DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment yl and lrp8

DIOPT Version :9

Sequence 1:	NP_996433.1	Gene:	yl / 32367	FlyBaseID:	FBgn0004649	Length:	1984	Species:	Drosophila melanogaster
Sequence 2:	XP_005166314.1	Gene:	lrp8 / 557734	ZFINID:	ZDB-GENE-050506-134	Length:	1008	Species:	Danio rerio

Alignment Length:	780	Identity:	255/780 - (32%)
Similarity:	368/780 - (47%)	Gaps:	167/780 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 LLLLVGLCGGTAAGTPGSADTRCDAGQFQCRDGGCILQAKMCDGRGDCKDSSDELDCDYRLCR-- 130
            ||||.||..|.......:.|  |::||||||:|.||.....||...||.|:|||.:|..:.|.
Zfish     8 LLLLHGLFVGFLVVNGTNLD--CESGQFQCRNGRCIPTPWRCDDDDDCSDNSDEENCPKKTCATT 70

  Fly   131 --------------------------------------PPHWFPCAQPHGACLAAELMCNGIDNC 157
                                                  ||..|.|......|::....|:|..:|
Zfish    71 DFACKNGQCVPGRWRCDGEPECPDGSDEADSACSRQTCPPEKFDCGGSTSKCVSLSWRCDGERDC 135

  Fly   158 PGGEDELNCP------------------VRPGF------RFGD-------TAHRMRSCSKYEFMC 191
            ..|.||..|.                  |.|.|      ..||       ||....:|..:||.|
Zfish   136 ENGADEEQCAADAKACPAKEFQCRNRMCVAPTFVCDGDDDCGDRSDEEKCTAATASTCGPHEFRC 200

  Fly   192 QQDRTCIPIDFMCDGRPDCTDKSDEVA-------------------GCKQAE------------- 224
             .|..|||..:.|||.|||.|||||..                   .|:..|
Zfish   201 -NDSECIPTPWSCDGDPDCRDKSDESLERCSRRTEPQKPHCSMGEFRCRSGECIHLNWKCDGDPD 264

  Fly   225 ------------ITCPGEGHLCANGRCLR-RKQWVCDGVDDCGDGSDERGCLNLCEPQKG--KFL 274
                        :||..:...|.:|.|:. .||  |:.|.||.|.|||.||:|.....:|  ||:
Zfish   265 CKDKSDEANCPVLTCRPDQFQCGDGSCIHGTKQ--CNKVHDCPDFSDEAGCVNRTNKCEGPLKFM 327

  Fly   275 CRNRETCLTLSEVCDGHSDCSDGSDETDLCHSKPDCDAKKCAL--GAKCHMMP--ASGAECFCPK 335
            |::.| |:..|:|||...||.|.|||     ...:|...:||:  |...|:..  ..|.||.||.
Zfish   328 CKSGE-CIDSSKVCDTIRDCKDWSDE-----PVKECGLNECAINNGGCSHICKDRQIGFECQCPS 386

  Fly   336 GFRLAKFEDK--CEDVDECKEQDDLCSQGCENTSGGYRCVCDAGYLLDKDNRTCRAVVYGSKEQQ 398
            |::|.   ||  |.|:||| |..:.|||.|.|..|.|:|.|..||.:|...:||:||     .:.
Zfish   387 GYKLL---DKKTCGDIDEC-ENPEACSQICINLKGDYKCECYEGYEMDPVTKTCKAV-----GKS 442

  Fly   399 PLLLYTTQMTIMGMHLREDNVRNHVYQVAGNLSKVIGVAYD--GSHIYWTNIQNE---AESIVKA 458
            |.|::|.:..|.    |.|.::....||...|...:.:..|  .:.:||.::.:.   :..|.||
Zfish   443 PYLMFTNRHEIR----RIDLLKKDYTQVVPTLKNAVALDVDVTTNKMYWCDLYHRKIFSAYINKA 503

  Fly   459 NGDGSNAEILLTSGLDAPEDLAVDWLTQNIYFSDNIMRHIAVCSNDGLNCAVLVTQDVHQPRSLA 523
            | :.|....|:.:.|.:||.||:||:.:|||::|:..:.|:|.:.||....||:..::.:||::|
Zfish   504 N-NSSEQITLIDTALHSPEGLAMDWVHKNIYWTDSGHKTISVANVDGKKRKVLIDTELGEPRAIA 567

