DRSC/TRiP Functional Genomics Resources

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Protein Alignment yl and lrp1bb

DIOPT Version :9

Sequence 1:NP_996433.1 Gene:yl / 32367 FlyBaseID:FBgn0004649 Length:1984 Species:Drosophila melanogaster
Sequence 2:XP_021334671.1 Gene:lrp1bb / 559293 ZFINID:ZDB-GENE-070912-401 Length:4600 Species:Danio rerio


Alignment Length:2565 Identity:578/2565 - (22%)
Similarity:864/2565 - (33%) Gaps:1024/2565 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly    74 LCGG-------------TAAGTPGSADTRCDAGQFQCRDGGCILQAKMCDGRGDCKDSSDE-LDC 124
            ||.|             |.:..|      |.||||.|.:|.|:.:|..||...||.|.||| ..|
Zfish   872 LCDGADDCGDNEDESNKTCSAQP------CRAGQFTCGNGRCVPEAWRCDQDDDCGDMSDESTSC 930

  Fly   125 DYRLCRPPHWFPCAQPHGACLAAELMCNGIDNCPGGEDELNC----------------------- 166
            .:..|.....|.||  :|.|::.:..|:..|:|....||..|                       
Zfish   931 SFPTCEALSQFSCA--NGRCISMKWHCDSDDDCGDNSDEAGCVHFCANGQYKCTSGRCIPDHWAC 993

  Fly   167 --------------------PVRPGFRFGDTAHRMRSCSKYEFMCQQDRTCIPIDFMCDGRPDCT 211
                                |..|..          .||..||.|:.|.||||..:.|||..||.
Zfish   994 DGDNDCGDFSDENVTCAGVAPALPPV----------ECSAEEFHCRADGTCIPERWRCDGDKDCE 1048

  Fly   212 DKSDEVAGCK--------QAEITCPGEGHLCANGRCLRRKQWVCDGVDDCGDGSDERGCL-NLCE 267
            |.||| ..||        ||:.||.      .:|:|: .|.|||||.|||.|.|||..|: ::|:
Zfish  1049 DGSDE-TNCKGVKRMCDPQAKFTCK------TSGKCI-SKSWVCDGDDDCEDRSDEESCVSSICK 1105

  Fly   268 PQKGKFLCRNRET-CLTLSEVCDGHSDCSDGSDETDLCHSKPDCDAKKCALG-----AKCHMMPA 326
            |....  |.|..: ||..:::|||..||:|.|||...|        ::|..|     .:|.::|:
Zfish  1106 PPTQP--CANDSSICLPQNKICDGRMDCADRSDEGPFC--------ERCLQGNGGCSHQCSVIPS 1160

  Fly   327 SGAECFCPKGFRLAKFEDKCEDVDECKEQDDLCSQGCENTSGGYRCVCDAGYLLDKDNRTCRA-- 389
            .|..|.||.|..|......||.||.|..... |||.||......:|.|..|:.||.|..:|.:  
Zfish  1161 KGVVCSCPAGLHLGSDNRTCEAVDYCSAHLK-CSQICEQHKTTVKCSCYPGWRLDADGESCHSTD 1224

  Fly   390 -----VVYGSKEQQPLLLYTTQMTIMGMHLREDNVRNHVYQ-VAGNLSKVIGVAYDGSH--IYWT 446
                 |::..:.:                :|..::..|.|. :...|...|.:.:..||  :|||
Zfish  1225 PFEAFVIFSIRHE----------------IRRIDLHKHDYSLLVPGLRNTIALDFHFSHSLLYWT 1273

  Fly   447 NIQNEA--ESIVKANGDGSNAEILLTSGLDAPEDLAVDWLTQNIYFSDNIMRHIAVCSNDGLNCA 509
            ::..:.  ...:...|..:..|:::..||..||.|||||:..|:|:.|:.:..|.|...:|....
Zfish  1274 DVVEDKIYRGKLSETGGVTGVEVVIQHGLATPEGLAVDWIAGNLYWIDSNLDQIEVAKLNGEMRT 1338

  Fly   510 VLVTQDVHQPRSLAVWPQKGLMFWTDWGEK-PMIGRASMDGSRSRPIVSDNIE---WPNGIALDM 570
            .|:...:..||:|||.|.:|::|||||... |.|...||.|| .|.:|..::|   ||||:.||.
Zfish  1339 TLIAGGMEHPRALAVDPGQGILFWTDWDATFPRIEATSMSGS-GRHVVYKDMEIGAWPNGLTLDH 1402

