DRSC/TRiP Functional Genomics Resources

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Protein Alignment yl and lrp2a

DIOPT Version :9

Sequence 1:NP_996433.1 Gene:yl / 32367 FlyBaseID:FBgn0004649 Length:1984 Species:Drosophila melanogaster
Sequence 2:NP_001181916.1 Gene:lrp2a / 568184 ZFINID:ZDB-GENE-050119-2 Length:4673 Species:Danio rerio


Alignment Length:2103 Identity:581/2103 - (27%)
Similarity:903/2103 - (42%) Gaps:377/2103 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    68 LLLLVGLCGGTAAGTPGSADTRCDAGQFQCRDGGCILQAKMCDGRGDCKDSSDELDCDYRLCR-- 130
            |||::.|| .......||.   |::|.|:|..|.||..::.|||..||.|:|||:.|....|.  
Zfish     5 LLLILTLC-ALQCDCQGSG---CESGFFRCGTGRCIPVSQRCDGTNDCSDNSDEIGCPQPTCESA 65

  Fly   131 -----------PPHW---------------------------FPCAQPHGACLAAELMCNGIDNC 157
                       |.||                           |.|.  :|||:.....|:.:.:|
Zfish    66 QFQCLSDGECIPQHWVCDDEEDCEDGSDERQHCPGRTCSSSQFTCT--NGACIPGGYRCDRVPDC 128

  Fly   158 PGGEDELNC--------------------------PVRPGFRFGDTAHRMRSCSKYEFMCQQDRT 196
            ..|.||.||                          ..|.|   .|.|:..:.||..:|.|.... 
Zfish   129 LDGADERNCFYPECSELRCANGACFNRSQRCDQVLNCRDG---SDEANCTQRCSSGQFQCSNGE- 189

  Fly   197 CIPIDFMCDGRPDCTDKSDEVAGCKQAEITCPGEGHLCANGRCLRRKQWVCDGVDDCGDGSDERG 261
            |||..::||...||.|:||| ..|...  ||.|....|.:|||: .:.|:|||.|||.|.:||:|
Zfish   190 CIPRGYICDHDDDCGDRSDE-QNCTYP--TCRGTYFTCPSGRCI-HQVWLCDGEDDCEDNADEKG 250

  Fly   262 CLNL---CEPQKGKFLCRNRETCLTLSEVCDGHSDCSDGSDETDLCHSKPDCDAKKCA-LGAK-- 320
            |.|:   |.|  |::.|.:...|:....:|||...|.||.|||::...: :|...:|| |..:  
Zfish   251 CDNVQQECYP--GEWPCPSSGVCIPFDHLCDGTVHCPDGEDETNITAGR-NCSIWRCASLSCEHH 312

  Fly   321 CHMMPASGAECFCPKGFRLAKFEDK-CEDVDECKEQDDLCSQGCENTSGGYRCVCDAGYLLDKDN 384
            ||..| .|..|.||.|:.:...:.: |.|.|:|... .:|.|.||:..|.:||.|..||:|:: :
Zfish   313 CHASP-DGGTCACPPGYVINTNDSRSCMDYDDCSLW-GMCDQLCEDRIGSHRCSCRDGYILEQ-H 374

  Fly   385 RTCRAVVYGSKEQQPLLLYTTQMTIMGMHLREDNVRNHVYQV---AGNLSKVIGV--AYDGSHIY 444
            |.|||   ......|.|:::.     |..|...:|..|..|.   :.|....:||  .|....::
Zfish   375 RYCRA---NPSSGVPSLIFSN-----GRDLLIADVHGHGSQTLVQSQNRGAAVGVDFHYQLQRVF 431

  Fly   445 WTN-IQNEAESIVKANGDGSNAEILLTSGLDAPEDLAVDWLTQNIYFSDNIMRHIAVCSNDGLNC 508
            ||: |||:..|:   :.|||..:::|...:|.||:|||||:...:|..:..:..|.:...||.|.
Zfish   432 WTDTIQNKVFSV---DMDGSRLQVVLNVSVDYPENLAVDWVNNKLYVVEASVNRIDMVDLDGSNR 493

