DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment yl and frac

DIOPT Version :9

Sequence 1:NP_996433.1 Gene:yl / 32367 FlyBaseID:FBgn0004649 Length:1984 Species:Drosophila melanogaster
Sequence 2:NP_001137905.1 Gene:frac / 38850 FlyBaseID:FBgn0035798 Length:1618 Species:Drosophila melanogaster


Alignment Length:1483 Identity:274/1483 - (18%)
Similarity:401/1483 - (27%) Gaps:675/1483 - (45%)


- Green bases have known domain annotations that are detailed below.


  Fly   208 PDCTDKSDEVA-----GCKQAEITCP--GEGHLCANGRCLRRKQ------WVCDGVDDCGDGSDE 259
            |:....||.:|     .|..|:|..|  ..|.:....|..|.|:      :|||...|..:|..|
  Fly    34 PEDPKVSDSLAASLDMSCSSAKILPPEINHGRVSVFDRRRRGKKVFLVAFFVCDDNYDFENGISE 98

  Fly   260 RGCLN--------LCEPQKGKFLCRNRETCLTLSEVCD--------GHSDCSDGSDE-------- 300
            ..|.|        .|.||. .|...:.:....|.:..|        .:||..:..||        
  Fly    99 MFCSNQKWVDEIPTCIPQL-NFEEHDEKVGYDLEDYSDETVPNDYVENSDIDEDDDEEVSEREPP 162

  Fly   301 -------TDLCHSKPD------------------------------------------------- 309
                   .|...|||:                                                 
  Fly   163 PPPPPPVVDGADSKPEPQIVIEINDDHANEVVESEPALAETETENEVLENETPLKAEVQTDVLNS 227

  Fly   310 --------------------C--DAKKCALGAKCHMMPASGA---ECFCPKGFRLAKFE-DKCED 348
                                |  |...||...|..:.|....   :|.|.:|:.|...: ..|.|
  Fly   228 SNASVKVTNDPYEPTFLDNNCGEDNGGCAHICKRLLYPDENQPINKCDCREGYTLDPNDYASCLD 292

  Fly   349 VDECKEQDDLCSQGCENTSGGYRCVCDAGYLLDKDNRTCRAV-----------VYGSKEQ----- 397
            :|||.|.:..||:.|||..|.|:|.|..||.||:..::|..:           ..|:.|.     
  Fly   293 IDECLESNGGCSEICENLPGEYKCSCQEGYYLDESGKSCVDINECANPELSSNCQGACENLPGSY 357

  Fly   398 ---QPLLLYTTQMTIMGMHLREDNVRNHVYQVAGNLSKVIGVAYDGSHIYWTNIQNE------AE 453
               :||               |:|         ..:::|:....:.::....|:...      ..
  Fly   358 RCVEPL---------------EEN---------PEITEVVENPIEKTNEVPVNVSESQPAGKTCN 398

  Fly   454 SIVKANGDGSNAEILLTSGLDAPEDLAVDWLTQNIYFSDNIMRHIAVCSNDGLNCAVLVTQDVHQ 518
            |..:.:.||::.:.:....:|.||||            ||    .|||                 
  Fly   399 SGFQLSADGTDCQDINECEVDGPEDL------------DN----NAVC----------------- 430

  Fly   519 PRSLAVWPQKGLMFWTDWGEKPMIGRASMDGSRSRPIVSDNIEWPNGIALDMHQQRIYWVDAKLG 583
                                                                 ||:         
  Fly   431 -----------------------------------------------------QQK--------- 433

  Fly   584 SVQTVRPDGTGRRTVLDGMLKHPYGLAIFEDQLYWSDWATKSVHACHKFSGKDHRILAKDRTIYA 648
            ...|:   |:.|.|.::|.  |     :.|||           .:|...|..|......:||   
  Fly   434 CENTI---GSFRCTCVEGY--H-----LLEDQ-----------RSCALDSCTDLENPQLNRT--- 474

