DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment yl and LRP1

DIOPT Version :9

Sequence 1:NP_996433.1 Gene:yl / 32367 FlyBaseID:FBgn0004649 Length:1984 Species:Drosophila melanogaster
Sequence 2:XP_016874792.1 Gene:LRP1 / 4035 HGNCID:6692 Length:4561 Species:Homo sapiens


Alignment Length:2011 Identity:535/2011 - (26%)
Similarity:779/2011 - (38%) Gaps:635/2011 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    29 FNLTSQTRAHPSSGGSTSSRYGN---CQRT-HLIINGRHVAISLLLLVGLCGGTAAGTPGSAD-- 87
            |:||.....|..........|.|   |::| ....|||.|:..|     .|.|......||.:  
Human  2557 FSLTCDGVPHCKDKSDEKPSYCNSRRCKKTFRQCSNGRCVSNML-----WCNGADDCGDGSDEIP 2616

  Fly    88 ---TRCDAGQFQCRDGGCILQAKMCDGRGDCKDSSDELDCD-------YR--------------- 127
               |.|..|:|:||||.||..:..|:...||:|:|||::|.       :|               
Human  2617 CNKTACGVGEFRCRDGTCIGNSSRCNQFVDCEDASDEMNCSATDCSSYFRLGVKGVLFQPCERTS 2681

  Fly   128 LCRPPHW-----------------------------FPCAQPHGACLAAELMCNGIDNCPGGEDE 163
            ||..|.|                             |.|  |.|.|:.....|:..|:|..||||
Human  2682 LCYAPSWVCDGANDCGDYSDERDCPGVKRPRCPLNYFAC--PSGRCIPMSWTCDKEDDCEHGEDE 2744

  Fly   164 LNCPVRPGFRFGDTAHRMRSCSKYEFMCQQDRTCIPIDFMCDGRPDCTDKSDEVAGCK-----QA 223
            .:|              .:.||:.:|.||..| ||...::|||..||.|.|||.|.|:     .:
Human  2745 THC--------------NKFCSEAQFECQNHR-CISKQWLCDGSDDCGDGSDEAAHCEGKTCGPS 2794

  Fly   224 EITCPGEGHLCANGRCLRRKQWVCDGVDDCGDGSDE---RGCL--NLCEPQKGKFLCRNRETCLT 283
            ..:|||. |:|...|      |:|||..||.||:||   .|||  :.|:.:  :|:|:||: |:.
Human  2795 SFSCPGT-HVCVPER------WLCDGDKDCADGADESIAAGCLYNSTCDDR--EFMCQNRQ-CIP 2849

  Fly   284 LSEVCDGHSDCSDGSDET-------------------------------DLCHSKPD-------- 309
            ...|||...||:|||||:                               :.||.:.|        
Human  2850 KHFVCDHDRDCADGSDESPECEYPTCGPSEFRCANGRCLSSRQWECDGENDCHDQSDEAPKNPHC 2914

  Fly   310 --------------CDAKKCALGA----------------KCHMMPA----------------SG 328
                          |.:.:|...|                .||:...                .|
Human  2915 TSQEHKCNASSQFLCSSGRCVAEALLCNGQDDCGDSSDERGCHINECLSRKLSGCSQDCEDLKIG 2979

  Fly   329 AECFCPKGFRLAKFEDKCEDVDECKEQDDLCSQGCENTSGGYRCVCDAGYL-LDKDNRTCRAVVY 392
            .:|.|..||||......|.|||||..... |||.|.||.|.|:|:|..||. ...|..:|:||. 
Human  2980 FKCRCRPGFRLKDDGRTCADVDECSTTFP-CSQRCINTHGSYKCLCVEGYAPRGGDPHSCKAVT- 3042

  Fly   393 GSKEQQPLLLYTTQMTIMGMHLREDNVRNHVYQ-VAGNLSKVIGVAYD--GSHIYWTNIQNEAES 454
               :::|.|::..:     .:||:.|:....|. :...|:..:.:.:|  ...||||::..:...
Human  3043 ---DEEPFLIFANR-----YYLRKLNLDGSNYTLLKQGLNNAVALDFDYREQMIYWTDVTTQGSM 3099

  Fly   455 IVKANGDGSNAEILLTSGLDAPEDLAVDWLTQNIYFSDNIMRHIAVCSNDGLNCAVLVTQDVHQP 519
            |.:.:.:|||.::|..:||..|:.|||||:..|:|:.|.....|.|...:|....|||:..:.:|
Human  3100 IRRMHLNGSNVQVLHRTGLSNPDGLAVDWVGGNLYWCDKGRDTIEVSKLNGAYRTVLVSSGLREP 3164

  Fly   520 RSLAVWPQKGLMFWTDWGEKPMIGRASMDGSRSRPIVSDNIEWPNGIALDMHQQRIYWVDAKLGS 584
            |:|.|..|.|.::|||||:..:|||..||||....||...|.||||:.||...:||||.||:...
Human  3165 RALVVDVQNGYLYWTDWGDHSLIGRIGMDGSSRSVIVDTKITWPNGLTLDYVTERIYWADAREDY 3229

