DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(1)G0007 and Dhx15

DIOPT Version :9

Sequence 1:	NP_572947.1	Gene:	l(1)G0007 / 32373	FlyBaseID:	FBgn0026713	Length:	1222	Species:	Drosophila melanogaster
Sequence 2:	NP_031865.2	Gene:	Dhx15 / 13204	MGIID:	1099786	Length:	795	Species:	Mus musculus

Alignment Length:	788	Identity:	316/788 - (40%)
Similarity:	468/788 - (59%)	Gaps:	92/788 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   470 SGTKLGNIMGVQRPQDEDDMRFDKEKDKADYRKDQKFADHMRDQD--------------TGG--- 517
            ||.|.....|..|.:|.|  |.|:.||: |..:|:...:..|:::              :.|
Mouse    15 SGKKRAGTDGKDRERDRD--REDRSKDR-DRERDRGDREREREKEKEKELRASTNAMLISAGLPP 76

  Fly   518 -KSDFSRKKT-------------------------------------------ISEQRRFLPVFA 538
             |:..|...|                                           |.::|..|||:.
Mouse    77 LKASHSAHSTHSAHSTHSTHSAHSTHTGHTGHTSLPQCINPFTNLPHTPRYYDILKKRLQLPVWE 141

  Fly   539 SRQELLNVIRENSVIIIVGETGSGKTTQLTQ----YLHEDGYSKRGMIGCTQPRRVAAMSVAKRV 599
            .:....:::..:...::|||||||||||:.|    |:......||| :.|||||||||||||:||
Mouse   142 YKDRFTDILVRHQSFVLVGETGSGKTTQIPQWCVEYMRSLPGPKRG-VACTQPRRVAAMSVAQRV 205

  Fly   600 SDEMDTQLGEDVGYAIRFEDCTSERTVIKYMTDGILLRESLRDPELDSYSAIIMDEAHERSLSTD 664
            :||||..||::|||:||||||:|.:|::||||||:||||::.||.|:.|..||:||||||:|:||
Mouse   206 ADEMDVMLGQEVGYSIRFEDCSSAKTILKYMTDGMLLREAMNDPLLERYGVIILDEAHERTLATD 270

  Fly   665 VLFGLLREIVARRHDLKLIVTSATMDSSKFATFFGNVPTFTIPGRTFPVDVMFSKNTCEDYVESA 729
            :|.|:|:|:|.:|.|||:||.|||:|:.||..:|.|.|..||||||.||::.::.....||:|:|
Mouse   271 ILMGVLKEVVRQRSDLKVIVMSATLDAGKFQIYFDNCPLLTIPGRTHPVEIFYTPEPERDYLEAA 335

  Fly   730 VKQALQVHL-TPNEGDMLIFMPGQEDIEVTCEVLEERLAEIDN-APA---LSILPIYSQLPSDLQ 789
            ::..:|:|: ...|||:|:|:.|||:|:..|:.::.   |:|: .|.   :.|:|:||.||...|
Mouse   336 IRTVIQIHMCEEEEGDLLLFLTGQEEIDEACKRIKR---EVDDLGPEVGDIKIIPLYSTLPPQQQ 397

  Fly   790 AKIFQ----KSSDGL--RKCVVATNIAETSLTVDGIIYVIDSGYCKLKVYNPRIGMDALQIYPIS 848
            .:||:    |..:|.  ||.||:|||||||||:||:::|||.|:.|.|||||||.:::|.:..||
Mouse   398 QRIFEPPPPKKQNGAIGRKVVVSTNIAETSLTIDGVVFVIDPGFAKQKVYNPRIRVESLLVTAIS 462

  Fly   849 QANANQRSGRAGRTGPGQAYRLYTQRQYKDELLALTVPEIQRTNLANTVLLLKSLGVVDLLQFHF 913
            :|:|.||:||||||.||:.:||||::.||.|:...|.|||.|:||.:.||.||.||:.||:.|.|
Mouse   463 KASAQQRAGRAGRTRPGKCFRLYTEKAYKTEMQDNTYPEILRSNLGSVVLQLKKLGIDDLVHFDF 527

  Fly   914 MDPPPQDNILNSLYQLWILGALDHTGALTTLGRQMAEFPLDPPQCQMLIVACRMGCSAEVLIIVS 978
            ||||..:.::.:|..|..|.||:..|.||.||..||||||||...:|:|.:|...||.|||.|.:
Mouse   528 MDPPAPETLMRALELLNYLAALNDDGDLTELGSMMAEFPLDPQLAKMVIASCDYNCSNEVLSITA 592

  Fly   979 MLSVPSIFYRPKGREDEADGVREKFQRPESDHLTYLNVYQQWRQNNYSSTWCNEHFIHIKAMRKV 1043
            |||||..|.||...:..||..:.:|...:.||||.||||..::||:.|..||.::||:.:::...
Mouse   593 MLSVPQCFVRPTEAKKAADEAKMRFAHIDGDHLTLLNVYHAFKQNHESVQWCYDNFINYRSLMSA 657

  Fly  1044 REVRQQLKDIMTQQNL---SVISCGIDWDI-VRKCICSAYFYQAARLKGIGEYVNLRTGMPCHLH 1104
            ..|||||..||.:.||   |......|:.| :||.:.:.||.|.|.|:..|.|:.::......||
Mouse   658 DNVRQQLSRIMDRFNLPRRSTDFTSRDYYINIRKALVTGYFMQVAHLERTGHYLTVKDNQVVQLH 722

  Fly  1105 PTSALYGLGTTPDYVVYHELIMTAKEYMQCATAVDGYWLAELGPMFFSVKESGRSGREKKKQAAE 1169
            |::.   |...|::|:|:|.::|.|.|::..|.:...||.::.|.::.:....:.  |.|:|...
Mouse   723 PSTV---LDHKPEWVLYNEFVLTTKNYIRTCTDIKPEWLVKIAPQYYDMSNFPQC--EAKRQLDR 782

  Fly  1170 HLKEMEEQ 1177
            .:.:::.:
Mouse   783 IIAKLQSK 790

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(1)G0007	NP_572947.1	DEXDc	529..715	CDD:214692	105/189 (56%)
		DEXDc	551..689	CDD:238005	86/141 (61%)
		HELICc	722..870	CDD:238034	72/158 (46%)
		HA2	932..1014	CDD:214852	40/81 (49%)
		OB_NTP_bind	1048..1148	CDD:285018	33/103 (32%)
Dhx15	NP_031865.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..111		18/98 (18%)
		HrpA	124..763	CDD:224557	294/645 (46%)
		DEAH box	260..263		2/2 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D354219at2759
OrthoFinder	1	1.000	-	-		FOG0000059
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100085
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X141
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.720