DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment yl and vldlr

DIOPT Version :9

Sequence 1:	NP_996433.1	Gene:	yl / 32367	FlyBaseID:	FBgn0004649	Length:	1984	Species:	Drosophila melanogaster
Sequence 2:	XP_005155618.1	Gene:	vldlr / 393897	ZFINID:	ZDB-GENE-040426-803	Length:	877	Species:	Danio rerio

Alignment Length:	955	Identity:	278/955 - (29%)
Similarity:	405/955 - (42%)	Gaps:	245/955 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 GGSTSSRYGNCQRTHLII-NGRHVAISLLLLVGLCGGTAAGTPGSADT-----RCDAGQFQCRDG 100
            |.|.:|| ..|:::.... |||.:.     .|..|.|....:.||.:|     .|....|.||.|
Zfish    20 GFSRASR-AECEQSQFQCGNGRCIP-----SVWQCDGDMDCSDGSDETSCVRKTCAEVDFVCRSG 78

  Fly   101 GCILQAKMCDGRGDCKDSSDEL--DCDYRLCR--------------PPHW--------------- 134
            .||.:...|||..||:|.|||.  .|..|.||              |..|
Zfish    79 QCIPKRWQCDGEPDCEDGSDESIEMCHTRTCRVNEFSCGVGSTQCIPVFWKCDGEKDCDNGEDEI 143

  Fly   135 -----------FPCAQPHGACLAAELMCNGIDNCPGGEDELNCPVRPGFRFGDTAHRMRSCSKYE 188
                       |.|:.  |.|::.:.:|||.|:|..|.||.:|  .|.           |||..|
Zfish   144 NCGNITCAPLEFTCSS--GRCVSRKFVCNGEDDCGDGSDEQDC--APS-----------SCSPSE 193

  Fly   189 FMCQQDRTCIPIDFMCDGRPDCTDKSDE-----------VAGCKQAEITCPGEGHLCANGRCLRR 242
            ..| .:.||||..::||...||.|:|||           .|.|..:|:.       |.:|.|:.|
Zfish   194 IPC-GNNTCIPRSWLCDDDVDCQDQSDESPERCGHNPTPPAKCSPSEMQ-------CGSGECIHR 250

  Fly   243 KQWVCDGVDDCGDGSDERGC-LNLCEPQKGKFLCRNRETCLTLSEVCDGHSDCSDGSDETDLCHS 306
            | |.|||..||.|||||:.| ...|.|.  :|.| :..:|:..|..|:|..||.||:||.: |.:
Zfish   251 K-WRCDGDPDCKDGSDEKNCSARNCRPD--QFKC-DDGSCIHGSRQCNGFRDCVDGTDEVN-CKN 310

  Fly   307 KPDC---DAKKCALG-----------------------AKCHMMP---------------ASGAE 330
            ...|   |..||..|                       .:|:|..               ..|.|
Zfish   311 LTQCNSSDQFKCRSGECIEMSKVCNKVRDCPDWSDEPIKECNMNECLINNGGCSHICRDLTIGFE 375

  Fly   331 CFCPKGFRLAKFEDKCEDVDECKEQDDLCSQGCENTSGGYRCVCDAGYLLDKDNRTCRAVVYGSK 395
            |.|..|.:|.. ...|.||:||. ...:|||.|.|..|||:|.|..||.:|.....|:||
Zfish   376 CDCTPGLQLID-RKTCGDVNECL-NPGICSQICINLKGGYKCECHNGYQMDPTTGVCKAV----- 433

  Fly   396 EQQPLLLYTTQMTI--MGMHLRE-----DNVRNHVYQVAGNLSKVIGVAYDGSHIYWTNI-QNEA 452
            .::|.|::|.:..|  :|:..||     :.:||.|...|..:.::         |:|.:: |...
Zfish   434 GKEPCLIFTNRRDIRKLGLERREYTQIVEQLRNTVALDADFIQQM---------IFWADLGQKAI 489

  Fly   453 ESIVKANGDGSNAEILLTSGLDAPEDLAVDWLTQNIYFSDNIMRHIAVCSNDGLNCAVLVTQDVH 517
            .|.|....|.|:.:::  ..:..|..:||||:.:|||:||...:.|.|.:.:|....||....:.
Zfish   490 FSTVLDKQDESHKKVI--DDVQMPVGIAVDWIYKNIYWSDLGSKSITVANFNGTKKKVLFNSGLK 552

  Fly   518 QPRSLAVWPQKGLMFWTDWGEKPMIGRASMDGSRSRPIVSDNIEWPNGIALDMHQQRIYWVDAKL 582
            :|.|:||.|..|.::|:||||...|.::.|:|:..:.:|..:|:|||||.||:.:.|:||||:||
Zfish   553 EPASIAVDPLSGFLYWSDWGEPAKIEKSGMNGNDRQVLVETDIQWPNGITLDLIKGRLYWVDSKL 617