  Fly   585 VQTVRPDGTGRRTVLDGMLKHPYGLAIFEDQLYWSDWATKSVHACHKFSGKDHRILAKDRTIYA- 648
            ::....||:.|..||...:.|.:.|.:|||.:||:||.|||::..||.:|.:..:|..  |::. 
Human  3230 IEFASLDGSNRHVVLSQDIPHIFALTLFEDYVYWTDWETKSINRAHKTTGTNKTLLIS--TLHRP 3292

  Fly   649 --VHIYHPAKQPNSP-HGCE--NATCSHLCLLAEPEIGGHSCACPDGMRLAPDHRRCMLMEKRQR 708
              :|::|..:||:.| |.|:  |..||:||||:..  |||.||||....|..|.|.|:       
Human  3293 MDLHVFHALRQPDVPNHPCKVNNGGCSNLCLLSPG--GGHKCACPTNFYLGSDGRTCV------- 3348

  Fly   709 LFIGLGQVLLEIEHTAFGRHQVSKSYTLPCLINEMVYNRINGSLIIADNDQRLILEFQPESHESN 773
                                                 :....|..:..||:              
Human  3349 -------------------------------------SNCTASQFVCKNDK-------------- 3362

  Fly   774 VLVRSNLGNVSALAFDHLSRNLYW-ADTERAVIEVLSLQTRHRALIRFFPGQEVPIGLTVMPAEG 837
                       .:.|       :| .||                                     
Human  3363 -----------CIPF-------WWKCDT------------------------------------- 3372

  Fly   838 YLYVVLKAKRHSHIDKIPLSGKGEQVHVFEDDLGDDDIKLVTDYETQTIFWSDSDLGRISYSNYR 902
                                         |||.||                              
Human  3373 -----------------------------EDDCGD------------------------------ 3378

  Fly   903 VPHSQIFRGKLRRPYSLAMVHHDLFWNELGTPRIYWTHKSNMGPRKVIDIMEKDDPAAIMPYVPV 967
              ||                                                 |:|    |..| 
Human  3379 --HS-------------------------------------------------DEP----PDCP- 3387

  Fly   968 ATPNGIPLAASSPVGQESHPCQQQNGGCSHICVGEGPYHSICLCPAGFVYRDAGNRTCVE----- 1027
                             ...|:.....||         ..||..|| |:.  .|:..|.:     
Human  3388 -----------------EFKCRPGQFQCS---------TGICTNPA-FIC--DGDNDCQDNSDEA 3423

  Fly  1028 ------ALDCEFRC-HSGECLTMNHRCNGRRDCVDNSDEMNCDEEHRRKPKVLCSPNQFACHSGE 1085
                  .|..:|:| ::..|:....||||:.:|.|..||.:|       |:|.|:||||.|...:
Human  3424 NCDIHVCLPSQFKCTNTNRCIPGIFRCNGQDNCGDGEDERDC-------PEVTCAPNQFQCSITK 3481

  Fly  1086 QC-----------------------------VDKER------------RCDNRKDCHDHSDE--Q 1107
            :|                             ||:.|            :||...||.|.|||  :
Human  3482 RCIPRVWVCDRDNDCVDGSDEPANCTQMTCGVDEFRCKDSGRCIPARWKCDGEDDCGDGSDEPKE 3546

  Fly  1108 HCEKFDKSKKCHVHQHGCDNGKCVDSSLVCDGTNDCGDNSDELLCEATSR-CEPGMFQCGSGSCI 1171
            .|::    :.|..:|..|.|.:||.....||..|||||||||..|  |.| |....|.|.:|.||
Human  3547 ECDE----RTCEPYQFRCKNNRCVPGRWQCDYDNDCGDNSDEESC--TPRPCSESEFSCANGRCI 3605

  Fly  1172 AGSWECDGRIDCSDGSDEHDKCVHRSCPPDMQRCLLGQCLDRSLVCDGHNDCGDKSDELNCGTDS 1236
            ||.|:|||..||:|||||.| |..| |..|..:|..|.|:.....||...||.|.|||..|||..
Human  3606 AGRWKCDGDHDCADGSDEKD-CTPR-CDMDQFQCKSGHCIPLRWRCDADADCMDGSDEEACGTGV 3668

  Fly  1237 STMNISCAEDQYQCTSNLKICLPSTVRCNGTTECPRGEDE--ADCGD-VCSIYE-FKCRSGRECI 1297
            .|    |..|::||.:.|  |.|...:|:|..:|....||  .:|.. ||.... |:|::.|.|:
Human  3669 RT----CPLDEFQCNNTL--CKPLAWKCDGEDDCGDNSDENPEECARFVCPPNRPFRCKNDRVCL 3727

  Fly  1298 RREFRCDGQKDCGDGSDELSCELEKGHHNQSQIQPWSTSSRSCRPHL-FDCQDGECVDLSRVCNN 1361
            ....:|||..:||||:||..||            |.:..:..|:... |.|::..|:..|..||.
Human  3728 WIGRQCDGTDNCGDGTDEEDCE------------PPTAHTTHCKDKKEFLCRNQRCLSSSLRCNM 3780