  Fly   524 VWPQKGLMFWTDWGEKPMIGRASMDGSRSRPIVSDNIEWPNGIALDMHQQRIYWVDAKLGSVQTV 588
            |.|::|.|:|:|||.:..|.:|.|:|...:.:||:.||||||||||:...|:||||:||..:.:|
Zfish   568 VDPRQGFMYWSDWGAQAKIEKAGMNGVDRQVLVSERIEWPNGIALDLSSSRLYWVDSKLHLISSV 632

  Fly   589 RPDGTGRRTVLDGM--LKHPYGLAIFEDQLYWSDWATKSVHACHKFSGKDHRILAKD-RTIYAVH 650
            ..:|..||.:|..|  |.||:.|.:|||::||:|...:::::.::.:|.|..:||:. .....|.
Zfish   633 DLNGDNRRILLSSMDQLGHPFALTLFEDRVYWTDLEYEAIYSVNRLTGNDVVMLAQHLNNPLDVV 697

  Fly   651 IYHPAKQPNSPHGCE-----NATCSHLCLLAEPEIGGHS----CACPDGMRLAPDHRRCMLMEKR 706
            ::|..:||..|..|.     |..|.:|||.| |:|..||    |||||.|.|.||.|||:.::.:
Zfish   698 VFHELRQPKVPDTCNMGNLPNGGCEYLCLRA-PQITEHSPKYTCACPDSMELGPDMRRCVSVKPK 761

Fly 707 706
Zfish 762 761

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
yl	NP_996433.1	LDLa	90..124	CDD:238060	18/33 (55%)
		LDLa	131..166	CDD:238060	11/34 (32%)
		LDLa	184..216	CDD:238060	17/31 (55%)
		LDLa	227..262	CDD:238060	14/35 (40%)
		LDLa	271..302	CDD:238060	16/32 (50%)
		FXa_inhibition	352..387	CDD:291342	14/34 (41%)
		Ldl_recept_b	442..482	CDD:278487	13/42 (31%)
		LY	466..508	CDD:214531	16/41 (39%)
		Ldl_recept_b	529..569	CDD:278487	20/39 (51%)
		LY	553..595	CDD:214531	21/41 (51%)
		LY	596..637	CDD:214531	14/42 (33%)
		FXa_inhibition	669..700	CDD:291342	19/34 (56%)
		LY	774..815	CDD:214531
		LDLa	1032..1062	CDD:238060
		LDLa	1074..1109	CDD:238060
		LDLa	1118..1152	CDD:238060
		LDLa	1157..1189	CDD:197566
		LDLa	1198..1232	CDD:238060
		LDLa	1243..1279	CDD:238060
		LDLa	1283..1318	CDD:238060
		LDLa	1340..1371	CDD:197566
		FXa_inhibition	1388..1416	CDD:291342
		EGF_CA	1418..1452	CDD:214542
lrp8	XP_005166314.1	LDLa	66..98	CDD:197566	1/31 (3%)
		Ldl_recept_a	107..144	CDD:278486	11/36 (31%)
		Ldl_recept_a	191..224	CDD:278486	17/33 (52%)
		Ldl_recept_a	240..274	CDD:278486	2/33 (6%)
		Ldl_recept_a	278..313	CDD:278486	15/36 (42%)
		LDLa	322..352	CDD:197566	14/30 (47%)
		FXa_inhibition	362..396	CDD:291342	13/36 (36%)
		EGF_CA	398..428	CDD:214542	15/30 (50%)
		LY	463..504	CDD:214531	8/40 (20%)
		LY	511..552	CDD:214531	16/40 (40%)
		Ldl_recept_b	573..613	CDD:278487	20/39 (51%)
		LY	597..639	CDD:214531	21/41 (51%)
		Ldl_recept_b	660..699	CDD:278487	9/38 (24%)
		FXa_inhibition	718..755	CDD:291342	20/37 (54%)
		IgaA	913..>985	CDD:284503
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1215
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002088
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.900