DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment yl and lrp1ab

DIOPT Version :9

Sequence 1:NP_996433.1 Gene:yl / 32367 FlyBaseID:FBgn0004649 Length:1984 Species:Drosophila melanogaster
Sequence 2:XP_021325646.1 Gene:lrp1ab / 565797 ZFINID:ZDB-GENE-030131-7126 Length:4562 Species:Danio rerio


Alignment Length:1823 Identity:499/1823 - (27%)
Similarity:744/1823 - (40%) Gaps:513/1823 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    90 CDAGQFQCRDGGCILQAKMCDGRGDCKDSSDE-LDCDYRLCRPPHWFPCAQPHGACLAAELMCNG 153
            |.:.||:|.:..||.:..:|||..||.|.:|| ..|..:.|.|.. |.|...| .|:....:|:|
Zfish  2738 CASNQFECGNHRCIFKTWVCDGTDDCGDGTDEDSRCKAKTCGPDS-FQCPGSH-VCILQRWVCDG 2800

  Fly   154 IDNCPGGEDELNCPVRPGFRFGDTAHRMRSCSKYEFMCQQDRTCIPIDFMCDGRPDCTDKSDEVA 218
            ..:||.|.||       |.:.|...:  ::|...||.||..: |||.:||||...||.|.|||..
Zfish  2801 DKDCPDGGDE-------GLKAGCVFN--KTCDDTEFQCQNSQ-CIPKNFMCDHDIDCRDGSDESP 2855

  Fly   219 GCKQAEITC-PGEGHLCANGRCLRRKQWVCDGVDDCGDGSDERGCLNLCEPQKGK-----FLCRN 277
            .|:..  || |.:.| ||||:||::|.|.|||..||.|.|||......|...:.:     |||.:
Zfish  2856 ECEYP--TCGPNDFH-CANGQCLKQKNWACDGEFDCRDQSDEAPKNLQCTDTESRCNDTAFLCSS 2917

  Fly   278 RETCLTLSEVCDGHSDCSDGSDETDLCHSKPDCDAKKCALGAK---CHMMPAS---GAECFCPKG 336
            .: |:..:.:||.::||.|||||.       :|...:| |.:|   |..:...   |.:|.|..|
Zfish  2918 GK-CVNETLLCDNNNDCGDGSDEN-------NCFVNEC-LNSKLSGCSQLCEDLKIGFKCRCNAG 2973

  Fly   337 FRLAKFEDKCEDVDECKEQDDLCSQGCENTSGGYRCVCDAGYLLDKDNRT-CRAVVYGSKEQQPL 400
            |||.:....|.|:|||..... |||.|.||.|.:.|:|..|::...|:.| |::    :.|::|.
Zfish  2974 FRLKQDGKTCVDLDECSTVYP-CSQRCINTHGSFHCLCVDGFVPRPDDHTSCKS----TAEEEPF 3033

  Fly   401 LLYTTQMTIMGMHLREDNVRNHVYQ-VAGNLSKVIGVAYDGSH--IYWTNIQNEAESIVKANGDG 462
            |::..:     .:||:.|:....|. :...|:..:.:.|..:.  ||||::..:...|.:.:.:|
Zfish  3034 LIFANR-----YYLRKLNLDGSNYTLIKQGLNNAVALDYHYAEQMIYWTDVTTQGSMIRRMHING 3093

  Fly   463 SNAEILLTSGLDAPEDLAVDWLTQNIYFSDNIMRHIAVCSNDGLNCAVLVTQDVHQPRSLAVWPQ 527
            ||.::|..:.|..|:.|||||:..|:|:.|.....|.|...:|...:|||...:.:||::||..:
Zfish  3094 SNVQVLHRTSLSNPDGLAVDWVGGNLYWCDKGRDTIEVSKLNGAYRSVLVNSGLREPRAVAVDVR 3158

  Fly   528 KGLMFWTDWGEKPMIGRASMDGSRSRPIVSDNIEWPNGIALDMHQQRIYWVDAKLGSVQTVRPDG 592
            .|.::|:|||:.|.|||..|||:..:.|:.|.|.||||:.||....||||.||:...:.....||
Zfish  3159 NGYLYWSDWGDVPHIGRIGMDGTDRQIIIQDKITWPNGLTLDFINDRIYWADAREDYIAFASLDG 3223

  Fly   593 TGRRTVLDGMLKHPYGLAIFEDQLYWSDWATKSVHACHKFSGKDHRILAKDRTIYA---VHIYHP 654
            :.|.|||:..:.|.:.:.:||:.:||:||.|||::..||..|.:..:|..  |::.   :||:||
Zfish  3224 SNRHTVLNHDIPHIFAMTLFEEFIYWTDWETKSINRAHKTLGTNKTLLIS--TLHRPMDIHIFHP 3286

