DRSC/TRiP Functional Genomics Resources

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Protein Alignment yl and lrp1aa

DIOPT Version :9

Sequence 1:NP_996433.1 Gene:yl / 32367 FlyBaseID:FBgn0004649 Length:1984 Species:Drosophila melanogaster
Sequence 2:XP_021335354.1 Gene:lrp1aa / 563149 ZFINID:ZDB-GENE-030131-7889 Length:4560 Species:Danio rerio


Alignment Length:2027 Identity:524/2027 - (25%)
Similarity:775/2027 - (38%) Gaps:632/2027 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    29 FNLTSQTRAHPSSGGSTSSRYGN---CQRTH-LIINGRHVAISLLLLVGLCGGTAAGTPGSAD-- 87
            :.||....||..........|..   |::.: ..:|||            |.|..:...|..|  
Zfish  2541 YTLTCDGMAHCKDKSDEKQSYCTNRVCKKGYKRCVNGR------------CVGHNSWCNGRDDCG 2593

  Fly    88 ----------TRCDAGQFQCRDGGCILQAKMCDGRGDCKDSSDELDCD----------------Y 126
                      |.|.|.|||||||.|:..:..|:...||.|:|||::|.                |
Zfish  2594 DNSDELFCNATLCTADQFQCRDGVCVSNSSRCNQVLDCDDASDEMNCSASDCSSYFRLGVKGVTY 2658

  Fly   127 R------LCRPPHW-----------------------------FPCAQPHGACLAAELMCNGIDN 156
            :      ||..|.|                             |.|  |:|.|:.....|:..::
Zfish  2659 QRCEFTSLCYAPSWVCDGANDCGDYSDERNCPDKKKRKCSSNFFAC--PNGRCIPMSWTCDKEND 2721

  Fly   157 CPGGEDELNCPVRPGFRFGDTAHRMRSCSKYEFMCQQDRTCIPIDFMCDGRPDCTDKSDEVAGCK 221
            |..|:||.:|.              :.||..:|.|...| ||...::|||..||.|.:||.:.||
Zfish  2722 CDNGDDEAHCD--------------KFCSATQFECGNHR-CISSSWVCDGADDCGDGTDEDSRCK 2771

  Fly   222 QAEITCPGEGHLCANGRCLRRKQWVCDGVDDCGDGSDE---RGCL--NLCEPQKGKFLCRNRETC 281
            ..  ||..:...|.:......::|||||..||.||:||   .||:  |.|  :.|:|:|:||: |
Zfish  2772 NK--TCSADAFQCPDSHKCVPQRWVCDGDRDCPDGADESVKAGCVFNNTC--KAGEFMCQNRQ-C 2831

  Fly   282 LTLSEVCDGHSDCSDGSDETD-------------------------------------------- 302
            :....|||..:||.|||||:.                                            
Zfish  2832 IPKHFVCDHDNDCGDGSDESVECEYPACKANEFRCDNGRCLIQKSWECDGEFDCHDHSDEAPKNP 2896

  Fly   303 ---------------------------LCHSKPDC----DAKKCALGAKCHMMPASGA------- 329
                                       ||:.:.||    |...|.:. :|.....||.       
Zfish  2897 HCSGTGEKQCNETEYACGNGKCISESLLCNREDDCGDGTDELNCFIN-ECLNSKLSGCSQLCEDQ 2960

  Fly   330 ----ECFCPKGFRLAKFEDKCEDVDECKEQDDLCSQGCENTSGGYRCVCDAGYLLDKDNRT-CRA 389
                :|.|..||||......|.|||||..... |:|.|.||.|.:||||..|:.|...:.| |::
Zfish  2961 KIGFKCRCHSGFRLKDDGKTCVDVDECSTTYP-CTQHCINTHGSFRCVCVDGFQLSPSDPTICKS 3024

