DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment yl and LRP2

DIOPT Version :9

Sequence 1:	NP_996433.1	Gene:	yl / 32367	FlyBaseID:	FBgn0004649	Length:	1984	Species:	Drosophila melanogaster
Sequence 2:	NP_004516.2	Gene:	LRP2 / 4036	HGNCID:	6694	Length:	4655	Species:	Homo sapiens

Alignment Length:	2048	Identity:	578/2048 - (28%)
Similarity:	896/2048 - (43%)	Gaps:	364/2048 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 PSSGGSTSSRYGNCQRTHLI-INGRHVAISLLLLVGLCGGTA-----AGTPGSADTRCDAGQFQC 97
            |:||....|.:..|...|.| .:.|            |.||.     |...|.|...|..|.|:|
Human    22 PASGQECDSAHFRCGSGHCIPADWR------------CDGTKDCSDDADEIGCAVVTCQQGYFKC 74

  Fly    98 R-DGGCILQAKMCDGRGDCKDSSDE-LDCDYRLCRPPHWFPCAQPHGACLAAELMCNGIDNCPGG 160
            : :|.||..:.:||...||.|.||| .||....| ..|...|:  :|.|:.:|..|:.:.:||.|
Human    75 QSEGQCIPNSWVCDQDQDCDDGSDERQDCSQSTC-SSHQITCS--NGQCIPSEYRCDHVRDCPDG 136

  Fly   161 EDELNCPVRPGFRF-----------------------GDTAHRMRSCSKYEFMCQQDRTCIPIDF 202
            .||.:|......:.                       .|..:....|...||.|.... |||..:
Human   137 ADENDCQYPTCEQLTCDNGACYNTSQKCDWKVDCRDSSDEINCTEICLHNEFSCGNGE-CIPRAY 200

  Fly   203 MCDGRPDCTDKSDEVAGCKQAEITCPGEGHLCANGRCLRRKQWVCDGVDDCGDGSDERGC----- 262
            :||...||.|.|||.| |...  ||.|....|.:|||: .:.|||||.|||.|..||.||
Human   201 VCDHDNDCQDGSDEHA-CNYP--TCGGYQFTCPSGRCI-YQNWVCDGEDDCKDNGDEDGCESGPH 261

  Fly   263 -LNLCEPQKGKFLCRNRETCLTLSEVCDGHSDCSDGSDETDLCHSK----PDCDAKKCALGAKCH 322
             ::.|.|:  ::.|.....|:::.:||||..||....||.:....|    ..|.|..|..  :||
Human   262 DVHKCSPR--EWSCPESGRCISIYKVCDGILDCPGREDENNTSTGKYCSMTLCSALNCQY--QCH 322

  Fly   323 MMPASGAECFCPKGFRLAKFEDK-CEDVDECKEQDDLCSQGCENTSGGYRCVCDAGYLLDKDNRT 386
            ..|..|| ||||.|:.:...:.: |.:.|:|:.. .:|.|.||:..|.:.|.|:.||:|:: .:.
Human   323 ETPYGGA-CFCPPGYIINHNDSRTCVEFDDCQIW-GICDQKCESRPGRHLCHCEEGYILER-GQY 384

  Fly   387 CRAVVYGSKEQQPLLLYTTQMTIMGMHLREDNVRNHVYQV---AGNLSKVIGVA--YDGSHIYWT 446
            |:|   .....:..::::.     |..|...::....:::   :.|....:|||  |....::||
Human   385 CKA---NDSFGEASIIFSN-----GRDLLIGDIHGRSFRILVESQNRGVAVGVAFHYHLQRVFWT 441

  Fly   447 N-IQNEAESIVKANGDGSNAEILLTSGLDAPEDLAVDWLTQNIYFSDNIMRHIAVCSNDGLNCAV 510
            : :||:..|:   :.:|.|.:.:|...::.||:|||||:...||..:..:..|.:.:.||.....
Human   442 DTVQNKVFSV---DINGLNIQEVLNVSVETPENLAVDWVNNKIYLVETKVNRIDMVNLDGSYRVT 503

