DRSC/TRiP Functional Genomics Resources

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Protein Alignment yl and Lrp4

DIOPT Version :9

Sequence 1:NP_996433.1 Gene:yl / 32367 FlyBaseID:FBgn0004649 Length:1984 Species:Drosophila melanogaster
Sequence 2:NP_112612.2 Gene:Lrp4 / 83469 RGDID:619731 Length:1905 Species:Rattus norvegicus


Alignment Length:2191 Identity:523/2191 - (23%)
Similarity:804/2191 - (36%) Gaps:627/2191 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    37 AHPSSGGSTSSRYGNCQRTHLIINGRHVAISLLLLVGLC----------GGTAAGTPGSAD---- 87
            ||    |:.|:....|.|:|..     .|:|.|   |.|          |....|.....|    
  Rat    16 AH----GTASNLECACGRSHFT-----CAVSAL---GECTCIPAQWQCDGDNDCGDHSDEDGCTL 68

  Fly    88 TRCDAGQFQCRDGGCILQAKMCDGRGDCKDSSDELDCDYRLCRPPHWFPCAQPH----------- 141
            ..|....|.|.:|.||.::.:|||..||:|.|||.||..|.|.... |||...:           
  Rat    69 PTCSPLDFHCDNGKCIRRSWVCDGDNDCEDDSDEQDCPPRECEEDE-FPCQNGYCIRSLWHCDGD 132

  Fly   142 -------------------------GACLAAELMCNGIDNCPGGEDELNCP-------------- 167
                                     |:|:|....|:|..:|..|.||.:||              
  Rat   133 NDCGDNSDEQCDMRKCSDKEFRCSDGSCIAEHWYCDGDTDCKDGSDEESCPSAVPSPPCNLEEFQ 197

  Fly   168 VRPGFRFGDTAH-----------------RMRSCSKYEFMCQQDRTCIPIDFMCDGRPDCTDKSD 215
            ...|.|..|..|                 ..:.|...||||... .|:...:.|||..||.|:||
  Rat   198 CAYGRRILDIYHCDGDDDCGDWSDESDCSSHQPCRSGEFMCDSG-LCVNAGWRCDGDADCDDQSD 261

  Fly   216 EVAGCKQAEITCPGEGHLCANGRCLRRKQWVCDGVDDCGDGSDERGCLNLCEPQ--KGKFLCRNR 278
            | ..|..:  .|..|...|.:|||: |..|.|||.|||.|.|||..|.|...||  ..:|||.|.
  Rat   262 E-RNCTTS--MCTAEQFRCRSGRCV-RLSWRCDGEDDCADNSDEENCENTGSPQCASDQFLCWNG 322

  Fly   279 ETCLTLSEVCDGHSDCSDGSDETDLCHSKP-----DCDAKKCALGAKCHMMPASGAECFCPKGFR 338
            . |:...::|:|.:||.|.|||:...:.:|     :|:........||.|: ....:|.|..|:|
  Rat   323 R-CIGQRKLCNGVNDCGDNSDESPQQNCRPRTGEENCNVNNGGCAQKCQMI-RGAVQCTCHTGYR 385

  Fly   339 LAKFEDKCEDVDECKEQDDLCSQGCENTSGGYRCVCDAGYLLDKDNRTCRAVVYGSKEQQPLLLY 403
            |.:....|:||:||.| :..|||||.|:.|.::|.|:|||.|..|.|:|:|:     ..:|:||:
  Rat   386 LTEDGRTCQDVNECAE-EGYCSQGCTNSEGAFQCWCEAGYELRPDRRSCKAL-----GPEPVLLF 444

  Fly   404 TTQMTIMGM--HLREDNVRNHVYQVAGNLSKVIGVAYDGSH----IYWTNIQNEAESIVKANGDG 462
            ..::.|..:  |      |:....:..||...|  |.|..|    ::|:::  ..:.|::||.:|
  Rat   445 ANRIDIRQVLPH------RSEYTLLLNNLENAI--ALDFHHRRELVFWSDV--TLDRILRANLNG 499

