DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment yl and CG32432

DIOPT Version :9

Sequence 1:	NP_996433.1	Gene:	yl / 32367	FlyBaseID:	FBgn0004649	Length:	1984	Species:	Drosophila melanogaster
Sequence 2:	NP_649266.1	Gene:	CG32432 / 40310	FlyBaseID:	FBgn0052432	Length:	1307	Species:	Drosophila melanogaster

Alignment Length:	1578	Identity:	287/1578 - (18%)
Similarity:	462/1578 - (29%)	Gaps:	627/1578 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 PSEQRIRVESPKMTASRRGFNLTSQTRAH-------PSSGGSTSSRYGNC-------QRTHLI-- 58
            ||||...|...::..|      ||.|:..       |::...|||..|:|       |:.|.:
  Fly    68 PSEQHRNVAKMRLKVS------TSATQCRAIKATETPATSKMTSSCSGHCQSQQQQQQQQHQLQQ 126

  Fly    59 -------INGRH---VAISLLLLVGLCGGTAAGTPGSADTRCDAGQFQCRDGGCILQAKMCDGRG 113
                   ...||   ..::|||.:|:..|.||       |...||     .||        .|.|
  Fly   127 QHQQSQHQQRRHPLPATLTLLLCLGISLGMAA-------TAAAAG-----GGG--------GGGG 171

  Fly   114 DCKDSSDELDCDYRLCRPPHWFPCAQPHGACLAAELMCNGIDNCPGGEDELNCPVRPGFRFGDTA 178
            .                               ||.:..:|....|.....::..:.||
  Fly   172 G-------------------------------AAPVSGSGAAGFPSSSSSISSSLGPG------- 198

  Fly   179 HRMRSCSKYEFMCQQDRTCIPIDFMCDGRPDCTDKSDEVAGCKQAEITCPGEGHLCANGRCLRRK 243
                               .|::.........|       ||..||.:       |:||||:...
  Fly   199 -------------------KPVNLQLAPGSSST-------GCSLAEFS-------CSNGRCVPLS 230

  Fly   244 QWVCDGVDDCGDGSDE-RGC----------------LNLCEPQKGK--FLCRNRETCLTLSEVCD 289
            :: |:.::|||||||| |.|                |.|..|::.:  |:|     .||.:....
  Fly   231 KY-CNNLNDCGDGSDEPRFCTRCNRTYYGDIGQTYALELHRPKQDRVPFVC-----VLTFTAAGG 289

  Fly   290 GHSDCSDGSDETDLCHSKPDCDAKKCALGAKCHMMPASGAECFCPKGFRLAKFEDKCEDVDECKE 354
            .|.|....:.::                                   |.:.:|
  Fly   290 QHGDVVQVTLDS-----------------------------------FTIGRF------------ 307

  Fly   355 QDDLCSQGCENTSGGYRCVCDAGYLLDKDNRTCRAVVYGSKEQQPLLLYT-TQMTIMGMHL---- 414
             .....:||.:   ||..:.::.       ||....::......|:|.|: |:..|..:.|
  Fly   308 -TSYVHEGCPD---GYMQIAESA-------RTPIGGMWCGSSWGPVLFYSETRSLIFTIRLNRLA 361

  Fly   415 REDNVRNH----VYQVAGNLSKVIGVAYDGSHI----YWTN---------IQNEAESIVKANGDG 462
            |:.:..|.    .|:|....|.|  ..|.|..:    .|.|         .|.:.:...:....|
  Fly   362 RDQSGYNFDFRIRYKVLSRDSSV--TRYGGIKLAELAQWHNRSSFLNQQQQQQQQQQQQQQQQQG 424

  Fly   463 SNAEILLTSGLDAPEDLAVDWLTQNIYFSDNIMRHIAVCSNDGLNCAVLVTQDVHQPRSLAVWPQ 527
                        || .:..|:...::..||...:..::.|....|...:.:.:    :|||
  Fly   425 ------------AP-GILEDFTNSSVARSDRYGQDFSLFSAYANNKTFMASLE----KSLA---- 468