  Fly   509 AVLVTQDVHQPRSLAVWPQKGLMFWTDW----GEKPMIGRASMDGSRSRPIVSDNIEWPNGIALD 569
            ..|:.:.:..||.||:.|..|.:|::||    || |.:.||.|||:....|:...:.||.||.||
Zfish   494 VTLIAEHLGNPRGLALDPTVGYLFFSDWDTLNGE-PGLERAYMDGTNRYGIIRTKLGWPAGITLD 557

  Fly   570 MHQQRIYWVDAKLGSVQTVRPDGTGRRTVLDG--MLKHPYGLAIFEDQLYWSDWATKSVHACHKF 632
            :..:|:||||::...::|...||..|:||:.|  ::.||:|:.:||..:|::||...:|...:|:
Zfish   558 LEAKRVYWVDSRYDYIETTTYDGLHRKTVVHGGSVIPHPFGITLFEHSVYYTDWTKMAVMKANKY 622

  Fly   633 SGKDHRILAK-DRTIYAVHIYHPAKQP--NSPHGCENATCSHLCLLA-EPEIG--GHSCACPDGM 691
            |..:.:.|.: .:..|.:.:.|..|||  ::|.|.:...|.|:|:|: ..:.|  |:.|.|..|.
Zfish   623 SDSNPQELYRTTQRPYGLTVVHSYKQPFVSNPCGADRGGCEHICVLSHRTDNGGLGYRCRCRMGY 687

  Fly   692 RLAPDHRRCMLMEKRQRLFIGLGQVLLEIEHTAFGRHQVSKSYT-LPCLINEMVYNRINGSLIIA 755
            .|..|.:||:.:  ||.|.......:..|......:..:....| .|.....:.::..:.|:..:
Zfish   688 DLHADGKRCVAV--RQFLLFSSQLAVRGIPFNLSTQEDIILPITGTPSYFVGVDFSAEDNSIFFS 750

  Fly   756 DNDQRLILEFQPESHESNVLVRSNLGNVSALAFDHLSRNLYWADTERAVIEVLSLQTR-HRALIR 819
            |..:.:|.:.:.:.....||..:.:..|..||:|.:|:||||.|.....|.|:.:..: .||::|
Zfish   751 DTVKDIIYKQKVDGTGREVLAANRVDGVEDLAYDWISKNLYWTDPRYRSISVMKVVDKSRRAIVR 815

  Fly   820 FFPGQEVPIGLTVMPAEGYLY--------VVLKAKRHSHIDKIPLSGKGEQVH-VFEDDLGDDDI 875
               ....|..:.|.|..|:::        .:::|           .|.|.... :....||..: 
Zfish   816 ---NLNNPRSIVVHPVAGFIFWTDWYRPAKIMRA-----------WGDGSHAQSIVNTTLGWPN- 865

  Fly   876 KLVTDYETQTIFWSDSDLGRISYSNY----RVPHSQIFRGKLRRPYSLAMVHHDLFWNELGTPRI 936
            .|..|:....::|.|:...:|.:||:    |:...:|  .::..|:.|.:....:::.:.....|
Zfish   866 GLAIDWSAMRLYWVDAFFDKIEHSNFDGQNRLSLDRI--TQISHPFGLTVFGGYVYFTDWRLGGI 928

  Fly   937 YWTHKSNMGPRKVIDIMEKDDPAAIMPYVPVATPNGIPLAASSPVGQESHPCQQQ---NGGCSHI 998
            ....|::.|....|       ...|...:.|.:.|     |.|.:|  .:.|.:|   ||.|||.
Zfish   929 VRVRKTDGGEMMTI-------RRGISHIMHVKSFN-----ADSQIG--FNFCSRQTNPNGDCSHF 979

  Fly   999 CVGEGPYHSICLCPAGFVYRDAGNRTCVE-------ALDC---EFRCHSGECLTMNHRCNGRRDC 1053
            |........:|.||.| :..:|..:|||:       .|.|   .|.|.:|:|:..:::|:|..||
Zfish   980 CFPAPNSQRVCGCPYG-MKLEANQQTCVDDPSNEPPTLQCGSNSFSCSNGKCVPHSYQCDGVDDC 1043

  Fly  1054 VDNSDEMNCDEEHRRKPKVLCSPNQFACHSGEQCVDKERRCDNRKDCHDHSDEQHCEKFDKSKKC 1118
            .|||||.:|...:.     .|||..|.| :.::||.:...||...||.|.|||:.|.. .....|
Zfish  1044 HDNSDEAHCGAHNN-----TCSPLAFTC-ANQRCVPRSWHCDGHNDCFDGSDERDCPT-QTPGTC 1101