  Fly   583 GSVQTVRPDGTGRRTVLDG--MLKHPYGLAIFEDQLYWSDWATKSVHACHKFSGKDHRILAKD-R 644
            ..:.:|..:|..||.||..  .|.||:.|.:|||:::|:|...::::..:||:|.|..:||.: .
Zfish   618 HMLCSVDLNGDNRRKVLQSPDYLAHPFALTVFEDRVFWTDGENEAIYGANKFTGSDVTLLASNLN 682

  Fly   645 TIYAVHIYHPAKQPNSPHGC----ENATCSHLCLLAEPEIGGHS----CACPDGMRLAPDHRRCM 701
            ....:.:||...|.:..:.|    ||..||.:||.| |:|..||    |.||:|..||.|..||.
Zfish   683 EPQDIIVYHELIQLSGTNWCNEKMENGGCSFMCLPA-PQINKHSPKYTCVCPEGQTLASDGLRCR 746

  Fly   702 LMEKRQRLFIGLGQVLLEIEHTAFGRHQVSKSYTLPCLINEMVYNRINGSLIIADNDQRLILEFQ 766
            ..........| |||.....|        .|:.::..:.:|.|:...|.|..|
Zfish   747 AEATSAAPQDG-GQVTTRPSH--------PKASSVSKVASEPVHTEGNLSTSI------------ 790

  Fly   767 PESHESNVLVRSNLGNVSALAFDHLSRNLYWADTERAVIEVLSLQTRHRALIRFFPGQEVPIGLT 831
               ||.|...|   |:.:|           |     |::.||.                    |.
Zfish   791 ---HEVNTSAR---GSAAA-----------W-----AILPVLL--------------------LA 813

  Fly   832 VMPAEGYLY---VVLKAKRHSHIDKIPLSGKGEQVHVFEDDLGDD 873
            :..|.|||.   ..:|.|:..:.|. |:     .:...|:||..|
Zfish   814 MAAAGGYLMWRNWQIKNKKSMNFDN-PV-----YLKTTEEDLNID 852

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
yl	NP_996433.1	LDLa	90..124	CDD:238060	16/35 (46%)
		LDLa	131..166	CDD:238060	14/60 (23%)
		LDLa	184..216	CDD:238060	14/31 (45%)
		LDLa	227..262	CDD:238060	16/34 (47%)
		LDLa	271..302	CDD:238060	12/30 (40%)
		FXa_inhibition	352..387	CDD:291342	14/34 (41%)
		Ldl_recept_b	442..482	CDD:278487	9/40 (23%)
		LY	466..508	CDD:214531	13/41 (32%)
		Ldl_recept_b	529..569	CDD:278487	16/39 (41%)
		LY	553..595	CDD:214531	18/41 (44%)
		LY	596..637	CDD:214531	15/42 (36%)
		FXa_inhibition	669..700	CDD:291342	16/34 (47%)
		LY	774..815	CDD:214531	7/40 (18%)
		LDLa	1032..1062	CDD:238060
		LDLa	1074..1109	CDD:238060
		LDLa	1118..1152	CDD:238060
		LDLa	1157..1189	CDD:197566
		LDLa	1198..1232	CDD:238060
		LDLa	1243..1279	CDD:238060
		LDLa	1283..1318	CDD:238060
		LDLa	1340..1371	CDD:197566
		FXa_inhibition	1388..1416	CDD:291342
		EGF_CA	1418..1452	CDD:214542
vldlr	XP_005155618.1	LDLa	29..63	CDD:238060	10/38 (26%)
		LDLa	67..99	CDD:197566	14/31 (45%)
		Ldl_recept_a	107..145	CDD:278486	5/37 (14%)
		Ldl_recept_a	149..184	CDD:278486	12/36 (33%)
		Ldl_recept_a	234..269	CDD:278486	18/42 (43%)
		Ldl_recept_a	272..308	CDD:278486	14/39 (36%)
		LDLa	316..346	CDD:238060	4/29 (14%)
		FXa_inhibition	356..390	CDD:291342	6/34 (18%)
		EGF_CA	392..426	CDD:214542	17/34 (50%)
		NHL	479..>570	CDD:302697	29/92 (32%)
		LY	504..541	CDD:214531	12/38 (32%)
		NHL repeat	511..551	CDD:271320	15/39 (38%)
		Ldl_recept_b	564..604	CDD:278487	16/39 (41%)
		LY	588..630	CDD:214531	18/41 (44%)
		Ldl_recept_b	651..690	CDD:278487	9/38 (24%)
		FXa_inhibition	707..745	CDD:291342	18/38 (47%)
		Mucin	<723..817	CDD:250634	33/156 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1215
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810