DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment yl and lrp1ba

DIOPT Version :9

Sequence 1:NP_996433.1 Gene:yl / 32367 FlyBaseID:FBgn0004649 Length:1984 Species:Drosophila melanogaster
Sequence 2:XP_021325253.1 Gene:lrp1ba / 565136 ZFINID:ZDB-GENE-050208-608 Length:4654 Species:Danio rerio


Alignment Length:2569 Identity:587/2569 - (22%)
Similarity:867/2569 - (33%) Gaps:1030/2569 - (40%)


- Green bases have known domain annotations that are detailed below.


  Fly    74 LCGGT--------AAGTPGSADTRCDAGQFQCRDGGCILQAKMCDGRGDCKDSSDE-LDCDYRLC 129
            ||.||        .:....||.| |..|||.|.:|.||.:...||...||.|.||| ..||:..|
Zfish   909 LCDGTDDCGSNEDESNRTCSAQT-CQPGQFPCANGRCIPENWRCDRDDDCGDQSDESSSCDFPTC 972

  Fly   130 RPPHWFPCAQPHGACLAAELMCNGIDNCPGGEDELNCPVRPGF-RF------------------- 174
            .|...|.|.  :|.|::.:..|:..|:|..|.||:.|...... :|                   
Zfish   973 EPLTQFGCT--NGKCISVKWHCDSEDDCGDGSDEVGCVHACSVAQFQCSSGKCIPEHWMCDGDND 1035

  Fly   175 -GD------TAHR-----MRSCSKYEFMCQQDRTCIPIDFMCDGRPDCTDKSDEVAGCKQAEITC 227
             ||      |..|     :..||:.||.|:.|.||||..:.|||..||.|.|||.| |:.|:..|
Zfish  1036 CGDLSDENATCSRTAISAINDCSEKEFHCRGDGTCIPEIWRCDGDKDCEDGSDEFA-CEGAKRMC 1099

  Fly   228 -PGEGHLC-ANGRCLRRKQWVCDGVDDCGDGSDERGC-LNLCEPQKGKFLCRN-RETCLTLSEVC 288
             |.....| .:|:|: .|.|||||..||.|.|||.|| :::|:|.  ||.|.| ...||....:|
Zfish  1100 DPKAKFTCKVSGKCV-SKDWVCDGDIDCEDQSDEEGCEVSVCKPP--KFPCANDTSVCLPPERIC 1161

  Fly   289 DGHSDCSDGSDETDLCHSKPDCDAKKCALGAKCHMMPASGAECFCPKGFRLAKFEDKCEDVDECK 353
            :|..||:|.|||...|   .:|..:|.....:|.:.|..|..|.||.||:|......||.:|.|.
Zfish  1162 NGWKDCADHSDEGPYC---DECSIRKGGCSHECSVAPGKGVVCSCPAGFQLGSDAQTCEILDYCS 1223

  Fly   354 EQDDLCSQGCENTSGGYRCVCDAGYLLDKDNRTCRAVVYGSKEQQPLLLYTTQMTIMGMHLREDN 418
            :. ..|||.||......:|.|..|:.|..|..:|    |.:...:..::::.:..|..::|.:.:
Zfish  1224 KH-LRCSQVCEQHKNTVKCSCYPGWSLGSDGDSC----YSTDPFEAFIIFSIRHEIRRINLHKGD 1283

  Fly   419 -------VRNHVYQVAGNLSKVIGVAYDGSHIYWTNIQNEA--ESIVKANGDGSNAEILLTSGLD 474
                   :||.:         .:...:..|.:|||::..:.  ...:...|..|..|:::..||.
Zfish  1284 YSLLVPGLRNTI---------ALDFHFSQSLLYWTDVVEDKIYRGKLSEGGGVSAIEVVVQHGLA 1339

  Fly   475 APEDLAVDWLTQNIYFSDNIMRHIAVCSNDGLNCAVLVTQDVHQPRSLAVWPQKGLMFWTDWGEK 539
            .||.|||||:..|:|:.|:.:..|.|...:|.....|:...:..||::||.|.:|.:|||||...
Zfish  1340 TPEGLAVDWIAGNLYWIDSNLDQIEVSKLNGELRTTLIAGGMEHPRAIAVDPGQGALFWTDWDAT 1404