  Fly   655 AKQPN-SPHGC--ENATCSHLCLLAEPEIGGHSCACPDGMRLAPDHRRCMLMEKRQRLFIGLGQV 716
            ::||. |.|.|  :|..||:||||:..  ||:.||||....||.|.::|:               
Zfish  3287 SRQPEVSGHPCQEDNGGCSNLCLLSPG--GGYKCACPTNFYLAADGKQCL--------------- 3334

  Fly   717 LLEIEHTAFGRHQVSKSYTLPCLINEMVYNRINGSLIIADNDQRLILEFQPESHESNVLVRSNLG 781
                                         :....|..:..||:                      
Zfish  3335 -----------------------------SNCTASQFVCKNDK---------------------- 3348

  Fly   782 NVSALAFDHLSRNLYW-ADTERAVIEVLSLQTRHRALIRFFPGQEVPIGLTVMPAEGYLYVVLKA 845
               .:.|       :| .||                                             
Zfish  3349 ---CIPF-------WWKCDT--------------------------------------------- 3358

  Fly   846 KRHSHIDKIPLSGKGEQVHVFEDDLGDDDIKLVTDYETQTIFWSDSDLGRISYSNYRVPHSQIFR 910
                                 |||.||                                      
Zfish  3359 ---------------------EDDCGD-------------------------------------- 3364

  Fly   911 GKLRRPYSLAMVHHDLFWNELGTPRIYWTHKSNMGPRKVIDIMEKDDPAAIMPYVPVATPNGIPL 975
                                                       ..|:||....:           
Zfish  3365 -------------------------------------------RSDEPADCPEF----------- 3375

  Fly   976 AASSPVGQESHPCQQQ--NGGC---SHICVGEGPYHSICLCPAGFVYRDAGNRTCVEALDCEFRC 1035
                    :..|.|.|  .|.|   ::||.|:..      |...   .|..|......|..:|:|
Zfish  3376 --------KCRPGQFQCGTGLCTNPAYICDGDND------CQDN---SDEANCDIHVCLPSQFKC 3423

  Fly  1036 -HSGECLTMNHRCNGRRDCVDNSDEMNCDEEHRRKPKVLCSPNQFACHSGEQCVDKERRCDNRKD 1099
             |...|:....||||:.:|....||.:|       |:|.|:||||.|...::|:.:...||...|
Zfish  3424 SHPSRCIPGILRCNGQNNCGQGEDEKDC-------PEVTCAPNQFQCAITKRCIPRVWVCDRDYD 3481

  Fly  1100 CHDHSDE-QHCEKFDKSKKCHVHQHGC-DNGKCVDSSLVCDGTNDCGDNSDELLCEATSR-CEPG 1161
            |.|.||| .:|.:.    ||.|.:..| |:|:|:.|...|||.:||||.|||...|...| |||.
Zfish  3482 CVDESDEPANCTQM----KCGVDEFRCKDSGRCIPSRWTCDGEDDCGDASDEPKEECDERTCEPY 3542

  Fly  1162 MFQCGSGSCIAGSWECDGRIDCSDGSDEHDKCVHRSCPPDMQRCLLGQCLDRSLVCDGHNDCGDK 1226
            .|:|.:..|:.|.|:||...||.|.||| :|||.|.|......|..|:|:.....|||.:||.|.
Zfish  3543 QFRCKNNRCVPGRWQCDYDNDCGDNSDE-EKCVPRQCSESEFACSNGRCIAGRWKCDGDHDCSDG 3606

  Fly  1227 SDELNCGTDSSTMNISCAEDQYQCTSNLKICLPSTVRCNGTTECPRGEDEA-------------- 1277
            |||..|       ::.|.|||:||.:.  .|:|...||:...:|..|.||.              
Zfish  3607 SDEDGC-------DLKCEEDQFQCKNG--HCIPLPWRCDADVDCLDGSDEERCEITEVRHCSSEE 3662

  Fly  1278 -------------------DCGD-------VCSIYE------FKCRSGRECIRREFRCDGQKDCG 1310
                               ||||       .|..::      |:||:.|.|:.|...|||..:||
Zfish  3663 FQCNNTLCKPLSWKCDGEDDCGDNSDENPEACRHFQCPPTRNFRCRNNRVCLTRSKLCDGVDNCG 3727