  Fly  1362 FPDCTNGHDE-----GPKCATACRSASGRQVC--QHKCRATPAGAVCSCFDGYRLDADQKSCLDI 1419
            |.||.:|.||     .|| .|:|  |:...:|  :.:|..|...|.|:|..|:.....|..|.||
Human  3781 FDDCGDGSDEEDCSIDPK-LTSC--ATNASICGDEARCVRTEKAAYCACRSGFHTVPGQPGCQDI 3842

  Fly  1420 DECQEQQPCAQLCENTLGGYQCQCHADFMLRQDRVSCKSLQSGATLLF-SSFNEVRNL------- 1476
            :||.....|:|||.||.||:.|.|..:||...:  :||:..|...:|: :..||:|:|       
Human  3843 NECLRFGTCSQLCNNTKGGHLCSCARNFMKTHN--TCKAEGSEYQVLYIADDNEIRSLFPGHPHS 3905

  Fly  1477 -SEQPVMLNVAWSANDS-RITGFDLAMHRQMGYFSAEDEGIV------------------YQIDL 1521
             .||      |:..::| ||...|:.:.....|::....|.:                  .||| 
Human  3906 AYEQ------AFQGDESVRIDAMDVHVKAGRVYWTNWHTGTISYRSLPPAAPPTTSNRHRRQID- 3963

  Fly  1522 QTKVIVRALGLPAPTKLSVDWVTGNVY-VLSGAQEIQACSFVGRMCGRIVH--VKSPRHVKHLAV 1583
            :....:...||..|..:::|||.|||| ..||...|:.....|.....::.  :..|..:   .|
Human  3964 RGVTHLNISGLKMPRGIAIDWVAGNVYWTDSGRDVIEVAQMKGENRKTLISGMIDEPHAI---VV 4025

  Fly  1584 DGYHARIFYIVIRTEGYGQTSSEIHMARLDGSRRDMLLQRSESFMTALTTDPHQQLLYFVDQHMR 1648
            |.....:::     ..:| ...:|..|.:||:.|:.|:|.:..:.|.|..|.|.:.||:.|..:.
Human  4026 DPLRGTMYW-----SDWG-NHPKIETAAMDGTLRETLVQDNIQWPTGLAVDYHNERLYWADAKLS 4084

  Fly  1649 TLERISYRLK-TGPMRRPEIMLQKSNALMHPSGLSVYENNAFIVNLGSVEAVQCALYGSRICHKI 1712
            .:.  |.||. |.|:    :.......|.||..:.|:|:..:.|...:....:...:|......:
Human  4085 VIG--SIRLNGTDPI----VAADSKRGLSHPFSIDVFEDYIYGVTYINNRVFKIHKFGHSPLVNL 4143

  Fly  1713 SINVLNAQDIVVAGRSRQPQKASHPCAHAHCHGLCLQADYGYECMCGNRLVAEGERCPHGS 1773
            :..:.:|.|:|:..:.:||: .::||....|..|||.:..|..|.|.|     |:|..:|:
Human  4144 TGGLSHASDVVLYHQHKQPE-VTNPCDRKKCEWLCLLSPSGPVCTCPN-----GKRLDNGT 4198

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ylNP_996433.1 LDLa 90..124 CDD:238060 16/33 (48%)
LDLa 131..166 CDD:238060 14/63 (22%)
LDLa 184..216 CDD:238060 15/31 (48%)
LDLa 227..262 CDD:238060 16/37 (43%)
LDLa 271..302 CDD:238060 15/61 (25%)
FXa_inhibition 352..387 CDD:291342 14/35 (40%)
Ldl_recept_b 442..482 CDD:278487 14/39 (36%)
LY 466..508 CDD:214531 15/41 (37%)
Ldl_recept_b 529..569 CDD:278487 20/39 (51%)
LY 553..595 CDD:214531 17/41 (41%)
LY 596..637 CDD:214531 17/40 (43%)
FXa_inhibition 669..700 CDD:291342 16/30 (53%)
LY 774..815 CDD:214531 4/41 (10%)
LDLa 1032..1062 CDD:238060 11/30 (37%)
LDLa 1074..1109 CDD:238060 18/77 (23%)
LDLa 1118..1152 CDD:238060 17/33 (52%)
LDLa 1157..1189 CDD:197566 18/32 (56%)
LDLa 1198..1232 CDD:238060 13/33 (39%)
LDLa 1243..1279 CDD:238060 12/37 (32%)
LDLa 1283..1318 CDD:238060 14/35 (40%)
LDLa 1340..1371 CDD:197566 11/31 (35%)
FXa_inhibition 1388..1416 CDD:291342 8/29 (28%)
EGF_CA 1418..1452 CDD:214542 16/33 (48%)
LRP1XP_016874792.1 None


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1215
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100345
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.710

Return to query results.
Submit another query.