DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment yl and sorl1

DIOPT Version :10

Sequence 1:NP_996433.1 Gene:yl / 32367 FlyBaseID:FBgn0004649 Length:1984 Species:Drosophila melanogaster
Sequence 2:XP_005157607.1 Gene:sorl1 / 497306 ZFINID:ZDB-GENE-050208-22 Length:2213 Species:Danio rerio


Alignment Length:1370 Identity:311/1370 - (22%)
Similarity:446/1370 - (32%) Gaps:555/1370 - (40%)


- Green bases have known domain annotations that are detailed below.


  Fly   253 CGDG-------SDER--GCLNLCEPQKGKFLCRNRETCLTLSEVCDGHSDCSDGSDETDLCHSKP 308
            |.:|       ||||  |||      .|:.:...|.:         .|:.|.:|.|         
Zfish   626 CSEGDYKLWSPSDERGNGCL------LGREMVYKRRS---------PHATCFNGED--------- 666

  Fly   309 DCDAKKCALGAKCHMMPASGAECFCPK-------GFRLAKFEDKCEDVDECKEQDDL-------- 358
                         ...|.|.:.|.|.:       ||:|:  ||...:|  |....:.        
Zfish   667 -------------FDRPISLSNCSCTRQDYECDYGFKLS--EDLSLEV--CVPDPEFSGNLYAPP 714

  Fly   359 --CSQGCE-NTSGGYRCV----CDAGYL---LDKDNRTCRAVVYGSKEQQPLLLYTTQMTIMGMH 413
              |..|.. :.|.|||.|    |..|.:   ||.:|..|..     .|....:||..:.:|    
Zfish   715 VPCPVGTTYHRSKGYRKVSGDSCTGGDVEARLDGENLPCPV-----GESNEFILYAVRNSI---- 770

  Fly   414 LREDNVRNHVYQVAGNLSKVIGVA-----------YDGSHIYWTNIQNEAESIVKANGDGSNAEI 467
                    |.|.:|....:.:.:.           |:.:.:||.:|..:....:..|| .|..|:
Zfish   771 --------HRYDLASGTDQQLPLTGLHEAVALDFDYEKNCLYWADISLDTIQRLCMNG-SSGQEV 826

  Fly   468 LLTSGLDAPEDLAVDWLTQNIYFSDNIMRHIAVCSNDG-LNCAVLVTQDVHQPRSLAVWPQKGLM 531
            ::...|...|.|:.|.:::.:|:.|...:.|.|.::|| |...::.:..|.|||:||:.|.:.||
Zfish   827 IVKRDLQNVEALSFDPISRLLYWVDAGAQKIEVSNSDGDLRRTLVNSSVVDQPRALALMPAESLM 891

  Fly   532 FWTDWGEKPM-IGRASMDGSRSRPIVSDNIEWPNGIALDMHQQRIYWVDAKLGSVQTVRPDGTGR 595
            ||||||::.. :.|:.||||....|||:.:.|||||..|  :..:||.:|....::....:|..|
Zfish   892 FWTDWGDRAAGVYRSWMDGSNISCIVSEGVRWPNGITAD--ESWLYWTEAYGDRIERADFNGGSR 954

  Fly   596 RTVLDGMLKHPYGLAIFEDQLYWSDWATKSVHACHKFSGKDHRILAKDRT-IYAVHIYHPAKQPN 659
            ..:::| |.|||.:|:|::.|||.||:...:....|....|..::....| :..:.|::..|. .
Zfish   955 TVIMEG-LPHPYAIAVFKNDLYWDDWSRMGIFKAPKSGSPDSELIVGRLTGVMDLKIFYKGKN-R 1017

  Fly   660 SPHGCENATCSHLCLLAEPEIGG-HSCACPDGMRLAPDHRRCMLMEKRQRLFIGLGQVLLEIEHT 723
            ..:.|.:..||.|||   |:.|. ..|.||||:                                
Zfish  1018 GQNACADQPCSLLCL---PQPGNQRHCVCPDGV-------------------------------- 1047