  Fly   571 HQQRIYWVDAKLGSVQTVRPDGTGRRTVLDG--MLKHPYGLAIFEDQLYWSDWATKSVHACHKFS 633
            .::||.|.||:..::.:...||:|...:|.|  .|.||:.:::|...:||:||.|.::...:|::
Zfish  1403 QERRIVWTDARSDAIYSALYDGSGVIEILRGHEYLSHPFAVSLFGGGVYWTDWRTNTLARANKWT 1467

  Fly   634 GKDHRILAKDRTI---YAVHIYHPAKQPNSPHGCE----NATCSHLCLLAEPEIGGHSCACPDGM 691
            |  |.:....:|.   :.:.||||::||.:.:.||    ...||||||:......  ||:||..|
Zfish  1468 G--HNVTVIQKTSAQPFDLEIYHPSRQPQASNPCEGNDGRGPCSHLCLIDYNRTA--SCSCPHLM 1528

  Fly   692 RLAPDHRRCMLMEK--------------------------------------------------- 705
            :|:.::|.|:.::|                                                   
Zfish  1529 KLSLNNRSCVALKKFLLYVRRSEIRGVDIDNPYMNVMTALTVPDIDDVTVVDYDALEERIYWADV 1593

  Fly   706 ----RQRLFI---GLGQVL---------LEIE--------------------------------- 721
                .:|.||   ||..|:         |.|:                                 
Zfish  1594 KTQTIKRAFINGTGLQTVISGDIQNCRGLAIDWLSRNMYWLSSENEETQINVARLDGSLKTSVIH 1658

  Fly   722 ----------HTAFGR----------------------HQ-----VSKSYTLPCLINEMVY---- 745
                      |.|.|:                      ||     |..|...|.  .:|.:    
Zfish  1659 GIDKPKCLTVHPAKGKIYWTDGNTINVANMDGSNRKVLHQNQKEPVGLSIDFPA--GKMYWISSA 1721

  Fly   746 ----NRIN--------------------------GSLIIADND---------------------- 758
                ||.|                          |.|..||:|                      
Zfish  1722 NGTINRCNLDGSGFEVIESMKRDLTKATALAVMGGKLWWADDDLAQLGTVAKRDGRNPVVLRNKT 1786

  Fly   759 ---------------------------------------------------QRLILE-------- 764
                                                               .||..|        
Zfish  1787 SGLVHMKVYDRDGQKGRNACQLNNGGCSQLCLPTSENTRTCACTIGYNLRNDRLSCEGLNSFLMY 1851

  Fly   765 ----------FQPESHESNV-------------------------------------------LV 776
                      ..|..|...:                                           ::
Zfish  1852 SFHEGIRGIALDPNDHTETLMPISGTLFAVGVDFHAGNDTVYWTDMGLNRISRAKRDQTWREDII 1916

  Fly   777 RSNLGNVSALAFDHLSRNLYWADTERAVIEVLSLQTRHRALIRFFPGQEVPIGLTVMPAEGYLY- 840
            .:.:..|..:|.|.::.||||.|....:||:..|...:|::: ...|.:.|..:.|.|..|||: 
Zfish  1917 TTGINRVEGIAVDWIAGNLYWTDHGLNLIEIARLNGLYRSVV-ISEGLDQPRAIAVHPQRGYLFW 1980

  Fly   841 -------------------VVLKAK----------------------RHSHIDKIPL-SGKGEQV 863
                               |.|.:.                      |...|::|.| :|:|.::
Zfish  1981 TEWGKNPCIGRARLDGSDQVTLVSSGIAWPNGITIDYEENRLYWCDARTDKIERINLETGEGREI 2045

  Fly   864 -------------------------HV-------FEDDLGD------------DDIK-------- 876
                                     |.       |:.|..|            .|:|        
Zfish  2046 VLSAANVDLFSVAVFGAYIYWSDRAHANGSIRRGFKSDATDAVTMRSGLGVNLKDVKVFNKGREK 2110

  Fly   877 --------------------------------LVTD------------YETQTIFWS-----DSD 892
                                            |..|            |..:||..|     :||
Zfish  2111 GTNPCARSNGGCQQLCFHLGSGRRTCSCAHGYLAEDGFACQRYGGYLLYSERTILKSIHLSDESD 2175

