Protein Alignment yl and lrp1bb

DIOPT Version :10

• Sequence 1: NP_996433.1
• Gene: yl / 32367
• FlyBaseID: FBgn0004649
• Length: 1984
• Species: Drosophila melanogaster
• Sequence 2: XP_073769005.1
• Gene: lrp1bb / 559293
• ZFINID: ZDB-GENE-070912-401
• Length: 4666
• Species: Danio rerio
• Alignment Length: 2565
• Identity: 578/2565 - (22%)
• Similarity: 864/2565 - (33%)
• Gaps: 1024/2565 - (39%)

  Fly    74 LCGG-------------TAAGTPGSADTRCDAGQFQCRDGGCILQAKMCDGRGDCKDSSDE-LDC 124
            ||.|             |.:..|      |.||||.|.:|.|:.:|..||...||.|.||| ..|
Zfish   938 LCDGADDCGDNEDESNKTCSAQP------CRAGQFTCGNGRCVPEAWRCDQDDDCGDMSDESTSC 996

  Fly   125 DYRLCRPPHWFPCAQPHGACLAAELMCNGIDNCPGGEDELNC----------------------- 166
            .:..|.....|.||  :|.|::.:..|:..|:|....||..|
Zfish   997 SFPTCEALSQFSCA--NGRCISMKWHCDSDDDCGDNSDEAGCVHFCANGQYKCTSGRCIPDHWAC 1059

  Fly   167 --------------------PVRPGFRFGDTAHRMRSCSKYEFMCQQDRTCIPIDFMCDGRPDCT 211
                                |..|..          .||..||.|:.|.||||..:.|||..||.
Zfish  1060 DGDNDCGDFSDENVTCAGVAPALPPV----------ECSAEEFHCRADGTCIPERWRCDGDKDCE 1114

  Fly   212 DKSDEVAGCK--------QAEITCPGEGHLCANGRCLRRKQWVCDGVDDCGDGSDERGCL-NLCE 267
            |.||| ..||        ||:.||.      .:|:|: .|.|||||.|||.|.|||..|: ::|:
Zfish  1115 DGSDE-TNCKGVKRMCDPQAKFTCK------TSGKCI-SKSWVCDGDDDCEDRSDEESCVSSICK 1171

  Fly   268 PQKGKFLCRNRET-CLTLSEVCDGHSDCSDGSDETDLCHSKPDCDAKKCALG-----AKCHMMPA 326
            |....  |.|..: ||..:::|||..||:|.|||...|        ::|..|     .:|.::|:
Zfish  1172 PPTQP--CANDSSICLPQNKICDGRMDCADRSDEGPFC--------ERCLQGNGGCSHQCSVIPS 1226

  Fly   327 SGAECFCPKGFRLAKFEDKCEDVDECKEQDDLCSQGCENTSGGYRCVCDAGYLLDKDNRTCRA-- 389
            .|..|.||.|..|......||.||.|..... |||.||......:|.|..|:.||.|..:|.:
Zfish  1227 KGVVCSCPAGLHLGSDNRTCEAVDYCSAHLK-CSQICEQHKTTVKCSCYPGWRLDADGESCHSTD 1290

  Fly   390 -----VVYGSKEQQPLLLYTTQMTIMGMHLREDNVRNHVYQ-VAGNLSKVIGVAYDGSH--IYWT 446
                 |::..:.:                :|..::..|.|. :...|...|.:.:..||  :|||
Zfish  1291 PFEAFVIFSIRHE----------------IRRIDLHKHDYSLLVPGLRNTIALDFHFSHSLLYWT 1339

  Fly   447 NIQNEA--ESIVKANGDGSNAEILLTSGLDAPEDLAVDWLTQNIYFSDNIMRHIAVCSNDGLNCA 509
            ::..:.  ...:...|..:..|:::..||..||.|||||:..|:|:.|:.:..|.|...:|....
Zfish  1340 DVVEDKIYRGKLSETGGVTGVEVVIQHGLATPEGLAVDWIAGNLYWIDSNLDQIEVAKLNGEMRT 1404

  Fly   510 VLVTQDVHQPRSLAVWPQKGLMFWTDWGEK-PMIGRASMDGSRSRPIVSDNIE---WPNGIALDM 570
            .|:...:..||:|||.|.:|::|||||... |.|...||.|| .|.:|..::|   ||||:.||.
Zfish  1405 TLIAGGMEHPRALAVDPGQGILFWTDWDATFPRIEATSMSGS-GRHVVYKDMEIGAWPNGLTLDH 1468