  Fly   724 AFGRHQVSKSYTLPCLINEMVYNRINGSLIIADNDQRLILEFQPESHESNVLVRSNLGNVSALAF 788
                                                                             
Zfish  1048 ----------------------------------------------------------------- 1047

  Fly   789 DHLSRNLYWADTERAVIEVLSLQTRHRALIRFFPGQEVPIGLTVMPAEGYLYVVLKAKRHSHIDK 853
                                                                             
Zfish  1048 ----------------------------------------------------------------- 1047

  Fly   854 IPLSGKGEQVHVFEDDLGDDDIKLVTDYETQTIFWSDSDLGRISYSNYRVPHSQIFRGKLRRPYS 918
                                                                             
Zfish  1048 ----------------------------------------------------------------- 1047

  Fly   919 LAMVHHDLFWNELGTPRIYWTHKSNMGPRKVIDIMEKDDPAAIMPYVPVATPNGIPLAASSPVGQ 983
                                                   |.:::|                    
Zfish  1048 ---------------------------------------PTSVLP-------------------- 1053

  Fly   984 ESHPCQQQNGGCSHICVGEGPYHSICLCPAGFVYRDAGNRTCVE----ALDCEFRCHSGECLTMN 1044
                            .||..    |.||:|:   ...|.|||:    .|..:.||.:|:|::..
Zfish  1054 ----------------SGERQ----CQCPSGY---QLHNNTCVKTEHTCLPNQHRCANGKCISSI 1095

  Fly  1045 HRCNGRRDCVDNSDEMNCDEEHRRKPKVLCSPN-QFACHSGEQCVDKERRCDNRKDCHDHSDEQH 1108
            .:|:...||.|.|||..|       |...|.|: ||.|.:...|:....:||:..||.|:|||:|
Zfish  1096 WKCDSDNDCGDMSDEQEC-------PTTSCDPSVQFRCVASGSCIPLAFKCDHEDDCGDNSDEEH 1153

  Fly  1109 CEKFDKSKKCHVHQHGCDNGKCVDSSLVCDGTNDCGDNSDELLCEATSR-CEPGMFQCGSGSCIA 1172
            ||    |.||...:..|..|.|:..:..|||.|||.|.|||..|..... ||...|||.:|.||.
Zfish  1154 CE----SHKCGPGEFTCARGACIRDAWRCDGDNDCRDWSDEANCTVGHHTCESSSFQCHTGHCIP 1214

  Fly  1173 GSWECDGRIDCSDGSDE------HDKC--------------VH----RSCP--PDMQRC------ 1205
            ..|.|||..||.|||||      ..||              .|    ..||  .|.|.|      
Zfish  1215 QRWVCDGDDDCQDGSDEDPTQCGRQKCNGFLCSNGTCLPASAHCNGVEDCPGGADEQNCGPLCAH 1279

  Fly  1206 -------LLGQCLDRSLVCDGHNDCGDKSDE----LNCGTDSSTMNISCAEDQYQCTSNLKICLP 1259
                   ...|||.:||||||...|.|.|||    ..|.| |.....:|....:|||:.:  |:.
Zfish  1280 YMEFVCRNRAQCLFQSLVCDGTRHCADGSDEDPIYAGCST-SVEFEKTCDGYNFQCTNGM--CVT 1341

  Fly  1260 STVRCNGTTECPRGEDEADCGD------VCSIYEFKCRSGRECIRREFRCDGQKDCGDGSDELSC 1318
            ...:|:|..:|....|||:|..      ..|.:.|:|::|| |:...::|||:.||||.|||..|
Zfish  1342 LEWKCDGMDDCGDYSDEANCASPTEEPGCTSYFRFECKNGR-CVPAWWKCDGENDCGDWSDESQC 1405