  Fly   893 LG------------------RISYSNYRVPHSQIFRGKLRRPYSLAMVHHDLFWN-------ELG 932
            |.                  ...|.....||::||...:... ::.|::.|  |:       .:|
Zfish  2176 LNSPLQPFENPDYFKNVIALAFDYRQESSPHNRIFFSDIHFG-NIQMINDD--WSGRQVIVENVG 2237

  Fly   933 T----------PRIYWTHKSN---------------MGPRKVIDIMEKDDPAAI----------- 961
            :          ..||||..:.               .|.:.|:.:.|.|.|..:           
Zfish  2238 SVEGLAYHRAWDTIYWTSSTTSSISRYTVDQSRQGAFGRQAVVTMSEDDHPHVLALDECQNLMFW 2302

  Fly   962 ------MPYV----------------PVATPNGIPL----------------------------- 975
                  .|.:                .|.||||:.:                             
Zfish  2303 TNWNEQRPSIMRSTLAGNNMKVIISTDVFTPNGLTIDHKAEKLYFSDGSLGKIERCEYDGSHRHV 2367

  Fly   976 ----------------------------------------------AASSPVG----------QE 984
                                                          ....|:|          .|
Zfish  2368 IVRSGPGTFFGLAIHGNYIFWSDWTRRAVLRTNKFTGGETKVLRADIPHQPMGIIAVAKDTNNCE 2432

  Fly   985 SHPCQQQNGGCSHICV--GEGPYHSICLCPAGFVYRDAGNRTCVEALDC----EFRCHSGECLTM 1043
            ..||:.|||||..:|:  .:|..:  |.|....|..| .||...:...|    ||.|.:|||:..
Zfish  2433 LSPCRVQNGGCGDLCLLTPDGTVN--CSCRGERVLLD-DNRCVSKTSSCNIHTEFECGNGECIDY 2494

  Fly  1044 NHRCNGRRDCVDNSDE--MNCDEEHRRKPKVLCSPNQFACHSGEQCVDKERRCDNRKDCHDHSDE 1106
            ...|:|...|.|.|||  ..||...       |......|:: .:||...|.||...||.|:|||
Zfish  2495 QLTCDGIAHCKDKSDEKMQYCDNRS-------CRKGHRPCYN-RRCVANSRFCDGIDDCGDNSDE 2551

  Fly  1107 QHCEKFDKSKKCHVHQHGCDNGK------------------------------------------ 1129
            ..|    .:..|...:..|.:|.                                          
Zfish  2552 AFC----NNVTCAASESSCQDGTCIPISSWCNQVIDCADASDEKNCNHTDCTDFYRIGVAEKVFV 2612

  Fly  1130 -------CVDSSLVCDGTNDCGDNSDELLCEAT--SRCEPGMFQCGSGSCIAGSWECDGRIDCSD 1185
                   ||..|.:|||.|||||.:||..|:.:  .:|..|.|.|.||:||:..|.|||:.||.|
Zfish  2613 SCNTTSLCVHHSWLCDGANDCGDYADERNCQVSQGQKCAEGHFACPSGNCISSVWLCDGQKDCED 2677

  Fly  1186 GSDEHDKCVHRSCPPDMQRCLLGQCLDRSLVCDGHNDCGDKSDEL--NCGTDSSTMNISCAEDQY 1248
            |:||. :| ..||..:...|...:|:.:..:|||.:||||..||.  .||      :::||...:
Zfish  2678 GADEF-QC-DSSCLWNQFACSKNKCIAKQWLCDGEDDCGDGVDESVDLCG------SVTCAPGLF 2734

  Fly  1249 QCTSNLKICLPSTVRCNGTTECPRGEDE---ADC--GDVCSIYEFKCRSGRECIRREFRCDGQKD 1308
            .|..:. .|:|....|:|..:||.|.||   |.|  .:.|....|:|.: :.||.:.|.||...|
Zfish  2735 SCPGSY-ACVPKRWLCDGERDCPDGSDELAAAGCAPNNTCDENSFRCLN-KGCIPKRFVCDHDND 2797

  Fly  1309 CGDGSDE-LSCELEKGHHNQSQIQPWSTSSRSCRPHLFDCQDGECVDLSR--VCNNFPDCTNGHD 1370
            ||||||| |.|..                 |||.|..|.|.||.|: ||.  .|:.:|||.:..|
Zfish  2798 CGDGSDESLECVY-----------------RSCGPDEFRCADGRCL-LSAQWECDGYPDCPDHSD 2844

