Protein Alignment Prp16 and dhx57

DIOPT Version :10

• Sequence 1: NP_572947.1
• Gene: Prp16 / 32373
• FlyBaseID: FBgn0026713
• Length: 1222
• Species: Drosophila melanogaster
• Sequence 2: NP_001163976.1
• Gene: dhx57 / 100124795
• XenbaseID: XB-GENE-976876
• Length: 1180
• Species: Xenopus tropicalis
• Alignment Length: 1288
• Identity: 313/1288 - (24%)
• Similarity: 505/1288 - (39%)
• Gaps: 373/1288 - (28%)

  Fly    17 GQETRGGLVIRKPKDAGAGGGGGFKVPQGSMLGLDKLAAKRRAEKERSERLISFKDSEFDDTGGG 81
            |:..:||    ..|..|.|.|||               :||                       |
 Frog     9 GKPNKGG----GGKRQGGGRGGG---------------SKR-----------------------G 31

  Fly    82 SSTPQANASGASSEFAFKKPDTKSFEKLRGQLREHKDDT-----PSHTGGVSEKARERLREHIQR 141
            .|.|||...|.... ..:|..:|::::        .||.     |..|....:.:|...|.
 Frog    32 RSRPQAGGGGGGGG-GSRKCSSKAWDE--------GDDVCFSSRPMRTLNCQQPSRLSSRP---- 83

  Fly   142 DRKRGPVSST-------AAEGRDRDRDWDRDRRRDRDRDRDRDRDRRQHRERERDRHRSWDRDRG 199
              :..||:||       ..|.::|.:...|| .:.:|.|.:.| |.....|.:.|...|.|.|:|
 Frog    84 --RSNPVASTPLQTLHMTTENQERVKALLRD-LQGQDLDAEID-DVGSEVEDQYDCLGSEDEDKG 144

  Fly   200 ---RDRDRDRSMSERSVHTPRE------PGTPGG----------SSGGISNSSWDDEDGEFGQRK 245
               .:.:.:.|.:..|.|...:      ||||.|          :.|.:|...:|.|.
 Frog   145 NSDEEEEEEESFNYWSSHPELQEAENLSPGTPVGLLPEAVISPFAVGKLSRYGFDKER------- 202

  Fly   246 SDWDMPTPRRHGNKSG-------------DWSVRSGGSRRNHGRQDDTVRPTPAHRYNQ------ 291
               .|.|.|.|.:..|             .:.:|:...|.   ..|.||......|..:
 Frog   203 ---CMNTLRSHDSDVGVSLEYLLQQCLSETFGIRTKTQRM---ASDFTVEECLERRQEEAFVLQS 261

  Fly   292 --------------WAHGRKRSGATPWGEDPESLDLWEEEQRRLDREWYNIDEGY-DDENNPFGG 341
                          |..|.:....|...:.|:..|..::..:::.|   ||.:.| ..||..||
 Frog   262 ICGEKFVERIPNKVWTVGLEMDYLTKRLQKPKKKDSDKDLFQQMPR---NICKYYMKGENCRFG- 322

  Fly   342 PNSEYFRKREEQLEQKRTKRISAQQRQNN----------RDNE---------LWERNRMLTSG-- 385
              |:...|.|...:..:.:........||          :||:         .:..|..|:.|
 Frog   323 --SKCRFKHEAPKQNFKDESHLCANGNNNCLYELEVRFPKDNKYPYQAPLLAFYSVNENLSMGCR 385

  Fly   386 ---------------------VVTLISVNDDFDEEALERVHLL--VHH---IIPPFL-----DGR 419
                                 |.||:|..:|.|    |.|.||  .||   |.||.|     |.|
 Frog   386 LHITEYLYEKALNIAQTSDPAVYTLVSCLEDED----EIVKLLANTHHKYSIPPPLLLTATSDTR 446

  Fly   420 IVFTKQP-----EPVVPVKDPTSDMALLARKGSALVRNYREQKERRKAQKKHWELSGTKLGNIMG 479
                |.|     :||.|.|.........||||...::                          |.
 Frog   447 ----KNPVITINKPVAPDKPSLLSYPSGARKGQKPIK--------------------------MD 481

  Fly   480 VQRPQDEDDMRFDKEKDKADYRKDQKFADHMRDQDTGGKSDFSRKKTIS---------------- 528
            :.:|.|.|:...|..:.::...:::.:|:..:.|  ..|..|:..|.::
 Frog   482 ISKPNDTDEDSLDDLESESVLVENESYANLKKKQ--AKKYSFNSNKAVAAENAKICKHYRAKKTT 544