  Fly  1311 DGSDELSCELEKGHHNQSQIQPWSTSSRSCRPHLFDCQDGECVDLSRVCNNFPDCTN-GHDE-GP 1373
            |.|||.||:.|.                :|....|.|.:|:|:..:..||.|.||.: |.|| |.
Zfish  3728 DNSDEASCDYES----------------TCDKDQFRCTNGKCISANLRCNFFNDCEDYGSDEIGC 3776

  Fly  1374 KCATA---CRSASGRQVC----QHKCRATPAGAVCSCFDGYRLDADQKSCLDIDECQEQQPCAQL 1431
            |..|.   |:  |.:.:|    :..|.:......|||..|:: .....:|.|.|||::...|:.:
Zfish  3777 KTDTMLNDCK--SNKSLCGDGDEAHCVSNGTDTFCSCKPGFQ-SVRHNTCEDKDECKQFGVCSHV 3838

  Fly  1432 CENTLGGYQCQCHADFMLRQDRV--SCKS--LQSGATLLF-SSFNEVRNLSEQPVMLNVAWSA-- 1489
            |.||.|.|:|.||..|    .|:  :||:  ..|...:|: :..||:|:|:  |.|.|..:..  
Zfish  3839 CNNTKGSYKCSCHKYF----TRINHTCKADGQNSNKQVLYIADDNEIRSLN--PGMPNWVYEQTF 3897

  Fly  1490 ---NDSRITGFDLAM---------------------------------HRQMGYFSAEDEGIVYQ 1518
               |:.||...||.:                                 ||.    :.:.||.|..
Zfish  3898 QGDNNVRIDAMDLHVKTNRIFWTNWHTYGISCFQLPSQSSASGPTSNSHRH----TRQSEGTVSN 3958

  Fly  1519 IDLQTKVIVRALGLPAPTKLSVDWVTGNVY-VLSGAQEIQACSFVGRMCGRIVHVKSPRHVKHL- 1581
            :::.        ||..|..::||||.||:| ..||...|:.....|            :|.|.| 
Zfish  3959 LEIP--------GLKMPRGIAVDWVAGNLYWTDSGRDVIEVAQITG------------QHRKTLI 4003

  Fly  1582 --AVDGYHARIFYIVIRTE-------GYGQTSSEIHMARLDGSRRDMLLQRSESFMTALTTDPHQ 1637
              .:|..||    ||:..:       .:| ...:|..|.:||:.|..|:..:..:.|.|..|...
Zfish  4004 SGMIDEPHA----IVVDPQRGTMYWTDWG-NHPKIETAAMDGTLRQTLVHENIQWPTGLAVDYFN 4063

  Fly  1638 QLLYFVDQHMRTLERISYRLKTGPMRRPEIMLQK-SNALMHPSGLSVYENNAFIVNLGSVEAVQC 1701
            :.||:.|..:..:.  |.||....   |.:.:.. .|.|:.|..:.::|:..:.|...:....:.
Zfish  4064 ERLYWADSKLSVIS--SVRLDGSD---PVVAVSNLKNNLLRPYSIDIFEDYIYGVTHTNNIVFRV 4123

  Fly  1702 ALYGSRICHKISINVLNAQDIVVAGRSRQPQKASHPCAHAHCHGLCLQADYGYECMCGNRLVAEG 1766
            ..:|......::..:.:|.|||:..|.:||: .::||....|..|||.:..|..|:|.|..|.:.
Zfish  4124 NKFGKGQAENLTTGINHATDIVLYHRYKQPE-MTNPCDRKKCEWLCLLSPSGPVCICPNDHVPDN 4187