  Fly  1371 EGP---KCATA---CRS-----ASGRQV---------------------------------CQHK 1391
            |.|   ||..|   |.|     ::||.:                                 |...
Zfish  2845 ELPLNLKCLAAESLCNSSFFMCSNGRCISEKSLCDMKDDCGDRSDEKNCNVNECLNRRVSGCTQD 2909

  Fly  1392 CRATPAGAVCSCFDGYRLDADQKSCLDIDECQEQQPCAQLCENTLGGYQCQCHADF-MLRQDRVS 1455
            |:..|.|..|.|:.|:.|..|.::|:|||||....||:|.|.||.|.|:|.|...: ..|:|..|
Zfish  2910 CQDLPVGYKCKCWPGFHLKNDGRTCVDIDECSTTLPCSQNCTNTYGSYKCLCVDGYEASRKDPNS 2974

  Fly  1456 CKSLQSGAT-LLFSSFNEVRNLSEQPVMLNVAWSANDSRITGFDLAMHRQMGY-------FSAED 1512
            ||||.:... |:.:..:|:|.||                :.|.:..:.:| |.       |..:.
Zfish  2975 CKSLSAEEPFLILADLHEIRKLS----------------VDGSNYTLLKQ-GLNNIISLDFDYKK 3022

  Fly  1513 EGIVYQID----------------LQTKVIVRALGLPAPTKLSVDWVTGNVYVLSGAQEIQACSF 1561
            | .:|.||                ...|::.|.   ..|:.|:|||:..|:|.....::....|.
Zfish  3023 E-FIYWIDSSRPSGRRINRIRLNGSDLKIVHRT---AVPSALAVDWIGKNLYWCDVERKTLEVSK 3083

  Fly  1562 VGRMCGRIVHVKSPRHVKHLAVDGYHARIFYIVIRTEGYGQTSSEIHMAR--LDGSRRDMLLQRS 1624
            ...:...|:.....::...||:|.....:|:|        ......|:.|  :||..:.:::.:.
Zfish  3084 SNGLYPTILVSSGLKNPTDLALDAQTGYVFWI--------DCCENPHVGRIGMDGQGQSVIVNKE 3140

  Fly  1625 ESFMTALTTDPHQQLLYFVDQHMRTLERISYRLKTGPMRR--PEIMLQKSNALMHPSGLSVYENN 1687
            ....:|||.|...:.:|:.|.:     .|.:....|..|.  |...:|   .:|   ||:::|:.
Zfish  3141 IYSPSALTIDYTNKRIYWADDN-----HILFANMDGSQRHRVPHDHIQ---GVM---GLTLFEDF 3194

  Fly  1688 AFIVNLGSVEAVQCALYGSRICHKI----SINVLNA----QDIVVAGRSRQPQKASHPC--AHAH 1742
            .:..: |..:::       |..||.    ::.:||:    :.::|....|||:...|.|  |:..
Zfish  3195 IYWTD-GKSKSL-------RRAHKTTGANAVELLNSWQAIKSVIVYHPLRQPEVPKHQCQVANGG 3251

  Fly  1743 CHGLC-LQADYGYECMCGNR--LVAEGERC 1769
            |..|| |....|::|.|...  |.|:.:.|
Zfish  3252 CSHLCLLSPGGGHKCACPTNFYLAADNKTC 3281

