DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment l(1)G0007 and Dhx57

DIOPT Version :9

Sequence 1:	NP_572947.1	Gene:	l(1)G0007 / 32373	FlyBaseID:	FBgn0026713	Length:	1222	Species:	Drosophila melanogaster
Sequence 2:	NP_001157231.1	Gene:	Dhx57 / 106794	MGIID:	2147067	Length:	1388	Species:	Mus musculus

Alignment Length:	1010	Identity:	256/1010 - (25%)
Similarity:	442/1010 - (43%)	Gaps:	237/1010 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   386 VVTLISVNDDFDEEALERVHLLVHHIIPPFLDGR-IVFTKQPEPVVPVKDPTSDMALLARKGSAL 449
            :|...|.|::.....  |:|      |..||.|: :.|.|..||||      ..:..|..:.|.:
Mouse   371 LVAFYSTNENLPLAC--RLH------ISEFLYGKALEFAKTSEPVV------YSLITLLEEESEI 421

  Fly   450 VR-------NY-----------REQKERRKAQKKHWELSGTKLGNIM-------GVQRPQDEDD- 488
            |:       .|           .|.:..:.|.:|....|.|.|.|.|       .::...|||:
Mouse   422 VKLLTHTQHKYSVPPVNVPPVPSETRISKPAYRKPVVPSNTFLSNQMLEGERLSELEEDADEDEG 486

  Fly   489 ---MRFDKEK----DKADYRKDQKFADHMRDQDTGGKSDFSRKK------TISEQRRFLPVFASR 540
               :..:.|.    .|..|::..:.|..:..:::.....|..|:      .|.::|:.||.:..|
Mouse   487 PASIIVENESYVNLKKRSYKRYDRPAKSLFAENSKICRQFQMKQASRQFHAILQERQLLPAWEER 551

  Fly   541 QELLNVIRENSVIIIVGETGSGKTTQLTQYLHEDGYS----KRGMIGCTQPRRVAAMSVAKRVSD 601
            :.:|.::.::.|::|.|.||.|||||:.|::.::..:    :...|.||||||::|:|||:||:.
Mouse   552 ETILKLLSKHQVVVISGMTGCGKTTQIPQFILDNSLNGPPERVANIICTQPRRISAISVAERVAK 616

  Fly   602 EMDTQLGEDVGYAIRFEDCTSERTVIKYMTDGILLRESLRDPELDSYSAIIMDEAHERSLSTDVL 666
            |...::|..|||.||.|...|..|.:.|.|.|:|||....|..|...:.||:||.|||:..:|.|
Mouse   617 ERAERVGLTVGYQIRLESVKSSATRLLYCTTGVLLRRLEGDATLQGVTHIIVDEVHERTEESDFL 681

  Fly   667 FGLLREIVARRHDLKLIVTSATMDSSKFATFFGNVPTFTIPGRTFPVDVMFSKN----------- 720
            ..:|::||.:|..|::|:.|||:|:..|:.:|...|..|||||.||||..|.::
Mouse   682 LLVLKDIVMQRATLQVILMSATLDAGLFSKYFSYCPVITIPGRAFPVDQFFLEDALAVTRYVLQD 746

  Fly   721 ----------------------TCEDYVESAVKQALQVHLTPNE--------------------- 742
                                  |.::.||..::  |.:||...|
Mouse   747 GSPYMRSMKQIAKEKLKARHNRTAQEEVEEDLR--LSLHLQDEEESVKDTIPDQQLDFKQLLIRY 809

  Fly   743 ----------------------------------------GDMLIFMPGQEDIEVTCEVLEER-L 766
                                                    |.:|:|:||..:|::..|.|:.. |
Mouse   810 KGVSKSVIKTMSVMDFEKVNLELIEALLEWIVDGKHAYPPGAVLVFLPGLAEIKMLYEQLQSNSL 874

