DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment yl and LRP4

DIOPT Version :9

Sequence 1:NP_996433.1 Gene:yl / 32367 FlyBaseID:FBgn0004649 Length:1984 Species:Drosophila melanogaster
Sequence 2:NP_002325.2 Gene:LRP4 / 4038 HGNCID:6696 Length:1905 Species:Homo sapiens


Alignment Length:1957 Identity:491/1957 - (25%)
Similarity:772/1957 - (39%) Gaps:515/1957 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    75 CGGTAAGTPGSADTRCDA-----GQFQCRDGGCILQAKMCDGRGDCKDSSDELDCDYRLCRPP-- 132
            ||       .::|.:||.     .:|:|.||.||.:...|||..||||.|||.:|...:..||  
Human   135 CG-------DNSDEQCDMRKCSDKEFRCSDGSCIAEHWYCDGDTDCKDGSDEENCPSAVPAPPCN 192

  Fly   133 -HWFPCAQPHGACLAAELMCNGIDNCPGGEDELNCPVRPGFRFGDTAHRMRSCSKYEFMCQQDRT 196
             ..|.||  :|.|:.....|:|.|:|....||.:|          ::|  :.|...||||... .
Human   193 LEEFQCA--YGRCILDIYHCDGDDDCGDWSDESDC----------SSH--QPCRSGEFMCDSG-L 242

  Fly   197 CIPIDFMCDGRPDCTDKSDEVAGCKQAEITCPGEGHLCANGRCLRRKQWVCDGVDDCGDGSDERG 261
            ||...:.|||..||.|:||| ..|..:  .|..|...|.:|||: |..|.|||.|||.|.|||..
Human   243 CINAGWRCDGDADCDDQSDE-RNCTTS--MCTAEQFRCHSGRCV-RLSWRCDGEDDCADNSDEEN 303

  Fly   262 CLNLCEPQ--KGKFLCRNRETCLTLSEVCDGHSDCSDGSDETDLCHSKP-----DCDAKKCALGA 319
            |.|...||  ..:|||.|.. |:...::|:|.:||.|.|||:...:.:|     :|:........
Human   304 CENTGSPQCALDQFLCWNGR-CIGQRKLCNGVNDCGDNSDESPQQNCRPRTGEENCNVNNGGCAQ 367

  Fly   320 KCHMMPASGAECFCPKGFRLAKFEDKCEDVDECKEQDDLCSQGCENTSGGYRCVCDAGYLLDKDN 384
            ||.|: ....:|.|..|:||.:....|:||:||.| :..|||||.|:.|.::|.|:.||.|..|.
Human   368 KCQMV-RGAVQCTCHTGYRLTEDGHTCQDVNECAE-EGYCSQGCTNSEGAFQCWCETGYELRPDR 430

  Fly   385 RTCRAVVYGSKEQQPLLLYTTQMTIMGM--HLREDNVRNHVYQVAGNLSKVIGVAYDGSH----I 443
            |:|:|:     ..:|:||:..::.|..:  |      |:....:..||...|  |.|..|    :
Human   431 RSCKAL-----GPEPVLLFANRIDIRQVLPH------RSEYTLLLNNLENAI--ALDFHHRRELV 482

  Fly   444 YWTNIQNEAESIVKANGDGSNAEILLTSGLDAPEDLAVDWLTQNIYFSDNIMRHIAVCSNDGLNC 508
            :|:::  ..:.|::||.:|||.|.::::||::|..|||||:...:|::|:....|.|.:.||.:.
Human   483 FWSDV--TLDRILRANLNGSNVEEVVSTGLESPGGLAVDWVHDKLYWTDSGTSRIEVANLDGAHR 545

  Fly   509 AVLVTQDVHQPRSLAVWPQKGLMFWTDWGEKPMIGRASMDGSRSRPIVSDNIEWPNGIALDMHQQ 573
            .||:.|::.:||::|:.|.:|.::|||||..|.|..:|||||..|.|...::.||||:.:|...:
Human   546 KVLLWQNLEKPRAIALHPMEGTIYWTDWGNTPRIEASSMDGSGRRIIADTHLFWPNGLTIDYAGR 610

  Fly   574 RIYWVDAKLGSVQTVRPDGTGRRTVLDGMLKHPYGLAIFEDQLYWSDWATKSVHACHKFSGKDHR 638
            |:||||||...::....||:.|:.|:...|.||:.:.:|||.|||:||.|||:::.:||:||:..
Human   611 RMYWVDAKHHVIERANLDGSHRKAVISQGLPHPFAITVFEDSLYWTDWHTKSINSANKFTGKNQE 675