  Fly  1119 HVHQHGCDNGKCVDSSLVCDGTNDCGDNSDELLCEATSRCEPGMFQCGSGSCIAGSWECDGRIDC 1183
            ...|..|.|..|:..:.:||..|||||.|||..|::...|.||.|||....||..::.|||..||
Zfish  1102 PADQFICANHYCIPRTWLCDTDNDCGDGSDENNCDSIGTCYPGQFQCPDHRCIDPNYVCDGDRDC 1166

  Fly  1184 SDGSDEHDKCVHRSCPPDMQRCLLG-QCLDRSLVCDGHNDCGDKSDELNCGTDSSTMNISC-AED 1246
            :||:||.. ||: :|.....:|... ||::....|||..||.|:|||..|.|....|   | .|.
Zfish  1167 ADGADEQG-CVY-NCTAYEFKCANDHQCVNSYYRCDGVFDCNDRSDESGCPTRPPGM---CHHES 1226

  Fly  1247 QYQCTSNLKICLPSTVRCNGTTECPRGEDE--ADCGDVCSIYEFKCRSGRECIRREFRCDGQKDC 1309
            ::||.|: ..|:|....|:|..:|..|.||  |.....|...:|:|.:| .|:.|.:.|||..||
Zfish  1227 EFQCQSD-GSCVPVNWECDGHPDCEDGSDEHHACPPRTCPTTQFRCDNG-NCVYRGWICDGDNDC 1289

  Fly  1310 GDGSDELSCELEKGHHNQSQIQPWSTSSR--SCRPHLFDCQDGECVDLSRVCNNFPDCTNGHDEG 1372
            .|||||..|          ...|:...||  .|..|      ..||:|||||:|.|||.||.||.
Zfish  1290 RDGSDERDC----------PTPPFRCPSRQWQCPGH------SVCVNLSRVCDNTPDCPNGADES 1338

  Fly  1373 PKC------ATACRSASGRQVCQHKCRATPAGAVCSCFDGYRLDADQKSCLDIDECQEQQPCAQL 1431
            |.|      ..:|  :.....|.|.|...|.||.|:|..|::|..|.|:|.|||||.....|:|.
Zfish  1339 PLCNEPLPDQESC--SDNNAGCTHGCIQGPFGAQCTCPMGFQLSNDSKTCEDIDECHPPGVCSQH 1401

  Fly  1432 CENTLGGYQCQCHADFMLRQDRVSCKSLQSG---ATLLFSSFNEVRN---LSEQPVMLNVAWSAN 1490
            |.|..|.::|.|...:.|..|..:||:  ||   |.||.:|.|::.:   |::...:.::.....
Zfish  1402 CFNERGSFRCHCQDGYTLEADARTCKA--SGSREALLLVASRNQIISDDILAQPNAIRSLVRDGR 1464

  Fly  1491 DSRITGFDLAMHR-------QMGYFSAEDEGIVYQIDLQTKVIVRALGLPAPTKLSVDWVTGNVY 1548
            :.....||....|       |...:||...|       ..:.::...|:.....|:||||..|:|
Zfish  1465 NIVAVDFDSVTERIYWSDTTQDRIWSAHKNG-------TDRTVIFDSGVTVTESLAVDWVGRNLY 1522

  Fly  1549 ------------VLSGA-QEIQACSFVGRMCGRIVHVKSPRHVKHLAVDGYHARIFYIVIRTEGY 1600
                        .|.|: :.:.....|....|.:|   .||:..||        :|:     ..:
Zfish  1523 WTDYILETIEVSKLDGSHRTVLISENVTNPRGLVV---DPRNNTHL--------MFW-----TDW 1571

  Fly  1601 GQTSSEIHMARLDGSRRDMLLQRSESFMTALTTDPHQQLLYFVDQHMRTLERISYRLKTGPMRRP 1665
            |: :..|..|.:||..|..::.....:...||.|....||||.|.::..::...|   .|..|:.
Zfish  1572 GR-NPRIERASMDGKLRTTIISNKLYWPNGLTIDYPNSLLYFADAYLDFIDYCDY---DGKNRKQ 1632

