Protein Alignment yl and si:dkey-88l16.3

DIOPT Version :10

• Sequence 1: NP_996433.1
• Gene: yl / 32367
• FlyBaseID: FBgn0004649
• Length: 1984
• Species: Drosophila melanogaster
• Sequence 2: XP_073770595.1
• Gene: si:dkey-88l16.3 / 796880
• ZFINID: ZDB-GENE-030131-6015
• Length: 3896
• Species: Danio rerio
• Alignment Length: 1785
• Identity: 451/1785 - (25%)
• Similarity: 674/1785 - (37%)
• Gaps: 517/1785 - (28%)

  Fly    48 RYGNCQRTHLIINGRHVAISLLLLVGLCGGTAAGTPGSADTRCDAGQFQCRDGGCILQAKMCDGR 112
            |:..|....::::      :|.:|.|:.||            |...|:||.||.|:.....|||.
Zfish     5 RFFCCTAVFVLLS------ALPVLSGVDGG------------CSRNQWQCDDGACVSHRWRCDGA 51

  Fly   113 GDCKDSSDELDCDYRLCRPPHWFPCAQPHGACLAAELMCNGIDNCPGGEDELNCPVRPGFRFGDT 177
            .||:|.|||::|   ||:|.. |.|....| |:....:|:|:.:||.|.||.:|..|.|
Zfish    52 SDCQDGSDEMEC---LCQPGD-FECLDGSG-CVIGSDVCDGVTHCPDGSDEWDCSWRSG------ 105

  Fly   178 AHRMRSCSKYEFMCQQDRTCIPIDFMCDGRPDCTDKSDE--VAGCKQAEITCPGEGHLCANGRCL 240
                  |...::.| ::..|||.:.:|:...||.|.|||  ...|.:..|.||
Zfish   106 ------CLSSDWKC-RNNICIPQELLCNDANDCGDDSDEETCGSCGRMSIRCP------------ 151

  Fly   241 RRKQWVCDGVDDCGDGSDERGCLNLCEPQKGKFLCRNRETCLTLSEVCDGHSDCSDGSDETDLCH 305
                          |||                       |||..:.|||.:.|||..||...|
Zfish   152 --------------DGS-----------------------CLTPRQRCDGVAQCSDSRDEPLTC- 178

  Fly   306 SKPDCDAKKCALG-AKC-HMMPAS--GAECFCPKGFRLAKFEDKCEDVDECKEQDDLCSQGCENT 366
                  .|.|.:| ..| |.....  ||.|.||.|..|:.....||||:||.:....|...|.||
Zfish   179 ------GKSCLVGNGGCSHFCTDKFWGALCSCPAGMTLSANGRDCEDVNECAQSVSPCMHLCSNT 237

  Fly   367 SGGYRCVCDAGYLLDKDNRTCRAVVYGSKEQQPLL-LYTTQMTIMGMHLREDNVRNHVYQ-VAGN 429
            .|.|||.|..|: ....|.:|.|       |.|:: :.||:..::|:    .||:..|:: :...
Zfish   238 PGSYRCQCANGF-KPLGNGSCEA-------QGPVMKILTTRKGLVGL----VNVKTRVFEPLFTT 290

  Fly   430 LSKVIGVAYD--GSHIYWTNIQNEAESIVKANGDG------SNAEILLTSGLDAPEDLAVDWLTQ 486
            .::.:.:..|  .:.|||            |:|:|      :....:|.||....:.|||||||.
Zfish   291 ETEPVAMTSDIQRNLIYW------------ADGNGGIFKTYNRKSTVLYSGQWGVKSLAVDWLTG 343

  Fly   487 NIYFSDNIMRHIAVCSNDGLNCAVLVTQDVHQPRSLAVWPQKGLMFWTDWG--EKPMIGRASMDG 549
            .:|::....:.|...:.||....:|:::.| .|..|.:.|.:|.|||.:.|  .:..|.|..|||
Zfish   344 QLYWTSVTQKAIYTGAADGSAVGMLMSKGV-DPSDLVLSPIEGFMFWMNKGVNGEMTIERVDMDG 407

  Fly   550 SRSRPIVSDNIEWPNGIALDMHQQRIYWVDAKLGSVQTVRPDGTGRRTVLDGMLKHP-YGLAIFE 613
            ...:.:|....:.|.|:.||:..:|:||:.....||::||.|||||.|..|.....| ..||:|.
Zfish   408 MNRKTLVFVTAQLPRGLTLDVSARRLYWISVHKMSVESVRTDGTGRHTFWDVFQGSPAQALAVFN 472