  Fly   463 SNAEILLTSGLDAPEDLAVDWLTQNIYFSDNIMRHIAVCSNDGLNCAVLVTQDVHQPRSLAVWPQ 527
            ||.|.::::||::|..|||||:...:|::|:....|.|.:.||.:..||:.|.:.:||::|:.|.
  Rat   500 SNVEEVVSTGLESPGGLAVDWVHDKLYWTDSGTSRIEVANLDGAHRKVLLWQSLEKPRAIALHPM 564

  Fly   528 KGLMFWTDWGEKPMIGRASMDGSRSRPIVSDNIEWPNGIALDMHQQRIYWVDAKLGSVQTVRPDG 592
            :|.::|||||..|.|..:|||||..|.|...::.||||:.:|...:|:||||||...::....||
  Rat   565 EGTIYWTDWGNTPRIEASSMDGSGRRIIADTHLFWPNGLTIDYAGRRMYWVDAKHHVIERANLDG 629

  Fly   593 TGRRTVLDGMLKHPYGLAIFEDQLYWSDWATKSVHACHKFSGKDHRILAKDRTIYA--VHIYHPA 655
            :.|:.|:...|.||:.:.:|||.|||:||.|||:::.:||:||:..|: :::..:.  :|..||.
  Rat   630 SHRKAVISQGLPHPFAITVFEDSLYWTDWHTKSINSANKFTGKNQEII-RNKLHFPMDIHTLHPQ 693

  Fly   656 KQPNSPHGC--ENATCSHLCLLAEPEIGGHSCACPDGMRLAPDHRRCMLMEKRQRLFIGLGQVLL 718
            :||...:.|  .|..|:||||   |....::||||.|.|....|.....::|    |: |....:
  Rat   694 RQPAGKNRCGDNNGGCTHLCL---PSGQNYTCACPTGFRKINSHACAQSLDK----FL-LFARRM 750

  Fly   719 EIEHTAFGRHQVSKSYTLPCLINEMVYNRINGSLIIADNDQR------------LILEFQPESHE 771
            :|...:|....:|         ::::......|.:..|.|.|            .|...:.:...
  Rat   751 DIRRISFDTEDLS---------DDVIPLADVRSAVALDWDSRDDHVYWTDVSTDTISRAKWDGTG 806

  Fly   772 SNVLVRSNLGNVSALAFDHLSRNLYWADTERAVIEVLSLQTRHRALIRFFPGQEVPIGLTVMPAE 836
            ..|:|.::|.:.:.||.|.::..|||.|.....|||.:.....|.:: .:...:.|..:.|.|..
  Rat   807 QKVVVDTSLESPAGLAIDWVTNKLYWTDAGTDRIEVANTDGSMRTVL-IWENLDRPRDIVVEPMG 870

  Fly   837 GYLYVV---LKAKRHSHIDKIPLSGKGEQVHVFEDDLGDDDIKLVTDYETQTIFWSDSDLGRISY 898
            ||:|..   ...|    |::..:.....||.:..:....:.  |..||.:|.::|:|:.:..|.:
  Rat   871 GYMYWTDWGASPK----IERAGMDASNRQVIISSNLTWPNG--LAIDYGSQRLYWADAGMKTIEF 929

  Fly   899 SNYRVPHSQIFRG-KLRRPYSLAMVHHDLFWNELGTPRIY----------WTHKSNMGPRKVIDI 952
            :.......::..| :|..|:.|.:....::|.:..|..|.          .|.:.|:.....|.:
  Rat   930 AGLDGSKRKVLIGSQLPHPFGLTLYGQRIYWTDWQTKSIQSADRLTGLDRETLQENLENLMDIHV 994

  Fly   953 MEKDDPAAIMPYVPVATPNGIPLAASSPVGQESHPCQQQNGGCSHICV-GEGPYHSICLCPAGFV 1016
            ..:..|       ||.|                 ||..:||||||:|: ...|....|.||.|..
  Rat   995 FHRQRP-------PVTT-----------------PCAVENGGCSHLCLRSPSPSGFSCTCPTGIN 1035