  Fly   571 HQQRIYWVDAKLGSVQTVRPDGTGRRTVLDG--MLKHPYGLAIFEDQLYWSDWATKSVHACHKFS 633
            .::||.|.||:..::.:...||:|...:|.|  .|.||:.:::|...:||:||.|.::...:|::
Zfish  1469 QERRIVWTDARSDAIYSALYDGSGVIEILRGHEYLSHPFAVSLFGGGVYWTDWRTNTLARANKWT 1533

  Fly   634 GKDHRILAKDRTI---YAVHIYHPAKQPNSPHGCE----NATCSHLCLLAEPEIGGHSCACPDGM 691
            |  |.:....:|.   :.:.||||::||.:.:.||    ...||||||:......  ||:||..|
Zfish  1534 G--HNVTVIQKTSAQPFDLEIYHPSRQPQASNPCEGNDGRGPCSHLCLIDYNRTA--SCSCPHLM 1594

  Fly   692 RLAPDHRRCMLMEK--------------------------------------------------- 705
            :|:.::|.|:.::|
Zfish  1595 KLSLNNRSCVALKKFLLYVRRSEIRGVDIDNPYMNVMTALTVPDIDDVTVVDYDALEERIYWADV 1659

  Fly   706 ----RQRLFI---GLGQVL---------LEIE--------------------------------- 721
                .:|.||   ||..|:         |.|:
Zfish  1660 KTQTIKRAFINGTGLQTVISGDIQNCRGLAIDWLSRNMYWLSSENEETQINVARLDGSLKTSVIH 1724

  Fly   722 ----------HTAFGR----------------------HQ-----VSKSYTLPCLINEMVY---- 745
                      |.|.|:                      ||     |..|...|.  .:|.:
Zfish  1725 GIDKPKCLTVHPAKGKIYWTDGNTINVANMDGSNRKVLHQNQKEPVGLSIDFPA--GKMYWISSA 1787

  Fly   746 ----NRIN--------------------------GSLIIADND---------------------- 758
                ||.|                          |.|..||:|
Zfish  1788 NGTINRCNLDGSGFEVIESMKRDLTKATALAVMGGKLWWADDDLAQLGTVAKRDGRNPVVLRNKT 1852

  Fly   759 ---------------------------------------------------QRLILE-------- 764
                                                               .||..|
Zfish  1853 SGLVHMKVYDRDGQKGRNACQLNNGGCSQLCLPTSENTRTCACTIGYNLRNDRLSCEGLNSFLMY 1917

  Fly   765 ----------FQPESHESNV-------------------------------------------LV 776
                      ..|..|...:                                           ::
Zfish  1918 SFHEGIRGIALDPNDHTETLMPISGTLFAVGVDFHAGNDTVYWTDMGLNRISRAKRDQTWREDII 1982

  Fly   777 RSNLGNVSALAFDHLSRNLYWADTERAVIEVLSLQTRHRALIRFFPGQEVPIGLTVMPAEGYLY- 840
            .:.:..|..:|.|.::.||||.|....:||:..|...:|::: ...|.:.|..:.|.|..|||:
Zfish  1983 TTGINRVEGIAVDWIAGNLYWTDHGLNLIEIARLNGLYRSVV-ISEGLDQPRAIAVHPQRGYLFW 2046

  Fly   841 -------------------VVLKAK----------------------RHSHIDKIPL-SGKGEQV 863
                               |.|.:.                      |...|::|.| :|:|.::
Zfish  2047 TEWGKNPCIGRARLDGSDQVTLVSSGIAWPNGITIDYEENRLYWCDARTDKIERINLETGEGREI 2111

  Fly   864 -------------------------HV-------FEDDLGD------------DDIK-------- 876
                                     |.       |:.|..|            .|:|
Zfish  2112 VLSAANVDLFSVAVFGAYIYWSDRAHANGSIRRGFKSDATDAVTMRSGLGVNLKDVKVFNKGREK 2176

  Fly   877 --------------------------------LVTD------------YETQTIFWS-----DSD 892
                                            |..|            |..:||..|     :||
Zfish  2177 GTNPCARSNGGCQQLCFHLGSGRRTCSCAHGYLAEDGFACQRYGGYLLYSERTILKSIHLSDESD 2241

  Fly   893 LG------------------RISYSNYRVPHSQIFRGKLRRPYSLAMVHHDLFWN-------ELG 932
            |.                  ...|.....||::||...:... ::.|::.|  |:       .:|
Zfish  2242 LNSPLQPFENPDYFKNVIALAFDYRQESSPHNRIFFSDIHFG-NIQMINDD--WSGRQVIVENVG 2303

