DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment yl and Sspo

DIOPT Version :9

Sequence 1:	NP_996433.1	Gene:	yl / 32367	FlyBaseID:	FBgn0004649	Length:	1984	Species:	Drosophila melanogaster
Sequence 2:	NP_001007017.1	Gene:	Sspo / 474348	RGDID:	1549716	Length:	5141	Species:	Rattus norvegicus

Alignment Length:	1792	Identity:	385/1792 - (21%)
Similarity:	545/1792 - (30%)	Gaps:	700/1792 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    83 PGSADTRCDAGQFQCRDGG-CILQAKMCDGRGDCKDSSDELDCDYRLCRPPHWFPCAQPHGACLA 146
            ||     |..|:..||:.| |:....:||.:.||.|.|||..||..:|.... ..|..  |.||.
  Rat  1379 PG-----CAEGEALCRESGHCVPLEWLCDNQDDCGDGSDEEGCDTSVCGEGQ-MSCQS--GRCLP 1435

  Fly   147 AELMCNGIDNCPGGEDELNCPVRPGFRFGDTAHRMRSCSKYEFMCQQDRTCIPIDFMCDGRPDCT 211
            ..|:|:|.|:|..|.||..|....||         .:|:        |..|:|...:|||.|||.
  Rat  1436 LSLICDGQDDCGDGTDEQGCLCPQGF---------LACA--------DGRCLPPALLCDGHPDCL 1483

  Fly   212 DKSDEVA-----GCKQAEITCPGEGHLCANGRCLRRKQWVCDGVDDCGDGSDERGCLNLCEP--- 268
            |.:||.:     .|...|::       |.:|.|:|..| :||||.||.||:|| |.::...|
  Rat  1484 DAADEESCLGWVSCTSGEVS-------CVDGPCIRTIQ-LCDGVWDCPDGADE-GPVHCSSPSLP 1539

  Fly   269 -------------------------------QKGKFLCRNRETCLTLSEVCDGHSDCSDGSDETD 302
                                           ...:|.|.:.| |......||...||:|||||.|
  Rat  1540 TPPAGIGQNPSTSSPDTSPSPVGSASPASPCSLSEFQCNSGE-CTPRGWRCDREEDCTDGSDELD 1603

  Fly   303 LCHSKPDCDAKKCALGAKCHMMP-ASGAECFCPKGFRLAKFEDKCEDVDEC----KEQDDLCSQG 362
                        |....|.:.|| |.|..|..|        ...|:.|.:|    .|..|:|.:
  Rat  1604 ------------CGGPCKLYQMPCAHGPHCLSP--------GQLCDGVAQCPDGSDEDPDVCEE- 1647

  Fly   363 CENTSGG----------YRC----------VCDAG---YLLDK-----DNRTCRAVVYGS-KEQQ 398
             .:.|||          :.|          |||..   .|.|:     |.:.|.  .:|| ...:
  Rat  1648 -RSASGGPNGTAVPCPEFSCPNGTCIDFLLVCDGSPDCELADETEPSLDEQGCG--TWGSWGPWE 1709

  Fly   399 PLLLYTTQMTIMGMHLREDNVRNHVYQVAGNLSKVIGVAYDGSHIYWTNIQNEAES----IVKAN 459
            |    .:|....|:..|..|.......|..|.               ..:|::::|    ....:
  Rat  1710 P----CSQTCGPGIQSRNRNCSISSLHVLQNC---------------PGLQHQSQSCFTEACPVD 1755

  Fly   460 GDGSNAEILLTSGLDAPEDLAVDWLTQNIYFSDNIMRHIAVC---SNDGLNCAVL--VTQDVHQP 519
            |:.|:..:               |...:......:.|| ..|   .|.|.:||:|  .|...||
  Rat  1756 GEWSSWSL---------------WSPCSEPCGGTMTRH-RQCRPPQNGGQDCALLPGSTHSTHQ- 1803

  Fly   520 RSLAVWPQKGLMFWTDWGE---KP----------MIGRASMDGSRSRPIVSDNIEWPNGIALDMH 571
              .:..||:|.:..|.:||   :|          :.|.|..  |..||..|.....|.|..|...
  Rat  1804 --TSPCPQEGCLNVTCFGELVFRPCAPCPLTCDDISGEAVC--SPDRPCSSPGCWCPEGKVLGTE 1864