  Fly  1017 YRDAGNRTCVEALDCEFRCHSGECLTMNHRCNGRRDCVD----------------NSDEMNCDEE 1065
            ....| :||...::        ..|....|.:.|...:|                |:..:..|  
  Rat  1036 LLLDG-KTCSPGMN--------SFLIFARRIDVRMVSLDIPYFADVVVPINMTMKNTIAIGVD-- 1089

  Fly  1066 HRRKPKVLCSPNQFACHSGEQCVDKERRCDNRKDCHDHSDEQHCEKFDKSKKCHVHQHGCDNGKC 1130
                      |.:...:..:..:.:..|..  .|...|.|                         
  Rat  1090 ----------PLEGKVYWSDSTLHRISRAS--LDGSQHED------------------------- 1117

  Fly  1131 VDSSLVCDGTNDCGDNSDELLCEATSRCEPGMFQCGSGSCIAGSWECDGRIDCS--DGSDEHDKC 1193
                ::..|.    ..:|.|..:|..|   .::...:|:         .||:..  |||      
  Rat  1118 ----IITTGL----QTTDGLAVDAIGR---KVYWTDTGT---------NRIEVGNLDGS------ 1156

  Fly  1194 VHRSCPPDMQRCLLGQCLD--RSLVCDGH------NDCGDKSDELNCGTDSSTMNISCAEDQYQC 1250
                    |::.|:.|.||  |::|....      .|.|:.:.....|.|.|             
  Rat  1157 --------MRKVLVWQNLDSPRAIVLYHEMGFMYWTDWGENAKLERSGMDGS------------- 1200

  Fly  1251 TSNLKICLPSTVRCNGTTECPRGEDEADCGDVCSIYEFKCRSGRECIRREFRCDGQKDCGDGSDE 1315
                    ..||..|.....|.|. ..|                       :...|....|...|
  Rat  1201 --------DRTVLINNNLGWPNGL-TVD-----------------------KTSSQLLWADAHTE 1233

  Fly  1316 LSCELE----KGHHNQSQIQP------------------WSTSSRSCRPHLFDCQDGECVDLSRV 1358
               .:|    .|.:..:.:.|                  |.|.|    .|..|...|..|.|.| 
  Rat  1234 ---RIEVADLNGANRHTLVSPVQHPYGLTLLDSYIYWTDWQTRS----IHRADKSTGSNVILVR- 1290

  Fly  1359 CNNFP---DCTNGHDEGPKCATACRSASGRQVCQHKCRATPAGAVCSCFDGYRLDADQKSCLDID 1420
             :|.|   |........|.....|.|.:|.  |.|.|...|:|..|:|..|.:|..|.|:|   |
  Rat  1291 -SNLPGLMDIQAVDRAQPLGFNKCGSRNGG--CSHLCLPRPSGFSCACPTGIQLKGDGKTC---D 1349

  Fly  1421 ECQEQQPCAQLCENTLGGYQCQCHADFMLRQDRVSCKSLQSGATLLFSSFNEVRNLS-------- 1477
            ...|                                      ..|||||...:|.:|        
  Rat  1350 PSPE--------------------------------------TYLLFSSRGSIRRISLDTDDHTD 1376

  Fly  1478 ---EQPVMLNVAWSANDSRITGFDLAMHRQMGYFSAEDEGIVYQIDLQTKVIVRA---------- 1529
               ..|.:.||.                 .:.|.|.  :|.||..|:...||.||          
  Rat  1377 VHVPVPGLNNVI-----------------SLDYDSV--DGKVYYTDVFLDVIRRADLNGSNMETV 1422

  Fly  1530 --LGLPAPTKLSVDWVTGNVY-VLSGAQEIQACSFVGRMCGRIV---HVKSPRHVKHLAVDGYHA 1588
              .||.....|:||||..|:| ..:|...|:|....| .|.:::   .:..||.:......||  
  Rat  1423 IGHGLKTTDGLAVDWVARNLYWTDTGRNTIEASRLDG-SCRKVLINNSLDEPRAIAVFPRKGY-- 1484