  Fly   614 DQLYWSD----WATKSVHACHKFSGKDHRILAKDRTIYAVHIYHPAKQPNSPHGCENATCSHLCL 674
            ...||:|    |....    ::.:.|.:..:.| .::.::.:|||.:||.....|:.:.| .|||
Zfish   473 GWFYWADDKRLWQAPQ----NQPAAKQNGFIIK-ASLPSLTVYHPLQQPQGFSACKGSGC-QLCL 531

  Fly   675 LAEPEIGGHSCACPDGMRLAPDHRRCMLMEKRQRLFIGLGQVLLEIEHTA--------FGRHQVS 731
            ..:....|.:|.||:|....| :..|    :..::.......:..:|.|.        |..::..
Zfish   532 PTKNSDTGFTCLCPEGALPMP-YGSC----ENFKVAYATSMAIYSLEFTGRTPVKTELFTSNEDI 591

  Fly   732 KSYTLPCLINEMVYNRINGSLIIADNDQRLILEFQPESHESNVLVRSNLGNVSALAFDHLSRNLY 796
            :|:       :|.:.:   .|:|..|....:....|....|..::  .|.....:..|..:.|||
Zfish   592 QSF-------DMFWQQ---GLVIWSNGTGHVKTNMPSEDLSEYIL--TLKPACIIRVDQRNGNLY 644

  Fly   797 WADTERAVIEVLSLQTRHRALIR-FFPGQEVPIGLTVMPAEGYLYVVLKAKRHSHIDKIPLSGKG 860
            |...:...|.|.::....:::.| .:.|:.....|.|....|.|| .|:.::...:....:.|..
Zfish   645 WLACDELSIGVSTIGPLDQSISRQLYQGRSAIQDLFVDWQRGKLY-WLEGQQIMRMKLGLIGGNA 708

  Fly   861 EQVHVFEDDLGDDDIKLVTDYETQTIFWSDSD----LGRISYSNYRVPHSQIFRGKLR---RPYS 918
            |.::.||:|..|   ::..|.:..:..|:...    ...:....|......:..|.:.   .||.
Zfish   709 ETIYTFEEDSID---RIAFDRKGNSFLWTTETYLQVFSLLKMRKYSASKEWVVPGFIMSAYEPYM 770

  Fly   919 LAMVHHDL-FWNELGTPRIYWTHKSN------MGPRKV-IDIMEKDDPAAIMP------YVPVAT 969
            :|:.::.| .||.....|:......|      :..|:| .:|:.||.|...:.      :.|.:|
Zfish   771 VALFNNILTIWNRRDGARVSGVAVENGVVSLSVALREVQQEIVTKDVPPTEVTCKSPQVFCPGST 835

  Fly   970 PNGIPLAASSPV-GQESHPCQQQNGGCSHICVGEGPYHSICLCPAG--FVYRDA---GNRTCVEA 1028
               :.::.|... |:...|.......|.|:|.....:    ||..|  .|.:|.   |...|.:.
Zfish   836 ---VCISRSQRCDGKRDCPDGSDEVSCLHMCAKADDF----LCKDGSKCVGKDLVCDGRSHCFDG 893

  Fly  1029 LD---C-----------EFRCHSG--------ECLTMNHRCNGRRDCVDNSDEMNCDEEHRRKPK 1071
            .|   |           ..||..|        :|:..:|.|:|.:||.|.|||..|...
Zfish   894 SDEDECPTMVAENSNSGPLRCRVGSKLCNDGRQCVLHDHVCDGEKDCEDGSDEQGCPNR------ 952

  Fly  1072 VLCSPNQFACHSGEQCVDKERRCDNRKDCHDHSDEQHCEKFDKSKKCHVHQHGCDN-GKCVDSSL 1135
              |..:||.|..|..|:||::.||....|.|.|||.:|  |.:|..|   :|.||| .:|:..|.
Zfish   953 --CKADQFRCAHGRMCIDKKQVCDGTPHCQDRSDELNC--FTQSHDC---RHQCDNKTRCIPESF 1010

  Fly  1136 VCDGTNDCGDNSDELLCEATSRCE-------------------------PGMFQC--------GS 1167
            :|||..||.|.:||..|..|||.|                         ||..:|        |.
Zfish  1011 LCDGERDCVDATDEANCPKTSRGEVSVMPIYEDTPTSSPPVCQSPSVLCPGTLECISPNRLCDGR 1075

  Fly  1168 GSCIAGSWE---------------------------CDGRIDCSDGSDE---------------- 1189
            ..|..||.|                           ||||..|:|||||
Zfish  1076 TDCPDGSDEDSCFDDCAKPDDFPCKDGSKCVGKDLVCDGRSHCTDGSDEDGCPTMASENSNSGPL 1140