  Fly   529 -------EQRRFLPVFASRQELLNVIRENSVIIIVGETGSGKTTQLTQYLHEDGY----SKRGMI 582
                   |:|:.||.:..:.::|.::.:..|:::.|.||.|||||:.|::.:...    |....|
 Frog   545 RNYQSMLEERQKLPAWQKQDQILELLSKYQVLVVSGMTGCGKTTQIPQFILDASLKGPPSHVSNI 609

  Fly   583 GCTQPRRVAAMSVAKRVSDEMDTQLGEDVGYAIRFEDCTSERTVIKYMTDGILLRESLRDPELDS 647
            .||||||::|:|||:||:.|...::|..|||.||.|...|..|.:.|.|.|:|||....|..|.:
 Frog   610 ICTQPRRISAISVAERVAQERAERVGISVGYQIRLESVKSAATRLLYCTTGVLLRRLEGDTTLQN 674

  Fly   648 YSAIIMDEAHERSLSTDVLFGLLREIVARRHDLKLIVTSATMDSSKFATFFGNVPTFTIPGRTFP 712
            .:.:::||.|||:..:|.|..:|::::..|.|||:|:.|||:::..|:.:|.:.|...|||||||
 Frog   675 VTHVVVDEVHERTEESDFLLLVLKDVMVLRPDLKIILMSATLNAELFSCYFQDCPVLHIPGRTFP 739

  Fly   713 VDVMF-------------------------------------SKNTCEDYVESAVKQALQV---- 736
            ||..|                                     |.|...|.:|..:..:|::
 Frog   740 VDQYFLEDAIAKTRYVLEDGSPYQRSSKQLPGPDSARGKKGNSYNELLDELEQQISSSLRIQDSK 804

  Fly   737 -------------------------------------------------------HLTPNEGDML 746
                                                                   |..| .|.:|
 Frog   805 IVKDSVPDQQLNVKELSVRYNGISKSVIKTLSSMDLDKINLDLIEALLEWIVNGDHSYP-PGAVL 868

  Fly   747 IFMPGQEDIEVTCEVLEERLAEIDN--APALSILPIYSQLPSDLQAKIFQKSSDGLRKCVVATNI 809
            :|:||..:|:...:.|:.. |..:|  :....|.|::|.|.||.|..:|.|...|:.|.:::|||
 Frog   869 VFLPGLAEIKTLYDQLQSN-ALFNNRRSKRCVIYPLHSSLSSDEQQSVFLKPPPGVTKIIISTNI 932

  Fly   810 AETSLTVDGIIYVIDSGYCKLKVYNPRIGMDALQIYPISQANANQRSGRAGRTGPGQAYRLYTQR 874
            ||||:|:|.::||||||..:.|.|:|...|::|:...:|:|||.||.|||||...|..:.|:|..
 Frog   933 AETSITIDDVVYVIDSGKMREKRYDPGKSMESLEDTWVSRANAMQRKGRAGRVASGVCFHLFTSH 997

  Fly   875 QYKDELLALTVPEIQRTNLANTVLLLKSLGV-----VDLLQFHFMDPPPQDNILNSLYQLWILGA 934
            .|:.:||...:|||||..|....|.:|.|.:     :||:....::||..:::..|..:|..|||
 Frog   998 HYQYQLLDQQLPEIQRIPLEQLCLRIKILEMFSECRLDLVFARLIEPPRMESLHASKIRLQDLGA 1062

  Fly   935 LDHTGALTTLGRQMAEFPLDPPQCQMLIVACRMGCSAEVLIIVSMLSVPSIFYRPKGREDEADGV 999
            |.....||.||..:|..|:|....::::......|....|.|.:.|:..|.|..|..:::||:..
 Frog  1063 LTKEEKLTPLGYHLASLPVDVRIGKLMLFGAIFRCLDPALTIAASLAFKSPFVCPWDKKEEANKK 1127

  Fly  1000 REKFQRPESDHLTYLNVYQQW-----RQNNYSSTWCNEHFIHIKAMRKVREVR 1047
            :::|....||||..|..||.|     ..:..:..:|.::|:.::.::::..::
 Frog  1128 KQEFATANSDHLALLQAYQAWSSVIKESSRAAYQYCRDNFLSVRVLQEIASLK 1180

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Prp16	NP_572947.1	HrpA	534..>1148	CDD:441249	184/626 (29%)
dhx57	NP_001163976.1	UBA_DHX57	185..222	CDD:270502	9/46 (20%)
		RWD_DHX57	246..424	CDD:467661	32/187 (17%)
		zf-CCCH_4	308..329	CDD:465626	8/23 (35%)
		HrpA	557..>1109	CDD:441249	167/553 (30%)