Protein Alignment Prp16 and TDRD9

DIOPT Version :10

• Sequence 1: NP_572947.1
• Gene: Prp16 / 32373
• FlyBaseID: FBgn0026713
• Length: 1222
• Species: Drosophila melanogaster
• Sequence 2: NP_694591.2
• Gene: TDRD9 / 122402
• HGNCID: 20122
• Length: 1382
• Species: Homo sapiens
• Alignment Length: 779
• Identity: 207/779 - (26%)
• Similarity: 339/779 - (43%)
• Gaps: 131/779 - (16%)

  Fly   387 VTLISVNDDFD-EEALERVHLLVHHIIPPFLDGRIVFTKQPEPVVPVKDPTSDMALL----ARKG 446
            :|:..:||.|. .:.:..|.||  ...|.|..|......|.:.|.|...|.:....|    ||..
Human     5 LTIEQINDWFTIGKTVTNVELL--GAPPAFPAGAAREEVQRQDVAPGAGPAAQAPALAQAPARPA 67

  Fly   447 SALVRNYREQKERRKAQKKHWELSGTKLGNIMGVQRPQDEDDMRFDKEK-------DKADYRKDQ 504
            :|..|:..::....:...|:.:|...:|.....|| |......|....|       ....|
Human    68 AAFERSLSQRSSEVEYINKYRQLEAQELDVCRSVQ-PTSGPGPRPSLAKLSSVTCIPGTTY---- 127

  Fly   505 KFADHMRDQDTGGKSDFSRKKTISEQRRFLPVFASRQELLNVIRENSVIIIVGETGSGKTTQLTQ 569
            |:.|                         ||:...::|::::|..|||:||.|.|||||:|||.|
Human   128 KYPD-------------------------LPISRYKEEVVSLIESNSVVIIHGATGSGKSTQLPQ 167

  Fly   570 YLHEDGYSKRG---MIGCTQPRRVAAMSVAKRVSDEMDTQLGEDVGYAIRFEDCTSERTVIKYMT 631
            |: .|.|.:|.   .|..||||::.|.|:|:.:|.|....||..|||.:..|...:|.|.:.|||
Human   168 YI-LDHYVQRSAYCSIVVTQPRKIGASSIARWISKERAWTLGGVVGYQVGLEKIATEDTRLIYMT 231

  Fly   632 DGILLRESLRDPELDSYSAIIMDEAHERSLSTDVLFGLLREIV-ARRHDLKLIVTSATMDSSKFA 695
            .|:||::.:....|..::.||:||.|||:...|.|..::|::: .....:|:::.|||:...:||
Human   232 TGVLLQKIVSAKSLMEFTHIIIDEVHERTEEMDFLLLVVRKLLRTNSRFVKVVLMSATISCKEFA 296

  Fly   696 TFFGNVPT---------FTIPGRTFPVDVMF----------------------SKNTCE------ 723
            .:|. ||.         |.:.|:...|:..:                      :|:..|
Human   297 DYFA-VPVQNKMNPAYIFEVEGKPHSVEEYYLNDLEHIHHSKLSPHLLEEPVITKDIYEVAVSLI 360

  Fly   724 ------DYVESAVKQALQVHLTPNEGDMLIFMPGQEDIEVTCEVLEERLAEIDNAPALSILPIYS 782
                  |..||..|.............:|:|:||..:|....|:|...:.:     .|.:.|::|
Human   361 QMFDDLDMKESGNKAWSGAQFVLERSSVLVFLPGLGEINYMHELLTSLVHK-----RLQVYPLHS 420

  Fly   783 QLPSDLQAKIFQKSSDGLRKCVVATNIAETSLTVDGIIYVIDSGYCKLKVYNPRIGMDALQIYPI 847
            .:..:.|..:|.....|.||.:::|||||:|:||..:.||||....:..|.:......:|::...
Human   421 SVALEEQNNVFLSPVPGYRKIILSTNIAESSVTVPDVKYVIDFCLTRTLVCDEDTNYQSLRLSWA 485

  Fly   848 SQANANQRSGRAGRTGPGQAYRLYTQRQYKDELLALTVPEIQRTNLANTVLLLK--SLGVVDLLQ 910
            |:.:.|||.|||||...|..|||..:..:.:.:....|||:.|..|.:|:|.:|  .:|....|.
Human   486 SKTSCNQRKGRAGRVSRGYCYRLVHKDFWDNSIPDHVVPEMLRCPLGSTILKVKLLDMGEPRALL 550

  Fly   911 FHFMDPPPQDNILNSLYQLWILGAL----------DHTGALTTLGRQMAEFPLDPPQCQMLIVAC 965
            ...:.||...:|..::..|..:|||          .|.|.||.|||.:|:.|::....:::::..
Human   551 ATALSPPGLSDIERTILLLKEVGALAVSGQREDENPHDGELTFLGRVLAQLPVNQQLGKLIVLGH 615

  Fly   966 RMGCSAEVLIIVSMLSVPSIFYRPKGREDEADGVREKFQ---RPESDHLTYLNVYQQWRQNNYSS 1027
            ..||..|.|||.:.||:.:.|..|  .....||.|.|..   ..:||.:..:..::.|:....:.
Human   616 VFGCLDECLIIAAALSLKNFFAMP--FRQHLDGYRNKVNFSGSSKSDCIALVEAFKTWKACRQTG 678

  Fly  1028 ---------TWCNEHFIHIKAMRKVREVRQQLKDIMTQQNLSVISCGIDWDIVRKCICSAYFYQ 1082
                     .|...::|.||.:|:|.|:.::||..::|.|:.|       |..|..:...|.|:
Human   679 ELRYPKDELNWGRLNYIQIKRIREVAELYEELKTRISQFNMHV-------DSRRPVMDQEYIYK 735

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Prp16	NP_572947.1	HrpA	534..>1148	CDD:441249	177/620 (29%)
TDRD9	NP_694591.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	36..62		5/25 (20%)
		HrpA	130..>716	CDD:441249	171/619 (28%)
		DEXHc_TDRD9	132..315	CDD:350746	68/184 (37%)
		DEAH box. /evidence=ECO:0000250|UniProtKB:Q14BI7	254..257		2/2 (100%)
		Tudor_TDRD9	905..1005	CDD:410502