DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment yl and Lrp4

DIOPT Version :10

Sequence 1:NP_996433.1 Gene:yl / 32367 FlyBaseID:FBgn0004649 Length:1984 Species:Drosophila melanogaster
Sequence 2:NP_727914.1 Gene:Lrp4 / 32552 FlyBaseID:FBgn0030706 Length:2009 Species:Drosophila melanogaster


Alignment Length:2149 Identity:508/2149 - (23%)
Similarity:805/2149 - (37%) Gaps:616/2149 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    30 NLTSQTRAHPSSGGSTSSRYGNCQRTH-----------LIIN--------GRHV-------AISL 68
            ||....:..||..|.|   |.|||.::           .:.|        |.||       .||.
  Fly   181 NLAVLVQDDPSQPGET---YSNCQNSNESDENCNPEEDAVPNLQRDCEKTGIHVMCPRTFRCISK 242

  Fly    69 LLLV---GLCGGTAAGTPGSADTRCDAGQFQCRDGGCILQAKMCDGRGDCKDSSDELDCDYRLCR 130
            ..|.   ..||..:..|...|.|.|...||:|.:|.||.:..:|||..||||.|||..|:...|.
  Fly   243 YWLCDGDDDCGDYSDETHCGARTNCTDDQFECLNGFCIPRTWVCDGENDCKDFSDETHCNRTTCT 307

  Fly   131 PPHW----------------------------------------FPC-------AQPHGACLAAE 148
            ..|:                                        |.|       ..|.|.|:...
  Fly   308 DEHFTCNDGYCISLAFRCDGEHDCNDNSDELKCAAVINSCPEGEFKCRGGLGGAGGPSGQCILNR 372

  Fly   149 LMCNGIDNCPGGEDELNCPVRPGFRFGDTAHRMRSCSKYEFMCQQDRTCIPIDFMCDGRPDCTDK 213
            ..|:|.::|....||.|||.:|..           |:..|:.| .|.||||..:.||...||...
  Fly   373 FRCDGDNDCGDWSDEENCPQKPSL-----------CTSNEYKC-ADGTCIPKRWKCDKEQDCDGG 425

  Fly   214 SDEVAGC----KQAEITCPGEGHLCANGRCLRRKQWVCDGVDDCGDGSDERGCLNLCEPQKGKFL 274
            .|| ..|    .:..:||..:...|.||||: .|.|:|||..||..|.||..|...|:  .|:||
  Fly   426 EDE-NDCGSLGSEHPLTCGSDEFTCNNGRCI-LKTWLCDGYPDCAAGEDEVECHLQCD--LGQFL 486

  Fly   275 C------RNRETCLTLSEVCDGHSDCSDGSDETDLCHSKPDCDAKKCALGAKCHMM----PASGA 329
            |      .|.:.|:....:||||::|..|.||.| |..:     :||:..:.|..:    .|...
  Fly   487 CPTKQNLTNLKICVHQKHICDGHNECPAGEDEAD-CPKE-----RKCSEPSPCEQLCIETTAGSN 545

  Fly   330 ECFCPKGFRLAKFEDKCEDVDECKE-QDDLCSQGCENTSGGYRCVCDAGYLLDKDNRTCRAVVYG 393
            ||.|..|:.:.|.:..|.|:|||:. ...:|||.|.||.|.::|.|:.||:|..|.|:|:|:  |
  Fly   546 ECACRLGYVMDKNKVNCTDIDECQYLTSPVCSQKCHNTMGSFKCSCETGYILRPDLRSCKAL--G 608

  Fly   394 SKEQQPLLLYTTQMTIMGMH---LREDNVRNHVYQVAGNLSKVI-----GVAYDGSH----IYWT 446
            .           .||::..:   :|...:.|:.|      |.::     .:|.|..|    ::|:
  Fly   609 G-----------AMTLLVANRWDIRRVTLSNNRY------SAIVKGLHNAIALDFHHRKGLMFWS 656

  Fly   447 NIQNEAESIVKANGDGSNAEILLTSGLDAPEDLAVDWLTQNIYFSDNIMRHIAVCSNDGLNCAVL 511
            ::..:...:|..|  |:....::..||::|..:||||:...::::|:..|.:.|.:..|....|:
  Fly   657 DVSTDVIKMVYMN--GTRVRDVIKWGLESPGGIAVDWIHDLLFWTDSGTRRVEVSNFQGNLRTVI 719