  Fly   528 KGLMFWTDWGEKPMIGRASMDGSRSRPIVSD------NIEWPNGIALDMHQQRIYWVDAKLGSVQ 586
            |....:|:  .|..:|.. :.|:....|.||      .::.||...:.......|:
  Fly   469 KDEQNYTE--PKYYLGDL-IPGTYCSRIFSDCDKKPCRLQSPNFPGIYPRNLTCYY--------- 521

  Fly   587 TVRPDGT--GRRTVLDGMLKHPYGLAIFEDQLYWSDWATKSVHACHKF------SGKDHRILAKD 643
            .||....  |:..::  ::|.|.|      .|.|.  :|:...|.:|.      |.||.:...:.
  Fly   522 AVRQHDVPHGKHALI--LVKQPKG------NLVWI--STQETAAANKMAPPPSASDKDKKFEPRL 576

  Fly   644 RT-IYAVHIYHPAKQPNSP--HGCENATCSHLCLLAEPEI-----GGHSCACPDGMRLAPDHRRC 700
            :| .|..:|....|    |  ...:..|........:|.|     ||.  |.|..:...|
  Fly   577 KTWNYCDYIQENVK----PKWKSTDYVTVYDGYTTRDPIILKFCGGGQ--AVPAAVSSGP----- 630

  Fly   701 MLMEKRQRLFIGLGQVLLEIEHTAFGRHQVSKSYTLPCL------------INEMVYNR------ 747
                          ::|:|...:.||....:.|..||..            |....|::
  Fly   631 --------------ELLVEFSTSPFGTFTGTSSQVLPLYGFQLEVEVQFVDIQSPTYSKNKKPCE 681

  Fly   748 --INGSLIIADNDQRLILEFQPESHESNVLVRSNLGNVSAL-AFDH----------------LSR 793
              |.|:       .|.|||....|...|.....:|..:... .|||                |||
  Fly   682 FWIRGA-------GRGILESPKHSLAPNSTCLYHLQGLGVFKTFDHLSLSRRTSSQSGMHQPLSR 739

  Fly   794 NLYWA---------------DTERAVIEVLSLQTRHRALIRFFPG--QEVPIGLTVMPA-EGYLY 840
            ...|.               :|....|.||..|.....::|.:.|  ::.|:...:..| |...|
  Fly   740 FKVWISVLKFNLDPEFGQIDETSVGAIGVLQTQEDCSGMLRIWDGTLRDAPVCKDLNCATETSSY 804

  Fly   841 VVLKAKRHSHIDKIPLSGKGEQVHVFE-DDLGDDDIKLVTDYETQTIFWSDSDLGRISYSNYRVP 904
            ..|....|:....|....:|......: .::.:...:..|..|:   :.|.||...:...|   .
  Fly   805 NTLGHYTHNSTSVIARFCRGTIPRTCDRSNINETYARPCTISES---YVSTSDAITLELRN---T 863

  Fly   905 HSQIFRG---KLRRPYSLAMVHHDLFWNELGTPRIYW---THKSNMGPRKVI-DIMEKDDPAAIM 962
            .|.:.|.   ||:  |....:|.|      |.|   |   .|..|   ||.: .:|::.|||...
  Fly   864 ESTVLRPLDFKLK--YEFIDLHQD------GLP---WGGGEHDCN---RKFLSSMMDRKDPAIFR 914

  Fly   963 PYVPVATPNGIPLAASSPVGQESHPCQQQNGGCSHICVGEGPYHSICLCPAGFVYRDAGNRTCVE 1027
            ....:                                               |::...|.|.
  Fly   915 SVRNI-----------------------------------------------FLFGRGGTRN--- 929

  Fly  1028 ALDC--EFRCHSGE--------CLTMNHRCNGRRDCVDNSDEMN---CDEEHRRKPKVLCSP--N 1077
             |.|  :|....||        ..|.|..|..|.|     :::|   |..:...:.::...|  :
  Fly   930 -LKCIYKFEAQRGERVRIKMRKVTTTNRPCYSRVD-----EDINRSFCYGDTNVRIEIFERPYHD 988