  Fly   390 VVYGSKEQQPLLLYTTQMTIMGMHLREDNVRNHVYQ-VAGNLSKVIGVAYD--GSHIYWTNIQNE 451
                :.:::|.|::..:     .:||:.|:....|. :...|:..:.:.:|  ...||||::..:
Zfish  3025 ----TSDEEPFLIFANR-----YYLRKLNLDGSNYTLLKQGLNNAVALDFDYRQQMIYWTDVTTQ 3080

  Fly   452 AESIVKANGDGSNAEILLTSGLDAPEDLAVDWLTQNIYFSDNIMRHIAVCSNDGLNCAVLVTQDV 516
            ...|.:.|.:|||.::|..:.|..|:.|||||:..|:|:.|.....|.|...:|....|||...:
Zfish  3081 GSMIRRMNINGSNVQVLHRTSLSNPDGLAVDWVGGNLYWCDKGRDTIEVSKLNGAYRTVLVNSGL 3145

  Fly   517 HQPRSLAVWPQKGLMFWTDWGEKPMIGRASMDGSRSRPIVSDNIEWPNGIALDMHQQRIYWVDAK 581
            .:||::||..:.|.::|:|||:.|.|||..|||:....||.|.|.||||:.||....||||.||:
Zfish  3146 REPRAVAVDVRNGYLYWSDWGDIPHIGRIGMDGTNRSVIVQDKITWPNGLTLDFINDRIYWADAR 3210

  Fly   582 LGSVQTVRPDGTGRRTVLDGMLKHPYGLAIFEDQLYWSDWATKSVHACHKFSGKDHRILAKDRTI 646
            ...::....|||.|.|||...:.|.:.:.:||:.:||:||.|||::..||..|.:..:|..  |:
Zfish  3211 EDYIEFASLDGTNRHTVLSQDIPHIFAMTLFEEFIYWTDWETKSINRAHKTQGTNKSMLIS--TL 3273

  Fly   647 YA---VHIYHPAKQPNSP-HGC--ENATCSHLCLLAEPEIGGHSCACPDGMRLAPDHRRCMLMEK 705
            :.   :||:||.:||..| |.|  :|..||:||||:..  ||:.||||....||.|.::||    
Zfish  3274 HRPMDIHIFHPYRQPEVPNHPCQTDNGGCSNLCLLSPG--GGYKCACPTNFYLAGDGKQCM---- 3332

  Fly   706 RQRLFIGLGQVLLEIEHTAFGRHQVSKSYTLPCLINEMVYNRINGSLIIADNDQRLILEFQPESH 770
                                                    :....|..:..||:           
Zfish  3333 ----------------------------------------SNCTASQFVCKNDK----------- 3346

  Fly   771 ESNVLVRSNLGNVSALAFDHLSRNLYW-ADTERAVIEVLSLQTRHRALIRFFPGQEVPIGLTVMP 834
                          .:.|       :| .||                                  
Zfish  3347 --------------CIPF-------WWKCDT---------------------------------- 3356

  Fly   835 AEGYLYVVLKAKRHSHIDKIPLSGKGEQVHVFEDDLGDDDIKLVTDYETQTIFWSDSDLGRISYS 899
                                            |||.||                           
Zfish  3357 --------------------------------EDDCGD--------------------------- 3362

  Fly   900 NYRVPHSQIFRGKLRRPYSLAMVHHDLFWNELGTPRIYWTHKSNMGPRKVIDIMEKDDPAAIMPY 964
                                                                  ..|:||....:
Zfish  3363 ------------------------------------------------------RSDEPADCPDF 3373

  Fly   965 VPVATPNGIPLAASSPVGQESHPCQQQNGGCSHICVGEGPYHSICLCPAGFVYRDAGNRTCVE-- 1027
                               :..|.|.|.|            ..||..||   |...|:..|.:  
Zfish  3374 -------------------KCRPGQFQCG------------TGICTNPA---YICDGDNDCQDNS 3404

