DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment yl and LRP8

DIOPT Version :9

Sequence 1:	NP_996433.1	Gene:	yl / 32367	FlyBaseID:	FBgn0004649	Length:	1984	Species:	Drosophila melanogaster
Sequence 2:	XP_005271230.1	Gene:	LRP8 / 7804	HGNCID:	6700	Length:	976	Species:	Homo sapiens

Alignment Length:	778	Identity:	245/778 - (31%)
Similarity:	360/778 - (46%)	Gaps:	179/778 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 RHVAISLLLLVGL------CGGTAA----GTPGSADTRCDAGQFQCRDGGCILQAKMCDGRGDCK 116
            |.:|:.||||:.|      ....||    |..|.|.. |:..|||||:..||.....||...||.
Human    10 RLLALLLLLLLLLLLQLQHLAAAAADPLLGGQGPAKD-CEKDQFQCRNERCIPSVWRCDEDDDCL 73

  Fly   117 DSSDELDCDYRLCRPPHWFPCAQPHGACLAAELMCNGIDNCPGGEDELN-------CPVRPGFRF 174
            |.|||.||..:.|.... |.|  .:|.|:.....|:|.:.||.|.||..       ||... ...
Human    74 DHSDEDDCPKKTCADSD-FTC--DNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEK-LSC 134

  Fly   175 GDTAHRMRSCSKYEFMCQQDRTCIPIDFMCDGRPDCTDKSDEVAGCKQAEITCPGEGHLCANGRC 239
            |.|:|:                |:|..:.|||..||...:|| |||  |.:..|.| ..|.|..|
Human   135 GPTSHK----------------CVPASWRCDGEKDCEGGADE-AGC--ATLCAPHE-FQCGNRSC 179

  Fly   240 LRRKQWVCDGVDDCGDGSDERGCLN----------------LCEPQK------------------ 270
            | ...:||||.||||||||||||.:                .|.|::
Human   180 L-AAVFVCDGDDDCGDGSDERGCADPACGPREFRCGGDGGGACIPERWVCDRQFDCEDRSDEAAE 243

  Fly   271 -------------------GKFLCRNRETCLTLSEVCDGHSDCSDGSDETDL------------- 303
                               .:|.||:.| |:.|...|||..||.|.|||.|.
Human   244 LCGRPGPGATSAPAACATASQFACRSGE-CVHLGWRCDGDRDCKDKSDEADCPLGTCRGDEFQCG 307

  Fly   304 ----------CHSKPDCDAKKCALGAKCHMMPAS------------------------------G 328
                      |:.:.||.......|  |..:|.:                              |
Human   308 DGTCVLAIKHCNQEQDCPDGSDEAG--CLQVPPTFLGNRRRPRGLNECLHNNGGCSHICTDLKIG 370

  Fly   329 AECFCPKGFRLAKFEDKCEDVDECKEQDDLCSQGCENTSGGYRCVCDAGYLLDKDNRTCRAVVYG 393
            .||.||.||:|.. :..|.|:||||: .|.|||.|.|..|.::|.|..||.:|...:.|:|
Human   371 FECTCPAGFQLLD-QKTCGDIDECKD-PDACSQICVNYKGYFKCECYPGYEMDLLTKNCKA---- 429

  Fly   394 SKEQQPLLLYTTQMTIMGMHLREDNVRNHVYQVAGNLSKVIG--VAYDGSHIYWTNIQNEA--ES 454
            :..:.|.|::|.:..:.    |.|.|:.:..::...|..|:.  |....:.|||.::....  .:
Human   430 AAGKSPSLIFTNRHEVR----RIDLVKRNYSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSA 490

  Fly   455 IVKANGDGSNAEILLTSGLDAPEDLAVDWLTQNIYFSDNIMRHIAVCSNDGLNCAVLVTQDVHQP 519
            .:....|....|:|:...|.:||.|||||:.::||::|:..:.|:|.:.||.....|.::::.:|
Human   491 YMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEP 555

  Fly   520 RSLAVWPQKGLMFWTDWGEKPMIGRASMDGSRSRPIVSDNIEWPNGIALDMHQQRIYWVDAKLGS 584
            |::||.|.:|.|:|:|||::..|.::.::|...:.:|||||||||||.||:..||:||||:||..
Human   556 RAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQ 620

  Fly   585 VQTVRPDGTGRRTVLDG--MLKHPYGLAIFEDQLYWSDWATKSVHACHKFSGKDHRILAKD-RTI 646
            :.::...|..|:|::..  .|.||:|:|:|||:::|:|...:::.:.::.:|.:..|||:: ...
Human   621 LSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNP 685

  Fly   647 YAVHIYHPAKQPNSPHGCE-----NATCSHLCLLAEPEIGGHS----CACPDGMRLAPDHRRC 700
            :.:.|:|..|||.:|..||     |..|.:|||.| |:|..||    |||||.|.|.||.:||
Human   686 HDIVIFHELKQPRAPDACELSVQPNGGCEYLCLPA-PQISSHSPKYTCACPDTMWLGPDMKRC 747

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
yl	NP_996433.1	LDLa	90..124	CDD:238060	16/33 (48%)
		LDLa	131..166	CDD:238060	11/41 (27%)
		LDLa	184..216	CDD:238060	7/31 (23%)
		LDLa	227..262	CDD:238060	20/34 (59%)
		LDLa	271..302	CDD:238060	15/30 (50%)
		FXa_inhibition	352..387	CDD:291342	14/34 (41%)
		Ldl_recept_b	442..482	CDD:278487	11/41 (27%)
		LY	466..508	CDD:214531	17/41 (41%)
		Ldl_recept_b	529..569	CDD:278487	19/39 (49%)
		LY	553..595	CDD:214531	22/41 (54%)
		LY	596..637	CDD:214531	12/42 (29%)
		FXa_inhibition	669..700	CDD:291342	18/34 (53%)
		LY	774..815	CDD:214531
		LDLa	1032..1062	CDD:238060
		LDLa	1074..1109	CDD:238060
		LDLa	1118..1152	CDD:238060
		LDLa	1157..1189	CDD:197566
		LDLa	1198..1232	CDD:238060
		LDLa	1243..1279	CDD:238060
		LDLa	1283..1318	CDD:238060
		LDLa	1340..1371	CDD:197566
		FXa_inhibition	1388..1416	CDD:291342
		EGF_CA	1418..1452	CDD:214542
LRP8	XP_005271230.1	LDLa	47..81	CDD:238060	16/33 (48%)
		LDLa	85..117	CDD:197566	10/34 (29%)
		LDLa	127..163	CDD:238060	15/53 (28%)
		LDLa	206..240	CDD:197566	2/33 (6%)
		Ldl_recept_a	262..294	CDD:278486	15/32 (47%)
		Ldl_recept_a	298..333	CDD:278486	4/36 (11%)
		FXa_inhibition	353..387	CDD:291342	8/34 (24%)
		EGF_CA	389..419	CDD:214542	15/30 (50%)
		LY	458..493	CDD:214531	6/34 (18%)
		LY	502..544	CDD:214531	17/41 (41%)
		Ldl_recept_b	565..605	CDD:278487	19/39 (49%)
		LY	589..631	CDD:214531	22/41 (54%)
		Ldl_recept_b	652..691	CDD:278487	7/38 (18%)
		FXa_inhibition	710..747	CDD:291342	19/37 (51%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1215
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002088
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810