  Fly  1589 RIFYIVIRTEGYGQTSSEIHMARLDGSRRDMLLQRSESFMTALTTDPHQQLLYFVDQHMRTLERI 1653
             :|:     ..:|.. ::|..|.||||.|.:|:.....:...||.|...:.:|:||.|   |:||
  Rat  1485 -LFW-----TDWGHI-AKIERANLDGSERKVLINADLGWPNGLTLDYDTRRIYWVDAH---LDRI 1539

  Fly  1654 SYRLKTGPMRRPEIMLQKSNALMHPSGLSVYENNAFIVNLGSVEAVQCALYGSRICHKISINVLN 1718
            ......|.:|:..:     :.:.||..|:..:...:..:..:....:...|..|....:..||..
  Rat  1540 ESADLNGKLRQVLV-----SHVSHPFALTQQDRWIYWTDWQTKSIQRVDKYSGRNKETVLANVEG 1599

  Fly  1719 AQDIVVAGRSRQPQKASHPCA--HAHCHGLCLQADYGYECMCGN------------------RLV 1763
            ..||:|.  |.|.|..::.|.  :..|..||......:.|.|.:                  |..
  Rat  1600 LMDIIVV--SPQRQTGTNACGVNNGGCSHLCFARASDFVCACPDEPDSHPCSLVPGLMPPAPRAT 1662

  Fly  1764 AEGERCP----------HGSGNEV---------------AVLG-AVNSLE---------LEHEHE 1793
            :..|:.|          |.|....               |.|| ..:|.|         |...:.
  Rat  1663 SLNEKSPVLPNTLPTTLHSSTTRTRTSPEGAEGRCSERDAQLGLCAHSNEAVPAAPGEGLHVSYA 1727

  Fly  1794 QNGHFHWLMALFVLAAGSLIAGLGYMYYQYRQRGHTDLNI-NMHFQNPLATLGGTKAFLEHE--- 1854
            ..|....|:.|.|.||        .|.|::|:...||..: |:.:.||.......:..:|..   
  Rat  1728 VGGLLSVLLILLVTAA--------LMLYRHRKSKFTDPGMGNLTYSNPSYRTSTQEVKIEAAPKP 1784

  Fly  1855 --------RAEAG-------------------VGFTTETGTV----SSRGS--NDTFTTTSATSS 1886
                    :.|.|                   .|...|.|.:    ||||.  .|.....:.|.|
  Rat  1785 AMYNQLCYKKEGGPDHSYTKEKIKIVEGIHLLAGHDAEWGDLKQLRSSRGGLLRDHVCMKTDTVS 1849

  Fly  1887 FAAQQFSVPNALQRLLRPRQSASG---DPMAQELLLESPSRESKLH 1929
            .                  |::||   |...::||.|..|..|.:|
  Rat  1850 I------------------QASSGSLDDTETEQLLQEEQSECSSVH 1877