  Fly  1190 -----------------HDK----------------CVHRSCPPDMQRCLLGQ-CLDRSLVCDGH 1220
                             ||.                |.:| |..|..||..|: |:|:..||||.
Zfish  1141 RCRVGSKLCNDGRQCVLHDHVCDGEKDCEDGSDEQGCPNR-CKADQFRCAHGRMCIDKKQVCDGT 1204

  Fly  1221 NDCGDKSDELNCGTDSSTMNISC---------------------AEDQYQCTSNLK--------- 1255
            ..|.|:||||||.|.|......|                     |.|:..| |.:|
Zfish  1205 PQCQDRSDELNCFTQSHDCKHQCDNKTRCIPESFLCDGERDCVDATDEANC-SEIKNVEKNVVTR 1268

  Fly  1256 -------------------------ICLPSTVRCNGTTECPRGEDEADCGDVCS-IYEFKCRSGR 1294
                                     :|:..|..|:|..:||.|.||..|...|| ..:|.|:..|
Zfish  1269 NTDRSDVQPPPPVCKRPSMLCPGTSLCISQTRLCDGKLDCPDGSDEVSCVHACSNPGDFLCKDRR 1333

  Fly  1295 ECIRREFRCDGQKDCGDGSDELSCELEKGHHNQSQIQPWSTSSRSCRPHLFDCQDG-ECVDLSRV 1358
            :|:.....|||:.||.|||||::|.|.....|:..::        ||.....|.|| :||....|
Zfish  1334 KCVDGNQVCDGRSDCFDGSDEMACYLSARTSNKVPLK--------CRVGSKPCNDGRQCVLHDHV 1390

  Fly  1359 CNNFPDCTNGHDEGPKCATAC-----RSASGR------QV----------------------CQH 1390
            |:...||.:|.|| ..|...|     |.|.||      ||                      |:|
Zfish  1391 CDGEKDCKDGSDE-RGCPNRCKADQFRCAHGRMCIDKKQVCDGTPQCQDRSDELNCFTRSHDCKH 1454

  Fly  1391 KC----RATPAGAVCSCFDGYR--LDA-DQKSCLDI------------DECQEQQP--------- 1427
            :|    |..|...:|   ||.|  :|| |:.:|.:|            |....|.|
Zfish  1455 QCDNKTRCIPESFLC---DGERDCVDATDEANCSEIKSVDINLVTLNKDRSDVQPPPPVCKSHSM 1516

  Fly  1428 -------C---AQLCENTL----GGYQCQC-HA-----DFMLRQDR--VSCKSLQSGATLLFSSF 1470
                   |   .:||:..|    |..:..| ||     ||:.:..|  |....:..|.:..|...
Zfish  1517 LCPGTSLCISQTRLCDGKLDCPDGSDEVSCVHACSNPGDFLCKDSRKCVDGNQVCDGRSDCFDGS 1581

  Fly  1471 NEV------RNLSEQPVMLNV-AWSANDSR 1493
            :|:      |.|::.|:...| :...||.|
Zfish  1582 DEMACYLSARTLNKVPLKCRVGSKPCNDGR 1611

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
yl	NP_996433.1	LDLa	90..124	CDD:238060	16/33 (48%)
		LDLa	131..166	CDD:238060	12/34 (35%)
		LDLa	184..216	CDD:238060	10/31 (32%)
		LDLa	227..262	CDD:238060	5/34 (15%)
		LDLa	271..302	CDD:238060	11/30 (37%)
		FXa_inhibition	352..387	CDD:464251	12/34 (35%)
		Ldl_recept_b	442..483	CDD:459654	12/46 (26%)
		LY	466..508	CDD:214531	14/41 (34%)
		Ldl_recept_b	529..569	CDD:459654	13/41 (32%)
		LY	553..595	CDD:214531	15/41 (37%)
		LY	596..637	CDD:214531	11/45 (24%)
		FXa_inhibition	669..700	CDD:464251	10/30 (33%)
		LY	774..815	CDD:214531	8/40 (20%)
		LDLa	1032..1062	CDD:238060	13/37 (35%)
		LDLa	1074..1109	CDD:238060	15/34 (44%)
		LDLa	1118..1152	CDD:238060	15/34 (44%)
		LDLa	1157..1189	CDD:197566	18/91 (20%)
		LDLa	1198..1232	CDD:238060	17/34 (50%)
		LDLa	1243..1279	CDD:238060	15/90 (17%)
		LDLa	1283..1318	CDD:238060	16/35 (46%)
		LDLa	1340..1371	CDD:197566	12/31 (39%)
		FXa_inhibition	1388..1416	CDD:464251	12/34 (35%)
		EGF_CA	1418..1452	CDD:214542	14/74 (19%)
si:dkey-88l16.3	XP_073770595.1	None