  Fly  1028 ---------ALDCEFRC-HSGECLTMNHRCNGRRDCVDNSDEMNCDEEHRRKPKVLCSPNQFACH 1082
                     .|..:|:| :...|:....||||:.:|.:..||.:|       |:|.|:||||.|.
Zfish  3405 DEANCDIHVCLPSQFKCTNPSRCIPGIFRCNGQDNCGEGEDEKDC-------PEVTCAPNQFQCT 3462

  Fly  1083 SGEQCVDKERRCDNRKDCHDHSDE-QHCEKFDKSKKCHVHQHGC-DNGKCVDSSLVCDGTNDCGD 1145
            ..::|:.:...||...||.|.||| .:|.:.    .|.|.:..| |:|:|:.:...|||.:||||
Zfish  3463 VTKRCIPRVWVCDRDNDCVDGSDEPANCTQM----TCGVDEFRCKDSGRCIPARWKCDGEDDCGD 3523

  Fly  1146 NSDELLCEATSR-CEPGMFQCGSGSCIAGSWECDGRIDCSDGSDEHDKCVHRSCPPDMQRCLLGQ 1209
            :|||...|...| |||..|:|.:..|:.|.|:||...||.|.||| ||||.|.|......|..|:
Zfish  3524 SSDEPKEECDERTCEPYQFRCKNNRCVPGRWQCDYDNDCGDNSDE-DKCVPRQCSESEFSCTSGR 3587

  Fly  1210 CLDRSLVCDGHNDCGDKSDELNCGTDSSTMNISCAEDQYQCTSNLKICLPSTVRCNGTTECPRGE 1274
            |:.....|||.:||.|.|||..|       ::.|..||:.|  |...|:|...||:...:|..|.
Zfish  3588 CIAGRWKCDGDHDCADGSDEHGC-------DVKCDNDQFLC--NNGHCIPFRWRCDADADCMDGS 3643

  Fly  1275 DEADC----GDVCSIYEFKCRSGRECIRREFRCDGQKDCGDGSDE-------LSCELEKGH--HN 1326
            ||.:|    |..|.:.||:| :...|....::|||:.||||.|||       ..|...:..  ||
Zfish  3644 DEENCHTGVGQFCPLDEFQC-NNTLCKPLGWKCDGEDDCGDNSDENPDVCKQFQCPPSRQFRCHN 3707

  Fly  1327 QSQIQPWS------------TSSRSCR---PHL-----FDCQDGECVDLSRVCNNFPDCTN-GHD 1370
            .....|.|            :..::|:   |.:     |.|..|:|:.|:..||.|.||.: |.|
Zfish  3708 DRVCLPLSKHCDGVNNCGDNSDEQNCQTPPPAVCGKSEFTCSSGKCISLNLRCNFFNDCEDYGSD 3772

  Fly  1371 EGPKC------ATACRSASGRQVC--QHKCRATPAGAVCSCFDGYRLDADQKSCLDIDECQEQQP 1427
            | ..|      ...||  ..|.:|  :..|....:.:.|||..|::....| :|.|::||::...
Zfish  3773 E-INCNKKDSGLNECR--LNRSMCGDEGHCVVNGSDSFCSCRPGFQKTHPQ-TCSDVNECRQFGI 3833

  Fly  1428 CAQLCENTLGGYQCQCHADFMLRQDRVSCKSLQSGATLLF-SSFNEVRNLSEQPVMLNVAW---- 1487
            |:.:|.||.||::|.||.:|:...|  :||:..|....|: :..||:|:|  .|.|.|  |    
Zfish  3834 CSHICNNTKGGHKCSCHKNFIRVND--TCKADSSDKQALYVADDNEIRSL--YPGMQN--WIYEQ 3892