  Fly   511 LVTQDVHQPRSLAVWPQKGLMFWTDW----GEKPMIGRASMDGSRSRPIVSDNIEWPNGIALDMH 571
            |:|:::..||.:||.|..|.:|::||    || |.:.||.||||..:.:|...:.||.|:.|||.
Human   504 LITENLGHPRGIAVDPTVGYLFFSDWESLSGE-PKLERAFMDGSNRKDLVKTKLGWPAGVTLDMI 567

  Fly   572 QQRIYWVDAKLGSVQTVRPDGTGRRTVLDG--MLKHPYGLAIFEDQLYWSDWATKSVHACHKFSG 634
            .:|:||||::...::||..||..|:||:.|  ::.||:|:::||.|::::||...:|...:||:.
Human   568 SKRVYWVDSRFDYIETVTYDGIQRKTVVHGGSLIPHPFGVSLFEGQVFFTDWTKMAVLKANKFTE 632

  Fly   635 KDHRIL--AKDRTIYAVHIYHPAKQPNSPHGCE--NATCSHLCLLA---EPEIGGHSCACPDGMR 692
            .:.::.  |..|. |.|.:||..:||.:.:.|:  |..|..:|:|:   :.:..|..|.|..|.:
Human   633 TNPQVYYQASLRP-YGVTVYHSLRQPYATNPCKDNNGGCEQVCVLSHRTDNDGLGFRCKCTFGFQ 696

  Fly   693 LAPDHRRCMLMEKRQRLFIGLGQVLLE-IEHTAFGRHQVSKSYT-LPCLINEMVYNRINGSLIIA 755
            |..|.|.|:.:   |...|...||.:. |..|...:..|....: .|.....:.::..:.::..:
Human   697 LDTDERHCIAV---QNFLIFSSQVAIRGIPFTLSTQEDVMVPVSGNPSFFVGIDFDAQDSTIFFS 758

  Fly   756 DNDQRLILEFQPESHESNVLVRSNLGNVSALAFDHLSRNLYWADTERAVIEVLSL--QTRHRALI 818
            |..:.:|.:.:.:.....:|..:.:.||.:||||.:|:||||.|:....|.|:.|  :|| |.::
Human   759 DMSKHMIFKQKIDGTGREILAANRVENVESLAFDWISKNLYWTDSHYKSISVMRLADKTR-RTVV 822

  Fly   819 RFFPGQEVPIGLTVMPAEGYLYV--------VLKA-KRHSHIDKIPLSGKGEQVHVFEDDLGDDD 874
            ::...   |..:.|.|..|||:.        :::| ...||:  :|         |....||..:
Human   823 QYLNN---PRSVVVHPFAGYLFFTDWFRPAKIMRAWSDGSHL--LP---------VINTTLGWPN 873

  Fly   875 IKLVTDYETQTIFWSDSDLGRISYSNY------RVPHSQIFRGKLRRPYSLAMVHHDLFWNELGT 933
             .|..|:....::|.|:...:|.:|.:      |:.|.:    ::..|:.||:....||:.:...
Human   874 -GLAIDWAASRLYWVDAYFDKIEHSTFDGLDRRRLGHIE----QMTHPFGLAIFGEHLFFTDWRL 933

  Fly   934 PRIYWTHKSNMGPRKVIDIMEKDDPAAIMPY----VPVATPNGIPLAASSPVGQESHPCQQQNGG 994
            ..|....|::.|...||    :...|.|:..    |.:.|       .|:...|.:||    ||.
Human   934 GAIIRVRKADGGEMTVI----RSGIAYILHLKSYDVNIQT-------GSNACNQPTHP----NGD 983

