DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment yl and LRP3

DIOPT Version :9

Sequence 1:NP_996433.1 Gene:yl / 32367 FlyBaseID:FBgn0004649 Length:1984 Species:Drosophila melanogaster
Sequence 2:XP_005259002.1 Gene:LRP3 / 4037 HGNCID:6695 Length:785 Species:Homo sapiens


Alignment Length:356 Identity:98/356 - (27%)
Similarity:120/356 - (33%) Gaps:105/356 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly  1032 EFRCHSGECLTMNHRCNGRRDCVDNSDEMNCDEEHRRKPKVLCSPNQFACHSGE--QCVDKERRC 1094
            ||||.:|:||....:||...:|.|.|||.||.......|..||....|.|....  :|:..||||
Human   170 EFRCDNGKCLPGPWQCNTVDECGDGSDEGNCSAPASEPPGSLCPGGTFPCSGARSTRCLPVERRC 234

  Fly  1095 DNRKDCHDHSDEQHCEKFDKSKK--------CHVHQHGCDNGKCVDSSLVCD------------- 1138
            |..:||.|.|||..|......::        ......|...|   .|.|.|.             
Human   235 DGLQDCGDGSDEAGCPDLACGRRLGSFYGSFASPDLFGAARG---PSDLHCTWLVDTQDSRRVLL 296

  Fly  1139 ------GTND-------CGDNSDELLCEATSRC--EPGMFQCGSGS------------------- 1169
                  |.:|       .|:..|.||...:.|.  .|...:...|.                   
Human   297 QLELRLGYDDYVQVYEGLGERGDRLLQTLSYRSNHRPVSLEAAQGRLTVAYHARARSAGHGFNAT 361

  Fly  1170 ------CIAGSWECDGRIDCSDGSDEHDKCVHRSCPPDMQRCLLGQCLDRSLVCDGHNDCGDKSD 1228
                  |:.....|....| |||....|    :.|..:.||            |||...|....|
Human   362 YQVKGYCLPWEQPCGSSSD-SDGGSLGD----QGCFSEPQR------------CDGWWHCASGRD 409

  Fly  1229 ELNCGTDSSTMNISCAEDQYQCTSNLKICLPSTVRCNGTTECPRGEDEADCGDVCSIYEFKCRSG 1293
            |..|.        :|..|||.|.....:|.....|||....||.|.||.:|        |.|:.|
Human   410 EQGCP--------ACPPDQYPCEGGSGLCYTPADRCNNQKSCPDGADEKNC--------FSCQPG 458

  Fly  1294 ------RECIRREFRCDGQKDCGDGSDELSC 1318
                  ..||...:|||||:||.|||||..|
Human   459 TFHCGTNLCIFETWRCDGQEDCQDGSDEHGC 489

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ylNP_996433.1 LDLa 90..124 CDD:238060
LDLa 131..166 CDD:238060
LDLa 184..216 CDD:238060
LDLa 227..262 CDD:238060
LDLa 271..302 CDD:238060
FXa_inhibition 352..387 CDD:291342
Ldl_recept_b 442..482 CDD:278487
LY 466..508 CDD:214531
Ldl_recept_b 529..569 CDD:278487
LY 553..595 CDD:214531
LY 596..637 CDD:214531
FXa_inhibition 669..700 CDD:291342
LY 774..815 CDD:214531
LDLa 1032..1062 CDD:238060 14/29 (48%)
LDLa 1074..1109 CDD:238060 15/36 (42%)
LDLa 1118..1152 CDD:238060 10/59 (17%)
LDLa 1157..1189 CDD:197566 9/58 (16%)
LDLa 1198..1232 CDD:238060 9/33 (27%)
LDLa 1243..1279 CDD:238060 14/35 (40%)
LDLa 1283..1318 CDD:238060 17/40 (43%)
LDLa 1340..1371 CDD:197566
FXa_inhibition 1388..1416 CDD:291342
EGF_CA 1418..1452 CDD:214542
LRP3XP_005259002.1 CUB 43..156 CDD:238001
LDLa 166..200 CDD:238060 14/29 (48%)
LDLa 212..249 CDD:238060 15/36 (42%)
CUB 254..364 CDD:238001 14/112 (13%)
LDLa 416..452 CDD:238060 14/35 (40%)
LDLa 455..489 CDD:238060 16/33 (48%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1215
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

Return to query results.
Submit another query.