DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment yl and sorl1

DIOPT Version :9

Sequence 1:NP_996433.1 Gene:yl / 32367 FlyBaseID:FBgn0004649 Length:1984 Species:Drosophila melanogaster
Sequence 2:XP_005157607.1 Gene:sorl1 / 497306 ZFINID:ZDB-GENE-050208-22 Length:2213 Species:Danio rerio


Alignment Length:1370 Identity:311/1370 - (22%)
Similarity:446/1370 - (32%) Gaps:555/1370 - (40%)


- Green bases have known domain annotations that are detailed below.


  Fly   253 CGDG-------SDER--GCLNLCEPQKGKFLCRNRETCLTLSEVCDGHSDCSDGSDETDLCHSKP 308
            |.:|       ||||  |||      .|:.:...|.:         .|:.|.:|.|         
Zfish   626 CSEGDYKLWSPSDERGNGCL------LGREMVYKRRS---------PHATCFNGED--------- 666

  Fly   309 DCDAKKCALGAKCHMMPASGAECFCPK-------GFRLAKFEDKCEDVDECKEQDDL-------- 358
                         ...|.|.:.|.|.:       ||:|:  ||...:|  |....:.        
Zfish   667 -------------FDRPISLSNCSCTRQDYECDYGFKLS--EDLSLEV--CVPDPEFSGNLYAPP 714

  Fly   359 --CSQGCE-NTSGGYRCV----CDAGYL---LDKDNRTCRAVVYGSKEQQPLLLYTTQMTIMGMH 413
              |..|.. :.|.|||.|    |..|.:   ||.:|..|..     .|....:||..:.:|    
Zfish   715 VPCPVGTTYHRSKGYRKVSGDSCTGGDVEARLDGENLPCPV-----GESNEFILYAVRNSI---- 770

  Fly   414 LREDNVRNHVYQVAGNLSKVIGVA-----------YDGSHIYWTNIQNEAESIVKANGDGSNAEI 467
                    |.|.:|....:.:.:.           |:.:.:||.:|..:....:..|| .|..|:
Zfish   771 --------HRYDLASGTDQQLPLTGLHEAVALDFDYEKNCLYWADISLDTIQRLCMNG-SSGQEV 826

  Fly   468 LLTSGLDAPEDLAVDWLTQNIYFSDNIMRHIAVCSNDG-LNCAVLVTQDVHQPRSLAVWPQKGLM 531
            ::...|...|.|:.|.:::.:|:.|...:.|.|.::|| |...::.:..|.|||:||:.|.:.||
Zfish   827 IVKRDLQNVEALSFDPISRLLYWVDAGAQKIEVSNSDGDLRRTLVNSSVVDQPRALALMPAESLM 891

  Fly   532 FWTDWGEKPM-IGRASMDGSRSRPIVSDNIEWPNGIALDMHQQRIYWVDAKLGSVQTVRPDGTGR 595
            ||||||::.. :.|:.||||....|||:.:.|||||..|  :..:||.:|....::....:|..|
Zfish   892 FWTDWGDRAAGVYRSWMDGSNISCIVSEGVRWPNGITAD--ESWLYWTEAYGDRIERADFNGGSR 954

  Fly   596 RTVLDGMLKHPYGLAIFEDQLYWSDWATKSVHACHKFSGKDHRILAKDRT-IYAVHIYHPAKQPN 659
            ..:::| |.|||.:|:|::.|||.||:...:....|....|..::....| :..:.|::..|. .
Zfish   955 TVIMEG-LPHPYAIAVFKNDLYWDDWSRMGIFKAPKSGSPDSELIVGRLTGVMDLKIFYKGKN-R 1017

  Fly   660 SPHGCENATCSHLCLLAEPEIGG-HSCACPDGMRLAPDHRRCMLMEKRQRLFIGLGQVLLEIEHT 723
            ..:.|.:..||.|||   |:.|. ..|.||||:                                
Zfish  1018 GQNACADQPCSLLCL---PQPGNQRHCVCPDGV-------------------------------- 1047

