DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment yl and Lrp8

DIOPT Version :9

Sequence 1:	NP_996433.1	Gene:	yl / 32367	FlyBaseID:	FBgn0004649	Length:	1984	Species:	Drosophila melanogaster
Sequence 2:	XP_006238632.1	Gene:	Lrp8 / 362558	RGDID:	1305729	Length:	1013	Species:	Rattus norvegicus

Alignment Length:	798	Identity:	245/798 - (30%)
Similarity:	362/798 - (45%)	Gaps:	182/798 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 RHVAISLLLLVGLCG----GTAAGTPGSAD--TRCDAGQFQCRDGGCILQAKMCDGRGDCKDSSD 120
            |.:|:.||||:.|..    .||...||...  ..|:..||:||:..||.....||...||.|:||
  Rat    10 RPLALLLLLLLLLLQLQHLSTADPLPGGQGPVKECEEDQFRCRNERCIPSVWRCDEDNDCSDNSD 74

  Fly   121 ELDCDYRLCRPPHWFPCAQPHGACLAAELMCNGIDNCPGGEDEL-------NCPVRPGFRFGDTA 178
            |.||..|.|.... |.|  .:|.|:.....|:|.:.||.|.||.       .||... ...|.|:
  Rat    75 EDDCPKRTCTDSD-FTC--DNGHCIPERWKCDGEEECPDGSDESKATCSSEECPAEK-LSCGPTS 135

  Fly   179 HRM-----------------------RSCSKYEFMCQQDRTCIPIDFMCDGRPDCTDKSDEVAGC 220
            |:.                       ..|:.:||.| .:|:|:...|:|||..||.|.||| .||
  Rat   136 HKCVPASWRCDGEKDCEGGADEAGCPTLCAPHEFQC-SNRSCLASVFVCDGDDDCGDGSDE-RGC 198

  Fly   221 KQAEITCPGEGHLCANGRCLRRKQWVCDGVDDCGDGSDERGCL------------NLCEPQKGKF 273
              ::..||.....|..|.....::|||||..||.|.|||...|            ..|.|.. :|
  Rat   199 --SDPACPPREFRCGGGGTCIPERWVCDGQFDCEDRSDEAAELCGRAGQGTTATPAACAPTT-QF 260

  Fly   274 LCRNRETCLTLSEVCDGHSDCSDGSDETDL------------------------CHSKPDC---- 310
            .||:.| |:.|...|||..||.|.|||.|.                        |:.:.||
  Rat   261 TCRSGE-CIHLGWRCDGDRDCKDKSDEADCSAPGPCRENDFQCGDGTCILAIKRCNQERDCLDGS 324

  Fly   311 DAKKCALGAKC------------------------------------------------------ 321
            |...|...:.|
  Rat   325 DEAGCLQESTCEGPRRFQCKSGECVDGGKVCDDQRDCRDWSDEPQKVCVAPIFQGNRRRPRGLNE 389

  Fly   322 ---------HMMP--ASGAECFCPKGFRLAKFEDKCEDVDECKEQDDLCSQGCENTSGGYRCVCD 375
                     |:..  ..|.||.||.||:|.. :..|.|:|||:: .|.|||.|.|..|.::|.|.
  Rat   390 CLHNNGGCSHICTDLKIGFECTCPAGFQLLD-QKTCGDIDECQD-PDACSQICVNYKGYFKCECH 452

  Fly   376 AGYLLDKDNRTCRAVVYGSKEQQPLLLYTTQMTIMGMHLREDNVRNHVYQVAGNLSKVIG--VAY 438
            .||.:|...:.|:||.    .:.|.|::|.:..:.    |.|.|:....::...|..|:.  |..
  Rat   453 PGYEMDTLTKNCKAVA----GRSPSLIFTNRHEVR----RIDLVKRDYSRLIPMLKNVVALDVEV 509

  Fly   439 DGSHIYWTNIQNEAESIVKANGDGSNAE----ILLTSGLDAPEDLAVDWLTQNIYFSDNIMRHIA 499
            |.:.|||.::  ....|..|:.|.::..    :|:...|.:||.|||||:.::||::|:..:.::
  Rat   510 DTNRIYWCDL--SYRKIYSAHMDKASIPDEQVVLIGEQLHSPEGLAVDWVHKHIYWTDSGNKTVS 572