  Fly   639 ILAKDRTIYA--VHIYHPAKQPNSPHGC--ENATCSHLCLLAEPEIGGHSCACPDGMRLAPDHRR 699
            |: :::..:.  :|..||.:||...:.|  .|..|:||||   |....::||||.|.|....|..
Human   676 II-RNKLHFPMDIHTLHPQRQPAGKNRCGDNNGGCTHLCL---PSGQNYTCACPTGFRKISSHAC 736

  Fly   700 CMLMEKRQRLFIGLGQVLLEIEHTAFGRHQVSKSYTLPCLINEMVYNRINGSLIIADNDQR---- 760
            ...::|    |: |....::|...:|....:|         ::::......|.:..|.|.|    
Human   737 AQSLDK----FL-LFARRMDIRRISFDTEDLS---------DDVIPLADVRSAVALDWDSRDDHV 787

  Fly   761 --------LILEFQPESHESNVLVRSNLGNVSALAFDHLSRNLYWADTERAVIEVLSLQTRHRAL 817
                    .|...:.:.....|:|.::|.:.:.||.|.::..|||.|.....|||.:.....|.:
Human   788 YWTDVSTDTISRAKWDGTGQEVVVDTSLESPAGLAIDWVTNKLYWTDAGTDRIEVANTDGSMRTV 852

  Fly   818 IRFFPGQEVPIGLTVMPAEGYLYVV---LKAKRHSHIDKIPLSGKGEQVHVFEDDLGDDDIKLVT 879
            : .:...:.|..:.|.|..||:|..   ...|    |::..:...|.||.:..:....:.  |..
Human   853 L-IWENLDRPRDIVVEPMGGYMYWTDWGASPK----IERAGMDASGRQVIISSNLTWPNG--LAI 910

  Fly   880 DYETQTIFWSDSDLGRISYSNYRVPHSQIFRG-KLRRPYSLAMVHHDLFWNELGTPRIY------ 937
            ||.:|.::|:|:.:..|.::.......::..| :|..|:.|.:....::|.:..|..|.      
Human   911 DYGSQRLYWADAGMKTIEFAGLDGSKRKVLIGSQLPHPFGLTLYGERIYWTDWQTKSIQSADRLT 975

  Fly   938 ----WTHKSNMGPRKVIDIMEKDDPAAIMPYVPVATPNGIPLAASSPVGQESHPCQQQNGGCSHI 998
                .|.:.|:.....|.:..:..|       ||:|                 ||..:||||||:
Human   976 GLDRETLQENLENLMDIHVFHRRRP-------PVST-----------------PCAMENGGCSHL 1016

  Fly   999 CV-GEGPYHSICLCPAGFVYRDAGNRTCVEALDCEFRCHSGECLTMNHRCNGRRDCVD------- 1055
            |: ...|....|.||.|......| :||...::        ..|....|.:.|...:|       
Human  1017 CLRSPNPSGFSCTCPTGINLLSDG-KTCSPGMN--------SFLIFARRIDIRMVSLDIPYFADV 1072

  Fly  1056 ---------NSDEMNCDEEHRRKPKVLCSPNQFACHSGEQCVDKERRCDNRKDCHDHSDEQHCEK 1111
                     |:..:..|            |.:...:..:..:.:..|.:  .|...|.|      
Human  1073 VVPINITMKNTIAIGVD------------PQEGKVYWSDSTLHRISRAN--LDGSQHED------ 1117

  Fly  1112 FDKSKKCHVHQHGCDNGKCVDSSLVCDGTNDCGDNSDELLCEATSRCEPGMFQCGSGSCIAGSWE 1176
                                   ::..|.    ..:|.|..:|..|   .::...:|:       
Human  1118 -----------------------IITTGL----QTTDGLAVDAIGR---KVYWTDTGT------- 1145

  Fly  1177 CDGRIDCS--DGSDEHDKCVHRSCPPDMQRCLLGQCLD--RSLV--------------------- 1216
              .||:..  |||              |::.|:.|.||  |::|                     
Human  1146 --NRIEVGNLDGS--------------MRKVLVWQNLDSPRAIVLYHEMGFMYWTDWGENAKLER 1194

  Fly  1217 --CDG-------HNDCG-------DKSDELNCGTDSSTMNISCAEDQYQCTSNLKICLPSTVRCN 1265
              .||       :|:.|       ||:.......|:.|..|..|:                  .|
Human  1195 SGMDGSDRAVLINNNLGWPNGLTVDKASSQLLWADAHTERIEAAD------------------LN 1241

  Fly  1266 GT--------TECPRGEDEADCGDVCSIY--EFKCRSGRECIRREFRCDGQKDCGDGSDELSCEL 1320
            |.        .:.|.|....|    ..||  :::.||    |.|       .|.|.||:.:..  
Human  1242 GANRHTLVSPVQHPYGLTLLD----SYIYWTDWQTRS----IHR-------ADKGTGSNVILV-- 1289