  Fly  1666 EIMLQKSNALMHPSGLSVYENNAFIVNLGSVEAVQCALYGSRICHKISINVLNAQDIVVAGRSRQ 1730
              :|.....|.||..::::|:..:..:......::...:..:....:..|:.....:|....:||
Zfish  1633 --VLASDLVLQHPHAITIFEDFVYWTDRYVNRVIRANKWHGQNQSVMLYNLPQPMGLVALHPARQ 1695

  Fly  1731 P------QKASHPCAHAHCHGLCLQADYG---YECMC--GNRLVAEGERC--------------- 1769
            |      ...|.||.|     :||.:..|   |.|.|  |..|.|:...|               
Zfish  1696 PAGYNPCDPHSSPCTH-----ICLLSAVGPRFYSCACPSGWTLAADQFTCARVEDPFLVVVRDSI 1755

  Fly  1770 -------PHGSGNE--VAVLGAVNSLELEHEH--------EQNGHFHWLMA------LFVLAA-- 1809
                   |:...|:  |.|.|.:|..:::.:.        |..|..|.:.:      .|..||  
Zfish  1756 IYGIPLNPNDKSNDAMVPVAGLLNGYDVDFDDAEQMIYWVEHPGEIHRVKSDGTNRTEFAPAAIL 1820

  Fly  1810 GSLIAGLGYMYYQYRQRGHTDLNINMHFQNP------LATLGG----TKAFLEHERAEAGVGFTT 1864
            ||.: ||...:          ::.|:::.||      :..|.|    .|..:.:..:..|.|...
Zfish  1821 GSPV-GLALDW----------MSQNLYYSNPSSQAIEVLRLKGEIQYRKTLITNNGSPTGAGAPV 1874

  Fly  1865 ETGTVSSRGS---NDTFTTTSATSSFAAQQFSVPNALQRLLRPRQSASGDPMAQELLLESPSRES 1926
            ......:||.   .|..|.:...:..|:......||........:...        .:.....|:
Zfish  1875 GIAVDPARGKMYWTDHGTESGIPAKVASADMDGSNAAILFTHNLEHVE--------FITIDITEN 1931