  Fly   724 AFGRHQVSKSYTLPCLINEMVYNRINGSLIIADNDQRLILEFQPESHESNVLVRSNLGNVSALAF 788
                                                                             
Zfish  1048 ----------------------------------------------------------------- 1047

  Fly   789 DHLSRNLYWADTERAVIEVLSLQTRHRALIRFFPGQEVPIGLTVMPAEGYLYVVLKAKRHSHIDK 853
                                                                             
Zfish  1048 ----------------------------------------------------------------- 1047

  Fly   854 IPLSGKGEQVHVFEDDLGDDDIKLVTDYETQTIFWSDSDLGRISYSNYRVPHSQIFRGKLRRPYS 918
                                                                             
Zfish  1048 ----------------------------------------------------------------- 1047

  Fly   919 LAMVHHDLFWNELGTPRIYWTHKSNMGPRKVIDIMEKDDPAAIMPYVPVATPNGIPLAASSPVGQ 983
                                                   |.:::|                    
Zfish  1048 ---------------------------------------PTSVLP-------------------- 1053

  Fly   984 ESHPCQQQNGGCSHICVGEGPYHSICLCPAGFVYRDAGNRTCVE----ALDCEFRCHSGECLTMN 1044
                            .||..    |.||:|:   ...|.|||:    .|..:.||.:|:|::..
Zfish  1054 ----------------SGERQ----CQCPSGY---QLHNNTCVKTEHTCLPNQHRCANGKCISSI 1095

  Fly  1045 HRCNGRRDCVDNSDEMNCDEEHRRKPKVLCSPN-QFACHSGEQCVDKERRCDNRKDCHDHSDEQH 1108
            .:|:...||.|.|||..|       |...|.|: ||.|.:...|:....:||:..||.|:|||:|
Zfish  1096 WKCDSDNDCGDMSDEQEC-------PTTSCDPSVQFRCVASGSCIPLAFKCDHEDDCGDNSDEEH 1153

  Fly  1109 CEKFDKSKKCHVHQHGCDNGKCVDSSLVCDGTNDCGDNSDELLCEATSR-CEPGMFQCGSGSCIA 1172
            ||    |.||...:..|..|.|:..:..|||.|||.|.|||..|..... ||...|||.:|.||.
Zfish  1154 CE----SHKCGPGEFTCARGACIRDAWRCDGDNDCRDWSDEANCTVGHHTCESSSFQCHTGHCIP 1214

  Fly  1173 GSWECDGRIDCSDGSDE------HDKC--------------VH----RSCP--PDMQRC------ 1205
            ..|.|||..||.|||||      ..||              .|    ..||  .|.|.|      
Zfish  1215 QRWVCDGDDDCQDGSDEDPTQCGRQKCNGFLCSNGTCLPASAHCNGVEDCPGGADEQNCGPLCAH 1279

  Fly  1206 -------LLGQCLDRSLVCDGHNDCGDKSDE----LNCGTDSSTMNISCAEDQYQCTSNLKICLP 1259
                   ...|||.:||||||...|.|.|||    ..|.| |.....:|....:|||:.:  |:.
Zfish  1280 YMEFVCRNRAQCLFQSLVCDGTRHCADGSDEDPIYAGCST-SVEFEKTCDGYNFQCTNGM--CVT 1341

  Fly  1260 STVRCNGTTECPRGEDEADCGD------VCSIYEFKCRSGRECIRREFRCDGQKDCGDGSDELSC 1318
            ...:|:|..:|....|||:|..      ..|.:.|:|::|| |:...::|||:.||||.|||..|
Zfish  1342 LEWKCDGMDDCGDYSDEANCASPTEEPGCTSYFRFECKNGR-CVPAWWKCDGENDCGDWSDESQC 1405