  Fly   995 CSHICVGEGPYHSICLCPAGFVYRDAGNRTCVEALDCE----------------FRCHSGECLTM 1043
            |||.|.....:..:|.||.|.  |.|.|.     |.||                |.|.:|.|:..
Human   984 CSHFCFPVPNFQRVCGCPYGM--RLASNH-----LTCEGDPTNEPPTEQCGLFSFPCKNGRCVPN 1041

  Fly  1044 NHRCNGRRDCVDNSDEMNCDEEHRRKPKVLCSPNQFACHSGEQCVDKERRCDNRKDCHDHSDEQH 1108
            .:.|:|..||.|||||..|...:.     .||.:.|.|..|| |:....|||.|.||.|.|||.:
Human  1042 YYLCDGVDDCHDNSDEQLCGTLNN-----TCSSSAFTCGHGE-CIPAHWRCDKRNDCVDGSDEHN 1100

  Fly  1109 CEKFDKSKKCHVHQHGCDNGKCVDSSLVCDGTNDCGDNSDELLCEATSRCEPGMFQCGSGSCIAG 1173
            |.....: .|...|:.|||.:|:..:.|||..|||||.|||..|.:|..|:|..|.|.:..||..
Human  1101 CPTHAPA-SCLDTQYTCDNHQCISKNWVCDTDNDCGDGSDEKNCNSTETCQPSQFNCPNHRCIDL 1164

  Fly  1174 SWECDGRIDCSDGSDEHDKCVHRSCPPDMQRCLLG-QCLDRSLVCDGHNDCGDKSDELNCGTDSS 1237
            |:.|||..||.|||||.. || .:|.....:|..| :|:..:..|||..||.|.|||..|.|...
Human  1165 SFVCDGDKDCVDGSDEVG-CV-LNCTASQFKCASGDKCIGVTNRCDGVFDCSDNSDEAGCPTRPP 1227

  Fly  1238 TMNISCAEDQYQCTSNLKICLPSTVRCNGTTECPRGEDE--ADCGDVCSIYEFKCRSGRECIRRE 1300
            .|   |..|::||..: .||:|:...|:|..:|..|.||  |.....|....|.|.:| .||.|.
Human  1228 GM---CHSDEFQCQED-GICIPNFWECDGHPDCLYGSDEHNACVPKTCPSSYFHCDNG-NCIHRA 1287

  Fly  1301 FRCDGQKDCGDGSDELSCELEKGHHNQSQIQPWSTSS--RSCRPHLFDCQDGECVDLSRVCNNFP 1363
            :.||...||||.|||..|          ..||:...|  ..|..|      ..||:||.||:...
Human  1288 WLCDRDNDCGDMSDEKDC----------PTQPFRCPSWQWQCLGH------NICVNLSVVCDGIF 1336

  Fly  1364 DCTNGHDEGPKC-ATACRSASGRQVCQHKCRATPAGAVCSCFDGYRLDADQKSCLDIDECQEQQP 1427
            ||.||.||.|.| ..:|...:|.  |.|:|...|.||.|.|..|:.|..|.|:|.|||||.....
Human  1337 DCPNGTDESPLCNGNSCSDFNGG--CTHECVQEPFGAKCLCPLGFLLANDSKTCEDIDECDILGS 1399

  Fly  1428 CAQLCENTLGGYQCQCHADFMLRQDRVSCKSLQSGATLLF----------SSFNEVRNL----SE 1478
            |:|.|.|..|.::|.|...:||..|..:||...|.:.||.          |..::|.|:    ..
Human  1400 CSQHCYNMRGSFRCSCDTGYMLESDGRTCKVTASESLLLLVASQNKIIADSVTSQVHNIYSLVEN 1464

  Fly  1479 QPVMLNVAWSANDSRITGFDLAMHRQMGYFSAEDEGIVYQIDLQTKVIVRALGLPAPTKLSVDWV 1543
            ...::.|.:.:...||...|....:.   :||...|...::...:.:|:       ...:::|||
Human  1465 GSYIVAVDFDSISGRIFWSDATQGKT---WSAFQNGTDRRVVFDSSIIL-------TETIAIDWV 1519