  Fly   572 QQRI-------------YW------VDAKL-----GSVQTVRPDGTGRRTVLDGMLKHPYGLAIF 612
            .:.:             ||      :|.:|     |.....||:..               .|:.
  Rat  1865 GRCVRPRQCPCLVDGIRYWPGQRIKMDCQLCFCQDGQPHRCRPNPE---------------CAVD 1914

  Fly   613 EDQLYWSDWA-------TKSVHACHKFSGKDHRILAKDRTIYAVHIYHPAKQPNSPHGCE----- 665
            .....||.||       ::|:....: |..:.|:....|....:|......|.....|||
  Rat  1915 CGWSSWSPWAECLGPCSSQSLQWSFR-SPNNPRLSGHGRQCRGIHRKARRCQTEPCEGCEQWGLT 1978

  Fly   666 --------NATCSHLCLLAEPEIGGHSCACPDGMRLAPDHRRCMLMEKRQRLFIGLGQVLLEIEH 722
                    ...|: :|......|...|..||.|.  .|  :..:|:|       |:|:...   |
  Rat  1979 YHVGERWRGGPCT-VCECLHRSITRCSPYCPIGS--CP--QSWVLVE-------GMGESCC---H 2028

  Fly   723 TAF-GRHQVSKSYTLPCLINEMVYNRINGSLIIADNDQRLILEFQPESHESNVLVRSNLGNVSAL 786
            .|. |::|.....|.|..: .....:|..||:                  :.||...:....|.|
  Rat  2029 CALPGKNQTMIPVTTPAPV-PTPSPQIGASLV------------------TYVLPPMSDACYSPL 2074

  Fly   787 AFDHLSRNLYWADTERAVIEVLSLQTRHRALIRFFPGQEVPIGLTVMP-------AEGY---LYV 841
            ....|..   ||.:     :.|...||...:       |.|   |..|       ||.:   ||:
  Rat  2075 GLAGLPT---WAPS-----QPLEHSTRAAPV-------EAP---TAGPGPREDAYAEWHTQPLYL 2121

  Fly   842 VLKAKRHSHIDKIPLSGKGEQVHVFEDDLGDDDIKLVTDYETQTIFWSDSDLGRIS--------- 897
            .|......::..|.:...|.......:        |...:.:..:.| .|.|..:|
  Rat  2122 QLDLLWPRNLTGIMVQRAGSSAAYISN--------LSLQFSSDGLQW-HSVLNSLSSTLPPPKPS 2177

  Fly   898 --YSNYRVPHSQIFRGKLRRPYSLAMVH---------HDLF-WNEL------------------- 931
              .||:.||....|...::..|.....|         .|:| |.||
  Rat  2178 PESSNHMVPEVWTFDQMVQARYIRVWPHGSHLRDNNQQDIFLWVELLGCKPVPPLAPLCPGTRHR 2242

  Fly   932 ---------GTP-------------------------RIYWT-----------HKSNMGPRKVID 951
                     |.|                         |::.|           .|....||:.:.
  Rat  2243 CANGDCALKGGPCDGAVDCEDGSDEEGCGPLRASTASRVHSTARTPALSPTQPGKFPFHPREGLA 2307

  Fly   952 IMEKDDPAAIMP-----YVPVATPNGIPLAASS----------PVGQES-HPCQQQNGGCSHICV 1000
            .||...|....|     ..|.|:...:|::..|          |.|.:| ||      |.:.:.|
  Rat  2308 DMEHQQPKQESPMPSAGVSPSASEGLLPVSGQSMQTLTTTSTFPPGLKSLHP------GMAAVTV 2366

  Fly  1001 GEGPYHSI--------CLCPAGFVYRDAGNRTCVEALDCEFRCHSGE-------CLTMNHRCNGR 1050
             ..| ||:        .:.|..|..               .||..|:       |:.....|:||
  Rat  2367 -HSP-HSVMPGTPVGQSVSPRPFPL---------------MRCGPGQVPCDVLGCVEQEQLCDGR 2414

