DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment l(1)G0007 and Dhx32

DIOPT Version :9

Sequence 1:	NP_572947.1	Gene:	l(1)G0007 / 32373	FlyBaseID:	FBgn0026713	Length:	1222	Species:	Drosophila melanogaster
Sequence 2:	NP_001272959.1	Gene:	Dhx32 / 101437	MGIID:	2141813	Length:	751	Species:	Mus musculus

Alignment Length:	677	Identity:	207/677 - (30%)
Similarity:	373/677 - (55%)	Gaps:	35/677 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   522 SRKKTISEQRRFLPVFASRQELLNVIRENSVIIIVGETGSGKTTQLTQYLHEDGYS---KRGMIG 583
            ||...:.::|..||::..:...:..:.:|.|:::.|::..||::|:.|:..|...|   :.|.:.
Mouse    57 SRYYKLLKEREELPIWKEKYSFMESLLQNQVVVVSGDSKCGKSSQVPQWCAEYCLSIHYQHGGVI 121

  Fly   584 CTQPRRVAAMSVAKRVSDEMDTQLGEDVGYAIRFEDCTSERTVIKYMTDGILLRESLRDPELDSY 648
            |||..:..|:.:|.||:||||..:|.:|||.|.||:|.:..|:::|.||.:|.||.:.:|.|.||
Mouse   122 CTQAHKQTAVQLALRVADEMDVNIGHEVGYVIPFENCCTTETILRYCTDDMLQREMMSNPFLGSY 186

  Fly   649 SAIIMDEAHERSLSTDVLFGLLREIVARRHDLKLIVTSATMDSSKFATFFGNVPTFTIPGRTFPV 713
            ..||:|:.|||||:||||.|||::::..|.:|||||..:.:.:||.::::|:||...:..: .||
Mouse   187 GVIILDDVHERSLATDVLLGLLKDVLLARPELKLIVNCSPLLTSKLSSYYGDVPVIEVRNK-HPV 250

  Fly   714 DVMFSKNTCEDYVESAVKQALQVHLTPNEGDMLIFMPGQEDIEVTCEVLEERLAEID-NAPALSI 777
            :|::.....:|..||.::...::|.:..:||:::|:..::|||.|.|::.:..:.:: :...|.:
Mouse   251 EVVYLSGAQKDSFESVIRLIFEIHRSGEKGDVVVFLACEQDIEKTYELVCQEGSNLNPDVGDLVV 315

  Fly   778 LPIYSQLPSDLQAKIFQKSSDGLRKC-------VVATNIAETSLTVDGIIYVIDSGYCKLKVYNP 835
            :|:|   |.: :..:|:...:..::|       |:.|:..|:.:....:.:|||.|..:.:||||
Mouse   316 IPLY---PKE-KCSLFRPVDETEKRCQVYQRRVVLTTSCGESLIWSHTVKFVIDVGLERRQVYNP 376

  Fly   836 RIGMDALQIYPISQANANQRSGRAGRTGPGQAYRLYTQRQYKDELLALTVPEIQRTNLANTVLLL 900
            ||..::|.:.||||:.|..|....|.:..|:.:.|||:.....::..|...|:|..||.:.||.:
Mouse   377 RIRANSLVLQPISQSQAEIRKQLLGSSPSGKLFCLYTEEFASKDMRPLKPAEMQEANLTSMVLFM 441

  Fly   901 KSLGVVDLLQFHFMDPPPQDNILNSLYQLWILGALDHTGALTTLGRQMAEFPLDPPQCQMLIVAC 965
            |.:.:..|.:..||:.|..::::.:|..|..|.|||:.|.|:..|..|:||||||...:.::.:|
Mouse   442 KRVDIAGLGRCDFMNRPAPESLMQALEDLDYLAALDNDGNLSEFGIIMSEFPLDPQLSKSILASC 506

  Fly   966 RMGCSAEVLIIVSMLSVPSIF-YRPKGREDEADGVREKFQRPESDHLTYLNVYQQWRQNNYSST- 1028
            ...|..|:|.|.:|::.||.| :.|.|.|:.|....:.|..||.||.|.:|||..::....:|.
Mouse   507 EFDCVDEMLTIAAMVTAPSCFLHVPHGAEEAAVTCWKTFLHPEGDHFTLINVYNAYQDTVLNSAN 571

  Fly  1029 ------WCNEHFIHIKAMRKVREVRQQLKDIMTQQNLSVI-------SCGIDWDIVRKCICSAYF 1080
                  ||::.|:...|:|....:|.:|.:|:.:..|...       ..|::   ::|.:.|.||
Mouse   572 EHCVEMWCHDCFLSCSALRMADVIRAELLEIIKRIELPYAEPAFGSKENGLN---IKKALLSGYF 633

  Fly  1081 YQAAR-LKGIGEYVNLRTGMPCHLHPTSALYGLGTTPDYVVYHELIMTAKEYMQCATAVDGYWLA 1144
            .|.|| :.|.|.|:.|.......|||.|:.......|::|::|:..::...|::.|:||......
Mouse   634 MQIARDVDGSGNYLMLTHKQVAQLHPLSSYSITKKMPEWVLFHQFSISENNYIRVASAVSPELFM 698

  Fly  1145 ELGPMFFSVKESGRSGREKKKQAAEHL 1171
            :|.|.::.........::..:|||.||
Mouse   699 QLVPQYYFSNLPPSESKDILQQAAGHL 725

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(1)G0007	NP_572947.1	DEXDc	529..715	CDD:214692	71/188 (38%)
		DEXDc	551..689	CDD:238005	60/140 (43%)
		HELICc	722..870	CDD:238034	40/155 (26%)
		HA2	932..1014	CDD:214852	33/82 (40%)
		OB_NTP_bind	1048..1148	CDD:285018	27/107 (25%)
Dhx32	NP_001272959.1	HrpA	19..687	CDD:224557	197/637 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D113216at33208
OrthoFinder	1	1.000	-	-		FOG0000059
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820