DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment yl and vldlr

DIOPT Version :9

Sequence 1:	NP_996433.1	Gene:	yl / 32367	FlyBaseID:	FBgn0004649	Length:	1984	Species:	Drosophila melanogaster
Sequence 2:	XP_002934223.1	Gene:	vldlr / 733485	XenbaseID:	XB-GENE-971958	Length:	868	Species:	Xenopus tropicalis

Alignment Length:	777	Identity:	227/777 - (29%)
Similarity:	338/777 - (43%)	Gaps:	194/777 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 LLLLVGLCGGTAAGTPGSADTRCDAGQFQCRDGGCILQAKMCDGRGDCKDSSDELDC-------- 124
            :|||:..|.....|...:..|.|:..||||.:|.||.....|||..||.|.|||..|
Frog     9 VLLLLLCCLHPDLGLVHATKTLCEGSQFQCANGHCITSLWKCDGDEDCSDGSDESSCVKKTCAET 73

  Fly   125 DY----RLCRPPHW--------------------------------------------------- 134
            |:    .||.|..|
Frog    74 DFVCNNGLCVPRRWECDGDPDCEDGSDETAELCHMRTCRATEISCGARSTQCIPLSWKCDGESDC 138

  Fly   135 ------------------FPCAQPHGACLAAELMCNGIDNCPGGEDELNCPVRPGFRFGDTAHRM 181
                              |.|:.  |.|:::..:|||.::|..|.||.|| |.|
Frog   139 PNAEDEENCGNITCSPAEFTCSS--GRCISSTFVCNGQNDCSDGSDEENC-VPP----------- 189

  Fly   182 RSCSKYEFMCQQDRTCIPIDFMCDGRPDCTDKSDE-VAGCKQAEIT---CPGEGHLCANGRCLRR 242
             :|..:||.| ::.:|||::::||...||.|.||| :..|.:..|.   |......|.:|.|:.:
Frog   190 -TCGAHEFQC-KNSSCIPLNWVCDDDSDCADHSDESLEQCGRQPIAPQKCSANEMPCGSGECIHK 252

  Fly   243 KQWVCDGVDDCGDGSDERGC-LNLCEPQK------------------------------------ 270
            | |.|||..||.|.|||..| ...|:|.:
Frog   253 K-WRCDGDPDCKDKSDEMNCPSRTCQPDQFKCEDGNCIHGSRQCDGVRDCLDGTDEIRCKNVNQC 316

  Fly   271 ---GKFLCRNRETCLTLSEVCDGHSDCSDGSDE-TDLCHSKPDCDAKKCALGAKCHMMPASGAEC 331
               |||.||:.| |:.:::||:...||.|.||| ...|:.. :|:.........||.: ..|.||
Frog   317 SGPGKFKCRSGE-CIDIAKVCNKQKDCKDWSDEPIKECYVN-ECEVNNGGCSHLCHNL-VIGYEC 378

  Fly   332 FCPKGFRLAKFEDKCEDVDECKEQDDLCSQGCENTSGGYRCVCDAGYLLDKDNRTCRAVVYGSKE 396
            .|..||:|.. ...|.|:||| :..::|||.|.|..|||:|.|..||.:|.....|:||     .
Frog   379 DCTAGFKLID-RKTCGDIDEC-QNPEICSQICVNLKGGYKCECSKGYQMDPSTGVCKAV-----G 436

  Fly   397 QQPLLLYTTQMTIMGMHLREDNVRNHVYQVAGNLSKVIGVAYD--GSHIYWTNIQNEAESIVKA- 458
            ::|.|::|.:..|..:.|.    |....|:...|...:.:..|  ...::|      |::|.||
Frog   437 REPCLIFTNRRDIRKVGLE----RKEYIQLVEQLRNTVALDADIKEQSLFW------ADTIQKAI 491