  Fly  1544 TGNVYVLSGAQEIQACSFVGRMCGRIVHVKSPRHVKHLAVD-------------GYHARIFYIVI 1595
            ..|:|....|.|....|.:......::..|:..:.:.||:|             |:|.|
Human  1520 GRNLYWTDYALETIEVSKIDGSHRTVLISKNLTNPRGLALDPRMNEHLLFWSDWGHHPR------ 1578

  Fly  1596 RTEGYGQTSSEIHMARLDGSRRDMLLQRSESFMTALTTDPHQQLLYFVDQHMRTLERISYRLKTG 1660
                       |..|.:|||.|.:::|....:...||.|...:||||:|.::..::...|   .|
Human  1579 -----------IERASMDGSMRTVIVQDKIFWPCGLTIDYPNRLLYFMDSYLDYMDFCDY---NG 1629

  Fly  1661 PMRRPEIMLQKSNALMHPSGLSVYENNAFIVNLGSVEAVQCALY--GSRICHKISINVLNAQ--- 1720
            ..||.  ::.....:.||..|:::|::.:..:..:...::...:  |::     |:.:.|.|
Human  1630 HHRRQ--VIASDLIIRHPYALTLFEDSVYWTDRATRRVMRANKWHGGNQ-----SVVMYNIQWPL 1687

  Fly  1721 DIVVAGRSRQPQKASHPCAHAHCHGLCLQADYG---YECMC--GNRLVAEGERC----------- 1769
            .||....|:||... :|||.:.|..|||.:..|   |.|:|  |..|..:...|
Human  1688 GIVAVHPSKQPNSV-NPCAFSRCSHLCLLSSQGPHFYSCVCPSGWSLSPDLLNCLRDDQPFLITV 1751

  Fly  1770 -----------PHGSGNE--VAVLGAVNSLELEHEH--------EQNGHFH---------WLMAL 1804
                       |....|:  |.:.|..|.|::|.:.        |..|..|         .:.|.
Human  1752 RQHIIFGISLNPEVKSNDAMVPIAGIQNGLDVEFDDAEQYIYWVENPGEIHRVKTDGTNRTVFAS 1816

  Fly  1805 FVLAAGSLIAGLGYMYYQYRQRGHTDLNINMHFQNP------LATLGG----TKAFLEHERAEAG 1859
            ..:...|:...|.:            ::.|::..||      :.||.|    .|..:.::....|
Human  1817 ISMVGPSMNLALDW------------ISRNLYSTNPRTQSIEVLTLHGDIRYRKTLIANDGTALG 1869

  Fly  1860 VGFTTETGTVSSRGS---NDTFTTTSATSSFAA 1889
            |||........:||.   :|..|.:...:..|:
Human  1870 VGFPIGITVDPARGKLYWSDQGTDSGVPAKIAS 1902

