Mouse   217 EMTIYIKQLGRRIFAREHGSNKKLAAQSCALSLVRQLYH------LGVIEAYSGLTKKKEGERVE 275

  Fly   392 -----VNDDFDEEALERVHLLVHHIIPPFLDGRIVFTKQPEPVVPVKDPTSDMALLARKGSALVR 451
                 ::.|.:.:....|..|...|:||.:|          |.:||   ..::..||
Mouse   276 PYKVFLSPDLELQLQNVVQELDLEIVPPPVD----------PSMPV---ILNIGKLA-------- 319

  Fly   452 NYREQKERRKA-----------QKKHWELSGTKLGNIMGVQRPQDEDDMRFDKEKDKADYRKDQK 505
             :.|..:|:.|           ....|..|....|.:......|...|:     |::..|:.:|
Mouse   320 -HFEPSQRQNAVGVVPWSPPQSNWNPWTSSNIDEGPLAYASTEQISMDL-----KNELTYQMEQ- 377

  Fly   506 FADHMRDQDTGGKSDFSRKKTISEQRRFLPVFASRQELLNVIRENSVIIIVGETGSGKTTQLTQY 570
              ||             ..:::.::|..|||.....|:|..|..|||:||.|.||.|||||:.||
Mouse   378 --DH-------------NLQSVLQERELLPVKKFEAEILEAISSNSVVIIRGATGCGKTTQVPQY 427

  Fly   571 LHEDGYSKRGMIGC----TQPRRVAAMSVAKRVSDEMDTQLGEDVGYAIRFEDCTSE-RTVIKYM 630
            :.:|.........|    |||||::|::||:||:.|...:.|:..||::|||..... ...|.:.
Mouse   428 ILDDFIQNDRAAECNIVVTQPRRISAVAVAERVAYERGEEPGKSCGYSVRFESILPRPHASIMFC 492

  Fly   631 TDGILLRESLRDPELDSYSAIIMDEAHERSLSTDVLFGLLREIVARRHDLKLIVTSATMDSSKFA 695
            |.|:|||:  .:..:...|.:|:||.|||.::||.|..:||::|....::::::.|||:|::.|.
Mouse   493 TVGVLLRK--LEAGIRGISHVIVDEIHERDINTDFLLVVLRDVVLAYPEVRIVLMSATIDTTMFC 555

  Fly   696 TFFGNVPTFTIPGRTFPVDVMF------------------------------------------- 717
            .:|.|.|...:.||||||...|
Mouse   556 EYFFNCPIIEVYGRTFPVQEYFLEDCIQMTQFIPPPKDKKKKDKEDDGGEDDDANCNLICGDEYG 620

  Fly   718 -----------SKNTCEDYVESAVK--QALQVHLTPNEGDMLIFMPG-------QEDIEVTCEVL 762
                       .|.|..:.:|:.:|  :.|.|     .|.:|:|:||       |:.:|......
Mouse   621 PETKLSMSQLNEKETPFELIEALLKYIETLNV-----PGAVLVFLPGWNLIYTMQKHLENNSHFG 680

  Fly   763 EERLAEIDNAPALSILPIYSQLPSDLQAKIFQKSSDGLRKCVVATNIAETSLTVDGIIYVIDSGY 827
            ..|         ..|||::||:|.:.|.|:|....||:.|.:::|||||||:|::.::|||||..
Mouse   681 SHR---------YQILPLHSQIPREEQRKVFDPVPDGVTKVILSTNIAETSITINDVVYVIDSCK 736

  Fly   828 CKLKVYNPRIGMDALQIYPISQANANQRSGRAGRTGPGQAYRLYTQRQYKDELLALTVPEIQRTN 892
            .|:|::.....|........|:.|..||.|||||..||..:.|.::.:: |.|.....||:.||.
Mouse   737 QKVKLFTAHNNMTNYATVWASKTNLEQRKGRAGRVRPGFCFHLCSRARF-DRLETHMTPEMFRTP 800

  Fly   893 LANTVLLLKSLGVVDLLQF--HFMDPPPQDNILNSLYQLWILGALDHTGALTTLGRQMAEFPLDP 955
            |....|.:|.|.:..:.||  ..::|||.|.::.:.:.|..|.|||....||.|||.:|:.|::|
Mouse   801 LHEIALSIKLLRLGGIGQFLAKAIEPPPLDAVIEAEHTLRELDALDANDELTPLGRILAKLPIEP 865

  Fly   956 PQCQMLIVACRMGCSAEVLIIVSMLSVPSIFYRPKGREDEADG-VREKFQRPE-SDHLTYLNVYQ 1018
            ...:|:|    |||...|...|..:|..:.|..|...|.:..| :...|.... |||:..|:|:|
Mouse   866 RFGKMMI----MGCIFYVGDAVCTISAATCFPEPFISEGKRLGYIHRNFAGNRFSDHVALLSVFQ 926

  Fly  1019 QWRQNNYSS-----TWCNEHFIHIKAMRKVREVRQQLKDIMTQQNLSVISCGIDWDIVRKCICSA 1078
            .|.....|.     .:|.:..:::..:|...|.:.|||:|:       |:.|...|    |:.:.
Mouse   927 AWDDARMSGEEAEIRFCEQKRLNMATLRMTWEAKVQLKEIL-------INSGFPED----CLLTQ 980

  Fly  1079 YFYQAARLKGIGEYVNLRTGMPCHLHPTSALYGLGTTPDYVVYHE 1123
            .|              ..||...:|....:|...|..|: |.||:
Mouse   981 VF--------------TNTGPDNNLDVVISLLAFGVYPN-VCYHK 1010

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(1)G0007	NP_572947.1	DEXDc	529..715	CDD:214692	74/190 (39%)
		DEXDc	551..689	CDD:238005	54/142 (38%)
		HELICc	722..870	CDD:238034	51/156 (33%)
		HA2	932..1014	CDD:214852	28/83 (34%)
		OB_NTP_bind	1048..1148	CDD:285018	18/76 (24%)
Dhx9	XP_011246220.1	DSRM_DHX9_rpt1	3..71	CDD:380683
		DSRM_DHX9_rpt2	181..255	CDD:380684	15/114 (13%)
		DEXHc_DHX9	333..566	CDD:350730	78/255 (31%)
		HrpA	337..>1055	CDD:224557	210/742 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810