  Fly  1321 EKGHHNQSQIQPWSTSSRSCRPHLFDCQDGECVDLSRVCNNFPDCTNGHDEGPKCATACRSASGR 1385
                             ||..|.|.|.|   .||.::               |.....|.|.:|.
Human  1290 -----------------RSNLPGLMDMQ---AVDRAQ---------------PLGFNKCGSRNGG 1319

  Fly  1386 QVCQHKCRATPAGAVCSCFDGYRLDADQKSCLDIDECQEQQPCAQLCENTLGGYQCQCHADFMLR 1450
              |.|.|...|:|..|:|..|.:|..|.|:|   |...|                          
Human  1320 --CSHLCLPRPSGFSCACPTGIQLKGDGKTC---DPSPE-------------------------- 1353

  Fly  1451 QDRVSCKSLQSGATLLFSSFNEVRNLSEQPVMLNVAWSANDSRITGFDLAMHRQMGYFSAEDEGI 1515
                        ..|||||...:|.:|     |:.: ...|..:...:|.....:.|.|.  :|.
Human  1354 ------------TYLLFSSRGSIRRIS-----LDTS-DHTDVHVPVPELNNVISLDYDSV--DGK 1398

  Fly  1516 VYQIDLQTKVIVRA------------LGLPAPTKLSVDWVTGNVY-VLSGAQEIQACSFVGRMCG 1567
            ||..|:...||.||            .||.....|:||||..|:| ..:|...|:|....| .|.
Human  1399 VYYTDVFLDVIRRADLNGSNMETVIGRGLKTTDGLAVDWVARNLYWTDTGRNTIEASRLDG-SCR 1462

  Fly  1568 RIV---HVKSPRHVKHLAVDGYHARIFYIVIRTEGYGQTSSEIHMARLDGSRRDMLLQRSESFMT 1629
            :::   .:..||.:......||   :|:     ..:|.. ::|..|.||||.|.:|:.....:..
Human  1463 KVLINNSLDEPRAIAVFPRKGY---LFW-----TDWGHI-AKIERANLDGSERKVLINTDLGWPN 1518

  Fly  1630 ALTTDPHQQLLYFVDQHMRTLERISYRLKTGPMRRPEIMLQKSNALMHPSGLSVYENNAFIVNLG 1694
            .||.|...:.:|:||.|   |:||......|.:|:..:     :.:.||..|:..:...:..:..
Human  1519 GLTLDYDTRRIYWVDAH---LDRIESADLNGKLRQVLV-----SHVSHPFALTQQDRWIYWTDWQ 1575

  Fly  1695 SVEAVQCALYGSRICHKISINVLNAQDIVVAGRSRQPQKASHPCA--HAHCHGLCLQADYGYECM 1757
            :....:...|..|....:..||....||:|.  |.|.|..::.|.  :..|..||......:.|.
Human  1576 TKSIQRVDKYSGRNKETVLANVEGLMDIIVV--SPQRQTGTNACGVNNGGCTHLCFARASDFVCA 1638

  Fly  1758 CGN------------------RLVAEGERCP-----------------HGSGNEV--------AV 1779
            |.:                  |.....|:.|                 ..|..||        |.
Human  1639 CPDEPDSRPCSLVPGLVPPAPRATGMSEKSPVLPNTPPTTLYSSTTRTRTSLEEVEGRCSERDAR 1703

  Fly  1780 LG-------AVNSLELEHEHEQ---NGHFHWLMALFVLAAGSLIAGLGYMYYQYRQRGHTDLNI- 1833
            ||       ||.:...|..|..   .|....|:.|.|:||        .|.|::::...||..: 
Human  1704 LGLCARSNDAVPAAPGEGLHISYAIGGLLSILLILVVIAA--------LMLYRHKKSKFTDPGMG 1760

