DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment yl and ldlra

DIOPT Version :9

Sequence 1:	NP_996433.1	Gene:	yl / 32367	FlyBaseID:	FBgn0004649	Length:	1984	Species:	Drosophila melanogaster
Sequence 2:	NP_001025454.1	Gene:	ldlra / 387529	ZFINID:	ZDB-GENE-031217-1	Length:	911	Species:	Danio rerio

Alignment Length:	970	Identity:	261/970 - (26%)
Similarity:	399/970 - (41%)	Gaps:	244/970 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 CGGTAAGTPGSADTR-CDAGQFQCRDGG----CILQAKMCDGRGDCKDSSDELDCDYRLCRPPHW 134
            ||......|.:...: |...||.|  ||    ||.::..|||:.||::::||..||.|.|....
Zfish    49 CGDGTDELPAACLAKTCRPSQFSC--GGRLNQCIPKSWKCDGKADCENNADEEGCDPRQCHDGE- 110

  Fly   135 FPCAQPHGACLAAELMCNGIDNCPGGEDELNCPVRPGFRFGDTAHRMRSCSKYEFMCQQDRTCIP 199
            |.|..  |.|:.|..:|:...:|..|.||::||             ..:|....|.| .:..|:|
Zfish   111 FRCGS--GQCVTAAFVCDDEIDCEDGSDEVSCP-------------PTTCGSSSFRC-NNAQCVP 159

  Fly   200 IDFMCDGRPDCTDKSDEV------AGCKQAEITCPGEGHLCANGRCLRRKQWVCDGVDD------ 252
            ..::|||..||.|.|||:      ...|..:..|......|.:|.|: ...|.|||..|
Zfish   160 RLWVCDGDADCADNSDELPEKCGPGTSKPTKNPCTSMEFHCGSGECI-HGSWKCDGGADCLDHSD 223

  Fly   253 ---------------CGDG------------------SDERGCLNL--CEPQKGKFLCRNRETCL 282
                           ||||                  |||.||:|.  |||.. :|.||:.| |:
Zfish   224 EQNCSLPTCRPDEFQCGDGSCIHGSRQCNHVYDCKDMSDELGCVNATHCEPPY-RFKCRSGE-CI 286

  Fly   283 TLSEVCDGHSDCSDGSDETDLCHSKP--DCDAKKCAL--GAKCHMMP--ASGAECFCPKGFRLAK 341
            ::.:||:...||.|.|||       |  :||:.:|..  |...|:..  ..|.||.||.||||..
Zfish   287 SMEKVCNKQRDCRDWSDE-------PLRECDSNECLYNNGGCSHICNDLKIGYECLCPTGFRLVD 344

  Fly   342 FEDKCEDVDECKEQDDLCSQGCENTSGGYRCVCDAGYLLDKDNRTCRA---VVYGSKEQQPLLLY 403
             :.:|||:||| ...|.|||.|.|..|.|:|.|:.||.:|..::.|:|   :.|        |.:
Zfish   345 -KRRCEDIDEC-ANPDTCSQICVNQMGSYKCECEDGYQMDPASKACKAIGTIAY--------LFF 399

  Fly   404 TTQMTIMGMHLREDNVRNHVYQVAGNLSKVIGVAYD--GSHIYWTNIQNEAESIVKANGDGSNAE 466
            |.:..:..|.|.    |:...:|...|..|:.:..:  ...|||:
Zfish   400 TNRHEVRKMTLD----RSEYIRVIPRLKNVVALDMNIASRDIYWS-------------------- 440

  Fly   467 ILLTSGLDAPEDLAVDWLTQNIYFSDNIMRHIAVCSNDGLNCAVLVTQDVHQPRSLAVWPQKGLM 531
                       ||::    :.||   :|...|:|.:.||.....|..:::.:||::.|.|.|..|
Zfish   441 -----------DLSL----KKIY---SIRGAISVATADGSRRKTLFKENLAKPRAIVVDPIKNFM 487

  Fly   532 FWTDWGEKPMIGRASMDGSRSRPIVSDNIEWPNGIALDMHQQRIYWVDAKLGSVQTVRPDGTGRR 596
            ||||||....|.::.::|.....:|:|:|.|||||.||:..:|:||||:||.::.::...|.|||
Zfish   488 FWTDWGTPAKIEKSGLNGVDRSTLVADDIVWPNGITLDLLTERLYWVDSKLHTLSSISVQGDGRR 552

  Fly   597 TVL--DGMLKHPYGLAIFEDQLYWSDWATKSVHACHKFSGKD------HRILAKDRTIYAVHIYH 653
            |::  .|.|.||..|.:||::::|:|.:..::.:.::.:|.|      |....:|     :.::|
Zfish   553 TLIIDQGKLAHPLSLTVFEEKVFWTDVSNNAILSANRVTGGDITKVAEHLSSPED-----IVLFH 612