  Fly  1051 RDCVDNSDEMNC-DEEHRRKP----------KVLCSPNQFACHSGEQCVDKERRCDNRKDCHDHS 1104
            .||:|.|||.:| ..|....|          :.||||:|.:|.||| |:..|.|||.:.:|.|.|
  Rat  2415 EDCLDGSDEQHCASPEPFTVPTTALPGLPASRALCSPSQLSCGSGE-CLPLEHRCDLQVNCQDGS 2478

  Fly  1105 DEQHCEK---------FDKSKKCH---VHQH---------------------------------- 1123
            ||..|..         .|.|:.|.   :.||
  Rat  2479 DEDDCVDCVLAPWSGWSDCSRSCGLGLIFQHRELLRPPLPGGSCLLDQLRSQPCFVQACPVAGAW 2543

  Fly  1124 -----------GCDNG------KCVDSSLVCDGTNDCGDNSDELLCE-----ATSRCEPGMFQ-- 1164
                       .|..|      .|||......|....|.:.:::||.     ..:.||||...
  Rat  2544 AKWGPWEPCSVSCGGGHQSRQRSCVDPPPKNGGAPCPGPSHEKVLCNLQLCPGDTDCEPGRVHVN 2608

  Fly  1165 ---CGSG-------SCI--AGSWECDGRIDCSDG---------SDEHDKCVHRS-CPPDMQRCLL 1207
               |..|       ||:  ..:..|.|.  |.:|         .|.|  |:..| ||     ||:
  Rat  2609 AELCQKGLLPPCPPSCLDPEANRSCSGH--CVEGCRCPPGLFLQDSH--CLPLSECP-----CLV 2664

  Fly  1208 GQCLDR---SLVCDGHNDCGDKSDELNCGTDSSTMNISCAEDQYQCTSNLKICLPSTVRCNGTTE 1269
            ||.|.:   :.:.|            ||             .|..|.|.:.:|.|
  Rat  2665 GQKLMQPGLAFLLD------------NC-------------SQCICESGILLCKP---------- 2694

  Fly  1270 CPRGEDEADCGDVC--------SIYEFKCRSGRECIRREFR-------------CDGQK------ 1307
                   |.|...|        :..:..|.||   :|..||             |:|.:
  Rat  2695 -------AACSQSCGWSAWSPWTACDHSCGSG---VRARFRSPTNPPAAFGGSPCEGDRQELQAC 2749

  Fly  1308 --DCGD-----------GSDELSCEL---EKGHHNQSQIQPWS---------TSSRSCRPHLFDC 1347
              |||.           .|...||.:   :.|...:|::.|.|         |....|.|.|...
  Rat  2750 YTDCGTDIPGWTPWTSWSSCSQSCLVPGGDPGRRQRSRLCPSSRDTFCPGEATQEEPCSPSLCPV 2814

  Fly  1348 QDGECVDLS-RVCNNFPDCTNG-HDEGPKCATACRSASGRQVC------QHKCRATPAGAVCSCF 1404
            .....:..| ..|:  ..|..| ...|..|:   .||.|..||      ...|...|..|.|
  Rat  2815 PSAWGLWASWSACS--ASCNGGIQTRGRSCS---GSAPGNPVCLGPHTQTRDCNVHPCTAQC--- 2871

  Fly  1405 DGYRLDADQKSCLDIDECQEQQPCAQLCENTLGGYQC 1441
            .|..:....:.||     :|..||.|||.....|.:|
  Rat  2872 PGNMVFRSAEKCL-----EEGGPCPQLCLAQDPGVEC 2903