  Fly  1767 ERC 1769
            ..|
Zfish  4188 GTC 4190

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ylNP_996433.1 LDLa 90..124 CDD:238060 14/34 (41%)
LDLa 131..166 CDD:238060 12/34 (35%)
LDLa 184..216 CDD:238060 16/31 (52%)
LDLa 227..262 CDD:238060 20/35 (57%)
LDLa 271..302 CDD:238060 13/35 (37%)
FXa_inhibition 352..387 CDD:291342 13/35 (37%)
Ldl_recept_b 442..482 CDD:278487 13/41 (32%)
LY 466..508 CDD:214531 14/41 (34%)
Ldl_recept_b 529..569 CDD:278487 19/39 (49%)
LY 553..595 CDD:214531 17/41 (41%)
LY 596..637 CDD:214531 16/40 (40%)
FXa_inhibition 669..700 CDD:291342 15/30 (50%)
LY 774..815 CDD:214531 4/41 (10%)
LDLa 1032..1062 CDD:238060 11/30 (37%)
LDLa 1074..1109 CDD:238060 15/35 (43%)
LDLa 1118..1152 CDD:238060 17/34 (50%)
LDLa 1157..1189 CDD:197566 15/32 (47%)
LDLa 1198..1232 CDD:238060 13/33 (39%)
LDLa 1243..1279 CDD:238060 14/68 (21%)
LDLa 1283..1318 CDD:238060 16/40 (40%)
LDLa 1340..1371 CDD:197566 11/31 (35%)
FXa_inhibition 1388..1416 CDD:291342 6/31 (19%)
EGF_CA 1418..1452 CDD:214542 14/33 (42%)
lrp1abXP_021325646.1 LDLa 36..69 CDD:197566
LDLa 81..114 CDD:197566
FXa_inhibition 170..198 CDD:317114
NHL <292..479 CDD:302697
NHL repeat 292..325 CDD:271320
LY 323..365 CDD:214531
NHL repeat 332..368 CDD:271320
LY 368..408 CDD:214531
NHL repeat 373..413 CDD:271320
NHL repeat 421..467 CDD:271320
FXa_inhibition 494..526 CDD:317114
LY 558..600 CDD:214531
LY 602..640 CDD:214531
LY 647..695 CDD:214531
LY <707..740 CDD:214531
FXa_inhibition 811..846 CDD:317114
LDLa 857..889 CDD:197566
LDLa 899..932 CDD:238060
LDLa 940..971 CDD:238060
LDLa 982..1015 CDD:238060
LDLa 1019..1052 CDD:238060
LDLa 1066..1101 CDD:238060
LDLa 1110..1144 CDD:238060
LDLa 1149..1185 CDD:238060
FXa_inhibition 1188..1224 CDD:317114
LY 1339..1381 CDD:214531
LY 1383..1426 CDD:214531
LY 1437..1470 CDD:214531
LY 1479..1515 CDD:214531
LY 1616..1652 CDD:214531
LY 1653..1696 CDD:214531
LY 1700..1739 CDD:214531
LY 1739..1780 CDD:214531
FXa_inhibition 1853..1889 CDD:317114
LY 1919..1959 CDD:214531
LY 1962..2002 CDD:214531
LY 2003..2046 CDD:214531
LY 2048..2090 CDD:214531
FXa_inhibition 2162..2197 CDD:317114
SGL 2236..2464 CDD:331563
Ldl_recept_b 2346..2387 CDD:278487
LY 2372..2413 CDD:214531
FXa_inhibition 2483..2518 CDD:317114
LDLa 2523..2559 CDD:294076
LDLa 2567..2601 CDD:238060
LDLa 2606..2640 CDD:238060
LDLa <2667..2689 CDD:238060
LDLa 2697..2731 CDD:238060
LDLa 2738..2769 CDD:197566 12/30 (40%)
LDLa 2777..2810 CDD:197566 11/34 (32%)
LDLa 2821..2853 CDD:197566 16/32 (50%)
Ldl_recept_a 2861..2895 CDD:278486 20/34 (59%)
LDLa 2908..2942 CDD:238060 13/41 (32%)
cEGF 2965..2988 CDD:315355 9/22 (41%)
EGF_CA 2985..3019 CDD:214542 14/34 (41%)
LY 3052..3096 CDD:214531 10/43 (23%)
LY 3097..3139 CDD:214531 14/41 (34%)
LY 3141..3183 CDD:214531 19/41 (46%)
LY 3184..3226 CDD:214531 17/41 (41%)
LY 3227..3267 CDD:214531 16/39 (41%)
FXa_inhibition 3297..3333 CDD:317114 17/37 (46%)
LDLa 3337..3368 CDD:238060 12/209 (6%)
LDLa 3377..3411 CDD:238060 10/42 (24%)
LDLa 3416..3451 CDD:238060 12/34 (35%)
LDLa 3455..3488 CDD:197566 13/32 (41%)
LDLa 3496..3529 CDD:197566 16/32 (50%)
LDLa 3539..3573 CDD:238060 16/34 (47%)
LDLa 3578..3612 CDD:238060 13/33 (39%)
LDLa 3616..3650 CDD:238060 14/35 (40%)
LDLa 3658..3690 CDD:238060 4/31 (13%)
LDLa 3699..3735 CDD:238060 15/35 (43%)
LDLa 3741..3776 CDD:238060 13/34 (38%)
EGF_CA 3825..3855 CDD:214542 14/33 (42%)
LY 3963..3999 CDD:214531 14/47 (30%)
Ldl_recept_b 4020..4060 CDD:278487 9/40 (23%)
LY 4044..4085 CDD:214531 10/42 (24%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1215
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100345
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
32.710

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