DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment l(1)G0007 and dhx37

DIOPT Version :9

Sequence 1:	NP_572947.1	Gene:	l(1)G0007 / 32373	FlyBaseID:	FBgn0026713	Length:	1222	Species:	Drosophila melanogaster
Sequence 2:	XP_005172500.1	Gene:	dhx37 / 100009635	ZFINID:	ZDB-GENE-030131-4505	Length:	1153	Species:	Danio rerio

Alignment Length:	993	Identity:	281/993 - (28%)
Similarity:	426/993 - (42%)	Gaps:	263/993 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   327 NIDEGYDDENNPFGGPNSEYFRKREEQLEQKRTKRISAQQRQNNRDNELWERNRMLTSGVVTLIS 391
            :::||.|      ||.:|.   |........|.:|..|.:.:...::|:.|             |
Zfish   130 SVNEGQD------GGSSSV---KISSLSGANRKRRREADEEEEENESEMSE-------------S 172

  Fly   392 VNDDFDEEALERVHLLVHHIIPPFLDGRIVFTKQPEPVVPVKDPTSDMALLARKGSALVRNYREQ 456
            ..||.|.|                                    .||.:              |:
Zfish   173 SEDDDDSE------------------------------------ESDSS--------------EE 187

  Fly   457 KERRKAQKKHWELSGTKLGNIMGVQRPQDEDDMRFDKEKDKADYRKDQKFADHMRDQDTGGKSD- 520
            ::.:.:::||.|             ..|.:..::.:.:..:||.::::|       .:|..|.|
Zfish   188 EKEKISEEKHTE-------------EQQQQQVLKEETKPKEADMKEEKK-------AETWTKEDC 232

  Fly   521 -------FSRKKTISEQRRFLPVFASRQELLNVIRENSVIIIVGETGSGKTTQLTQYLHEDGY-S 577
                   ..|...|.|.|..|||.|..|.::..::::..:::.||||||||||:.|:|:|.|: |
Zfish   233 KPAVFIPVERLPEIQEARLRLPVLAEEQIIMEAVKDHECVVLCGETGSGKTTQVPQFLYEAGFAS 297

  Fly   578 KRGMIGCTQPRRVAAMSVAKRVSDEMDTQLGEDVGYAIRFEDCTSERTVIKYMTDGILLRESLRD 642
            ..|:||.|:||||||:|::.||:.||:...|. |.|.||:|...:|.|.||.||||:||:|..||
Zfish   298 SGGIIGVTEPRRVAAISMSHRVATEMNLSSGV-VSYQIRYEGNVTENTKIKVMTDGVLLKEIQRD 361

  Fly   643 PELDSYSAIIMDEAHERSLSTDVLFGLLREIVARRH----DLKLIVTSATMDSSKFA----TFFG 699
            ..|..||.||:|||||||:.||:|.|||..||..|:    .:|||:.|||:....|.    .|..
Zfish   362 FLLQKYSVIIIDEAHERSVYTDILIGLLSRIVPLRNKKGLPMKLIIMSATLRVEDFTENKRLFSS 426

  Fly   700 NVPTFTIPGRTFPVDVMFSKNT-CEDYVESAVKQALQVHLTPNEGDMLIFMPGQEDIEVTCEVL- 762
            ..|...:..|.|.|.|.|:|.| .:||.....::..::|.....|.:|:|:.||.::...|..|
Zfish   427 PPPVIKVEARQFAVTVHFNKRTPMDDYTGETFRKICKIHRMLPPGGILVFLTGQAEVHSVCRRLR 491

  Fly   763 ---------------------------------------------------EERLAEIDN----- 771
                                                               |:|.|.||.
Zfish   492 KAFPYKPNREHTDMMETEEDLKKSKRAKKKNVSLPRINLDNYSALPVDEGDEDRQAGIDEDDGEG 556