  Fly  1319 ELEKGHHNQSQIQPWSTSSRSCRPHLFDCQDGECVDLSRVCNNFPDCTNGHDEGPKCATACRSA- 1382
            ...:..|..      :....:|.|:.|.|..|.|:..:.||:.:.||.:..||. .|.|...|. 
Zfish  1406 SGGEALHTP------APGPATCAPNRFRCGSGACIVDTWVCDGYADCPDSSDEA-GCPTVKGSVT 1463

  Fly  1383 -------SGRQVC---QHKCRATPAGAVCSCFDGYRLDADQKSCLD-IDE--CQEQQPCAQLCEN 1434
                   |||  |   |..|...||     |...::.......||| .||  |....|.  ||.|
Zfish  1464 SVTTLPPSGR--CTKDQFLCVKPPA-----CISDWKRCDGHSHCLDGSDEANCPTHGPL--LCAN 1519

  Fly  1435 ----------TLGGYQCQCHADFMLRQDRVSCKSLQSGATLLFSSFNEVRNLSEQPV--MLNVAW 1487
                      .|...:|....|...|.|..:|                   ..||.|  :.|:.|
Zfish  1520 GTRCADGEACLLNSERCDGFIDCSDRSDEHNC-------------------TDEQQVYKVQNLQW 1565

  Fly  1488 SANDS 1492
            :||.|
Zfish  1566 TANFS 1570

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ylNP_996433.1 LDLa 90..124 CDD:238060
LDLa 131..166 CDD:238060
LDLa 184..216 CDD:238060
LDLa 227..262 CDD:238060 6/17 (35%)
LDLa 271..302 CDD:238060 6/30 (20%)
FXa_inhibition 352..387 CDD:291342 13/52 (25%)
Ldl_recept_b 442..482 CDD:278487 10/39 (26%)
LY 466..508 CDD:214531 12/42 (29%)
Ldl_recept_b 529..569 CDD:278487 21/40 (53%)
LY 553..595 CDD:214531 13/41 (32%)
LY 596..637 CDD:214531 13/40 (33%)
FXa_inhibition 669..700 CDD:291342 12/31 (39%)
LY 774..815 CDD:214531 0/40 (0%)
LDLa 1032..1062 CDD:238060 11/29 (38%)
LDLa 1074..1109 CDD:238060 14/35 (40%)
LDLa 1118..1152 CDD:238060 14/33 (42%)
LDLa 1157..1189 CDD:197566 17/32 (53%)
LDLa 1198..1232 CDD:238060 19/52 (37%)
LDLa 1243..1279 CDD:238060 11/35 (31%)
LDLa 1283..1318 CDD:238060 16/34 (47%)
LDLa 1340..1371 CDD:197566 10/30 (33%)
FXa_inhibition 1388..1416 CDD:291342 6/30 (20%)
EGF_CA 1418..1452 CDD:214542 12/46 (26%)
sorl1XP_005157607.1 VPS10 130..754 CDD:214740 38/168 (23%)
Sortilin_C 589..754 CDD:292523 38/168 (23%)
LY 781..822 CDD:214531 6/41 (15%)
LY 825..864 CDD:214531 9/38 (24%)
LY 868..912 CDD:214531 19/43 (44%)
LY 916..954 CDD:214531 13/39 (33%)
LDLa 1079..1113 CDD:238060 12/33 (36%)
LDLa 1118..1154 CDD:238060 14/35 (40%)
LDLa 1159..1193 CDD:238060 14/33 (42%)
LDLa 1242..1273 CDD:238060 5/30 (17%)
LDLa 1282..1310 CDD:197566 12/27 (44%)
LDLa 1327..1361 CDD:238060 11/35 (31%)
LDLa 1376..1405 CDD:238060 15/29 (52%)
LDLa 1421..1455 CDD:238060 12/34 (35%)
LDLa 1474..1509 CDD:238060 11/39 (28%)
LDLa 1522..1551 CDD:238060 5/28 (18%)
FN3 1559..>1630 CDD:238020 5/12 (42%)
FN3 1653..1743 CDD:238020
FN3 1750..1827 CDD:238020
FN3 1931..2007 CDD:238020
FN3 2022..2097 CDD:214495
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1215
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.810

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