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
yl	NP_996433.1	LDLa	90..124	CDD:238060	15/35 (43%)
		LDLa	131..166	CDD:238060	11/34 (32%)
		LDLa	184..216	CDD:238060	13/31 (42%)
		LDLa	227..262	CDD:238060	17/34 (50%)
		LDLa	271..302	CDD:238060	10/30 (33%)
		FXa_inhibition	352..387	CDD:291342	11/34 (32%)
		Ldl_recept_b	442..482	CDD:278487	12/40 (30%)
		LY	466..508	CDD:214531	13/41 (32%)
		Ldl_recept_b	529..569	CDD:278487	17/43 (40%)
		LY	553..595	CDD:214531	16/41 (39%)
		LY	596..637	CDD:214531	14/42 (33%)
		FXa_inhibition	669..700	CDD:291342	10/33 (30%)
		LY	774..815	CDD:214531	18/42 (43%)
		LDLa	1032..1062	CDD:238060	14/45 (31%)
		LDLa	1074..1109	CDD:238060	17/34 (50%)
		LDLa	1118..1152	CDD:238060	17/33 (52%)
		LDLa	1157..1189	CDD:197566	15/31 (48%)
		LDLa	1198..1232	CDD:238060	13/34 (38%)
		LDLa	1243..1279	CDD:238060	14/37 (38%)
		LDLa	1283..1318	CDD:238060	16/34 (47%)
		LDLa	1340..1371	CDD:197566	12/30 (40%)
		FXa_inhibition	1388..1416	CDD:291342	12/27 (44%)
		EGF_CA	1418..1452	CDD:214542	14/33 (42%)
LRP2	NP_004516.2	LDLa	28..62	CDD:238060	9/45 (20%)
		LDLa	108..142	CDD:238060	12/36 (33%)
		LDLa	149..179	CDD:238060	1/29 (3%)
		LDLa	183..217	CDD:238060	16/35 (46%)
		LDLa	222..256	CDD:238060	17/34 (50%)
		LDLa	266..300	CDD:238060	12/35 (34%)
		LY	415..457	CDD:214531	11/44 (25%)
		LDL-receptor class B 1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	436..478		15/44 (34%)
		LY	461..501	CDD:214531	13/39 (33%)
		LDL-receptor class B 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	479..521		12/41 (29%)
		LY	503..548	CDD:214531	20/45 (44%)
		LDL-receptor class B 3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	522..568		20/46 (43%)
		LY	551..591	CDD:214531	16/39 (41%)
		LDL-receptor class B 4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	569..613		18/43 (42%)
		FXa_inhibition	663..704	CDD:291342	12/40 (30%)
		LDL-receptor class B 5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	753..795		9/41 (22%)
		LY	776..818	CDD:214531	16/41 (39%)
		LDL-receptor class B 6. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	796..837		14/44 (32%)
		LDL-receptor class B 7. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	838..881		12/54 (22%)
		Ldl_recept_b	838..878	CDD:278487	11/51 (22%)
		LY	864..904	CDD:214531	9/40 (23%)
		LDL-receptor class B 8. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	882..925		9/46 (20%)
		FXa_inhibition	981..1013	CDD:291342	14/38 (37%)
		LDLa	1026..1060	CDD:238060	13/33 (39%)
		LDLa	1067..1101	CDD:238060	17/34 (50%)
		LDLa	1109..1143	CDD:238060	17/33 (52%)
		LDLa	1149..1183	CDD:238060	17/34 (50%)
		LDLa	1187..1222	CDD:238060	13/34 (38%)
		LDLa	1230..1264	CDD:238060	13/34 (38%)
		LDLa	1271..1305	CDD:238060	16/34 (47%)
		LDLa	1311..1344	CDD:197566	13/38 (34%)
		FXa_inhibition	1353..1388	CDD:291342	14/36 (39%)
		EGF_CA	1390..1429	CDD:214542	15/38 (39%)
		LY	1461..1500	CDD:214531	7/41 (17%)
		LDL-receptor class B 9. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	1478..1520		9/51 (18%)
		LY	1501..1543	CDD:214531	9/48 (19%)
		LDL-receptor class B 10. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	1521..1563		9/41 (22%)
		LY	1545..1589	CDD:214531	12/60 (20%)
		LDL-receptor class B 11. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	1566..1609		13/59 (22%)
		LY	1591..1632	CDD:214531	11/43 (26%)
		LDL-receptor class B 12. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	1610..1654		13/48 (27%)
		LDL-receptor class B 13. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	1655..1695		6/44 (14%)
		LDL-receptor class B 14. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	1790..1832		6/53 (11%)
		LDL-receptor class B 15. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	1833..1882		11/48 (23%)
		LDL-receptor class B 16. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	1883..1930		4/20 (20%)