  Fly   459 ------NGDGSNAEILLTSGLDAPEDLAVDWLTQNIYFSDNIMRHIAVCSNDGLNCAVLVTQDVH 517
                  ..:.....|.:...:.:|..:|:||:.:|||:.|..::.|:|.:.||.....|....:.
Frog   492 FRAPFDTREKVGTHIKVVEDVHSPSAIAIDWIYKNIYWMDTGLKTISVSNFDGSKRKTLFNSGLQ 556

  Fly   518 QPRSLAVWPQKGLMFWTDWGEKPMIGRASMDGSRSRPIVSDNIEWPNGIALDMHQQRIYWVDAKL 582
            .|.|:||.|..|.::|:||||...|.:|.|:|...:..|:.:::.|:|||:|:.:.|:||||:||
Frog   557 DPTSIAVDPISGFIYWSDWGEPAKIEKAGMNGIDRQQFVTADVQRPSGIAIDVVKSRLYWVDSKL 621

  Fly   583 GSVQTVRPDGTGRRTVLDG--MLKHPYGLAIFEDQLYWSDWATKSVHACHKFSGKDHRIL----- 640
            .::.:|..:|..||.:|..  .|.||..|.||||::||.|...::::..:||||::...|
Frog   622 HTLSSVDLNGLDRRVILKSHEFLAHPLALTIFEDRVYWIDGENEAIYGANKFSGQELETLVNNLN 686

  Fly   641 -AKDRTIYAVHIYHPAKQPNSPHGC----ENATCSHLCLLAEPEIGGHS----CACPDGMRL 693
             |:|     |.:||...||...:.|    ||..|.:|||.| |:|..:|    |.||||..|
Frog   687 EAQD-----VIVYHELVQPLGRNWCNEQIENGGCKYLCLPA-PQISDNSPKYTCVCPDGFEL 742

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
yl	NP_996433.1	LDLa	90..124	CDD:238060	17/33 (52%)
		LDLa	131..166	CDD:238060	13/103 (13%)
		LDLa	184..216	CDD:238060	13/31 (42%)
		LDLa	227..262	CDD:238060	15/34 (44%)
		LDLa	271..302	CDD:238060	15/31 (48%)
		FXa_inhibition	352..387	CDD:291342	14/34 (41%)
		Ldl_recept_b	442..482	CDD:278487	8/46 (17%)
		LY	466..508	CDD:214531	13/41 (32%)
		Ldl_recept_b	529..569	CDD:278487	15/39 (38%)
		LY	553..595	CDD:214531	15/41 (37%)
		LY	596..637	CDD:214531	17/42 (40%)
		FXa_inhibition	669..700	CDD:291342	14/29 (48%)
		LY	774..815	CDD:214531
		LDLa	1032..1062	CDD:238060
		LDLa	1074..1109	CDD:238060
		LDLa	1118..1152	CDD:238060
		LDLa	1157..1189	CDD:197566
		LDLa	1198..1232	CDD:238060
		LDLa	1243..1279	CDD:238060
		LDLa	1283..1318	CDD:238060
		LDLa	1340..1371	CDD:197566
		FXa_inhibition	1388..1416	CDD:291342
		EGF_CA	1418..1452	CDD:214542
vldlr	XP_002934223.1	LDLa	31..65	CDD:238060	17/33 (52%)
		Ldl_recept_a	68..101	CDD:365841	5/32 (16%)
		Ldl_recept_a	109..147	CDD:365841	0/37 (0%)
		Ldl_recept_a	151..186	CDD:365841	11/36 (31%)
		LDLa	190..222	CDD:197566	13/32 (41%)
		Ldl_recept_a	236..271	CDD:365841	15/35 (43%)
		Ldl_recept_a	274..310	CDD:365841	2/35 (6%)
		LDLa	316..348	CDD:197566	13/32 (41%)
		FXa_inhibition	358..392	CDD:373209	10/35 (29%)
		EGF_CA	394..424	CDD:214542	15/30 (50%)
		LY	505..547	CDD:214531	13/41 (32%)
		LY	548..591	CDD:214531	16/42 (38%)
		LY	592..634	CDD:214531	15/41 (37%)
		Ldl_recept_b	655..694	CDD:393440	12/43 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910