  Fly   512 VTQDVHQPRSLAVWPQKGLMFWTDWGEKPMIGRASMDGSRSRPIVSDNIEWPNGIALDMHQQRIY 576
            .:.|:.:||::.|.|.:.|.||:|||..|.|.||.|||::.:.|:|..:.||||:|:|....:||
  Fly   720 ASYDLDKPRAIVVHPGEALAFWSDWGPNPKIERAYMDGTQRKVIISKGVTWPNGLAIDFPNSKIY 784

  Fly   577 WVDAKLGSVQTVRPDGTGRRTVLDGMLKHPYGLAIFEDQLYWSDWATKSVHACHKFSGKDHRILA 641
            |.|||..:::....||:.|..:|...|.||:.|.:|||.:||:||.||:|.|..|.:||:.|.:.
  Fly   785 WADAKQHAIECSNLDGSDRNKILSTHLPHPFALTLFEDTMYWTDWNTKTVSAADKITGKEFRAVH 849

  Fly   642 KD-RTIYAVHIYHPAKQPNSPHGCE------NATCSHLCLLAEPEIGGHSCACPDGMRLAPDHRR 699
            :: .....:|.||||:||.....|:      ...||||||   |......|.||.|:.|..|.:.
  Fly   850 ENFHFPMDIHAYHPARQPEYADRCQKDRRGLRGGCSHLCL---PNKTSRRCGCPIGLSLKEDGKT 911

  Fly   700 C-------MLMEKRQRLFIGLGQVLLEIEHTAFG----------------RHQVSKSYTLPCLIN 741
            |       :|:.:|:.         :.:.|....                :|.|:..:   |...
  Fly   912 CKSTADKLVLVARRKD---------IRLRHLRDNQADPNDVDMIVPLDNLKHAVALDW---CSDT 964

  Fly   742 EMVY------NRINGSLIIADNDQRLILEFQPESHESNVLVRSNLGNVSALAFDHLSRNLYWADT 800
            :.:|      :.||.:.:.....||              :|.|||.:...||.|.::..|||.|.
  Fly   965 DFIYWTDVERSTINKAHLNGSYQQR--------------VVHSNLVSPVGLALDWITDKLYWTDP 1015

  Fly   801 ERAVIEVLSLQTRHRALIRFFPGQEVPIGLTVMPAEGYLY--------VVLKAKRHSHIDKIPLS 857
            ....|||.:...:.|.|: .:.....|..:.|.|.||:::        ::.:|....| :::.::
  Fly  1016 STNRIEVATTNGKMRTLL-IWEKLYKPRDIVVNPIEGFMFWSDWGDDPMIERANMDGH-ERVTIT 1078

  Fly   858 GKGEQVHVFEDDLGDDDIKLV------TDYETQTIFWSDSDLGRISYSNYRVPHSQIFRGKLRRP 916
            .|                ||:      .|||...|::.|.....:...|:.....|:....|..|
  Fly  1079 SK----------------KLIYPNGLAIDYEKSKIYFVDGGTKTLENMNFDGSGRQVILNGLGHP 1127

  Fly   917 YSLAMVHHDLFWNELGTPRIYWTHKSNMGPRKVIDIMEKDDPAAIMPYVPVATPNGIPLAASSPV 981
            :.|.:....:||.:       |..||.|...|   :..||              ..:.:|.|:.:
  Fly  1128 FGLDVNEGRVFWTD-------WDTKSVMSANK---LTGKD--------------TNVIIANSTDL 1168

  Fly   982 ----------GQESHPCQQQNGGCSHICVGEGPYHSICLCPAGFVYRDAGNRTCVEALDCEFRCH 1036
                      .:..:.|.:.||||||:|: ..|....|.|..|...:: ...||.|.        
  Fly  1169 MDIRVFHRTRRRIFNACDKLNGGCSHLCL-LNPTSYTCACTVGVQLKE-DRHTCSEG-------- 1223

  Fly  1037 SGECLTMNHRCNGRRDCVDNSDEMNCDEEHRRKPKVLCSPNQFACHSGEQCVDKERRCDNRKDCH 1101
            ..:.:...||.:.|        :::.|.:|.....:...|     .|....:|.:|:..      
  Fly  1224 PTQYILFAHRIDIR--------QISLDFDHLIDVVLPLPP-----ISNAVALDVDRKTG------ 1269

  Fly  1102 DHSDEQHCEKFDKSKKCHVHQHGCDNGKCVDSSLVCDG------TNDCGDNSDELLCEATSRCEP 1160
                               :.:..|..:.|..|...||      ..|..:|.|.|:.::..|   
  Fly  1270 -------------------YIYWSDTIENVIMSSSPDGLHVQKIVGDSLENPDGLVVDSIGR--- 1312

