DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment yl and VLDLR

DIOPT Version :9

Sequence 1:NP_996433.1 Gene:yl / 32367 FlyBaseID:FBgn0004649 Length:1984 Species:Drosophila melanogaster
Sequence 2:NP_003374.3 Gene:VLDLR / 7436 HGNCID:12698 Length:873 Species:Homo sapiens


Alignment Length:775 Identity:238/775 - (30%)
Similarity:348/775 - (44%) Gaps:162/775 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly    41 SGGSTSSRYGNCQRTHL-IINGRHVAISLLLLVGLCGGTAAGTPGSADTR-----CDAGQFQCRD 99
            ||.:.:.|...|:.:.. ..|||     .:.|:..|.|......||.:..     |....|.|.:
Human    22 SGATGTGRKAKCEPSQFQCTNGR-----CITLLWKCDGDEDCVDGSDEKNCVKKTCAESDFVCNN 81

  Fly   100 GGCILQAKMCDGRGDCKDSSDEL--DCDYRLCR--------------PPHW-------------- 134
            |.|:.....|||..||:|.|||.  .|..|.||              |..|              
Human    82 GQCVPSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDE 146

  Fly   135 ------------FPCAQPHGACLAAELMCNGIDNCPGGEDELNCPVRPGFRFGDTAHRMRSCSKY 187
                        |.|:.  |.|::...:|||.|:|..|.|||:| ..|            :|..:
Human   147 ENCGNITCSPDEFTCSS--GRCISRNFVCNGQDDCSDGSDELDC-APP------------TCGAH 196

  Fly   188 EFMCQQDRTCIPIDFMCDGRPDCTDKSDE-VAGCKQAEI---TCPGEGHLCANGRCLRRKQWVCD 248
            ||.|... :||||.::||...||:|:||| :..|.:..:   .||.....|.:|.|:.:| |.||
Human   197 EFQCSTS-SCIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCGSGECIHKK-WRCD 259

  Fly   249 GVDDCGDGSDERGC-LNLCEPQK---------------------------------------GKF 273
            |..||.|||||..| ...|.|.:                                       |||
Human   260 GDPDCKDGSDEVNCPSRTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNCKNVNQCLGPGKF 324

  Fly   274 LCRNRETCLTLSEVCDGHSDCSDGSDETDLCHSKPDCDAKKCAL--GAKCHMMP--ASGAECFCP 334
            .||:.| |:.:|:||:...||.|.|||     ...:|...:|.:  |...|:..  ..|.||.|.
Human   325 KCRSGE-CIDISKVCNQEQDCRDWSDE-----PLKECHINECLVNNGGCSHICKDLVIGYECDCA 383

  Fly   335 KGFRLAKFEDKCEDVDECKEQDDLCSQGCENTSGGYRCVCDAGYLLDKDNRTCRAVVYGSKEQQP 399
            .||.|.. ...|.|:||| :...:|||.|.|..|||:|.|..||.:|.....|:||     .::|
Human   384 AGFELID-RKTCGDIDEC-QNPGICSQICINLKGGYKCECSRGYQMDLATGVCKAV-----GKEP 441

  Fly   400 LLLYTTQMTIMGMHLREDNVRNHVYQVAGNLSKVIGVAYD--GSHIYWTNIQNEAESIVKAN-GD 461
            .|::|.:..|..:.|.    |....|:...|...:.:..|  ...::|.::..:|  |..|: .|
Human   442 SLIFTNRRDIRKIGLE----RKEYIQLVEQLRNTVALDADIAAQKLFWADLSQKA--IFSASIDD 500

  Fly   462 GSNAEILLTSGLDAPEDLAVDWLTQNIYFSDNIMRHIAVCSNDGLNCAVLVTQDVHQPRSLAVWP 526
            .....:.:...:..|..:||||:.:.||::|...:.|:|.:.||.....|...|:.:|.|:||.|
Human   501 KVGRHVKMIDNVYNPAAIAVDWVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDP 565

  Fly   527 QKGLMFWTDWGEKPMIGRASMDGSRSRPIVSDNIEWPNGIALDMHQQRIYWVDAKLGSVQTVRPD 591
            ..|.::|:||||...|.:|.|:|...||:|:.:|:|||||.||:.:.|:||:|:||..:.:|..:
Human   566 LSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLN 630

  Fly   592 GTGRRTVLDGM--LKHPYGLAIFEDQLYWSDWATKSVHACHKFSGKDHRIL------AKDRTIYA 648
            |..||.||..:  |.||..|.||||::||.|...::|:..:||:|.:...|      |:|     
Human   631 GQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQD----- 690

  Fly   649 VHIYHPAKQPNSPHGC----ENATCSHLCLLAEPEIGGHS----CACPDGMRLAPDHRRC 700
            :.:||...||:..:.|    ||..|.:|||.| |:|..||    |:||.|..:..:.|.|
Human   691 IIVYHELVQPSGKNWCEEDMENGGCEYLCLPA-PQINDHSPKYTCSCPSGYNVEENGRDC 749

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ylNP_996433.1 LDLa 90..124 CDD:238060 14/35 (40%)
LDLa 131..166 CDD:238060 15/60 (25%)
LDLa 184..216 CDD:238060 14/31 (45%)
LDLa 227..262 CDD:238060 17/34 (50%)
LDLa 271..302 CDD:238060 16/30 (53%)
FXa_inhibition 352..387 CDD:291342 14/34 (41%)
Ldl_recept_b 442..482 CDD:278487 7/40 (18%)
LY 466..508 CDD:214531 12/41 (29%)
Ldl_recept_b 529..569 CDD:278487 19/39 (49%)
LY 553..595 CDD:214531 19/41 (46%)
LY 596..637 CDD:214531 18/42 (43%)
FXa_inhibition 669..700 CDD:291342 14/34 (41%)
LY 774..815 CDD:214531
LDLa 1032..1062 CDD:238060
LDLa 1074..1109 CDD:238060
LDLa 1118..1152 CDD:238060
LDLa 1157..1189 CDD:197566
LDLa 1198..1232 CDD:238060
LDLa 1243..1279 CDD:238060
LDLa 1283..1318 CDD:238060
LDLa 1340..1371 CDD:197566
FXa_inhibition 1388..1416 CDD:291342
EGF_CA 1418..1452 CDD:214542
VLDLRNP_003374.3 LDLa 33..67 CDD:238060 9/38 (24%)
LDLa 71..103 CDD:197566 12/31 (39%)
Ldl_recept_a 111..149 CDD:278486 5/37 (14%)
LDLa 154..188 CDD:238060 13/35 (37%)
Ldl_recept_a 192..224 CDD:278486 14/32 (44%)
Ldl_recept_a 237..273 CDD:278486 17/36 (47%)
Ldl_recept_a 276..312 CDD:278486 2/35 (6%)
Ldl_recept_a 320..350 CDD:278486 14/30 (47%)
FXa_inhibition 360..394 CDD:291342 10/34 (29%)
EGF_CA 396..426 CDD:214542 15/30 (50%)
Ldl_recept_b 481..521 CDD:278487 7/41 (17%)
LY 505..547 CDD:214531 12/41 (29%)
Ldl_recept_b 568..608 CDD:278487 19/39 (49%)
LY 592..634 CDD:214531 19/41 (46%)
Ldl_recept_b 655..694 CDD:278487 11/43 (26%)
FXa_inhibition 706..749 CDD:291342 17/43 (40%)
Mucin <751..813 CDD:250634
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1215
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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