  Fly   649 VHIYHPAKQPNSPHGCENATCSHLCLLAEPEIGGHSCACPDGMRLAPDHRRCMLMEKRQRLFIGL 713
                               .|:|.| ...|| |.:.|.||.|..|:.|...|::.|.        
  Fly   475 -------------------RCAHEC-QDLPE-GSYRCVCPKGYELSEDQHSCLVQES-------- 510

  Fly   714 GQVLLEIEHTAFGRHQVSKSYTLPCLINEMVYNRINGSLIIADNDQRLILEFQPESHESNVLVRS 778
                                   ||...:.| .:.:....:|..|........|..:.|...   
  Fly   511 -----------------------PCSTEKGV-EKCSPGTCLASEDNTSFSCICPTGYRSEAF--- 548

  Fly   779 NLGNVSALAFD-HLSRNLYWADTERAVIEVLSLQTRHRALIRFFPGQEVPIGLTVMPAEGYLYVV 842
            :..::...|.| ||..:..                           |..|.|......||     
  Fly   549 SCQDIDECAEDTHLCSHTC---------------------------QNTPGGYQCQCPEG----- 581

  Fly   843 LKAKRHSHIDKIPLSGKGEQVHVFEDDLGDDDIKLVTDYETQTIFWSDSDLGRISYSNYRVPHSQ 907
                                            :.||.:|.                         
  Fly   582 --------------------------------LNLVEEYT------------------------- 589

  Fly   908 IFRGKLRRPYSLAMVHHDLFWNELGTPRIYWTHKSNMGPRKVIDIMEKDDPAAIMPYVPVATPNG 972
                      .||                     .|:                            
  Fly   590 ----------CLA---------------------ENL---------------------------- 595

  Fly   973 IPLAASSPVGQESHPCQQQNGGCSHICV-GEGPYHSICLCPAGFVYRDAGNRTCVEALDCEFRCH 1036
                           |:..|.||..||: ..|   .:|.|..||       |...:...||   .
  Fly   596 ---------------CEVNNNGCEQICLTARG---GVCACREGF-------RLSADGKSCE---D 632

  Fly  1037 SGECLTMNHRCNGRRDCVDNSDEMNCDEEHRRKPKVLCSPNQFACHSGEQ----------CVDKE 1091
            ..|||..|..|  ::.|.:......|                 .|.:|.:          |.|.:
  Fly   633 VDECLVNNGGC--QQVCRNLPGSYGC-----------------ICAAGYELLKLDGIRGYCFDID 678

  Fly  1092 RRCDNRKDCHDHSDEQHCEKFDKSKKCHV---HQHGCDNG--KCVDSSLVCDGTND-------CG 1144
             .|..|  .|..||:..||..:.|..|..   :..|.||.  ..::||.:.|.|:.       |.
  Fly   679 -ECSQR--THGCSDQMLCENLNGSYTCLCPPGYALGLDNHIVTSLNSSFITDSTSSETPSAHTCL 740

  Fly  1145 DNSDELLCE-ATSRC------EPGMFQCGSGSCIAGSWECDGRIDCSDGSDEHDKCVHRSCPPDM 1202
            | .||  |. |...|      |||.|||                               :||   
  Fly   741 D-IDE--CSLANGNCSHFCQNEPGGFQC-------------------------------ACP--- 768

  Fly  1203 QRCLLGQCLDRSL-VCDGHNDCGDKSDELNCGTDSSTMNISCAEDQYQCTSNLKICLPSTVRCNG 1266
                ||..|...: .|...::|.|.:.:.:....:.....:||     |.:..:: .|....|..
  Fly   769 ----LGYALSEDMRTCQDIDECLDSNGQCSQLCLNQPGGFACA-----CETGFEL-TPDGFGCAD 823

  Fly  1267 TTECPRGEDEADCGDVC----SIYEFKCRSGRECIRREFRCDGQKDCGD--------------GS 1313
            ..||  .:|..:|.|:|    ..:...|..|.|..:.:..|....:|..              |:
  Fly   824 IDEC--SQDYGNCSDICINLLGTHACACERGYELAKDKLSCLDVDECAGLLSGGCSHECINKAGT 886