  Fly  1319 ELEKGHHNQSQIQPWSTSSRSCRPHLFDCQDGECVDLSRVCNNFPDCTNGHDEGPKCATACRSA- 1382
            ...:..|..      :....:|.|:.|.|..|.|:..:.||:.:.||.:..||. .|.|...|. 
Zfish  1406 SGGEALHTP------APGPATCAPNRFRCGSGACIVDTWVCDGYADCPDSSDEA-GCPTVKGSVT 1463

  Fly  1383 -------SGRQVC---QHKCRATPAGAVCSCFDGYRLDADQKSCLD-IDE--CQEQQPCAQLCEN 1434
                   |||  |   |..|...||     |...::.......||| .||  |....|.  ||.|
Zfish  1464 SVTTLPPSGR--CTKDQFLCVKPPA-----CISDWKRCDGHSHCLDGSDEANCPTHGPL--LCAN 1519

  Fly  1435 ----------TLGGYQCQCHADFMLRQDRVSCKSLQSGATLLFSSFNEVRNLSEQPV--MLNVAW 1487
                      .|...:|....|...|.|..:|                   ..||.|  :.|:.|
Zfish  1520 GTRCADGEACLLNSERCDGFIDCSDRSDEHNC-------------------TDEQQVYKVQNLQW 1565

  Fly  1488 SANDS 1492
            :||.|
Zfish  1566 TANFS 1570

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ylNP_996433.1 LDLa 90..124 CDD:238060
LDLa 131..166 CDD:238060
LDLa 184..216 CDD:238060
LDLa 227..262 CDD:238060 6/17 (35%)
LDLa 271..302 CDD:238060 6/30 (20%)
FXa_inhibition 352..387 CDD:464251 13/52 (25%)
Ldl_recept_b 442..483 CDD:459654 10/40 (25%)
LY 466..508 CDD:214531 12/42 (29%)
Ldl_recept_b 529..569 CDD:459654 21/40 (53%)
LY 553..595 CDD:214531 13/41 (32%)
LY 596..637 CDD:214531 13/40 (33%)
FXa_inhibition 669..700 CDD:464251 12/31 (39%)
LY 774..815 CDD:214531 0/40 (0%)
LDLa 1032..1062 CDD:238060 11/29 (38%)
LDLa 1074..1109 CDD:238060 14/35 (40%)
LDLa 1118..1152 CDD:238060 14/33 (42%)
LDLa 1157..1189 CDD:197566 17/32 (53%)
LDLa 1198..1232 CDD:238060 19/52 (37%)
LDLa 1243..1279 CDD:238060 11/35 (31%)
LDLa 1283..1318 CDD:238060 16/34 (47%)
LDLa 1340..1371 CDD:197566 10/30 (33%)
FXa_inhibition 1388..1416 CDD:464251 6/30 (20%)
EGF_CA 1418..1452 CDD:214542 12/46 (26%)
sorl1XP_005157607.1 VPS10 130..754 CDD:214740 38/168 (23%)
LY 781..822 CDD:214531 6/41 (15%)
LY 825..864 CDD:214531 9/38 (24%)
LY 868..912 CDD:214531 19/43 (44%)
LY 916..954 CDD:214531 13/39 (33%)
LDLa 1079..1113 CDD:238060 12/33 (36%)
LDLa 1118..1154 CDD:238060 14/35 (40%)
LDLa 1159..1193 CDD:238060 14/33 (42%)
LDLa 1242..1273 CDD:238060 5/30 (17%)
LDLa 1282..1310 CDD:197566 12/27 (44%)
LDLa 1327..1361 CDD:238060 11/35 (31%)
LDLa 1376..1405 CDD:238060 15/29 (52%)
LDLa 1421..1455 CDD:238060 12/34 (35%)
LDLa 1474..1509 CDD:238060 11/39 (28%)
LDLa 1522..1551 CDD:238060 5/28 (18%)
FN3 1589..2079 CDD:442628
FN3 1653..1743 CDD:238020
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.