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ylNP_996433.1 LDLa 90..124 CDD:238060 15/33 (45%)
LDLa 131..166 CDD:238060 12/70 (17%)
LDLa 184..216 CDD:238060 13/31 (42%)
LDLa 227..262 CDD:238060 18/34 (53%)
LDLa 271..302 CDD:238060 13/30 (43%)
FXa_inhibition 352..387 CDD:291342 17/34 (50%)
Ldl_recept_b 442..482 CDD:278487 14/43 (33%)
LY 466..508 CDD:214531 15/41 (37%)
Ldl_recept_b 529..569 CDD:278487 19/39 (49%)
LY 553..595 CDD:214531 16/41 (39%)
LY 596..637 CDD:214531 19/40 (48%)
FXa_inhibition 669..700 CDD:291342 13/30 (43%)
LY 774..815 CDD:214531 13/40 (33%)
LDLa 1032..1062 CDD:238060 5/45 (11%)
LDLa 1074..1109 CDD:238060 5/34 (15%)
LDLa 1118..1152 CDD:238060 3/33 (9%)
LDLa 1157..1189 CDD:197566 7/33 (21%)
LDLa 1198..1232 CDD:238060 9/41 (22%)
LDLa 1243..1279 CDD:238060 5/35 (14%)
LDLa 1283..1318 CDD:238060 3/34 (9%)
LDLa 1340..1371 CDD:197566 9/33 (27%)
FXa_inhibition 1388..1416 CDD:291342 11/27 (41%)
EGF_CA 1418..1452 CDD:214542 2/33 (6%)
Lrp4NP_112612.2 LDLa 27..66 CDD:238060 11/46 (24%)
Ldl_recept_a 70..105 CDD:278486 15/34 (44%)
LDLa 110..142 CDD:238060 4/32 (13%)
LDLa 148..182 CDD:238060 9/33 (27%)
LDLa 231..265 CDD:238060 15/35 (43%)
LDLa 270..304 CDD:238060 18/34 (53%)
LDLa 311..343 CDD:197566 12/32 (38%)
FXa_inhibition 358..393 CDD:291342 9/35 (26%)
EGF_CA 395..434 CDD:214542 20/39 (51%)
NHL <471..622 CDD:302697 60/154 (39%)
NHL repeat 471..507 CDD:271320 12/39 (31%)
LDL-receptor class B 1 480..522 16/43 (37%)
LY 505..545 CDD:214531 14/39 (36%)
NHL repeat 510..550 CDD:271320 15/39 (38%)
LDL-receptor class B 2 523..565 13/41 (32%)
NHL repeat 555..589 CDD:271320 17/33 (52%)
LDL-receptor class B 3 566..609 20/42 (48%)
LY 590..632 CDD:214531 16/41 (39%)
NHL repeat 598..622 CDD:271320 12/23 (52%)
LDL-receptor class B 4 610..652 16/41 (39%)
LY 633..673 CDD:214531 18/39 (46%)
LDL-receptor class B 5 653..693 15/40 (38%)
FXa_inhibition 702..>729 CDD:291342 13/29 (45%)
LY 766..806 CDD:214531 5/39 (13%)
LDL-receptor class B 6 785..827 7/41 (17%)
LY 808..850 CDD:214531 13/41 (32%)
LDL-receptor class B 7 828..870 11/42 (26%)
LDL-receptor class B 8 871..914 10/48 (21%)
Ldl_recept_b 871..911 CDD:278487 8/45 (18%)
LY 895..937 CDD:214531 9/43 (21%)
LDL-receptor class B 9 915..956 8/40 (20%)
LY 938..979 CDD:214531 7/40 (18%)
LDL-receptor class B 10 957..998 6/40 (15%)
FXa_inhibition 1006..1043 CDD:291342 14/37 (38%)
NHL <1085..1277 CDD:302697 44/316 (14%)
NHL repeat 1085..1123 CDD:271320 6/80 (8%)
LDL-receptor class B 11 1093..1135 8/76 (11%)
NHL repeat 1128..1161 CDD:271320 10/58 (17%)
LDL-receptor class B 12 1136..1178 14/67 (21%)
NHL repeat 1166..1203 CDD:271320 9/57 (16%)
LDL-receptor class B 13 1179..1222 11/87 (13%)
NHL repeat 1212..1244 CDD:271320 8/58 (14%)
LDL-receptor class B 14 1223..1263 6/42 (14%)
NHL repeat 1253..1277 CDD:271320 3/27 (11%)
LDL-receptor class B 15 1264..1306 12/47 (26%)
FXa_inhibition 1313..1348 CDD:291342 14/36 (39%)
LY 1379..1418 CDD:214531 13/57 (23%)
LDL-receptor class B 16 1397..1439 14/41 (34%)
LY 1420..1460 CDD:214531 13/40 (33%)
LDL-receptor class B 17 1440..1482 9/42 (21%)
LDL-receptor class B 18 1483..1526 15/51 (29%)
Ldl_recept_b 1483..1523 CDD:278487 14/48 (29%)
LY 1507..1547 CDD:214531 11/42 (26%)
LDL-receptor class B 19 1527..1568 12/48 (25%)
LY 1549..1589 CDD:214531 5/44 (11%)
LDL-receptor class B 20 1569..1610 8/42 (19%)
FXa_inhibition 1617..>1641 CDD:291342 6/23 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1659..1696 5/36 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1853..1905 9/25 (36%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1215
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100345
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.710

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