		Ldl_recept_b	1883..1927	CDD:278487	4/20 (20%)
		LY	1911..1953	CDD:214531
		LDL-receptor class B 17. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	1931..1972
		LDL-receptor class B 18. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	1973..2013
		FXa_inhibition	2022..2058	CDD:291342
		NHL	2091..2300	CDD:302697
		YncE	2092..>2285	CDD:225926
		NHL repeat	2097..2142	CDD:271320
		LDL-receptor class B 19. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	2107..2156
		NHL repeat	2147..2186	CDD:271320
		LDL-receptor class B 20. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	2157..2201
		NHL repeat	2192..2231	CDD:271320
		LDL-receptor class B 21. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	2202..2245
		NHL repeat	2235..2275	CDD:271320
		LDL-receptor class B 22. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	2246..2289
		FXa_inhibition	2346..2382	CDD:291342
		LDL-receptor class B 23. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	2431..2477
		LY	2459..2500	CDD:214531
		LDL-receptor class B 24. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	2478..2518
LY	2500..2542	CDD:214531
LDL-receptor class B 25. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	2519..2562
LY	2545..2585	CDD:214531
LDL-receptor class B 26. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	2563..2604
LDL-receptor class B 27. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	2605..2646
FXa_inhibition	2655..2692	CDD:291342
LDLa	2700..2732	CDD:238060
LDLa	2741..2775	CDD:238060
LDLa	2784..2817	CDD:238060
LDLa	2821..2854	CDD:197566
Ldl_recept_a	2863..2895	CDD:278486
LDLa	2905..2937	CDD:197566
LDLa	2948..2988	CDD:238060
LDLa	2993..3027	CDD:238060
LDLa	3031..3063	CDD:197566
LDLa	3075..3109	CDD:238060
cEGF	3132..3155	CDD:289433
vWFA	<3147..3190	CDD:294047
LY	3219..3260	CDD:214531
LDL-receptor class B 28. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	3239..3281
LY	3262..3304	CDD:214531
Ldl_recept_b	3282..3329	CDD:278487
LDL-receptor class B 29. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	3282..3324
LDL-receptor class B 30. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	3333..3376
Ldl_recept_b	3333..3373	CDD:278487
LY	3358..3399	CDD:214531
LDL-receptor class B 31. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	3377..3419
LY	<3408..3441	CDD:214531
LDL-receptor class B 32. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	3420..3460
FXa_inhibition	3469..>3498	CDD:291342
LDLa	3512..3544	CDD:197566
LDLa	3553..3584	CDD:197566
LDLa	3594..3626	CDD:238060
LDLa	3634..3666	CDD:197566
LDLa	3682..3714	CDD:238060
LDLa	3719..3754	CDD:238060
LDLa	3759..3793	CDD:238060
LDLa	3798..3832	CDD:238060
LDLa	3885..3915	CDD:197566
LDLa	3928..3962	CDD:238060
EGF_CA	4007..4047	CDD:214542
LY	4141..4176	CDD:214531
LDL-receptor class B 33. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	4154..4196
LDL-receptor class B 34. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	4197..4240
Ldl_recept_b	4197..4237	CDD:278487
LY	4222..4264	CDD:214531
LDL-receptor class B 35. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	4242..4283
SH3-binding. /evidence=ECO:0000255	4453..4462
PxLPxI/L motif 1, mediates interaction with ANKRA2. /evidence=ECO:0000250\|UniProtKB:P98158	4456..4461
PxLPxI/L motif 2, mediates interaction with ANKRA2. /evidence=ECO:0000250\|UniProtKB:P98158	4459..4464
Endocytosis signal. /evidence=ECO:0000255	4521..4526
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	4550..4574
Interaction with DAB2. /evidence=ECO:0000269\|PubMed:10769163	4589..4602
NPXY motif	4595..4598
SH2-binding. /evidence=ECO:0000255	4598..4601
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	4601..4655
SH3-binding. /evidence=ECO:0000255	4611..4622
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100345
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810