  Fly   767 AEIDNAPALSILPIYSQLPSDLQAKIFQKSSDGLRKCVVATNIAETSLTVDGIIYVIDSGYCKLK 831
            .....:....|.|::|.|.|:.|..:|.|...|:.|.:::|||||||:|:|.::||||||..|.|
Mouse   875 FNNRRSHRCVIHPLHSSLSSEEQQAVFVKPPMGVTKIIISTNIAETSITIDDVVYVIDSGKMKEK 939

  Fly   832 VYNPRIGMDALQIYPISQANANQRSGRAGRTGPGQAYRLYTQRQYKDELLALTVPEIQRTNLANT 896
            .|:...||::|:...:|||||.||.|||||...|..:.|:|...|..:||...:|||||..|...
Mouse   940 RYDAGKGMESLEDTFVSQANALQRKGRAGRVASGVCFHLFTSHHYNHQLLKQQLPEIQRVPLEQL 1004

  Fly   897 VLLLKSLGVVDLLQFH--------FMDPPPQDNILNSLYQLWILGALDHTGALTTLGRQMAEFPL 953
            .|.:|   ::::...|        .::||..|::..|..:|..||||.....||.||..:|..|:
Mouse  1005 CLRIK---ILEMFSTHNLQSVFSRLIEPPHIDSLRASKVRLRDLGALTPDEKLTPLGYHLASLPV 1066

  Fly   954 DPPQCQMLIVACRMGCSAEVLIIVSMLSVPSIFYRPKGREDEADGVREKFQRPESDHLTYLNVYQ 1018
            |....:::::.....|....|.|.:.|:..|.|..|..:::||:..:.:|....||:|..|..|:
Mouse  1067 DVRIGKLMLLGSIFRCLDPALTIAASLAFKSPFVSPWDKKEEANQKKLEFAFANSDYLALLCAYK 1131

  Fly  1019 QWRQNNYSS-----TWCNEHFIHIKAMRKVREVRQQLKDIMTQQNLSVISCGI------------ 1066
            .|:.:...|     .:|.::|:..:.::::..:::|..::::  ::..:..|:
Mouse  1132 GWQLSTKESARASYNYCRQNFLSGRTLQEMASLKRQFTELLS--DIGFVKEGLRAKEIEKRAQGG 1194

  Fly  1067 ----------------DWDIVRKCICSAYFYQAARLK-GIGEYVNLRTGMP-------------- 1100
                            :..::...:|:|.:....::| ..|::....:|:.
Mouse  1195 DGVLDATGEEANTNAENPKLISAVLCAALYPNVVQVKTPEGKFQKTSSGVVRLQPKSAELKFVTK 1259

  Fly  1101 ----CHLHPTSALYGLG--TTPDYVVYHELIMTAKEYMQCATAVDGYWLA-----------ELGP 1148
                .|:||:|..|.:.  .:| |::|||.|.|::.:::..:.|..|.|.           :.|.
Mouse  1260 NDGYVHIHPSSVNYQVRHFDSP-YLLYHEKIKTSRVFIRDCSMVSVYPLVLFGGGQVNVQLQRGA 1323

  Fly  1149 MFFSVKESGRSGREKKKQAAEHLKEME---EQMLK 1180
            ...|:.:..........|.||.:||:.   :|:|:
Mouse  1324 FVVSLDDGWIRFVAASHQVAELVKELRCELDQLLQ 1358

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(1)G0007	NP_572947.1	DEXDc	529..715	CDD:214692	77/189 (41%)
		DEXDc	551..689	CDD:238005	59/141 (42%)
		HELICc	722..870	CDD:238034	59/209 (28%)
		HA2	932..1014	CDD:214852	24/81 (30%)
		OB_NTP_bind	1048..1148	CDD:285018	22/159 (14%)
Dhx57	NP_001157231.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..107
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	121..154
		UBA_DHX57	181..218	CDD:270502
		RWD	246..419	CDD:368608	16/61 (26%)
		HrpA	501..1298	CDD:224557	213/804 (26%)
		DEVH box	669..672		2/2 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810