  Fly  1161 GMFQCGSGSCIAGSWECDGR----IDCSDGSDEH-----DKCVHRSCPPDMQRCLL-------GQ 1209
                       ...|...||    :...|||:.|     |....|....|.:..||       .:
  Fly  1313 -----------TIYWADAGRHTIEVASLDGSNRHVIAYKDLESPRGLALDYEAGLLFWTDWGHYR 1366

  Fly  1210 CLDRSLVCDGHNDCGDKSD--ELNCG------TDSSTMNISCAE------DQYQCTSNLKICLPS 1260
            .::||     |.|..::|.  ..|.|      .|..:..|...:      |....|.|.:..:.|
  Fly  1367 KIERS-----HLDGNERSRIVTANLGWPNGLSLDLKSKRIYWVDARLKTIDSCDYTGNQRKLIMS 1426

  Fly  1261 TVRCNGTTECPRGEDEADCGDVCSIY--EFKCRSGRECIRREFRCDGQKDCGDGSDELSCELEKG 1323
            ::  :........:|        :||  ::|.::.....||..  ..::|.....|.| .:::..
  Fly  1427 SL--HHPYALALSDD--------NIYWTDWKSKALHMTERRNI--SAKRDIITNIDGL-MDIKII 1478

  Fly  1324 HHNQSQIQPWSTSSRSCRPHLFDCQDGECVDLSRVCNNFPDCTNGHDEGPKCATACRSASGRQVC 1388
            :.||:|    ||...:|.                  ||     ||:                  |
  Fly  1479 YQNQNQ----STMKNACG------------------NN-----NGN------------------C 1498

  Fly  1389 QHKCRATPAGAVCSCFDGYRLDADQKSCLDIDECQEQQPCAQLCENTLGGYQCQCHADFMLRQDR 1453
            .|.|...|:|..|.|..|.||               :|.....|:|        ...|::|    
  Fly  1499 SHLCLRNPSGYSCQCPIGLRL---------------RQNSTTQCQN--------LPEDYLL---- 1536

  Fly  1454 VSCKSLQSGATLLFSSFNEVRNLSEQPVMLNVAWSANDSRITGFDLAMHRQMGYFSAEDEGIVYQ 1518
               .:|:||..::  |.|. .:..:..:.:|....|     ...|....:.:.:|:..:..::.:
  Fly  1537 ---IALRSGIGMI--SLNS-GDFMDVVLPINGVHGA-----VVLDYHYRKNLLFFADVNLDVIRR 1590

  Fly  1519 IDL----QTKVIVRALGLPAPTKLSVDWVTGNVYVLSGAQEIQACSFVGRMC-GRIV--HVKSPR 1576
            ::|    ::|||| ...:..|..::|||:..|:|.....:::...|.:...| .|||  ::..||
  Fly  1591 VNLLNLTESKVIV-GTDVLTPNGIAVDWIADNLYWSDTDRKLIEVSRLDGSCRKRIVEDNLGDPR 1654

  Fly  1577 HVKHLAVDGYHARIFYIVIRTEGYGQTSSEIHMARLDGSRRDMLLQRSESFMTALTTDPHQQLLY 1641
               .|.|....|.:|:      ....:.::|..:.||||.|.:::.....|.|.||.|...:.|.
  Fly  1655 ---SLIVHPKKAYLFW------SDWSSPAKIERSYLDGSNRTVIITSGIGFPTGLTIDFTNRRLL 1710

  Fly  1642 FVDQHMRTLERISYRLKTGPMRRPEIMLQKSNALMHPSGLSVYENNAFIVN-------------- 1692
            :.|.....:.::.:..|    ||..|:....    ||.||:::||:.|..:              
  Fly  1711 WADALEDNIGQVDFNGK----RRQTIVPYAP----HPFGLTLFENSIFWTDWYNKSVYRSQKLAR 1767

  Fly  1693 --LGSVEAVQCALYGSRICHKISINVLNAQDIVVAGRSRQPQKASHPCA--HAHCHGLCLQADYG 1753
              .|:...|:.||.|             |.||.....||||:..:| ||  :..|..|||..:..
  Fly  1768 SGYGNPFEVRDALSG-------------ALDIRAVSLSRQPKSVNH-CAQDNGGCTHLCLNRNVD 1818

  Fly  1754 YECMCGNRLVAEGERCP-------HGS----------------GNEVAVLGAVNSLELEHEHEQN 1795
            |.|.|.:.:..:...|.       |.:                .....:||..|      :|..:
  Fly  1819 YVCACPDVMDPKDVACSIKPKVLVHANLENDQLLEYSDESTDDSTPPELLGESN------DHGDD 1877