  Fly  1834 NMHFQNP 1840
            |:.:.||
Human  1761 NLTYSNP 1767

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ylNP_996433.1 LDLa 90..124 CDD:238060 18/38 (47%)
LDLa 131..166 CDD:238060 13/37 (35%)
LDLa 184..216 CDD:238060 14/31 (45%)
LDLa 227..262 CDD:238060 18/34 (53%)
LDLa 271..302 CDD:238060 13/30 (43%)
FXa_inhibition 352..387 CDD:291342 16/34 (47%)
Ldl_recept_b 442..482 CDD:278487 14/43 (33%)
LY 466..508 CDD:214531 15/41 (37%)
Ldl_recept_b 529..569 CDD:278487 19/39 (49%)
LY 553..595 CDD:214531 16/41 (39%)
LY 596..637 CDD:214531 19/40 (48%)
FXa_inhibition 669..700 CDD:291342 13/30 (43%)
LY 774..815 CDD:214531 13/40 (33%)
LDLa 1032..1062 CDD:238060 5/45 (11%)
LDLa 1074..1109 CDD:238060 5/34 (15%)
LDLa 1118..1152 CDD:238060 3/33 (9%)
LDLa 1157..1189 CDD:197566 7/33 (21%)
LDLa 1198..1232 CDD:238060 13/72 (18%)
LDLa 1243..1279 CDD:238060 5/43 (12%)
LDLa 1283..1318 CDD:238060 10/36 (28%)
LDLa 1340..1371 CDD:197566 6/30 (20%)
FXa_inhibition 1388..1416 CDD:291342 11/27 (41%)
EGF_CA 1418..1452 CDD:214542 2/33 (6%)
LRP4NP_002325.2 LDLa 27..66 CDD:238060
Ldl_recept_a 70..105 CDD:278486
LDLa 110..142 CDD:238060 3/13 (23%)
LDLa 148..182 CDD:238060 16/33 (48%)
LDLa 231..265 CDD:238060 16/35 (46%)
LDLa 270..304 CDD:238060 18/34 (53%)
LDLa 311..343 CDD:197566 12/32 (38%)
FXa_inhibition 358..393 CDD:291342 9/35 (26%)
EGF_CA 395..434 CDD:214542 19/39 (49%)
NHL <471..622 CDD:302697 60/154 (39%)
NHL repeat 471..507 CDD:271320 12/39 (31%)
LDL-receptor class B 1 480..522 16/43 (37%)
LY 505..545 CDD:214531 14/39 (36%)
NHL repeat 510..550 CDD:271320 15/39 (38%)
LDL-receptor class B 2 523..565 13/41 (32%)
NHL repeat 555..589 CDD:271320 17/33 (52%)
LDL-receptor class B 3 566..609 20/42 (48%)
LY 590..632 CDD:214531 16/41 (39%)
NHL repeat 598..622 CDD:271320 12/23 (52%)
LDL-receptor class B 4 610..652 16/41 (39%)
LY 633..673 CDD:214531 18/39 (46%)
LDL-receptor class B 5 653..693 15/40 (38%)
FXa_inhibition 702..>729 CDD:291342 13/29 (45%)
LY 766..806 CDD:214531 5/39 (13%)
LDL-receptor class B 6 785..827 7/41 (17%)
LY 808..850 CDD:214531 13/41 (32%)
LDL-receptor class B 7 828..870 11/42 (26%)
LDL-receptor class B 8 871..914 11/48 (23%)
Ldl_recept_b 871..911 CDD:278487 9/45 (20%)
LY 895..937 CDD:214531 9/43 (21%)
LDL-receptor class B 9 915..956 8/40 (20%)
LY 938..979 CDD:214531 7/40 (18%)
LDL-receptor class B 10 957..998 6/40 (15%)
FXa_inhibition 1006..1043 CDD:291342 14/37 (38%)
NHL <1085..1277 CDD:302697 44/290 (15%)
NHL repeat 1085..1123 CDD:271320 6/80 (8%)
LDL-receptor class B 11 1093..1135 8/76 (11%)
NHL repeat 1128..1161 CDD:271320 10/58 (17%)
LDL-receptor class B 12 1136..1178 14/67 (21%)
NHL repeat 1166..1203 CDD:271320 6/36 (17%)
LDL-receptor class B 13 1179..1222 6/42 (14%)
Ldl_recept_b 1179..1219 CDD:278487 4/39 (10%)
NHL repeat 1212..1244 CDD:271320 8/49 (16%)
LDL-receptor class B 14 1223..1263 9/61 (15%)
NHL repeat 1253..1277 CDD:271320 8/31 (26%)
LDL-receptor class B 15 1264..1306 18/74 (24%)
FXa_inhibition 1313..1348 CDD:291342 14/36 (39%)
LY 1379..1418 CDD:214531 11/40 (28%)
LDL-receptor class B 16 1397..1439 14/41 (34%)
LY 1420..1460 CDD:214531 13/40 (33%)
LDL-receptor class B 17 1440..1482 9/42 (21%)
LDL-receptor class B 18 1483..1526 15/51 (29%)
Ldl_recept_b 1483..1523 CDD:278487 14/48 (29%)
LY 1507..1547 CDD:214531 11/42 (26%)
LDL-receptor class B 19 1527..1568 12/48 (25%)
LY 1549..1589 CDD:214531 5/44 (11%)
LDL-receptor class B 20 1569..1610 8/42 (19%)
FXa_inhibition 1617..>1641 CDD:291342 6/23 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1659..1686 3/26 (12%)
Endocytosis signal. /evidence=ECO:0000255 1766..1769 2/2 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1852..1905
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1215
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100345
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.710

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