  Fly   540 -PMIGRASMDGSRSRPIVSDNIE---WPNGIALDMHQQRIYWVDAKLGSVQTVRPDGTGRRTVLD 600
             |.|..|||.| :.|.:|..:::   ||||:.||..:.||.|.||:..::.:...||||...:|.
Zfish  1405 FPRIEGASMSG-KQRHVVFKDMDTGAWPNGLTLDHMESRIIWTDARSDAIYSALYDGTGVIEILR 1468

  Fly   601 G--MLKHPYGLAIFEDQLYWSDWATKSVHACHKFSGKDHRILAK-DRTIYAVHIYHPAKQPNSPH 662
            |  .|.||:.:::|...:||:||.|.::...:|::|.:..::.| ....:.:.||||::||.:..
Zfish  1469 GHEFLSHPFAVSLFGGNVYWTDWRTNTLTKANKWTGANVTVIQKTSAQPFDLEIYHPSRQPQTVS 1533

  Fly   663 GCE----NATCSHLCLLAEPEIGGHSCACPDGMRLAPDHRRCMLMEKRQRLFIGLGQVLLEIEHT 723
            .|.    ...|||||||...  |..||:||..|:|:.::..|.          |:.:.||....:
Zfish  1534 PCAGNGGRGHCSHLCLLNYN--GSASCSCPHLMKLSANNSTCQ----------GVKRFLLYARRS 1586

  Fly   724 AFGRHQVSKSY-------TLPCL--INEMVYNRINGSLIIADNDQRLILEFQPESHESNVLVRSN 779
            ......:...|       |:|.:  :..|.|:.:...:..||...|.|........:...::..:
Zfish  1587 EIRGVDIDNPYLNVIMALTVPDIDDVTSMDYDAVEERIYWADVKSRTIKRAFINGTQLQTVLSGD 1651

  Fly   780 LGNVSALAFDHLSRNLYW--ADTERAVIEVL----SLQT-------RHRALI------RFF---- 821
            |.||..||.|.||||:||  :|.:...|.|.    ||:|       :.::|:      :.|    
Zfish  1652 LSNVRGLAIDWLSRNMYWMSSDNDETHINVARLDGSLKTTVVHGMDKPKSLVLHPSKGKMFWMDG 1716

  Fly   822 -----------------PGQEVPIGL--------------------------------------- 830
                             ..|:.|:||                                       
Zfish  1717 GTINMANMDGSNIKILHQNQKEPVGLSIDFSSNKLYWISSGNGTINRCNLDGSGLDVIDSMKSQL 1781

  Fly   831 ------------------------TVMPAEGYLYVVLKAKRHS--HI---DK------------- 853
                                    ||...:|....||:.|...  ||   ||             
Zfish  1782 RKATALAVMGGKLWWADDVLAQLGTVNKRDGKNLTVLRNKTTGLVHIKVYDKDTQKGRNPCVLNN 1846

  Fly   854 -------------------------------------------------------------IPLS 857
                                                                         .|||
Zfish  1847 GGCSQICLPTSEITRTCSCTTGYNLRQDRSTCEGLQSFLMYSVNEGIRGLSLDPSDNSEVLTPLS 1911

  Fly   858 GK----GEQVHVFED-----DLGDDDIK----------------------LVTDYETQTIFWSDS 891
            |.    |...|...|     |:|.:.|.                      |..|:....|:|:|.
Zfish  1912 GTLFAVGLDYHAKNDTLYWTDMGSNKISRSSRDQTWREDIITSGLGRVEGLAVDWIAGNIYWADH 1976

  Fly   892 DLGRISYS--------------------------------------------------------- 899
            .|..|..:                                                         
Zfish  1977 GLNLIEVARLNGMYRAVVISEELDQPRAIAVHPVKGFLFWTEWGQSPTISRSRLDGSEQSVLVST 2041

  Fly   900 -----------------------NYRVPHSQIFRGKLRR---------PYSLAMVHHDLFW---- 928
                                   |.::....:.||:.|.         .:|:|:....|||    
Zfish  2042 GLARPNGVSIDYQENKLYWCDARNNKIERINLERGEQREIVFSSSGVDMFSIAVFGAYLFWSDRA 2106

  Fly   929 ----------------------------------------------------------------- 928
                                                                             
Zfish  2107 YANGSIRRASKKDAVDVVTIRSGLSVSLKDVKVFNQDREKGTNACSKSNGGCQQLCFYLGNNRKT 2171

  Fly   929 --------------------------------------NEL------------------------ 931
                                                  |:|                        
Zfish  2172 CACAHGYLAQDGLRCIRYEGYLLYSERTVLRTIHLSDENDLNSPIRAYENPVYFKNIIALAFDHR 2236