  Fly   772 ---------------------APALSILPIYSQLPSDLQAKIFQKSSDGLRKCVVATNIAETSLT 815
                                 :..|.:||:||.|..:.|||:|:....|.|.||||||:||||||
Zfish   557 SDLELELGDHPDTDHEEKADPSIPLYVLPLYSLLAPEQQAKVFRPPPAGSRLCVVATNVAETSLT 621

  Fly   816 VDGIIYVIDSGYCKLKVYNPRIGMDALQIYPISQANANQRSGRAGRTGPGQAYRLYTQRQYKDEL 880
            :.||.||:|.|..|.:.|:...|:.:.::..||||:||||:||||||.||..||||:...:.|..
Zfish   622 IPGIKYVVDCGRVKKRFYDRVTGVSSFKVTWISQASANQRAGRAGRTEPGHCYRLYSSAVFGDFS 686

  Fly   881 LALTVPEIQRTNLANTVLLLKSLGVVDLLQFHFMDPPPQDNILNSLYQLWILGALDHTG------ 939
            | .:..||.|..:.:.||.:|.|.:..::.|.|..||..:.::.:...|..||||:...
Zfish   687 L-FSEAEITRRPVEDLVLQMKDLNIEKVVNFPFPTPPSSEALIAAEELLISLGALEKPARHGRLS 750

  Fly   940 ---------ALTTLGRQMAEFPLDPPQCQMLIVACRMGCSAEVLIIVSMLSVPSIFY---RPKGR 992
                     .::.|||.||.||:.|...:||.:..:.||...::.|||.::|..||.   ||.|.
Zfish   751 EMEKARLSCPISPLGRAMAAFPVAPRYAKMLALGRQQGCMQYIITIVSAMTVREIFEDYDRPAGS 815

  Fly   993 EDEADGVREKFQRPES-----------------DHLTYLNVYQQWRQNNYSSTWCNEHFIHIKAM 1040
            |:|  .|:...::..|                 |.:..|...........:..:|.|:.:..|||
Zfish   816 EEE--NVKMSGKKARSVQMRRLWAGQGASLLLGDLMVLLGAVGACEFAGLTPQFCEENGLRFKAM 878

  Fly  1041 RKVREVRQQL----------KDIMTQQNLS------------VISCGIDWDIVRKCICSAYFYQA 1083
            .::|.:|.||          .|:.....::            ::..|:...|.|:       .||
Zfish   879 LEIRRLRGQLTNAVNAVCADADVYVDNKMAPPTEAQVLCLRQIVLAGLGDHIARR-------VQA 936

  Fly  1084 ARL---KGIGEYVNLRTGMPCHLHPTSALYGLGTTPDYVVYHELIMTAKEYMQCATAVDGYWLAE 1145
            ..|   |....|.......|..:||:|||:  .|.|::|||.|::.|.|.||:...||...|:.:
Zfish   937 EELLDPKWRNAYKTPLLDDPVFIHPSSALH--KTLPEFVVYQEIMETTKMYMRGVCAVQDDWIPK 999

  Fly  1146 LGPMF--FSVKESGRSGR 1161
            |.|.:  ||..|...:.|
Zfish  1000 LLPQYCHFSAPEESPAPR 1017

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(1)G0007	NP_572947.1	DEXDc	529..715	CDD:214692	89/194 (46%)
		DEXDc	551..689	CDD:238005	75/142 (53%)
		HELICc	722..870	CDD:238034	65/225 (29%)
		HA2	932..1014	CDD:214852	30/116 (26%)
		OB_NTP_bind	1048..1148	CDD:285018	31/124 (25%)
dhx37	XP_005172500.1	HrpA	200..1007	CDD:224557	254/826 (31%)
		DEXDc	272..412	CDD:238005	75/140 (54%)
		HELICc	583..667	CDD:197757	43/83 (52%)
		HA2	730..781	CDD:282288	13/50 (26%)
		HA2	761..>813	CDD:214852	19/51 (37%)
		OB_NTP_bind	<918..1004	CDD:285018	29/94 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D354219at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820