  Fly  1314 DELSCELEKGHHNQSQIQPWSTSSRSCRPHLFDCQDGE------CVDLSRVCNNFPDCTNGHDEG 1372
            .|..|.|  |:       ..:...|||.|.|..|..|.      |..:.  ||  |..|.|.|: 
  Fly   887 FECGCPL--GY-------ILNDDGRSCSPALVGCPPGTQRSADGCAPIE--CN--PGYTLGSDD- 937

  Fly  1373 PKCA--TACRSASGRQVCQHKCRATPAGAVCSCFDGYRLDADQKSCLDIDEC-QEQQPC-AQLCE 1433
             ||.  ..|:..:|.  |.|:|..|.....|||..||.||:|||:|.||||| |::..| ...|.
  Fly   938 -KCVDIDECQKQNGG--CSHRCSNTEGSFKCSCPPGYELDSDQKTCQDIDECDQDKTSCITGTCI 999

  Fly  1434 NTLGGYQCQCHADFMLRQDRVSCKSLQSG-----ATLLFSSFNEVRN-LSEQP 1480
            |.:||::|: ...|.:..:..:..||...     .|..:..|.|:.| :.|.|
  Fly  1000 NEIGGFRCE-FPKFPVLPEIPTASSLPESPKIELKTPKYPDFTELSNEIPENP 1051

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ylNP_996433.1 LDLa 90..124 CDD:238060
LDLa 131..166 CDD:238060
LDLa 184..216 CDD:238060 2/7 (29%)
LDLa 227..262 CDD:238060 11/42 (26%)
LDLa 271..302 CDD:238060 7/53 (13%)
FXa_inhibition 352..387 CDD:291342 15/34 (44%)
Ldl_recept_b 442..482 CDD:278487 9/45 (20%)
LY 466..508 CDD:214531 10/41 (24%)
Ldl_recept_b 529..569 CDD:278487 0/39 (0%)
LY 553..595 CDD:214531 4/41 (10%)
LY 596..637 CDD:214531 8/40 (20%)
FXa_inhibition 669..700 CDD:291342 12/30 (40%)
LY 774..815 CDD:214531 4/41 (10%)
LDLa 1032..1062 CDD:238060 7/29 (24%)
LDLa 1074..1109 CDD:238060 9/44 (20%)
LDLa 1118..1152 CDD:238060 12/45 (27%)
LDLa 1157..1189 CDD:197566 7/37 (19%)
LDLa 1198..1232 CDD:238060 8/34 (24%)
LDLa 1243..1279 CDD:238060 8/35 (23%)
LDLa 1283..1318 CDD:238060 8/52 (15%)
LDLa 1340..1371 CDD:197566 11/36 (31%)
FXa_inhibition 1388..1416 CDD:291342 14/27 (52%)
EGF_CA 1418..1452 CDD:214542 13/35 (37%)
fracNP_001137905.1 FXa_inhibition 296..331 CDD:291342 15/34 (44%)
cEGF 396..415 CDD:289433 3/18 (17%)
FXa_inhibition 425..458 CDD:291342 16/136 (12%)
FXa_inhibition 476..505 CDD:291342 12/30 (40%)
vWFA <550..586 CDD:294047 10/99 (10%)
FXa_inhibition 596..630 CDD:291342 12/43 (28%)
FXa_inhibition 636..>664 CDD:291342 8/46 (17%)
EGF_CA 676..715 CDD:284955 12/41 (29%)
FXa_inhibition 745..780 CDD:291342 14/72 (19%)
FXa_inhibition 786..821 CDD:291342 6/40 (15%)
FXa_inhibition 827..862 CDD:291342 8/36 (22%)
FXa_inhibition 874..904 CDD:291342 6/38 (16%)
FXa_inhibition 945..980 CDD:291342 16/36 (44%)
CCP 1110..1170 CDD:153056
CCP 1183..1235 CDD:153056
DUF5011 1468..1536 CDD:295940
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - P PTHR24034
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
22.010

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