  Fly   932 ----GTPRI------------------------------------------YWT----------- 939
                ||.||                                          |||           
Zfish  2237 QNAHGTNRIFFSDVHYGNIQVINDDWTGRRIIAENVGSVEGLAYHRGWDVLYWTSSTTASITRHH 2301

  Fly   940 ---HKSNMGPR-KVIDIMEKDDP---------------------------------AAIMPYVPV 967
               .::|...| .|:.:.|:|.|                                 ..|:....|
Zfish  2302 IDQSRTNAFDRDTVVSLSEEDHPHVLTLDECQNLMFWTNWNEQHPSIMRSTLTGRNIRIIVSTDV 2366

  Fly   968 ATPNG------------------------------------------------------------ 972
            .||||                                                            
Zfish  2367 ITPNGLTIDHKAEKLYFSDGSLGHIERCDFDGSQRYVIVKSGPGTFFGLAIYRDFIFWSDWTRRA 2431

  Fly   973 ------------------IP------LAASSPVGQ-ESHPCQQQNGGCSHICVGEGPYHSICLCP 1012
                              ||      :|.|:.... |:.||...||||..:|:         |.|
Zfish  2432 VIRSDKFTGANTKVLRSDIPHQPMGIIAVSNDTNSCEASPCSVNNGGCHDLCL---------LTP 2487

  Fly  1013 AGFVYRDA-GNRTCVEALDC-----------EFRCHSGECLTMNHRCNGRRDCVDNSDE--MNCD 1063
            .|.|.... |.|..::...|           ||:|.:|||:.....|:|...|.|.|||  ..|:
Zfish  2488 LGVVNCSCRGERILLDDNRCVSPNSSCNIHSEFQCGNGECIDYQLTCDGIAHCKDRSDEKMQYCE 2552

  Fly  1064 EEHRRKPKVLCSPNQFACHSGEQCVDKERRCDNRKDCHDHSDEQHCEKFDKSKKCHVHQHGCDNG 1128
            ..:       |.....:|:: ::||..:|.|:...||.|:|||.:|    .:..|...:|.|.:|
Zfish  2553 NRN-------CRHGFKSCYN-QRCVSNQRFCNGVNDCGDNSDEVYC----NNSSCLSSEHRCADG 2605

  Fly  1129 KCVDS----------------------------------------------------SLVCDGTN 1141
            .|:.:                                                    |.:|||.|
Zfish  2606 SCIPTSSWCNQIIDCADASDEKSCNNTDCMGYYRLGARASNTERFLSCNSTSLCVHPSWICDGAN 2670

  Fly  1142 DCGDNSDELLCEATS--RCEPGMFQCGSGSCIAGSWECDGRIDCSDGSDEHDKCVHRSCPPDMQR 1204
            ||||.:||..|.|::  .||.|.|.|.||:||:..|.|||:.||.||:||. :| ..||..:...
Zfish  2671 DCGDYADETHCHASAVHTCEDGHFACPSGNCISSVWLCDGQKDCEDGADEF-QC-DSSCLWNQFA 2733

  Fly  1205 CLLGQCLDRSLVCDGHNDCGDKSDELN--CGTDSSTMNISCAEDQYQCTSNLKICLPSTVRCNGT 1267
            |...:|:.:..:|||.:||||..||..  ||      :.||:...:.|..:. .|:.....|:|.
Zfish  2734 CSKNKCISKQWLCDGEDDCGDGLDESQEICG------SASCSPGLFSCPGSY-ACVSRNWLCDGE 2791

  Fly  1268 TECPRGEDE---ADC--GDVCSIYEFKCRSGRECIRREFRCDGQKDCGDGSDE-LSCELEKGHHN 1326
            .:||.|.||   |.|  .:.|:...|:||: :.||.|.|.||...||||.||| |.||.      
Zfish  2792 RDCPDGSDELALAGCAPNNTCTDSTFQCRN-QNCIPRRFVCDHDDDCGDASDESLECEY------ 2849

  Fly  1327 QSQIQPWSTSSRSCRPHLFDCQDGECVDLSRV---CNNFPDCTNGHDE---GPKCATA---CRS- 1381
                       |.|:...|.|.||.|  |.|.   |:.||||.:..||   .|||:.|   |.. 
Zfish  2850 -----------RLCKEEEFRCADGRC--LLRAQWECDGFPDCQDQSDELPLNPKCSAAESLCNGT 2901