  Fly  1488 ----SANDSRITGFDLAMHRQMGYFSAEDEGIVYQID---------------LQTKVIVRAL--- 1530
                .|| .||...||.:..:..:::....|.:...:               .||...|..|   
Zfish  3893 AFQGDAN-VRIDAMDLHIKSKRIFWTNWHTGRISSFEQPSAGPTSPNSNRNRRQTDPRVTDLEIP 3956

  Fly  1531 GLPAPTKLSVDWVTGNVY-VLSGAQEIQACSFVGR-----MCGRI-----VHVKSPRHVKHLAVD 1584
            ||..|..::||||..|:| ..||...|:.....||     :.|.|     :.|...|...:.|..
Zfish  3957 GLKMPRGIAVDWVANNIYWTDSGRDVIEVAQMNGRNRKTLISGMIDEPYAIVVDPQRGTMYWADW 4021

  Fly  1585 GYHARIFYIVIRTEGYGQTSSEIHMARLDGSRRDMLLQRSESFMTALTTDPHQQLLYFVDQHMRT 1649
            |.|.:                 |..|.:||:.|:.|:..:..:.|.|..|...:.||:.|..:..
Zfish  4022 GNHPK-----------------IETAAMDGTLRETLVHDNIQWPTGLAVDYFNERLYWADAKLSV 4069

  Fly  1650 LERISYRLK-TGPMRRPEIMLQK-SNALMHPSGLSVYENNAFIVNLGSVEAVQCALYGSRICHKI 1712
            :.  |.||. |.|:    |.:.. .|.|..|..:.::|:..:.|...:....:...:|......:
Zfish  4070 IG--SVRLNGTDPV----IAVSSIKNNLQQPFSIDIFEDFIYGVTYHNNFVFRVNKFGKSSVEHL 4128

  Fly  1713 SINVLNAQDIVVAGRSRQPQKASHPCAHAHCHGLCLQADYGYECMCGNRLVAEGERC---PHGSG 1774
            :..:.:|.|:|:....:||:.| :||....|..|||.:..|..|.|.|..:.:...|   |..:.
Zfish  4129 TTGMNHATDLVLYHPYKQPEMA-NPCDRKKCEWLCLLSPSGPVCTCPNGRILDNGTCVEIPAPTL 4192