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
yl	NP_996433.1	LDLa	90..124	CDD:238060	14/34 (41%)
		LDLa	131..166	CDD:238060	12/34 (35%)
		LDLa	184..216	CDD:238060	11/31 (35%)
		LDLa	227..262	CDD:238060	15/34 (44%)
		LDLa	271..302	CDD:238060	13/30 (43%)
		FXa_inhibition	352..387	CDD:291342	14/66 (21%)
		Ldl_recept_b	442..482	CDD:278487	4/43 (9%)
		LY	466..508	CDD:214531	6/44 (14%)
		Ldl_recept_b	529..569	CDD:278487	13/52 (25%)
		LY	553..595	CDD:214531	13/65 (20%)
		LY	596..637	CDD:214531	7/47 (15%)
		FXa_inhibition	669..700	CDD:291342	8/30 (27%)
		LY	774..815	CDD:214531	10/40 (25%)
		LDLa	1032..1062	CDD:238060	13/36 (36%)
		LDLa	1074..1109	CDD:238060	18/34 (53%)
		LDLa	1118..1152	CDD:238060	10/87 (11%)
		LDLa	1157..1189	CDD:197566	12/54 (22%)
		LDLa	1198..1232	CDD:238060	8/36 (22%)
		LDLa	1243..1279	CDD:238060	6/35 (17%)
		LDLa	1283..1318	CDD:238060	13/74 (18%)
		LDLa	1340..1371	CDD:197566	7/32 (22%)
		FXa_inhibition	1388..1416	CDD:291342	6/33 (18%)
		EGF_CA	1418..1452	CDD:214542	8/24 (33%)
Sspo	NP_001007017.1	VWD	192..341	CDD:214566
		C8	393..468	CDD:285899
		TIL	472..527	CDD:280072
		VWD	556..716	CDD:214566
		C8	769..826	CDD:285899
		TIL	830..883	CDD:280072
		VWD	1019..1168	CDD:278521
		C8	1206..1276	CDD:285899
		TIL	1280..1336	CDD:280072
		LDLa	1381..1416	CDD:238060	14/34 (41%)
		LDLa	1421..1455	CDD:238060	13/36 (36%)
		LDLa	1457..1491	CDD:238060	15/50 (30%)
		LDLa	1497..1528	CDD:197566	15/38 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1533..1567		1/33 (3%)
		Ldl_recept_a	1568..1604	CDD:278486	14/48 (29%)
		TSP1	1702..1753	CDD:214559	11/69 (16%)
		TSP1	1758..1812	CDD:214559	15/72 (21%)
		TIL	1822..1873	CDD:280072	10/52 (19%)
		TSP1	1917..1970	CDD:214559	10/53 (19%)
		FA58C	2070..2226	CDD:214572	36/182 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2087..2109		7/31 (23%)
		FA58C	<2111..2225	CDD:238014	24/122 (20%)
		LDLa	2236..2270	CDD:238060	2/33 (6%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2262..2335		11/72 (15%)
		LDLa	2392..2426	CDD:238060	12/33 (36%)
		LDLa	2449..2483	CDD:238060	18/34 (53%)
		TSP1	2490..2538	CDD:214559	5/47 (11%)
		TSP1	2543..2595	CDD:214559	9/51 (18%)
		TIL	2618..2660	CDD:280072	10/45 (22%)
		TSP1	2703..2752	CDD:214559	8/51 (16%)
		TSP1	2760..2813	CDD:214559	11/52 (21%)
		TSP_1	2819..2867	CDD:278517	12/52 (23%)
		TIL	2871..2930	CDD:280072	12/41 (29%)
		VWC_out	2932..2979	CDD:214565
		TSP1	2972..3023	CDD:214559
		TIL	3075..3127	CDD:280072
		TSP1	3240..3292	CDD:214559
		TIL	3300..3350	CDD:280072
		TSP1	3396..3439	CDD:214559
		TSP1	3460..3504	CDD:214559
		TIL	3514..3570	CDD:280072
		TSP1	3633..3677	CDD:214559
		TSP1	3810..3862	CDD:214559
		TSP1	3879..3927	CDD:214559
		TSP1	3945..3998	CDD:214559
		TSP1	4003..4055	CDD:214559
		TIL	4058..4113	CDD:280072
		TSP1	4158..4208	CDD:214559
		TSP1	4252..4303	CDD:214559
		TSP1	4367..4418	CDD:214559
		TIL	4422..4477	CDD:280072
		TSP1	4611..4659	CDD:214559
		TIL	4673..4719	CDD:280072
		TSP1	4763..4812	CDD:214559
		TIL	4814..4868	CDD:280072
		TIL	4920..4978	CDD:280072
		VWC	4980..5035	CDD:302663
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1215
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810