  Fly  1078 QFACHSGEQCVDKERRCDNRKDCHDHSDEQH--CEKFDKSKKCHVHQHGCDNGKCVDSSLVCDGT 1140
            ....|.|..|              :.|::.|  .|....|:...||             .:....
  Fly   989 SILLHRGCMC--------------NSSNQSHLPVEYTSTSRDVEVH-------------FIAQNM 1026

  Fly  1141 NDCGD----NSDEL--LCEATSRCEPGMFQCGSGSCI---AGSWECDGR---IDCSDGS------ 1187
            ....|    |.:.:  ..:|.:.|:.|..:.|....|   .|..||..|   |:.|:|:
  Fly  1027 TTLDDPDTVNFEGMFEFVKAPTSCKDGRRKFGPSGTIDMTFGDVECRSRPWLIEPSNGNKFLYVR 1091

  Fly  1188 ------DEHD---------------KCVHRS--------------CP--PDMQRCLLGQCLDRSL 1215
                  .:|:               :|..:|              ||  ||.......:     :
  Fly  1092 LKAIFLSKHNPTQTLNATYVQTDTWRCETKSRAVLTTSEGLTIVACPLSPDSNAYEFVE-----I 1151

  Fly  1216 VCDGHNDCGD----------KSDELNCGTDSSTMN---------ISCAED-QYQCTSNLKICLPS 1260
            ...|.|:..:          ..:.|..|....:.|         :|.||| |::| :.|..|:.:
  Fly  1152 FSSGWNERPNFALVNRSRAISVEFLRPGNGEYSFNWMELIPRPTLSMAEDCQFKC-AELGACVNA 1215

  Fly  1261 TVRCNGTTECPRGEDEA--DC-----------GDVCSIYEFKCRSGREC---------IRREFRC 1303
            :|.|:|...||.|:||.  .|           ..:|.|:...|     |         |:|:.|
  Fly  1216 SVWCDGVVHCPSGDDETFLQCSALMKLPAEILATLCLIFVLSC-----CAFAAFAYKKIKRKLR- 1274

  Fly  1304 DGQKDCGDGSDELSCELE 1321
                    ||..|...|:
  Fly  1275 --------GSSVLQTRLK 1284

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
yl	NP_996433.1	LDLa	90..124	CDD:238060	6/33 (18%)
		LDLa	131..166	CDD:238060	4/34 (12%)
		LDLa	184..216	CDD:238060	2/31 (6%)
		LDLa	227..262	CDD:238060	15/35 (43%)
		LDLa	271..302	CDD:238060	6/32 (19%)
		FXa_inhibition	352..387	CDD:291342	5/34 (15%)
		Ldl_recept_b	442..482	CDD:278487	6/52 (12%)
		LY	466..508	CDD:214531	6/41 (15%)
		Ldl_recept_b	529..569	CDD:278487	9/45 (20%)
		LY	553..595	CDD:214531	8/49 (16%)
		LY	596..637	CDD:214531	10/46 (22%)
		FXa_inhibition	669..700	CDD:291342	7/35 (20%)
		LY	774..815	CDD:214531	13/72 (18%)
		LDLa	1032..1062	CDD:238060	9/40 (23%)
		LDLa	1074..1109	CDD:238060	6/38 (16%)
		LDLa	1118..1152	CDD:238060	4/39 (10%)
		LDLa	1157..1189	CDD:197566	11/49 (22%)
		LDLa	1198..1232	CDD:238060	7/45 (16%)
		LDLa	1243..1279	CDD:238060	15/38 (39%)
		LDLa	1283..1318	CDD:238060	10/43 (23%)
		LDLa	1340..1371	CDD:197566
		FXa_inhibition	1388..1416	CDD:291342
		EGF_CA	1418..1452	CDD:214542
CG32432	NP_649266.1	LDLa	214..245	CDD:197566	15/38 (39%)
		CUB	503..646	CDD:238001	34/186 (18%)
		LDLa	1203..1231	CDD:197566	10/28 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1215
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900