  Fly  1796 GH---------FHWLMALFVLAAGSLIAGLGYMYYQY---------RQRGHTDLNINMHFQNPLA 1842
            ||         |..|:||.|:....:|..|......:         ..||.:  ...:.|.||..
  Fly  1878 GHTKKSDQEREFFVLVALGVVIVMVVIIILVIFMLAFNTSKKKNKRNSRGSS--RSVLTFSNPNY 1940

  Fly  1843 TLGGT---------KAF----LEHERAEAGV----GFTTETG-------TVSSRGSNDTFT---T 1880
            .:.||         |.|    ...||  |||    ..||||.       |.|...|..|.|   |
  Fly  1941 NVDGTPMEPKTNIWKRFKYDKTHQER--AGVYEERSLTTETASSSLFVPTPSPMASPSTKTIQLT 2003

  Fly  1881 TSAT 1884
            |.:|
  Fly  2004 TLST 2007

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ylNP_996433.1 LDLa 90..124 CDD:238060 17/33 (52%)
LDLa 131..166 CDD:238060 11/81 (14%)
LDLa 184..216 CDD:238060 12/31 (39%)
LDLa 227..262 CDD:238060 16/34 (47%)
LDLa 271..302 CDD:238060 14/36 (39%)
FXa_inhibition 352..387 CDD:464251 15/35 (43%)
Ldl_recept_b 442..483 CDD:459654 10/44 (23%)
LY 466..508 CDD:214531 11/41 (27%)
Ldl_recept_b 529..569 CDD:459654 20/39 (51%)
LY 553..595 CDD:214531 16/41 (39%)
LY 596..637 CDD:214531 19/40 (48%)
FXa_inhibition 669..700 CDD:464251 13/30 (43%)
LY 774..815 CDD:214531 14/40 (35%)
LDLa 1032..1062 CDD:238060 3/29 (10%)
LDLa 1074..1109 CDD:238060 4/34 (12%)
LDLa 1118..1152 CDD:238060 9/39 (23%)
LDLa 1157..1189 CDD:197566 7/35 (20%)
LDLa 1198..1232 CDD:238060 8/42 (19%)
LDLa 1243..1279 CDD:238060 5/41 (12%)
LDLa 1283..1318 CDD:238060 8/36 (22%)
LDLa 1340..1371 CDD:197566 5/30 (17%)
FXa_inhibition 1388..1416 CDD:464251 10/27 (37%)
EGF_CA 1418..1452 CDD:214542 5/33 (15%)
Lrp4NP_727914.1 LDLa 267..301 CDD:238060 17/33 (52%)
LDLa 306..340 CDD:238060 2/33 (6%)
LDLa 347..390 CDD:238060 10/42 (24%)
LDLa 397..431 CDD:238060 14/35 (40%)
LDLa 442..476 CDD:238060 16/34 (47%)
LDLa 480..521 CDD:238060 16/43 (37%)
FXa_inhibition 576..604 CDD:464251 14/27 (52%)
LY 634..671 CDD:214531 6/38 (16%)
LY 680..714 CDD:214531 10/33 (30%)
LY 718..760 CDD:214531 19/41 (46%)
Ldl_recept_b 740..777 CDD:459654 19/36 (53%)
LY 761..803 CDD:214531 16/41 (39%)
LY 806..838 CDD:214531 16/31 (52%)
FXa_inhibition 882..912 CDD:464251 13/32 (41%)
LY 946..985 CDD:214531 6/41 (15%)
NHL <967..1142 CDD:302697 43/213 (20%)
LY 988..1030 CDD:214531 16/55 (29%)
NHL repeat 998..1037 CDD:271333 12/39 (31%)
NHL repeat 1038..1080 CDD:271333 7/42 (17%)
NHL repeat 1084..1119 CDD:271333 6/34 (18%)
FXa_inhibition 1185..1220 CDD:464251 12/36 (33%)
NHL 1260..>1445 CDD:302697 40/238 (17%)
NHL repeat 1260..1296 CDD:271320 7/60 (12%)
LY 1292..1334 CDD:214531 11/55 (20%)
NHL repeat 1302..1337 CDD:271320 10/48 (21%)
NHL repeat 1345..1383 CDD:271320 9/42 (21%)
FXa_inhibition <1499..1525 CDD:464251 10/40 (25%)
LY 1600..1640 CDD:214531 11/40 (28%)
LY 1643..1686 CDD:214531 14/51 (27%)
LY 1688..1729 CDD:214531 8/44 (18%)
FXa_inhibition 1801..>1825 CDD:464251 9/23 (39%)

Return to query results.
Submit another query.