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ylNP_996433.1 LDLa 90..124 CDD:238060 17/34 (50%)
LDLa 131..166 CDD:238060 10/34 (29%)
LDLa 184..216 CDD:238060 17/31 (55%)
LDLa 227..262 CDD:238060 16/34 (47%)
LDLa 271..302 CDD:238060 13/31 (42%)
FXa_inhibition 352..387 CDD:291342 12/34 (35%)
Ldl_recept_b 442..482 CDD:278487 12/43 (28%)
LY 466..508 CDD:214531 16/41 (39%)
Ldl_recept_b 529..569 CDD:278487 19/43 (44%)
LY 553..595 CDD:214531 16/44 (36%)
LY 596..637 CDD:214531 13/42 (31%)
FXa_inhibition 669..700 CDD:291342 13/30 (43%)
LY 774..815 CDD:214531 11/83 (13%)
LDLa 1032..1062 CDD:238060 13/31 (42%)
LDLa 1074..1109 CDD:238060 13/34 (38%)
LDLa 1118..1152 CDD:238060 16/82 (20%)
LDLa 1157..1189 CDD:197566 16/31 (52%)
LDLa 1198..1232 CDD:238060 12/35 (34%)
LDLa 1243..1279 CDD:238060 13/38 (34%)
LDLa 1283..1318 CDD:238060 17/35 (49%)
LDLa 1340..1371 CDD:197566 13/32 (41%)
FXa_inhibition 1388..1416 CDD:291342 9/27 (33%)
EGF_CA 1418..1452 CDD:214542 16/34 (47%)
lrp1bbXP_021334671.1 LDLa 38..76 CDD:294076
FXa_inhibition 128..156 CDD:317114
LY 238..274 CDD:214531
LY 282..324 CDD:214531
LY 326..367 CDD:214531
FXa_inhibition 452..484 CDD:317114
LY 516..558 CDD:214531
LY 559..598 CDD:214531
LY 605..654 CDD:214531
LY 655..697 CDD:214531
FXa_inhibition 766..801 CDD:317114
LDLa 854..887 CDD:238060 3/14 (21%)
LDLa 895..926 CDD:197566 15/30 (50%)
LDLa 939..970 CDD:238060 10/32 (31%)
LDLa 974..1005 CDD:197566 0/30 (0%)
LDLa 1021..1056 CDD:238060 19/35 (54%)
LDLa 1065..1099 CDD:238060 19/40 (48%)
FXa_inhibition 1144..1180 CDD:317114 10/35 (29%)
FXa_inhibition 1192..1220 CDD:317114 11/27 (41%)
LY 1248..1289 CDD:214531 8/40 (20%)
LY 1295..1337 CDD:214531 16/41 (39%)
LY 1339..1382 CDD:214531 19/43 (44%)
LY <1394..1427 CDD:214531 13/32 (41%)
Ldl_recept_b 1586..1625 CDD:278487 7/38 (18%)
LY 1609..1651 CDD:214531 3/41 (7%)
LY 1653..1693 CDD:214531 3/39 (8%)
LY <1703..1734 CDD:214531 7/32 (22%)
FXa_inhibition 1806..1842 CDD:317114 2/35 (6%)
NHL <1858..1941 CDD:302697 10/82 (12%)
NHL repeat 1879..1916 CDD:271320 0/36 (0%)
LY 1915..1955 CDD:214531 11/39 (28%)
Ldl_recept_b 1976..2016 CDD:278487 5/39 (13%)
LY 2001..2041 CDD:214531 5/39 (13%)
FXa_inhibition 2115..2150 CDD:317114 2/34 (6%)
Ldl_recept_b 2298..2339 CDD:278487 6/40 (15%)
LY 2323..2365 CDD:214531 5/41 (12%)
FXa_inhibition 2436..2470 CDD:317114 12/36 (33%)
LDLa 2482..2511 CDD:238060 12/28 (43%)
LDLa 2520..2554 CDD:238060 13/34 (38%)
LDLa 2559..2593 CDD:238060 3/33 (9%)
LDLa <2613..2642 CDD:294076 13/28 (46%)
LDLa 2650..2684 CDD:238060 18/34 (53%)
LDLa 2688..2719 CDD:238060 10/30 (33%)
LDLa 2728..2761 CDD:197566 10/33 (30%)
LDLa 2772..2804 CDD:197566 14/32 (44%)
LDLa 2813..2846 CDD:238060 14/33 (42%)
LDLa 2859..2893 CDD:238060 4/33 (12%)
cEGF 2916..2939 CDD:315355 9/22 (41%)
EGF_CA 2936..2969 CDD:214542 15/32 (47%)
LY 3003..3047 CDD:214531 7/45 (16%)
LY 3050..3086 CDD:214531 9/38 (24%)
LY 3135..3174 CDD:214531 8/43 (19%)
FXa_inhibition 3245..3281 CDD:317114 11/35 (31%)
LDLa 3285..3316 CDD:197566
LDLa 3325..3359 CDD:238060
LDLa 3364..3399 CDD:238060
LDLa 3404..3439 CDD:238060
LDLa 3444..3478 CDD:238060
LDLa 3483..3517 CDD:238060
LDLa 3521..3555 CDD:238060
LDLa 3563..3597 CDD:238060
LDLa 3601..3636 CDD:238060
LDLa 3643..3675 CDD:238060
LDLa 3730..3765 CDD:238060
Ldl_recept_b 4008..4048 CDD:278487
LY 4032..4073 CDD:214531
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1215
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100345
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
32.710

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