  Fly   933 T----------PRIYWTHKSN---------------MGPRKVIDIMEKDDPAAI----------- 961
            :          ..||||..:.               .|.:.|:.:.|.|.|..:
Zfish  2304 SVEGLAYHRAWDTIYWTSSTTSSISRYTVDQSRQGAFGRQAVVTMSEDDHPHVLALDECQNLMFW 2368

  Fly   962 ------MPYV----------------PVATPNGIPL----------------------------- 975
                  .|.:                .|.||||:.:
Zfish  2369 TNWNEQRPSIMRSTLAGNNMKVIISTDVFTPNGLTIDHKAEKLYFSDGSLGKIERCEYDGSHRHV 2433

  Fly   976 ----------------------------------------------AASSPVG----------QE 984
                                                          ....|:|          .|
Zfish  2434 IVRSGPGTFFGLAIHGNYIFWSDWTRRAVLRTNKFTGGETKVLRADIPHQPMGIIAVAKDTNNCE 2498

  Fly   985 SHPCQQQNGGCSHICV--GEGPYHSICLCPAGFVYRDAGNRTCVEALDC----EFRCHSGECLTM 1043
            ..||:.|||||..:|:  .:|..:  |.|....|..| .||...:...|    ||.|.:|||:..
Zfish  2499 LSPCRVQNGGCGDLCLLTPDGTVN--CSCRGERVLLD-DNRCVSKTSSCNIHTEFECGNGECIDY 2560

  Fly  1044 NHRCNGRRDCVDNSDE--MNCDEEHRRKPKVLCSPNQFACHSGEQCVDKERRCDNRKDCHDHSDE 1106
            ...|:|...|.|.|||  ..||...       |......|:: .:||...|.||...||.|:|||
Zfish  2561 QLTCDGIAHCKDKSDEKMQYCDNRS-------CRKGHRPCYN-RRCVANSRFCDGIDDCGDNSDE 2617

  Fly  1107 QHCEKFDKSKKCHVHQHGCDNGK------------------------------------------ 1129
            ..|    .:..|...:..|.:|.
Zfish  2618 AFC----NNVTCAASESSCQDGTCIPISSWCNQVIDCADASDEKNCNHTDCTDFYRIGVAEKVFV 2678

  Fly  1130 -------CVDSSLVCDGTNDCGDNSDELLCEAT--SRCEPGMFQCGSGSCIAGSWECDGRIDCSD 1185
                   ||..|.:|||.|||||.:||..|:.:  .:|..|.|.|.||:||:..|.|||:.||.|
Zfish  2679 SCNTTSLCVHHSWLCDGANDCGDYADERNCQVSQGQKCAEGHFACPSGNCISSVWLCDGQKDCED 2743

  Fly  1186 GSDEHDKCVHRSCPPDMQRCLLGQCLDRSLVCDGHNDCGDKSDEL--NCGTDSSTMNISCAEDQY 1248
            |:||. :| ..||..:...|...:|:.:..:|||.:||||..||.  .||      :::||...:
Zfish  2744 GADEF-QC-DSSCLWNQFACSKNKCIAKQWLCDGEDDCGDGVDESVDLCG------SVTCAPGLF 2800

  Fly  1249 QCTSNLKICLPSTVRCNGTTECPRGEDE---ADC--GDVCSIYEFKCRSGRECIRREFRCDGQKD 1308
            .|..:. .|:|....|:|..:||.|.||   |.|  .:.|....|:|.: :.||.:.|.||...|
Zfish  2801 SCPGSY-ACVPKRWLCDGERDCPDGSDELAAAGCAPNNTCDENSFRCLN-KGCIPKRFVCDHDND 2863

  Fly  1309 CGDGSDE-LSCELEKGHHNQSQIQPWSTSSRSCRPHLFDCQDGECVDLSR--VCNNFPDCTNGHD 1370
            ||||||| |.|..                 |||.|..|.|.||.|: ||.  .|:.:|||.:..|
Zfish  2864 CGDGSDESLECVY-----------------RSCGPDEFRCADGRCL-LSAQWECDGYPDCPDHSD 2910

  Fly  1371 EGP---KCATA---CRS-----ASGRQV---------------------------------CQHK 1391
            |.|   ||..|   |.|     ::||.:                                 |...
Zfish  2911 ELPLNLKCLAAESLCNSSFFMCSNGRCISEKSLCDMKDDCGDRSDEKNCNVNECLNRRVSGCTQD 2975