  Fly  1775 NEVAVLGAVNSL 1786
            :.|:..|..|.|
Zfish  4193 SPVSPSGTCNLL 4204

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ylNP_996433.1 LDLa 90..124 CDD:238060 17/33 (52%)
LDLa 131..166 CDD:238060 12/63 (19%)
LDLa 184..216 CDD:238060 13/31 (42%)
LDLa 227..262 CDD:238060 13/37 (35%)
LDLa 271..302 CDD:238060 16/30 (53%)
FXa_inhibition 352..387 CDD:291342 14/35 (40%)
Ldl_recept_b 442..482 CDD:278487 14/39 (36%)
LY 466..508 CDD:214531 14/41 (34%)
Ldl_recept_b 529..569 CDD:278487 20/39 (51%)
LY 553..595 CDD:214531 19/41 (46%)
LY 596..637 CDD:214531 16/40 (40%)
FXa_inhibition 669..700 CDD:291342 15/30 (50%)
LY 774..815 CDD:214531 4/41 (10%)
LDLa 1032..1062 CDD:238060 10/30 (33%)
LDLa 1074..1109 CDD:238060 15/35 (43%)
LDLa 1118..1152 CDD:238060 16/34 (47%)
LDLa 1157..1189 CDD:197566 15/32 (47%)
LDLa 1198..1232 CDD:238060 13/33 (39%)
LDLa 1243..1279 CDD:238060 13/35 (37%)
LDLa 1283..1318 CDD:238060 15/41 (37%)
LDLa 1340..1371 CDD:197566 13/39 (33%)
FXa_inhibition 1388..1416 CDD:291342 7/29 (24%)
EGF_CA 1418..1452 CDD:214542 13/33 (39%)
lrp1aaXP_021335354.1 LDLa 37..70 CDD:197566
LDLa 82..115 CDD:197566
FXa_inhibition 171..199 CDD:317114
LY 281..324 CDD:214531
LY 326..368 CDD:214531
LY 371..411 CDD:214531
FXa_inhibition 497..529 CDD:317114
LY 561..603 CDD:214531
LY 605..643 CDD:214531
LY 650..699 CDD:214531
LY <710..743 CDD:214531
FXa_inhibition 812..848 CDD:317114
LDLa 859..891 CDD:197566
LDLa 901..934 CDD:238060
LDLa 941..973 CDD:197566
LDLa 984..1017 CDD:238060
LDLa 1021..1052 CDD:197566
LDLa 1068..1103 CDD:238060
LDLa 1112..1146 CDD:238060
LDLa 1151..1187 CDD:238060
FXa_inhibition 1190..1226 CDD:317114
LY 1342..1383 CDD:214531
LY 1385..1428 CDD:214531
LY 1429..1472 CDD:214531
LY 1618..1653 CDD:214531
LY 1655..1698 CDD:214531
LY 1702..1738 CDD:214531
LY <1749..1780 CDD:214531
FXa_inhibition 1852..1888 CDD:317114
LY 1918..1958 CDD:214531
LY 1961..2001 CDD:214531
LY 2002..2045 CDD:214531
LY 2047..2089 CDD:214531
FXa_inhibition 2161..2196 CDD:317114
SGL 2235..>2439 CDD:331563
Ldl_recept_b 2345..2386 CDD:278487
LY 2371..2412 CDD:214531
FXa_inhibition 2483..2518 CDD:317114
LDLa 2530..2559 CDD:294076 4/17 (24%)
LDLa 2567..2601 CDD:238060 8/45 (18%)
LDLa 2606..2640 CDD:238060 17/33 (52%)
LDLa <2667..2689 CDD:238060 3/21 (14%)
LDLa 2697..2731 CDD:238060 10/35 (29%)
LDLa 2735..2767 CDD:238060 14/32 (44%)
LDLa 2774..2807 CDD:197566 12/32 (38%)
LDLa 2818..2850 CDD:197566 15/34 (44%)
LDLa 2859..2891 CDD:197566 0/31 (0%)
LDLa 2906..2940 CDD:238060 5/33 (15%)
cEGF 2963..2986 CDD:315355 9/22 (41%)
EGF_CA 2983..3013 CDD:214542 16/30 (53%)
LY 3050..3094 CDD:214531 11/43 (26%)
LY 3095..3137 CDD:214531 14/41 (34%)
LY 3139..3181 CDD:214531 19/41 (46%)
LY 3183..3224 CDD:214531 19/40 (48%)
LY 3225..3265 CDD:214531 16/39 (41%)
FXa_inhibition 3295..3331 CDD:317114 17/37 (46%)
LDLa 3335..3366 CDD:238060 12/209 (6%)
LDLa 3375..3409 CDD:238060 11/48 (23%)
LDLa 3414..3449 CDD:238060 11/34 (32%)
LDLa 3453..3486 CDD:197566 13/32 (41%)
LDLa 3494..3527 CDD:197566 14/32 (44%)
LDLa 3537..3571 CDD:238060 17/34 (50%)
LDLa 3576..3610 CDD:238060 13/33 (39%)
LDLa 3614..3648 CDD:238060 13/35 (37%)
LDLa 3656..3688 CDD:238060 14/32 (44%)
LDLa 3697..3733 CDD:238060 5/35 (14%)
LDLa 3741..3776 CDD:238060 13/35 (37%)
LY 3957..3993 CDD:214531 14/35 (40%)
Ldl_recept_b 4014..4054 CDD:278487 11/56 (20%)
LY 4038..4079 CDD:214531 10/42 (24%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100345
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.810

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