  Fly  1382 ----ASGRQV---------------------------------CQHKCRATPAGAVCSCFDGYRL 1409
                |:||.|                                 |...|:..|.|..|||:.|:||
Zfish  2902 VFMCANGRCVPLGSVCNQHDDCGDRSDERNCHVNECLNRKVSGCTQDCQDLPVGYKCSCWPGFRL 2966

  Fly  1410 DADQKSCLDIDECQEQQPCAQLCENTLGGYQCQCHADFMLR--QDRVSCKSLQSGAT-LLFSSFN 1471
            ..|.:.|:|:|||.||.||:|.|.||.|.:.|.| ||...|  .:..||:||.:... |:.:..:
Zfish  2967 KHDGRMCIDVDECSEQFPCSQQCVNTYGSFHCLC-ADGYQRPASNTHSCRSLSAEQPFLILADHH 3030

  Fly  1472 EVRNLS-------------EQPVMLN-------VAW---------SANDSRITGFDL-AMHRQMG 1506
            |:|.:|             ...:.|:       :.|         ..|..|:.|.|| .:||...
Zfish  3031 EIRKISLDGSNYTLLKQGLSNVISLDFDSRKELIYWIDTSRPSGRRINRMRLNGSDLKVVHRTSV 3095

  Fly  1507 YFSAEDEGI---VYQIDLQTK-------------VIVRALGLPAPTKLSVDWVTGNVYVLSGAQE 1555
            ..:...:.|   :|..|.:.|             |::|. ||..||.|::|.:||.|:.:...::
Zfish  3096 PSALAVDWIGKNLYWCDGERKTLEVAKANGLYPTVLLRT-GLRNPTALALDTLTGYVFWIDCCEQ 3159

  Fly  1556 IQACSFVGR--MCG---RIV---HVKSPRHVKHLAVDGYHARIFYIVIRTEGYGQTSSEIHM--A 1610
            .|    :||  |.|   |::   .::||   ..|.:|..:.||::           :.|.|:  |
Zfish  3160 PQ----IGRIGMDGSKPRVIIDTEIRSP---SALTIDHVNKRIYW-----------ADENHILFA 3206

  Fly  1611 RLDGSRRDMLLQRSESFMTALTTDPHQQLLYFVDQHMRTLERISYRLKTGPMRRPEIMLQKSNAL 1675
            .:||::|..:..:....:|.||.  .:..:|:.||..:||.|..   ||...::.|:        
Zfish  3207 NIDGTKRHKVPIQDIGGVTGLTL--FEDFIYWSDQKSKTLSRSH---KTSGGKQTEL-------- 3258

  Fly  1676 MHPSGLSVYENNAFIVNLGSVEAVQCALYGSRICHKISINVLNAQDIVVAGRSRQPQKASHPC-- 1738
                             |.|.:.:                    :||.|....|||....|.|  
Zfish  3259 -----------------LSSWQTI--------------------RDIQVYHPLRQPDVPKHQCQV 3286

  Fly  1739 AHAHCHGLC-LQADYGYECMCGNR--LVAEGERC 1769
            .:..|..|| |....||:|.|...  |..:.:.|
Zfish  3287 TNGGCSHLCLLSPGGGYKCACPTHFYLANDNKTC 3320