  Fly  1392 CRATPAGAVCSCFDGYRLDADQKSCLDIDECQEQQPCAQLCENTLGGYQCQCHADF-MLRQDRVS 1455
            |:..|.|..|.|:.|:.|..|.::|:|||||....||:|.|.||.|.|:|.|...: ..|:|..|
Zfish  2976 CQDLPVGYKCKCWPGFHLKNDGRTCVDIDECSTTLPCSQNCTNTYGSYKCLCVDGYEASRKDPNS 3040

  Fly  1456 CKSLQSGAT-LLFSSFNEVRNLSEQPVMLNVAWSANDSRITGFDLAMHRQMGY-------FSAED 1512
            ||||.:... |:.:..:|:|.||                :.|.:..:.:| |.       |..:.
Zfish  3041 CKSLSAEEPFLILADLHEIRKLS----------------VDGSNYTLLKQ-GLNNIISLDFDYKK 3088

  Fly  1513 EGIVYQID----------------LQTKVIVRALGLPAPTKLSVDWVTGNVYVLSGAQEIQACSF 1561
            | .:|.||                ...|::.|.   ..|:.|:|||:..|:|.....::....|.
Zfish  3089 E-FIYWIDSSRPSGRRINRIRLNGSDLKIVHRT---AVPSALAVDWIGKNLYWCDVERKTLEVSK 3149

  Fly  1562 VGRMCGRIVHVKSPRHVKHLAVDGYHARIFYIVIRTEGYGQTSSEIHMAR--LDGSRRDMLLQRS 1624
            ...:...|:.....::...||:|.....:|:|        ......|:.|  :||..:.:::.:.
Zfish  3150 SNGLYPTILVSSGLKNPTDLALDAQTGYVFWI--------DCCENPHVGRIGMDGQGQSVIVNKE 3206

  Fly  1625 ESFMTALTTDPHQQLLYFVDQHMRTLERISYRLKTGPMRR--PEIMLQKSNALMHPSGLSVYENN 1687
            ....:|||.|...:.:|:.|.:     .|.:....|..|.  |...:|   .:|   ||:::|:.
Zfish  3207 IYSPSALTIDYTNKRIYWADDN-----HILFANMDGSQRHRVPHDHIQ---GVM---GLTLFEDF 3260

  Fly  1688 AFIVNLGSVEAVQCALYGSRICHKI----SINVLNA----QDIVVAGRSRQPQKASHPC--AHAH 1742
            .:..: |..:::       |..||.    ::.:||:    :.::|....|||:...|.|  |:..
Zfish  3261 IYWTD-GKSKSL-------RRAHKTTGANAVELLNSWQAIKSVIVYHPLRQPEVPKHQCQVANGG 3317

  Fly  1743 CHGLC-LQADYGYECMCGNR--LVAEGERC 1769
            |..|| |....|::|.|...  |.|:.:.|
Zfish  3318 CSHLCLLSPGGGHKCACPTNFYLAADNKTC 3347

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
yl	NP_996433.1	LDLa	90..124	CDD:238060	17/34 (50%)
		LDLa	131..166	CDD:238060	10/34 (29%)
		LDLa	184..216	CDD:238060	17/31 (55%)
		LDLa	227..262	CDD:238060	16/34 (47%)
		LDLa	271..302	CDD:238060	13/31 (42%)
		FXa_inhibition	352..387	CDD:464251	12/34 (35%)
		Ldl_recept_b	442..483	CDD:459654	13/44 (30%)
		LY	466..508	CDD:214531	16/41 (39%)
		Ldl_recept_b	529..569	CDD:459654	19/43 (44%)
		LY	553..595	CDD:214531	16/44 (36%)
		LY	596..637	CDD:214531	13/42 (31%)
		FXa_inhibition	669..700	CDD:464251	13/30 (43%)
		LY	774..815	CDD:214531	11/83 (13%)
		LDLa	1032..1062	CDD:238060	13/31 (42%)
		LDLa	1074..1109	CDD:238060	13/34 (38%)
		LDLa	1118..1152	CDD:238060	16/82 (20%)
		LDLa	1157..1189	CDD:197566	16/31 (52%)
		LDLa	1198..1232	CDD:238060	12/35 (34%)
		LDLa	1243..1279	CDD:238060	13/38 (34%)
		LDLa	1283..1318	CDD:238060	17/35 (49%)
		LDLa	1340..1371	CDD:197566	13/32 (41%)
		FXa_inhibition	1388..1416	CDD:464251	9/27 (33%)
		EGF_CA	1418..1452	CDD:214542	16/34 (47%)
lrp1bb	XP_073769005.1	None