  Fly  1927 KLH-ALDGGGA--GGDGDGGRGV 1946
            ||: |:.|.|.  .||.||...:
Zfish  1932 KLYWAVTGTGVIERGDPDGSNRI 1954

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ylNP_996433.1 LDLa 90..124 CDD:238060 16/33 (48%)
LDLa 131..166 CDD:238060 13/61 (21%)
LDLa 184..216 CDD:238060 13/31 (42%)
LDLa 227..262 CDD:238060 16/34 (47%)
LDLa 271..302 CDD:238060 11/30 (37%)
FXa_inhibition 352..387 CDD:291342 13/34 (38%)
Ldl_recept_b 442..482 CDD:278487 15/40 (38%)
LY 466..508 CDD:214531 13/41 (32%)
Ldl_recept_b 529..569 CDD:278487 17/43 (40%)
LY 553..595 CDD:214531 15/41 (37%)
LY 596..637 CDD:214531 14/42 (33%)
FXa_inhibition 669..700 CDD:291342 11/33 (33%)
LY 774..815 CDD:214531 14/41 (34%)
LDLa 1032..1062 CDD:238060 13/29 (45%)
LDLa 1074..1109 CDD:238060 15/34 (44%)
LDLa 1118..1152 CDD:238060 15/33 (45%)
LDLa 1157..1189 CDD:197566 15/31 (48%)
LDLa 1198..1232 CDD:238060 13/34 (38%)
LDLa 1243..1279 CDD:238060 14/38 (37%)
LDLa 1283..1318 CDD:238060 16/34 (47%)
LDLa 1340..1371 CDD:197566 15/30 (50%)
FXa_inhibition 1388..1416 CDD:291342 12/27 (44%)
EGF_CA 1418..1452 CDD:214542 13/33 (39%)
lrp2aNP_001181916.1 LDLa 23..57 CDD:238060 16/33 (48%)
Ldl_recept_a 61..96 CDD:278486 4/34 (12%)
LDLa 103..137 CDD:238060 10/35 (29%)
LDLa 143..174 CDD:238060 4/33 (12%)
LDLa 178..212 CDD:238060 15/35 (43%)
LDLa 217..251 CDD:238060 16/34 (47%)
LDLa 258..292 CDD:238060 13/35 (37%)
NHL <429..610 CDD:302697 66/184 (36%)
NHL repeat 461..496 CDD:271320 12/34 (35%)
LY 495..540 CDD:214531 18/45 (40%)
LY 543..583 CDD:214531 15/39 (38%)
NHL repeat 550..591 CDD:271320 18/40 (45%)
FXa_inhibition 655..696 CDD:291342 12/40 (30%)
LY 768..804 CDD:214531 14/35 (40%)
Ldl_recept_b 830..870 CDD:278487 7/51 (14%)
LY 854..896 CDD:214531 9/42 (21%)
FXa_inhibition 973..1005 CDD:291342 11/32 (34%)
LDLa 1018..1052 CDD:238060 14/33 (42%)
LDLa 1059..1093 CDD:238060 15/34 (44%)
LDLa 1101..1135 CDD:238060 15/33 (45%)
LDLa 1141..1175 CDD:238060 17/34 (50%)
LDLa 1179..1214 CDD:238060 13/34 (38%)
LDLa 1222..1255 CDD:197566 11/33 (33%)
LDLa 1264..1298 CDD:238060 16/34 (47%)
LDLa 1304..1337 CDD:197566 17/38 (45%)
FXa_inhibition 1351..1386 CDD:291342 13/36 (36%)
EGF_CA 1388..1418 CDD:214542 12/29 (41%)
LY 1459..1498 CDD:214531 7/45 (16%)
LY 1500..1541 CDD:214531 10/40 (25%)
LY 1543..1585 CDD:214531 12/58 (21%)
LY 1589..1630 CDD:214531 10/43 (23%)
FXa_inhibition 1709..1740 CDD:291342 11/35 (31%)
NHL <1799..1978 CDD:302697 34/175 (19%)
NHL repeat 1823..1866 CDD:271320 8/53 (15%)
NHL repeat 1872..1913 CDD:271320 7/40 (18%)
Ldl_recept_b 1883..1927 CDD:278487 6/51 (12%)
LY 1912..1953 CDD:214531 10/48 (21%)
NHL repeat 1920..1946 CDD:271320 6/33 (18%)
FXa_inhibition 2022..2058 CDD:291342
NHL <2125..2295 CDD:302697
NHL repeat 2149..2186 CDD:271320
LY 2182..2225 CDD:214531
NHL repeat 2189..2226 CDD:271320
LY 2228..2267 CDD:214531
NHL repeat 2235..2276 CDD:271320
FXa_inhibition 2346..2382 CDD:291342
LY 2461..2500 CDD:214531
Ldl_recept_b 2519..2559 CDD:278487
LY 2545..2585 CDD:214531
Ldl_recept_b 2603..2642 CDD:278487
FXa_inhibition 2655..2691 CDD:291342
LDLa 2759..2793 CDD:238060
LDLa 2798..2835 CDD:238060
LDLa 2838..2872 CDD:294076
LDLa 2882..2913 CDD:238060
LDLa 2923..2955 CDD:197566
LDLa 2965..3002 CDD:197566
LDLa 3011..3045 CDD:238060
LDLa 3050..3083 CDD:238060
LDLa 3093..3127 CDD:238060
cEGF 3150..3173 CDD:289433
vWFA <3165..3206 CDD:294047
LY 3237..3279 CDD:214531
LY 3282..3321 CDD:214531
Ldl_recept_b 3350..3390 CDD:278487
LY 3376..3416 CDD:214531
LY 3417..3458 CDD:214531
FXa_inhibition 3486..>3514 CDD:291342
LDLa 3529..3561 CDD:238060
LDLa 3570..3602 CDD:238060
LDLa 3611..3643 CDD:238060
LDLa 3651..3683 CDD:197566
LDLa 3699..3731 CDD:238060
LDLa 3738..3771 CDD:238060
LDLa 3776..3810 CDD:238060
LDLa 3815..3849 CDD:238060
LDLa 3859..3891 CDD:238060
LDLa 3902..3932 CDD:197566
LDLa 3945..3979 CDD:238060
EGF_CA 4024..4055 CDD:214542
LY 4158..4193 CDD:214531
Ldl_recept_b 4214..4254 CDD:278487
LY 4238..4281 CDD:214531
FXa_inhibition 4356..>4377 CDD:291342
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100345
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
32.810

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