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ylNP_996433.1 LDLa 90..124 CDD:238060 16/34 (47%)
LDLa 131..166 CDD:238060 11/34 (32%)
LDLa 184..216 CDD:238060 17/31 (55%)
LDLa 227..262 CDD:238060 17/36 (47%)
LDLa 271..302 CDD:238060 14/31 (45%)
FXa_inhibition 352..387 CDD:291342 11/34 (32%)
Ldl_recept_b 442..482 CDD:278487 12/41 (29%)
LY 466..508 CDD:214531 16/41 (39%)
Ldl_recept_b 529..569 CDD:278487 18/43 (42%)
LY 553..595 CDD:214531 16/44 (36%)
LY 596..637 CDD:214531 13/42 (31%)
FXa_inhibition 669..700 CDD:291342 14/30 (47%)
LY 774..815 CDD:214531 18/53 (34%)
LDLa 1032..1062 CDD:238060 13/31 (42%)
LDLa 1074..1109 CDD:238060 12/34 (35%)
LDLa 1118..1152 CDD:238060 16/85 (19%)
LDLa 1157..1189 CDD:197566 17/31 (55%)
LDLa 1198..1232 CDD:238060 12/35 (34%)
LDLa 1243..1279 CDD:238060 11/38 (29%)
LDLa 1283..1318 CDD:238060 18/35 (51%)
LDLa 1340..1371 CDD:197566 13/33 (39%)
FXa_inhibition 1388..1416 CDD:291342 11/27 (41%)
EGF_CA 1418..1452 CDD:214542 18/35 (51%)
lrp1baXP_021325253.1 LDLa 30..62 CDD:197566
LDLa 74..107 CDD:197566
FXa_inhibition 163..191 CDD:317114
LY 276..309 CDD:214531
LY 317..359 CDD:214531
LY 362..402 CDD:214531
FXa_inhibition 487..519 CDD:317114
LY 553..593 CDD:214531
LY 594..633 CDD:214531
LY 640..689 CDD:214531
LY 690..732 CDD:214531
FXa_inhibition 801..838 CDD:317114
LDLa 891..924 CDD:238060 4/14 (29%)
LDLa 974..1007 CDD:238060 11/34 (32%)
LDLa 1011..1042 CDD:197566 3/30 (10%)
LDLa 1057..1092 CDD:238060 20/35 (57%)
LDLa 1104..1135 CDD:238060 15/31 (48%)
LDLa 1140..1173 CDD:197566 14/34 (41%)
FXa_inhibition 1180..1216 CDD:317114 11/35 (31%)
LY 1284..1322 CDD:214531 6/46 (13%)
LY 1331..1370 CDD:214531 15/38 (39%)
LY 1375..1418 CDD:214531 18/43 (42%)
LY <1430..1463 CDD:214531 14/32 (44%)
LY 1604..1643 CDD:214531 8/38 (21%)
LY 1645..1687 CDD:214531 15/41 (37%)
LY 1689..1728 CDD:214531 3/38 (8%)
LY <1739..1770 CDD:214531 3/30 (10%)
FXa_inhibition 1842..1878 CDD:317114 0/35 (0%)
NHL 1923..>2095 CDD:302697 16/171 (9%)
NHL repeat 1923..1956 CDD:271320 4/32 (13%)
NHL repeat 1961..1996 CDD:271320 7/34 (21%)
NHL repeat 2002..2040 CDD:271320 0/37 (0%)
NHL repeat 2043..2084 CDD:271320 4/40 (10%)
FXa_inhibition 2151..2186 CDD:317114 0/34 (0%)
LY 2265..2305 CDD:214531 3/39 (8%)
Ldl_recept_b 2334..2375 CDD:278487 6/40 (15%)
LY 2359..2401 CDD:214531 6/41 (15%)
FXa_inhibition 2472..2506 CDD:317114 12/42 (29%)
LDLa 2518..2547 CDD:238060 12/28 (43%)
LDLa 2556..2590 CDD:238060 12/34 (35%)
LDLa 2595..2629 CDD:238060 5/33 (15%)
LDLa <2652..2681 CDD:294076 11/28 (39%)
LDLa 2689..2723 CDD:238060 19/34 (56%)
LDLa 2727..2758 CDD:238060 10/30 (33%)
LDLa 2768..2801 CDD:238060 9/33 (27%)
LDLa 2811..2843 CDD:197566 15/32 (47%)
LDLa 2852..2884 CDD:197566 13/33 (39%)
LDLa 2898..2932 CDD:238060 5/33 (15%)
cEGF 2955..2978 CDD:315355 10/22 (45%)
EGF_CA 2975..3005 CDD:214542 17/30 (57%)
LY 3042..3086 CDD:214531 5/43 (12%)
LY 3088..3125 CDD:214531 6/36 (17%)
Ldl_recept_b 3149..3189 CDD:278487 11/46 (24%)
LY 3173..3213 CDD:214531 12/53 (23%)
FXa_inhibition 3284..3320 CDD:317114 10/35 (29%)
LDLa 3324..3355 CDD:197566
LDLa 3364..3398 CDD:238060
LDLa 3403..3438 CDD:238060
LDLa 3443..3478 CDD:238060
LDLa 3483..3517 CDD:238060
LDLa 3522..3556 CDD:238060
LDLa 3560..3594 CDD:238060
LDLa 3608..3642 CDD:238060
LDLa 3646..3681 CDD:238060
LDLa 3688..3720 CDD:238060
LDLa 3729..3765 CDD:238060
LDLa 3775..3809 CDD:238060
Ldl_recept_b 4051..4091 CDD:278487
LY 4075..4116 CDD:214531
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100345
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
32.810

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