  Fly   654 PAKQPNSPHGC--ENATCSHLCLLAEPEIG----GHSCACPDGMRLAPDHRRCMLMEKRQRLFIG 712
            ..|||...:.|  .|..|..|| ||.|:|.    .::|||||.|.||.|.|:|:     ..:...
Zfish   613 NLKQPTGINWCRINNGGCEFLC-LAAPQINRFSPKYTCACPDNMMLARDMRKCV-----PAVVTA 671

  Fly   713 LGQVLLEIEHTAFGRHQVSKSYT----LPCLINEM--------VYNRINGSLIIADNDQRLILEF 765
            ...|..||..|.  |.||....|    .|...|..        :.||...:..:..:.....|.|
Zfish   672 ATPVRPEIPTTI--RPQVPSETTPKPARPSTTNSQPLPTPAPKIPNRPTQAATLVPSQATTKLPF 734

  Fly   766 --QPESHESNVLVRSNLGNVSALAFDHLSRNLYWA--DTERAVIEVLSLQTRHRALIRFF----P 822
              |.:.|         .|:|.|::  ..|.:..||  .....|..::.....|:.:...|    |
Zfish   735 FTQTDVH---------FGDVKAVS--DTSSSTLWALYIVVPLVPFIIHSGMNHQLIQHVFRQRMP 788

  Fly   823 GQEVPIGLTVMPAEGYLYVVLKAKRHSH-IDKIPLSGKGEQVHVFEDDLGDDDIKLVTDYETQTI 886
            .|..||                :::|.| :...........:|::...:|:......:.:|.:
Zfish   789 FQPQPI----------------SRKHPHTLIHTDTDNLAYPIHLYRLTVGETGAPGGSPHEHR-- 835

  Fly   887 FWSDSDLGRISYSNYRVPHSQIFRGKLRRP----YSLAMVHHDLFWNELGTPRIYWTHKS 942
                        .|.:.||.....|..:||    ..|.:....|||.:       |..|:
Zfish   836 ------------ENIQTPHRNTSCGLNQRPSCSLLCLVVGGAALFWRK-------WRQKN 876

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
yl	NP_996433.1	LDLa	90..124	CDD:238060	15/37 (41%)
		LDLa	131..166	CDD:238060	10/34 (29%)
		LDLa	184..216	CDD:238060	12/31 (39%)
		LDLa	227..262	CDD:238060	16/73 (22%)
		LDLa	271..302	CDD:238060	13/30 (43%)
		FXa_inhibition	352..387	CDD:291342	14/34 (41%)
		Ldl_recept_b	442..482	CDD:278487	5/39 (13%)
		LY	466..508	CDD:214531	9/41 (22%)
		Ldl_recept_b	529..569	CDD:278487	17/39 (44%)
		LY	553..595	CDD:214531	18/41 (44%)
		LY	596..637	CDD:214531	13/48 (27%)
		FXa_inhibition	669..700	CDD:291342	17/34 (50%)
		LY	774..815	CDD:214531	7/42 (17%)
		LDLa	1032..1062	CDD:238060
		LDLa	1074..1109	CDD:238060
		LDLa	1118..1152	CDD:238060
		LDLa	1157..1189	CDD:197566
		LDLa	1198..1232	CDD:238060
		LDLa	1243..1279	CDD:238060
		LDLa	1283..1318	CDD:238060
		LDLa	1340..1371	CDD:197566
		FXa_inhibition	1388..1416	CDD:291342
		EGF_CA	1418..1452	CDD:214542
ldlra	NP_001025454.1	LDLa	23..55	CDD:197566	2/5 (40%)
		Ldl_recept_a	63..101	CDD:365841	15/39 (38%)
		LDLa	106..140	CDD:238060	11/36 (31%)
		LDLa	144..176	CDD:197566	12/32 (38%)
		Ldl_recept_a	192..227	CDD:365841	9/35 (26%)
		Ldl_recept_a	231..266	CDD:365841	7/34 (21%)
		LDLa	274..304	CDD:238060	12/31 (39%)
		FXa_inhibition	314..348	CDD:373209	12/34 (35%)
		EGF_CA	350..380	CDD:214542	15/30 (50%)
		Ldl_recept_b	437..481	CDD:278487	15/81 (19%)
		Ldl_recept_b	485..525	CDD:278487	17/39 (44%)
		LY	510..551	CDD:214531	18/40 (45%)
		Ldl_recept_b	572..611	CDD:278487	6/43 (14%)
		FXa_inhibition	623..664	CDD:373209	19/41 (46%)
		PHA03247	<666..808	CDD:223021	31/170 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1215
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002088
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.810