  Fly   500 VCSNDGLNCAVLVTQDVHQPRSLAVWPQKGLMFWTDWGEKPMIGRASMDGSRSRPIVSDNIEWPN 564
            |.:.||.....|..:|:.:||::||.|.:|.|:|:|||.:..|.:|.::|:..:.:|||||||||
  Rat   573 VATTDGRRRCTLFNRDLSEPRAIAVDPLRGFMYWSDWGFQAKIEKAGLNGADRQTLVSDNIEWPN 637

  Fly   565 GIALDMHQQRIYWVDAKLGSVQTVRPDGTGRRTVL--DGMLKHPYGLAIFEDQLYWSDWATKSVH 627
            ||.||:..||:||||:||..:.::..:|..|:.::  ...|.||:|:|:|||:::|:|...:::.
  Rat   638 GITLDLLSQRLYWVDSKLHQLSSIDFNGGNRKMLIFSTDFLSHPFGVAVFEDKVFWTDLENEAIF 702

  Fly   628 ACHKFSGKDHRILAKD-RTIYAVHIYHPAKQPNSPHGCE-----NATCSHLCLLAEPEIGGHS-- 684
            :.::.:|.:..|||:: ...:.:.|:|..|||.:...||     |..|.:|||.| |:|..||
  Rat   703 SANRLNGLEISILAENLNNPHDIVIFHELKQPKAADACELSAQPNGGCEYLCLPA-PQISSHSPK 766

  Fly   685 --CACPDGMRLAPDHRRC 700
              |||||.|.|.||.:||
  Rat   767 YTCACPDTMWLGPDMKRC 784

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
yl	NP_996433.1	LDLa	90..124	CDD:238060	15/33 (45%)
		LDLa	131..166	CDD:238060	11/41 (27%)
		LDLa	184..216	CDD:238060	14/31 (45%)
		LDLa	227..262	CDD:238060	15/34 (44%)
		LDLa	271..302	CDD:238060	15/30 (50%)
		FXa_inhibition	352..387	CDD:291342	13/34 (38%)
		Ldl_recept_b	442..482	CDD:278487	12/43 (28%)
		LY	466..508	CDD:214531	15/45 (33%)
		Ldl_recept_b	529..569	CDD:278487	20/39 (51%)
		LY	553..595	CDD:214531	22/41 (54%)
		LY	596..637	CDD:214531	11/42 (26%)
		FXa_inhibition	669..700	CDD:291342	18/34 (53%)
		LY	774..815	CDD:214531
		LDLa	1032..1062	CDD:238060
		LDLa	1074..1109	CDD:238060
		LDLa	1118..1152	CDD:238060
		LDLa	1157..1189	CDD:197566
		LDLa	1198..1232	CDD:238060
		LDLa	1243..1279	CDD:238060
		LDLa	1283..1318	CDD:238060
		LDLa	1340..1371	CDD:197566
		FXa_inhibition	1388..1416	CDD:291342
		EGF_CA	1418..1452	CDD:214542
Lrp8	XP_006238632.1	LDLa	44..78	CDD:238060	15/33 (45%)
		LDLa	82..114	CDD:197566	10/34 (29%)
		LDLa	124..160	CDD:238060	5/36 (14%)
		LDLa	203..235	CDD:197566	13/31 (42%)
		LDLa	256..289	CDD:238060	16/34 (47%)
		LDLa	295..329	CDD:238060	4/33 (12%)
		LDLa	333..369	CDD:294076	1/35 (3%)
		FXa_inhibition	390..424	CDD:291342	9/34 (26%)
		EGF_CA	426..456	CDD:214542	14/30 (47%)
		LY	495..530	CDD:214531	9/36 (25%)
		LY	540..581	CDD:214531	15/40 (38%)
		Ldl_recept_b	602..642	CDD:278487	20/39 (51%)
		LY	626..668	CDD:214531	22/41 (54%)
		Ldl_recept_b	689..728	CDD:278487	7/38 (18%)
		FXa_inhibition	747..784	CDD:291342	19/37 (51%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1215
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002088
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.900